CN1476867A - Freeze-dried garlic powder preparation and its preparation method - Google Patents
Freeze-dried garlic powder preparation and its preparation method Download PDFInfo
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- CN1476867A CN1476867A CNA021365938A CN02136593A CN1476867A CN 1476867 A CN1476867 A CN 1476867A CN A021365938 A CNA021365938 A CN A021365938A CN 02136593 A CN02136593 A CN 02136593A CN 1476867 A CN1476867 A CN 1476867A
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Abstract
The present invention relates to a freeze-dried garlic powder preparation and its preparation method. Said preparation composition includes (wt%) 65-75% of freeze-dried garlic powder, 10-15% of microcrystal cellulose 101, 5-7% of low substituted hydroxycellulose, 1-2% of silicone dioxide, 5-7% of carboxymethyl starch sodium, 0.4-0.6% of magnesium stearate and 7-8% of colour coating pre-mixed material, and its preparation method includes the following steps: proportioning main material and auxiliary material, mixing them, pulverizing, granulating, adding other auxiliary material, tableting and coating.
Description
Technical field
The present invention relates to full powder preparation of plant and preparation method thereof, be specifically related to a kind of freeze-dried garlic powder preparation and preparation method thereof.
Background technology
Freeze-dried garlic powder is a kind of active bio intermediate, has anti-platelet aggregation and thrombolytic effect (Chinese Medical Sciences University's journal, 1992:21 (6) 436-439), and blood fat reducing, reducing blood viscosity effect (institute of materia medica, Xinjiang publication arranged, 1991:33,13-19), therefore the cardiovascular and cerebrovascular vessel to human body have significant protective effect; As natural broad-spectrum antibiotic, it is antibiotic, protozoacide and the effect of killing the virus are early admitted (Lie group etc., 1954, Chinese Medical Journal, 40:189 by people; Liu Zhi, 1989, journal of shanghai Chinese medicine, (5): 45).In addition, it also has function of tumor inhibition (Wu Yongfang, 1995, Chinese clinical tumor, 22 (9): 662-663).Therefore freeze-dried garlic powder is as the primary raw material of medicine and health food, and its application has clinical meaning widely.
The production process of freeze-dried garlic powder is: bright Bulbus Allii peeling is cleaned after liquid nitrogen freezing (196 ℃) back hammer is pulverized, and low-temperature vacuum drying gets odourless garlic powder.The whole active ingredients that kept bright Bulbus Allii in the freeze-dried garlic powder mainly comprise organic compounds containing sulfur (being mainly alliin etc.), enzyme (allinase, SOD etc.), contain selenium organic compound (selenocysteine etc.) three major types.
Because freeze-dried garlic powder has activity, moisture absorption is strong, and allinase is reason such as promptly be activated under 40% the condition at room temperature and relative humidity, gives and brings very big difficulty when being processed into preparation.Traditional film-making technology comprises the steps:
1, places mixer fully to mix principal agent and adjuvant, make uniform mixed dust formulation;
2, add wetting agent or binding agent, stir into suitable soft material;
3, granulate and sieve and make wet granular through granulation machine;
4, drying is made thousand granules;
5, sieve granulate and add adjuvants such as lubricant, disintegrating agent;
6, through the tablet machine tabletting;
7, enteric coated film obtains finished product.
Be to add behind the wetting agent dry again with the maximum difficult point of above-mentioned prepared freeze-dried garlic powder preparation.Under the influence, activate allinase and alliin generation chemical reaction in humidity and temperature dual condition, active component easily runs off in the freeze-dried garlic powder thereby cause.Traditional handicraft also exists problems such as the easy moisture absorption, the easy sticking of tabletting process simultaneously, and made preparation has strong garlicky generation.Be difficult to guarantee the quality of product.
Summary of the invention
The object of the present invention is to provide a kind of freeze-dried garlic powder preparation prescription.
The present invention also aims to seek suitable freeze-dried garlic powder preparation manufacturing process, easily run off to solve the easy moisture absorption of traditional freeze-dried garlic powder preparation manufacturing process, active component, easy defective such as sticking in the tabletting process.
