CN1486701A - Artificial tear - Google Patents
Artificial tear Download PDFInfo
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- CN1486701A CN1486701A CNA021357080A CN02135708A CN1486701A CN 1486701 A CN1486701 A CN 1486701A CN A021357080 A CNA021357080 A CN A021357080A CN 02135708 A CN02135708 A CN 02135708A CN 1486701 A CN1486701 A CN 1486701A
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- water
- chloride
- artificial tears
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- regulator
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
The artificial tear consists of water, water soluble chitin derivative, pH regulator, penetration pressure regulator and sterilizing agent in weight ratio of 1000 to 1-6 to 4-8 to 5-8 to 0.001-0.3. The present invention has the advantages of adoption of water soluble chitin derivative as main material, simple preparation process, good moisture absorbing and moisture maintaining performance, no chemical preservative contained, bacterostasis and bactericidal effect on many kinds of bacteria, relatively high viscosity at low concentration and shearing dilution; accords with the requirement on tear; and has excellent eye membrane protecting effect.
Description
The present invention relates to a kind of artificial tears.
The excretory tear similar performance of artificial tears and human body self can play additional moisture content, moistening eye surface to eyes, kills antibacterial, protects eyes, eliminates ophthalmic uncomfortable, treats xerophthalmia, alleviate other oculopathy that is caused by eye disease.At present artificial tears's commonly used primary raw material has polymer substances such as hyaluronate sodium and polyacrylic acid, polyvinyl alcohol, carboxymethyl cellulose, hydroxypropyl emthylcellulose.Wherein with the tear best results of hyaluronate sodium system, but the cost height, the tear biocompatibility of other material system is poor, and eye mask is had infringement.
The purpose of this invention is to provide a kind of artificial tears, it can overcome existing artificial tears's above-mentioned shortcoming.
A kind of artificial tears is characterized in that containing water, water-solubility chitin derivative, pH regulator agent, osmotic pressure regulator and biocide, and their part by weight scope is respectively 1000: 1-6: 4-8: 5-8: 0.001-0.3.
Advantage of the present invention is that employing biomaterial water-solubility chitin derivative is a primary raw material; its preparation method is simple; moisture absorption, moisture retention are good; do not contain the general chemistry antiseptic, but various bacteria is had antibacterial sterilization functions, both had viscosity higher during low concentration; the shear shinning characteristic is arranged again; meet the requirement of tear, not only do not damage eyes, and eye mask is had the better protect effect.
Below by embodiment the present invention is described.
Embodiment 1
Get ethoxyl chitin 3.0g, n-trimethyl chitosan chloride 0.2g, sodium chloride 5g, calcium chloride 0.4g, potassium dihydrogen phosphate 3.4g, sodium hydrogen phosphate 3.7g, earlier with the dissolving of 400ml water for injection, refilter, filtrate is diluted to 1000ml with water for injection, 100 ℃ of circulation steam sterilizations, packing, the little sticking artificial tears's preparation of achromatism and clarity.It is splashed in the eye, can keep the skin wet, the wetting eye surface produces mucus, water absorption solution is covered in the eye surface, can eliminate ophthalmic uncomfortable, and the protection eyes are effectively alleviated and treated xerophthalmia.
N-trimethyl chitosan chloride in the present embodiment is with hydroxypropyl chitosan or oligochitosan (ChitosanOLigosaccharide, molecular weight≤5000) in alkaline isopropanol medium, stir down in molar ratio 1: the ratio of 0.8-1.2 drips the aqueous isopropanol of aliphatic group dimethyl (+)-2,3-Epoxy-1-propanol ammonium chloride (wherein the aliphatic group carbon number is 10-16), 45-55 ℃ is reacted 15-20h down, use the acetic acid neutralization precipitation then, filter, make crude product at 50-65 ℃ of following vacuum drying with isopropyl alcohol, washing with acetone.In this dissolving crude product water, remove by filter insoluble matter, after dialysis or ultrafiltration removal mineral salt and small organic molecule matter,, lyophilization concentrated through rotary evaporation makes pure product then.
Embodiment 2
Get hydroxypropyl chitosan 4g, n-trimethyl chitosan chloride 0.1g, sodium chloride 8g, calcium chloride 0.2g, potassium dihydrogen phosphate 1.2g, sodium hydrogen phosphate 4.3g, earlier with after the dissolving of 400ml water for injection, cross the elimination insoluble matter, filtrate is diluted to 1000ml with water for injection, packing behind 100 ℃ of circulation steam sterilizations, artificial tears's preparation, have the effect of embodiment 1 product equally.
