CN1488669A - Medicinal PVC sheet formulation - Google Patents
Medicinal PVC sheet formulation Download PDFInfo
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- CN1488669A CN1488669A CNA021436789A CN02143678A CN1488669A CN 1488669 A CN1488669 A CN 1488669A CN A021436789 A CNA021436789 A CN A021436789A CN 02143678 A CN02143678 A CN 02143678A CN 1488669 A CN1488669 A CN 1488669A
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Abstract
The formula of medicinal PVC tablet material comprises (by weight) medicinal resin WH-800, stabilizing agent organo-tin M282, antioxidant PDOP, impact modifier m-61, plasticizer LDN and processing adjuvant PA201, and its key lies in that on the basis of said formula the modifier 181 and lubricant 70S are added, so that the tensile strength of said product is 450 Kg+/sq.cm greater than or equal to 61.5, its falling ball impact breakage ratio is zero, heating expansion rate is plus or minus, 1.4-5.8, and its vapor permeability is g/sq.m.24h less than or equal to 0.016. and its over-all performance is more stable, its surface is smooth and its transparency is raised.
Description
The invention belongs to a kind of production formula technology that is used for the PVC sheet material of drug packaging.
Glass or Plastic Bottle are the main articles for use of drug packaging, but because the frangible and weight of vial is big, give to make to increase energy consumption and transport and increase certain cost, though Plastic Bottle is lighter, but,, usually need not the purchase of whole bottle for the user as the medicine of tablet or capsule formulation, only need several pieces or tens to get final product, tens of or become hundred one bottle packing just inconvenience use or be not suitable for market sale.Along with the development of new package material production technology, occurred through certain processing method, having realized to tablet or capsule formulation pharmaceutical packing with aluminium foil and nontoxic PVC sheet material; The PVC sheet material also can be made the interior pad of pin water or oral liquid packing bottle behind hot pressing, plastic uptake, play fixing, pallet effect, and these packaged forms are all more general.With its light weight, inexpensive, transparent, be convenient for carrying, advantage such as transportation, long quality-guarantee period won pharmaceutical packing market.Chang Yong drug packaging PVC sheet material in the market, its prescription by weight, mainly by 100 parts of medical resin WH-800,2 parts of stablizer organotin M282,0.3-0.6 part oxidation inhibitor PDOD, 5 parts of impact modifier m-61,0.8 part of softening agent LDN, 2 parts of processing aid PA201 form through plastic film production technique commonly used.In addition, its refining mould temperature on be limited on 110 ℃, rolling temperature and be limited to 175 ℃.The finished product of producing exists surface flatness and the thickness uniformity coefficient is poor, and stretching intensity is low, and impact cutting loss rate and heating expansion and contraction height are poor with the compound adsorptive power of aluminium foil, cause the water vapor permeation amount bigger than normal.Influenced the quality and the storage life of drug packaging, also made weakness such as wrapping body self intensity reduction.
The technical problem to be solved in the present invention is to add properties-correcting agent and lubricant on the production formula basis of existing PVC sheet material, and suitably increase the consumption of anti-impact modifier, processing aid and stablizer, reach the tensile strength, the shock resistance breakage rate that improve the medicinal PVC sheet material, reduce physical and chemical index such as heating expansion and contraction and water vapor permeation amount.
The scheme that solves the problems of the technologies described above is as follows:
The prescription of medicinal PVC sheet material by weight, comprise medical resin WH-800, stablizer organotin M282, oxidation inhibitor PDOP, anti-impact modifier m-61, softening agent LDN, processing aid PA201, key is to add 0.4-0.6 part properties-correcting agent 181,0.6-1.5 part lubricant 70S on the aforementioned formula basis.
Prescription according to aforesaid medicinal PVC sheet material, further scheme is the weight by constituent, 100 parts of medical resin WH-800 have been comprised in the prescription, 3.5 part stablizer organotin M282,0.3-0.6 part oxidation inhibitor PDOP, 8 parts of anti-impact modifier m-61,0.8 part softening agent LDN, 4 parts of processing aid PA201,0.4-0.6 part properties-correcting agent 181,0.6-1.5 part lubricant 70S.
According to above-mentioned prescription, after major ingredient medicinal polyvinyl chloride resin-oatmeal WH-800 dust suction, the processing of sieving, auxiliary materials such as stablizer M282, lubricant 70S, processing aid PA201, properties-correcting agent 181, oxidation inhibitor PDOP, softening agent LDN, anti-impact modifier m-61 are accurately measured, stir through homogenizer, reaching processing requirement sends material in the plastics processing mill refining by the grinding feeder and moulds, again through mediate, roll, peel off, cool off, roll, cut, operation such as check, obtain medicinal PVC sheet material finished product.
Advantage of the present invention is to have increased 0.4-0.6 part properties-correcting agent 181 on existing PVC sheet production prescription basis, 0.6-1.5 part lubricant 70S, again stablizer, organotin M282, bring up to 3.5 parts from original 2 parts, anti-impact modifier is brought up to 8 parts by original 5 parts, and processing aid is brought up to 4 parts by original 2 parts.Thereby the tensile strength that makes product is by 450Kgf/cm
2〉=45 bring up to 450Kgf/cm
2〉=61.5, it is 0 that the ball falling impact breakage rate is reduced to breakage rate by 7%, and the heating expansion and contraction is reduced to ± 1.4-5.8 by ± 7%, and the water vapor permeation amount is by g/m
2.24h≤2.5 be reduced to g/m
2.24h≤0.016.Simultaneously, smooth transparent, the stable of composite performance of product surface have all had tangible improvement, and the processing of product is also easier.
Fig. 1, technological process of production figure.
Below in conjunction with accompanying drawing,, aforementioned schemes is described further as embodiments of the invention.
