CN1486975A - Precipitation process of extracting arginine - Google Patents
Precipitation process of extracting arginine Download PDFInfo
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- CN1486975A CN1486975A CNA03132309XA CN03132309A CN1486975A CN 1486975 A CN1486975 A CN 1486975A CN A03132309X A CNA03132309X A CN A03132309XA CN 03132309 A CN03132309 A CN 03132309A CN 1486975 A CN1486975 A CN 1486975A
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- arginine
- arginic
- sulfonate
- henzene
- sodium dodecyl
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Abstract
The present invention is precipitation process of extracting arginine. Sodium dodecyl henzene sulfonate and arginine in the stoichiometric ratio of 1-4 are mixed in solution with pH regulator via stirring; composite precipitate of sodium dodecyl henzene sulfonate and arginine is then obtained via filtering; the composite precipitate is dessolved in water solution with pH value higher than 8 to decompose the composition; and through further elimination of sodium dodecyl henzene sulfonate, concentration and refining, arginine product is obtained. The present invention separates arginine selectively with non-toxic and pollution-free sodium dodecyl henzene sulfonate as precipitant, realizes non-toxic operation and easy treatment of mother liquor, and has arginine yield as high as 80%.
Description
Technical field
The invention belongs to a kind of from contain arginic mixed solution the arginic technology of separation and Extraction, relate in particular to the Sodium dodecylbenzene sulfonate precipitate and separate and extract arginic method.
Background technology
Arginine is the semi-dispensable amino acid of human body, and the arginic method of present industrial production mainly contains fermentation method and proteolysis extraction method.No matter be which kind of method is produced arginine, all to relate to arginine and a large amount of isolating problems of other impurity, just how from contain arginic mixed solution, to isolate arginic problem.
At present, can be used for separating arginic method and mainly contain the precipitator method and ion exchange method.
The precipitator method are to utilize precipitation agent energy highly selective and arginine to form the character of the very little mixture of solubleness, in containing arginic mixed solution, add precipitation agent, arginine is precipitated out from solution with the form of mixture, realize initial gross separation with most of impurity, usually used precipitation agent is phenyl aldehyde and Pentachlorophenol, but these two kinds of precipitation agents are deleterious compound, may operator's health be damaged, and have extracted the mother liquor difficult treatment behind the arginine.
It is more that ion exchange method is extracted arginic research report, but have many problems during actual enforcement.Lower as arginic concentration in the elutriant, need to concentrate in a large number, production cost is higher; Wash-out causes arginic total efficiency of separation on the low side owing to wash-out will occur intersecting inevitably; The raw material Macrodilution, is produced a large amount of waste liquids again at the repetitive scrubbing of ion exchange column, and these have all strengthened the treatment capacity of waste liquid.Therefore, ion exchange method extraction arginine is not the ideal method.
Summary of the invention
The purpose of this invention is to provide a kind of precipitator method and extract arginic technology, overcome the existing shortcoming of above-mentioned technology,, avoid poisonous operation, and improve arginic yield to make things convenient for the processing of mother liquor.
The present invention can realize by following process: Sodium dodecylbenzene sulfonate was joined pH value in 1: 1 to 4: 1 by stoichiometric ratio and be adjusted in containing in the arginic solution between the 0-4, stir, filter, get Witco 1298 Soft Acid and arginic mixture precipitation; Leach throw out, throw out be dissolved in PH be higher than in 8 the water, Witco 1298 Soft Acid and arginic mixture are decomposed, remove dodecylbenzene sulfonate, step such as concentrate and refining, get final product the arginine product.
After adopting above-mentioned technology, the present invention is because of being precipitation agent with nontoxic, free of contamination Sodium dodecylbenzene sulfonate, the arginine highly selective is separated from its mixed solution, so, overcome and commonly use the existing shortcoming of technology, realized nontoxic operation, the processing of mother liquor is easy, and arginic yield is increased to 80%.
Embodiment
Most preferred embodiment of the present invention is:
Get except that the cystine mother liquor 100L behind the inorganic salt, transfer the pH value to 2 of mother liquor with hydrochloric acid, according to the contained arginic amount of mother liquor, ratio by amount of substance is a sodium laurylsulfonate: L-arginine=2: 1 adding Sodium dodecylbenzene sulfonatees, stirred 5 hours, after treating that precipitin reaction reaches balance, filter, get the mixture throw out of Witco 1298 Soft Acid and Gelucystine, throw out is dissolved in PH in the deionized water more than 8, remove Sodium dodecylbenzene sulfonate with Bubbling method, PH to 3 with hydrochloric acid conditioning solution, be concentrated into thickly, processing industry alcohol is settled out arginic hydrochloride; Filter, get final product the arginine monohydrochloride crude product, through refining, can get the elaboration of arginine monohydrochloride.In arginic content in the mother liquor, yield is more than 80%.
Claims (1)
1, a kind of precipitator method are extracted arginic technology, be to realize: Sodium dodecylbenzene sulfonate was joined pH value in 1: 1 to 4: 1 by stoichiometric ratio and be adjusted in containing in the arginic solution between the 0-4 by following process, stir, filter, get Witco 1298 Soft Acid and arginic mixture precipitation; Leach throw out, throw out be dissolved in PH be higher than in 8 the water, Witco 1298 Soft Acid and arginic mixture are decomposed, remove dodecylbenzene sulfonate, step such as concentrate and refining, get final product the arginine product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03132309XA CN1211358C (en) | 2003-08-08 | 2003-08-08 | Precipitation process of extracting arginine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03132309XA CN1211358C (en) | 2003-08-08 | 2003-08-08 | Precipitation process of extracting arginine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1486975A true CN1486975A (en) | 2004-04-07 |
| CN1211358C CN1211358C (en) | 2005-07-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB03132309XA Expired - Fee Related CN1211358C (en) | 2003-08-08 | 2003-08-08 | Precipitation process of extracting arginine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1211358C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102126970A (en) * | 2010-11-24 | 2011-07-20 | 重庆工贸职业技术学院 | Methods for separating leucine and arginine by selective precipitation |
-
2003
- 2003-08-08 CN CNB03132309XA patent/CN1211358C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102126970A (en) * | 2010-11-24 | 2011-07-20 | 重庆工贸职业技术学院 | Methods for separating leucine and arginine by selective precipitation |
| CN102126970B (en) * | 2010-11-24 | 2014-08-27 | 重庆工贸职业技术学院 | Methods for separating leucine and arginine by selective precipitation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1211358C (en) | 2005-07-20 |
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