CN1481798A - Large capacity gingko damole injection and its preparation method - Google Patents
Large capacity gingko damole injection and its preparation method Download PDFInfo
- Publication number
- CN1481798A CN1481798A CNA031389309A CN03138930A CN1481798A CN 1481798 A CN1481798 A CN 1481798A CN A031389309 A CNA031389309 A CN A031389309A CN 03138930 A CN03138930 A CN 03138930A CN 1481798 A CN1481798 A CN 1481798A
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- dipyridamole
- injection
- ginkgo
- adjusting agent
- water
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Abstract
The great capacity injection is compounded with gingko leaf extractive and didyridamole, and each ampule contains gingko general flavone 9.0-55 mg and didyridamole 3.6-22 mg, isoosmotic regulator, buffering agent, co-solvent and injection water. It may be used in direct intravenous infusion without secondary pollution, and is suitable for preventing and treating coronary heart disease, thrombotic disease, etc.
Description
Technical field:
The present invention relates to medical technical field, it is ginkgo bilobate extract transfusion and preparation method in definite saying.
Background technology:
Ginkgo total flavones has dilating coronary blood vessel, cerebrovascular, improves symptom and memory function that cerebral ischemia produces.Dipyridamole can suppress blood and pull gathering for a short time, and high concentration (50 μ g/ml) can suppress platelet and discharge.
Platelet aggregation is to form coronary heart disease, all kinds of arrhythmia in the human vas, the major reason of disease such as hypertension, ischemic cardiomyopathy, these diseases have become the frequently-occurring disease in the daily life, commonly encountered diseases, the serious threat human health is so anti-platelet aggregation just becomes the key point of these diseases of treatment.
The ginkgo bilobate extract preparation, toxic and side effects is little, and can slow down anesthetized cat and dog heart rate have obvious preventive and therapeutic effect to myocardial ischemia due to the cat coronary ligation, and can dwindle myocardial infarct size.Protective effect to ischemic myocardium is obvious, can improve ischemic tissue's blood supply, reduces oxygen consumption, repairs the cell tissue of damaging because of ischemia rapidly.
Summary of the invention:
The object of the present invention is to provide a kind of ginkgo bilobate extract high-capacity injection and preparation method that can be directly used in the anti-platelet aggregation of intravenous drip, every bottle contains Ginkgo total flavones 9.0-55mg, dipyridamole 3.6～22mg, isoosmotic adjusting agent, buffer agent, cosolvent and water for injection are an amount of.This product is used convenient, and directly intravenous drip avoids causing secondary pollution.
The specific embodiment: following example is 1 bottle of consumption
Embodiment 1:
Prescription: Ginkgo total flavones 10mg
Dipyridamole 4mg
Sodium chloride 0.9g
Water for injection adds to 100ml
Embodiment 2:
Prescription: Ginkgo total flavones 10mg
Dipyridamole 4mg
Glucose 5g
Water for injection adds to 100ml embodiment 3:
Prescription: Ginkgo total flavones 25mg
Dipyridamole 10mg
Glucose 5g
Water for injection adds to 100ml
Embodiment 4:
Prescription: Ginkgo total flavones 25mg
Dipyridamole 10mg
Glucose 12.5g
Water for injection adds to 250ml
Embodiment 5:
Prescription: Ginkgo total flavones 10mg
Dipyridamole 4mg
Sodium chloride 2.25g
Water for injection adds to 250ml
Embodiment 6:
Prescription: Ginkgo total flavones 25mg
Dipyridamole 10mg
Glucose 12.5g
Water for injection adds to 250ml
Embodiment 7:
Prescription: Ginkgo total flavones 20mg
Dipyridamole 8mg
Sodium chloride 2.25g
Water for injection adds to 250ml
Embodiment 8:
Prescription: Ginkgo total flavones 20mg
Dipyridamole 8mg
Sodium chloride 4.5g
Water for injection adds to 500ml
Embodiment 9:
Prescription: Ginkgo total flavones 25mg
Dipyridamole 10mg
Glucose 25g
Water for injection adds to 500ml
(1) weighing: press proportional quantity precision weighing Semen Ginkgo extrac, dipyridamole, isoosmotic adjusting agent.
(2) dense joining: load weighted isoosmotic adjusting agent is joined in the water for injection of total dosing amount 50%, stir to make and dissolve fully.After adding Semen Ginkgo extrac, dipyridamole stir and make dissolving fully, add the active carbon of dosing amount 0.05%, boiled 20 minutes, put cold.