The present invention finds, adopts secondary compressing dry granulation technology, can avoid the negative effect to the principal agent raw material of moisture and temperature in the preparation process of freeze-dried garlic powder tablet.The process that is adopted is:
1, places mixer fully to mix principal agent and adjuvant, make uniform mixed dust formulation;
2, mixed powder is placed tablet machine be pressed into sheet just;
3, first sheet is smashed through granulation machine and granulated and sieve;
4, add adjuvants such as fluidizer, disintegrating agent, secondary mixes;
5, be pressed into plain sheet through tablet machine;
6, enteric coated film obtains finished product.
The prescription (by weight percentage) of the freeze-dried garlic powder preparation that the present invention proposes is:
Freeze-dried garlic powder (water content＜4%) 65-75%
Microcrystalline Cellulose 101 10-15%
Low-substituted hydroxypropyl cellulose 5-7%
Silica 1-2%
Carboxymethyl starch sodium 5-7%
Magnesium stearate 0.4-0.6%
Colored coating premix material 7-8%
The present invention tests confirmation, and the optimization formula of freeze-dried garlic powder preparation (by weight percentage) is:
Freeze-dried garlic powder 70%
Microcrystalline Cellulose 101 10%
Low-substituted hydroxypropyl cellulose 5%
Silica 1 %
Carboxymethyl starch sodium 6%
Magnesium stearate 0.5%
Colored coating premix material 7.5%
The specific embodiment:
The equipment that the preparation of freeze-dried garlic powder preparation is adopted among the present invention comprises: the ZPW21A rotary tablet machine; 40LV type mixer YK-160 oscillating granulator; First sheet tabletting mould and plain sheet tabletting mould etc.Principal agent and various adjuvant are taken by weighing by formula proportion, make tablet (500mg/ sheet) by following technology then:
1, freeze-dried garlic powder adds binding agent through the mixer mix homogeneously;
2, being pressed into the first pressing chip size is Φ 18mm, and thickness is 2.5mm;
3, advance to wave the granulation machine 14-16 mesh sieve of granulating;
4, granule adds to help and collapses agent, fluidizer, lubricant;
5, secondary mixes through V-Mixer;
6, press plain sheet (circular, special-shaped, single face is carved characters);
7, enteric coated film.
Can not contact with water in the whole process flow, the relative humidity in workshop is 25-30%, and temperature is 25 ℃, 100,000 grades of purifications.
Beneficial effect
1, the present invention has avoided Bulbus Allii powder to the contacting of moisture content and temperature, and has guaranteed that active ingredient is not activated and does not influence the preparation quality.
2, the present invention has taken the characteristic of freeze-dried garlic powder into account comprehensively, makes the existence that guarantees whole active component behind the preparation, and tissue is not had side effects (such as to the stimulation of gastric mucosa etc.), does not garlickyly overflow from the oral cavity, does not influence doings.
3, the invention solves traditional freeze-dried garlic powder preparation preparation technology's main difficulty (easily the moisture absorption, active component easily run off, easy sticking etc. in the tabletting process), held the skill level that the full powder of plant is prepared into peroral dosage form preferably.
Embodiment
Take by weighing principal agent and each adjuvant by following proportioning:
Freeze-dried garlic powder 100kg
Microcrystalline Cellulose 101 14.3kg
Low-substituted hydroxypropyl cellulose 7.15kg
Silica 1 .43kg
Sodium Hydroxymethyl Stalcs 8.58kg
Magnesium stearate 0.7kg
Colored premix coating material 10.7kg
Preparation method is as follows:
With the 100kg freeze-dried garlic powder; after 14.3kg microcrystalline Cellulose 101 and 5.72kg low-substituted hydroxypropyl cellulose place V-Mixer fully to be mixed into mixed powder; place 21 towards rotary tablet machine; select the drift of Ф 18mm for use; tabletting; control strip is thick to be 2.5mm; make tabletting just; then first tabletting is smashed; place and wave the granulation machine granulation; cross 14 mesh sieves; material grain after sieving adds low-substituted hydroxypropyl cellulose 1.43kg; silica 1 .43kg; Sodium Hydroxymethyl Stalcs 8.58kg; magnesium stearate 0.7kg is in V-Mixer behind the mix homogeneously, and with 21 towards the rotary tablet machine tabletting, sheet heavily is controlled at every 465mg; Hardness Control is at 5kg/ pressure; make plain sheet, with plain sheet after enteric coated, final finished product.