With reference to process flow sheet, the production technique program for select materials 1, grinding material loading 2, refining mould 3, mediate 4, calendering 5, peel off 6, traction 7, cooling 8, roll 9, cut 10, check 11, packing 12, warehouse-in 13.Through dust suction, the medical polyvinyl of handling that sieves is the WH-800 powder, its quality index is Vcm<5ppm, choose 100Kg, get 3.5kg organotin M282 again as stablizer, 0.4Kg oxidation inhibitor PDOP, 8Kg anti-impact modifier m-61,0.8Kg softening agent LDN, 4Kg processing aid PA201,0.5Kg properties-correcting agent 181,1.2Kg lubricant 70S promptly finishes and selects materials and by the prescription burden process. the material of choosing inserted in the homogenizer stir, the material that stirs is sent into and is become the powder material loading in the grinding feeder, does to refine under 70 ℃ of-120 ℃ of temperature condition through machine again and moulds processing, send into and under 165 ℃ of-170 ℃ of temperature condition, be kneaded into soft shape in the forcing machine and extrude, under 70 ℃ of-180 ℃ of conditions, be rolled into thin slice through rolling press, peel off down thin slice and traction, be cooled to product in the bath in service of cooling roller to the cooling system that constitutes by several cooling roller, become tubular to roll, cutting into the specification that drug packaging is used again, is finished product through after the assay was approved, and member packing back warehouse-in is preserved.
According to the medicinal PVC sheet material that above-mentioned technological process is produced, its tensile strength is 450Kgf/cm
2〉=61.5, the ball falling impact breakage rate is 0, and the heating expansion and contraction is ± 1.4-5.8 that the water vapor permeation amount is g/m
2.24h≤0.016; Its over-all properties is more stable.In production technique, the upper limit that temperature is moulded in refining rises to 120 ℃ by 110 ℃ in addition, and the upper limit of rolling temperature rises to 180 ℃ by 175 ℃, and common relatively production technology exceeds 10 ℃ and 5 ℃ respectively.The slipperiness and the transparency of product surface have been increased.Make calendering and stretching more easy, thickness is more even.
Claims (2)
1, a kind of prescription of medicinal PVC sheet material, the prescription of medicinal PVC sheet material by weight, comprise medical resin WH-800, stablizer organotin M282, part oxidation inhibitor PDOP, anti-impact modifier m-61, softening agent LDN, processing aid PA201 is characterized in that adding 0.4-0.6 part properties-correcting agent 181,0.6-1.5 part lubricant 70S on the aforementioned formula basis.
2, the prescription of medicinal PVC sheet material according to claim 1, its feature is being weight by constituent, 100 parts of medical resin WH-800 have been comprised in the prescription, 3.5 part stablizer: organotin M282,0.3-0.6 part oxidation inhibitor PDOP, 8 parts of anti-impact modifier m-61,0.8 part softening agent LDN, 4 parts of processing aid PA201,0.4-0.6 part properties-correcting agent 181,0.6-1.5 part lubricant 70S.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNA021436789A CN1488669A (en) | 2002-10-08 | 2002-10-08 | Medicinal PVC sheet formulation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CNA021436789A CN1488669A (en) | 2002-10-08 | 2002-10-08 | Medicinal PVC sheet formulation |
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CN1488669A true CN1488669A (en) | 2004-04-14 |
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CNA021436789A Pending CN1488669A (en) | 2002-10-08 | 2002-10-08 | Medicinal PVC sheet formulation |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103172950A (en) * | 2013-03-29 | 2013-06-26 | 扬州新天然橡塑制品有限公司 | Production method of environment-friendly PVC (Polyvinyl Chloride) sheets |
CN105061929A (en) * | 2015-08-05 | 2015-11-18 | 江苏亚邦天龙医用新材料有限公司 | Non-phthalate medical PVC pellet |
CN106380746A (en) * | 2016-10-21 | 2017-02-08 | 扬州凯尔化工有限公司 | PVC (polyvinyl chloride) hard sheet applicable to medicinal package |
CN106800729A (en) * | 2016-12-30 | 2017-06-06 | 雷笑天 | A kind of preparation method of high grade of transparency medical PVC stiff sheet |
CN110091528A (en) * | 2018-01-29 | 2019-08-06 | 上海龙驭塑业有限公司 | A kind of universal five rollers press production line of hard soft film of PVC |
-
2002
- 2002-10-08 CN CNA021436789A patent/CN1488669A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103172950A (en) * | 2013-03-29 | 2013-06-26 | 扬州新天然橡塑制品有限公司 | Production method of environment-friendly PVC (Polyvinyl Chloride) sheets |
CN105061929A (en) * | 2015-08-05 | 2015-11-18 | 江苏亚邦天龙医用新材料有限公司 | Non-phthalate medical PVC pellet |
CN106380746A (en) * | 2016-10-21 | 2017-02-08 | 扬州凯尔化工有限公司 | PVC (polyvinyl chloride) hard sheet applicable to medicinal package |
CN106380746B (en) * | 2016-10-21 | 2018-07-06 | 扬州凯尔化工有限公司 | A kind of PVC stiff sheet suitable for medical packaging |
CN106800729A (en) * | 2016-12-30 | 2017-06-06 | 雷笑天 | A kind of preparation method of high grade of transparency medical PVC stiff sheet |
CN106800729B (en) * | 2016-12-30 | 2019-01-25 | 上海舟易生物科技有限公司 | A kind of preparation method of high grade of transparency medical PVC stiff sheet |
CN110091528A (en) * | 2018-01-29 | 2019-08-06 | 上海龙驭塑业有限公司 | A kind of universal five rollers press production line of hard soft film of PVC |
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