(3) rare joining: add water to full dose, add the active carbon of dosing amount 0.05%, stirred 20 minutes, regulate pH value to 3.5～5.5, after the inspection of semifinished product is qualified, filter reuse 0.8um microporous filter membrane fine straining through husky filter stick.
(4) check that clarity is qualified after, fill is in infusion bottle, through 115 pressure sterilizings 30 minutes.
(5) finished product inspection, packing.
Sodium chloride, glucose can substitute with other an amount of isoosmotic adjusting agent among the above embodiment.
Claims (4)
1, ginkgo bilobate extract high-capacity injection and preparation method is characterized in that: it contains Semen Ginkgo extrac and dipyridamole, and its proportioning is Semen Ginkgo extrac: dipyridamole=1-9: 9-1.
2, ginkgo bilobate extract high-capacity injection according to claim 1 is characterized in that: every bottle of infusion pump contains Semen Ginkgo total flavones 9-55mg, dipyridamole 3.6～22mg, isoosmotic adjusting agent, water for injection, or is added with buffer agent, cosolvent in addition.
3, ginkgo bilobate extract high-capacity injection according to claim 1 is characterized in that: described isoosmotic adjusting agent is a kind of or several combination arbitrarily in glucose, sodium chloride, fructose, xylitol, mannitol, sorbitol, calcium chloride, magnesium chloride, potassium chloride, lactose, sodium lactate, the glycerol.
4, Ginkgo Leaf Extract and Dipyridamole Injection according to claim 1, its preparation method is:
(1) weighing: press proportional quantity precision weighing Semen Ginkgo extrac, dipyridamole, isoosmotic adjusting agent.
(2) dense joining: load weighted isoosmotic adjusting agent is joined in the water for injection of total dosing amount 50%, stir to make and dissolve fully.After adding Semen Ginkgo extrac, dipyridamole stir and make dissolving fully, add the active carbon of dosing amount 0.05%, boiled 20 minutes, put cold.
(3) rare joining: add water to full dose, add the active carbon of dosing amount 0.05%, stirred 20 minutes, regulate pH value to 3.5～5.5, after the inspection of semifinished product is qualified, decarburization after filtration, reuse 0.22 μ m～0.8 μ m microporous filter membrane fine straining.
(4) clarity test qualified after, fill is in 50ml, 100ml, 200ml, 250ml, 500ml infusion bottle, through 115 ℃ of pressure sterilizings 30 minutes.
(5) finished product inspection, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031389309A CN1481798A (en) | 2003-07-31 | 2003-07-31 | Large capacity gingko damole injection and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031389309A CN1481798A (en) | 2003-07-31 | 2003-07-31 | Large capacity gingko damole injection and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1481798A true CN1481798A (en) | 2004-03-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031389309A Pending CN1481798A (en) | 2003-07-31 | 2003-07-31 | Large capacity gingko damole injection and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1481798A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100352455C (en) * | 2005-11-08 | 2007-12-05 | 贵州益佰制药股份有限公司 | Ginkgo Damo freeze-drying prepn. and its prepn. method |
| CN100353944C (en) * | 2004-06-24 | 2007-12-12 | 杨立新 | Urapidil large volume injection, its preparation method and application |
| CN108379332A (en) * | 2018-05-22 | 2018-08-10 | 南华大学 | Compound gingkgo gynostemma pentaphylla Trimetazidine injection and preparation method |
| CN112545982A (en) * | 2020-12-18 | 2021-03-26 | 西安达莫制药有限公司 | Large-capacity injection prepared from dipyridamole and preparation method thereof |
-
2003
- 2003-07-31 CN CNA031389309A patent/CN1481798A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100353944C (en) * | 2004-06-24 | 2007-12-12 | 杨立新 | Urapidil large volume injection, its preparation method and application |
| CN100352455C (en) * | 2005-11-08 | 2007-12-05 | 贵州益佰制药股份有限公司 | Ginkgo Damo freeze-drying prepn. and its prepn. method |
| CN108379332A (en) * | 2018-05-22 | 2018-08-10 | 南华大学 | Compound gingkgo gynostemma pentaphylla Trimetazidine injection and preparation method |
| CN112545982A (en) * | 2020-12-18 | 2021-03-26 | 西安达莫制药有限公司 | Large-capacity injection prepared from dipyridamole and preparation method thereof |
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