Detect behind the coating: 1, apparent smooth, no cracked, the moon clear 2, disintegrate of mark of carving characters: simulated gastric fluid (9-1000) did not have cracking, ruckbildung in 120 minutes.45 minutes (adding baffle plate) disintegrate (not adding baffle plate is 55 minutes) 3 fully, tablet free from extraneous odour in the phosphate buffer.
More than operation is all 100,000 grades of cleaning shops, and 25 ℃ of room temperatures are carried out under the relative humidity 25-30% condition.
Claims (3)
1. freeze-dried garlic powder preparation, it consists of: (by weight percentage)
Freeze-dried garlic powder 65-75%
Microcrystalline Cellulose 101 10-15%
Low-substituted hydroxypropyl cellulose 5-7%
Silica 1-2%
Carboxymethyl starch sodium 5-7%
Magnesium stearate 0.4-0.6%
Colored coating premix material 7-8%
2. freeze-dried garlic powder preparation according to claim 1, it consists of: (by weight percentage)
Freeze-dried garlic powder 70%
Microcrystalline Cellulose 101 10%
Low-substituted hydroxypropyl cellulose 5%
Silica 1 %
Carboxymethyl starch sodium 6%
Magnesium stearate 0.5%
Colored coating premix material 7.5%
3. the preparation method of freeze-dried garlic powder preparation according to claim 1; it is characterized in that adopting secondary compressing dry granulation technology; its step is that freeze-dried garlic powder adds binding agent through the mixer mix homogeneously; be pressed into and be of a size of Φ 18mm, thickness is the first tabletting of 2.5mm, smashes then through waving the granulation machine 14-16 mesh sieve of granulating; in granule with disintegrating agent, fluidizer, antiplastering aid; mix through mixer once more, press plain sheet (circular, special-shaped, single face is carved characters), enteric coated film gets finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02136593 CN1220505C (en) | 2002-08-21 | 2002-08-21 | Freeze-dried garlic powder preparation and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02136593 CN1220505C (en) | 2002-08-21 | 2002-08-21 | Freeze-dried garlic powder preparation and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1476867A true CN1476867A (en) | 2004-02-25 |
| CN1220505C CN1220505C (en) | 2005-09-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02136593 Expired - Fee Related CN1220505C (en) | 2002-08-21 | 2002-08-21 | Freeze-dried garlic powder preparation and its preparation method |
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| CN (1) | CN1220505C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102380020A (en) * | 2011-11-10 | 2012-03-21 | 新疆维吾尔自治区中药民族药研究所 | Garlic enteric-coated tablets and production method thereof |
| CN107296799A (en) * | 2017-07-05 | 2017-10-27 | 北京罗麦科技有限公司 | A kind of allicin tablet and preparation method thereof |
| CN107788478A (en) * | 2017-10-31 | 2018-03-13 | 江苏天元中科生物技术有限公司 | A kind of assistant agent for preventing the lyophilized pollen cream moisture absorption, preparation method and applications |
-
2002
- 2002-08-21 CN CN 02136593 patent/CN1220505C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102380020A (en) * | 2011-11-10 | 2012-03-21 | 新疆维吾尔自治区中药民族药研究所 | Garlic enteric-coated tablets and production method thereof |
| CN107296799A (en) * | 2017-07-05 | 2017-10-27 | 北京罗麦科技有限公司 | A kind of allicin tablet and preparation method thereof |
| CN107788478A (en) * | 2017-10-31 | 2018-03-13 | 江苏天元中科生物技术有限公司 | A kind of assistant agent for preventing the lyophilized pollen cream moisture absorption, preparation method and applications |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1220505C (en) | 2005-09-28 |
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Owner name: JIN JIANING |
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Free format text: CORRECT: ADDRESS; FROM: 200030 ROOM D, 7/F, YUJIA BUILDING, NO.1336, HUASHAN ROAD, SHANGHAI CITY TO: 200061 ROOM 708, NO.1715, ZHONGSHAN NORTH ROAD, SHANGHAI CITY |
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Effective date of registration: 20100531 Address after: 200061 room 1715, No. 708, Shanghai, Zhongshan North Road Co-patentee after: Jin Jianing Patentee after: Shanghai Fangyuan Science & Technology Development Co., Ltd. Address before: 200030 D room, 7 floor, jade mansion, 1336 Huashan Road, Shanghai Patentee before: Shanghai Fangyuan Science & Technology Development Co., Ltd. |
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Granted publication date: 20050928 Termination date: 20100821 |