Embodiment 3
Get oligochitosan and claim chitin oligosaccharide (molecular weight≤5000) 5.0g, n-trimethyl chitosan chloride 0.3g, sodium chloride 6.0g, calcium chloride 0.6g, potassium dihydrogen phosphate 2.0g again, sodium hydrogen phosphate 3.8g, earlier with after the dissolving of 400-500ml water for injection, filter, filtrate is diluted to 1000ml with water for injection, 100 ℃ the circulation steam sterilizations after packing, artificial tears's preparation, have the effect of embodiment 1 product equally.
Embodiment 4
Get carboxymethyl chitosan 4g, sodium chloride 7.0g, calcium chloride 0.2g, potassium dihydrogen phosphate 1.1g, sodium hydrogen phosphate 3.7g, earlier with after the dissolving of 500ml water for injection, filter, filtrate is diluted to 1000ml with water for injection, after the cooling of 100 ℃ of circulation steam sterilizations, drip lysozyme 1.0-2.0mg, stir evenly the back packing, artificial tears's preparation, have embodiment 1 preparation effect equally.
Embodiment 5
Have the n-trimethyl chitosan chloride among the embodiment 1-3 effect of sterilization concurrently, available lysozyme (1.0-2.0mg) substitutes, and all the other components are constant, and the preparation order is identical with embodiment 4, and the gained preparation has the effect of embodiment 1 preparation equally.
Water-solubility chitin derivative of the present invention is ethoxyl chitin, hydroxypropyl chitosan, oligochitosan, carboxylic carapace polysaccharide, osmotic pressure regulator described in the present invention is sodium chloride and calcium chloride, both part by weight are 10: the pH regulator agent described in 0.2-0.6 the present invention is the potassium dihydrogen phosphate sodium hydrogen phosphate, and both part by weight are 1.2-3.4: 3.7-4.3.Biocide described in the present invention is n-trimethyl chitosan chloride or lysozyme.
Claims (3)
1, a kind of artificial tears is characterized in that containing water, water-solubility chitin derivative, pH regulator agent, osmotic pressure regulator and biocide, and their part by weight scope is respectively 1000: 1-6: 4-8: 5-8: 0.001-0.3.
2, artificial tears as claimed in claim 1 is characterized in that described water-solubility chitin derivative is ethoxyl chitin, hydroxypropyl chitosan, oligochitosan or carboxylic carapace polysaccharide; Described osmotic pressure regulator is sodium chloride and calcium chloride, both part by weight are 5-8: 0.2-0.6, described pH regulator agent is the potassium dihydrogen phosphate sodium hydrogen phosphate, and both part by weight are 1.2-3.4: 3.7-4.3, and described biocide is n-trimethyl chitosan chloride or lysozyme.
3, artificial tears as claimed in claim 1, it is characterized in that described n-trimethyl chitosan chloride be with hydroxypropyl chitosan or oligochitosan in alkaline isopropanol medium, stirring and dripping the aliphatic group carbon number down is the aqueous isopropanol of the aliphatic group dimethyl (+)-2,3-Epoxy-1-propanol ammonium chloride of 10-16,45-55 ℃ is reacted 15-20h down, use the acetic acid neutralization precipitation then, filter,, make crude product at 50-65 ℃ of following vacuum drying with isopropyl alcohol, washing with acetone.This dissolving crude product in water, is removed by filter insoluble matter, and after dialysis or ultrafiltration removal mineral salt and small organic molecule matter,, lyophilization concentrated through rotary evaporation makes pure product then.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021357080A CN1193768C (en) | 2002-10-01 | 2002-10-01 | Artificial tear |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021357080A CN1193768C (en) | 2002-10-01 | 2002-10-01 | Artificial tear |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1486701A true CN1486701A (en) | 2004-04-07 |
| CN1193768C CN1193768C (en) | 2005-03-23 |
Family
ID=34146240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021357080A Expired - Fee Related CN1193768C (en) | 2002-10-01 | 2002-10-01 | Artificial tear |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1193768C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100387238C (en) * | 2006-05-12 | 2008-05-14 | 胡军 | Medical hemostasis anti-adhesive irrigation solution |
| WO2010083636A1 (en) * | 2009-01-20 | 2010-07-29 | 沈阳兴齐制药有限公司 | An eyedrops of the deproteinized calf blood extract |
| CN110604812A (en) * | 2018-06-14 | 2019-12-24 | 陕西慧康生物科技有限责任公司 | Novel artificial tear containing recombinant human lysozyme |
-
2002
- 2002-10-01 CN CNB021357080A patent/CN1193768C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100387238C (en) * | 2006-05-12 | 2008-05-14 | 胡军 | Medical hemostasis anti-adhesive irrigation solution |
| WO2010083636A1 (en) * | 2009-01-20 | 2010-07-29 | 沈阳兴齐制药有限公司 | An eyedrops of the deproteinized calf blood extract |
| CN110604812A (en) * | 2018-06-14 | 2019-12-24 | 陕西慧康生物科技有限责任公司 | Novel artificial tear containing recombinant human lysozyme |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1193768C (en) | 2005-03-23 |
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