CN1474944A - 利用亲和捕获串联质谱分析表征分子间作用的方法 - Google Patents

利用亲和捕获串联质谱分析表征分子间作用的方法 Download PDF

Info

Publication number
CN1474944A
CN1474944A CNA008199639A CN00819963A CN1474944A CN 1474944 A CN1474944 A CN 1474944A CN A008199639 A CNA008199639 A CN A008199639A CN 00819963 A CN00819963 A CN 00819963A CN 1474944 A CN1474944 A CN 1474944A
Authority
CN
China
Prior art keywords
binding partner
probe
binding
protein
affinity capture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA008199639A
Other languages
English (en)
Chinese (zh)
Inventor
�޲��ء���ά
斯科特·维恩伯格
��Ī������
蒂娜·莫里斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Aspira Womens Health Inc
Original Assignee
Human Genome Sciences Inc
Ciphergen Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Ciphergen Biosystems Inc filed Critical Human Genome Sciences Inc
Publication of CN1474944A publication Critical patent/CN1474944A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNA008199639A 2000-10-11 2000-10-12 利用亲和捕获串联质谱分析表征分子间作用的方法 Pending CN1474944A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/028261 WO2002031484A2 (en) 2000-10-11 2000-10-11 Methods for characterizing molecular interactions using affinity capture tandem mass spectrometry

Publications (1)

Publication Number Publication Date
CN1474944A true CN1474944A (zh) 2004-02-11

Family

ID=21741885

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA008199639A Pending CN1474944A (zh) 2000-10-11 2000-10-12 利用亲和捕获串联质谱分析表征分子间作用的方法

Country Status (7)

Country Link
US (1) US20030219731A1 (https=)
EP (1) EP1327151A2 (https=)
JP (1) JP2004511773A (https=)
CN (1) CN1474944A (https=)
AU (1) AU1199501A (https=)
CA (1) CA2425434A1 (https=)
WO (1) WO2002031484A2 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1314968C (zh) * 2004-03-11 2007-05-09 复旦大学 痕量多肽或蛋白质富集及其直接分析方法
CN100376895C (zh) * 2004-11-03 2008-03-26 中国科学院计算技术研究所 一种使用串联质谱数据鉴定肽的方法
CN100483394C (zh) * 2006-04-14 2009-04-29 中国科学院计算技术研究所 一种质谱数据处理中噪音基线识别方法
CN103268851A (zh) * 2012-05-21 2013-08-28 核工业北京地质研究院 热电离飞行时间质谱仪及热电离飞行时间质谱分析方法
CN107148572A (zh) * 2014-10-30 2017-09-08 Dh科技发展私人贸易有限公司 用于选择离子进行离子碎裂的方法和系统
CN110073465A (zh) * 2016-12-06 2019-07-30 拉皮斯坎系统股份有限公司 用于检测样本中的成分的设备及其使用方法
CN114383984A (zh) * 2021-12-06 2022-04-22 浙江大学 一种捕获颗粒物并测量其相态、形貌和化学组分的系统

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0101555D0 (sv) * 2001-05-04 2001-05-04 Amersham Pharm Biotech Ab Fast variable gain detector system and method of controlling the same
US6946653B2 (en) * 2001-11-27 2005-09-20 Ciphergen Biosystems, Inc. Methods and apparatus for improved laser desorption ionization tandem mass spectrometry
US7846748B2 (en) * 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
EP3270407B1 (en) * 2010-12-28 2021-07-07 Quest Diagnostics Investments LLC Quantitation of insulin by mass spectrometry
GB201110272D0 (en) 2011-06-17 2011-08-03 Isis Innovation Metod of detection by mass spectrometry
JP6647224B2 (ja) * 2014-06-13 2020-02-14 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析を用いる脂質の分析のための方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288644A (en) * 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5202563A (en) * 1991-05-16 1993-04-13 The Johns Hopkins University Tandem time-of-flight mass spectrometer
US5144127A (en) * 1991-08-02 1992-09-01 Williams Evan R Surface induced dissociation with reflectron time-of-flight mass spectrometry
US5382793A (en) * 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
US6020208A (en) * 1994-05-27 2000-02-01 Baylor College Of Medicine Systems for surface-enhanced affinity capture for desorption and detection of analytes
ATE242485T1 (de) * 1993-05-28 2003-06-15 Baylor College Medicine Verfahren und massenspektrometer zur desorption und ionisierung von analyten
US6017693A (en) * 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
US5777324A (en) * 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
GB9717926D0 (en) * 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
US6348688B1 (en) * 1998-02-06 2002-02-19 Perseptive Biosystems Tandem time-of-flight mass spectrometer with delayed extraction and method for use
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
US6723564B2 (en) * 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1314968C (zh) * 2004-03-11 2007-05-09 复旦大学 痕量多肽或蛋白质富集及其直接分析方法
CN100376895C (zh) * 2004-11-03 2008-03-26 中国科学院计算技术研究所 一种使用串联质谱数据鉴定肽的方法
CN100483394C (zh) * 2006-04-14 2009-04-29 中国科学院计算技术研究所 一种质谱数据处理中噪音基线识别方法
CN103268851A (zh) * 2012-05-21 2013-08-28 核工业北京地质研究院 热电离飞行时间质谱仪及热电离飞行时间质谱分析方法
CN103268851B (zh) * 2012-05-21 2015-12-30 核工业北京地质研究院 热电离飞行时间质谱仪及热电离飞行时间质谱分析方法
CN107148572A (zh) * 2014-10-30 2017-09-08 Dh科技发展私人贸易有限公司 用于选择离子进行离子碎裂的方法和系统
CN110073465A (zh) * 2016-12-06 2019-07-30 拉皮斯坎系统股份有限公司 用于检测样本中的成分的设备及其使用方法
CN114383984A (zh) * 2021-12-06 2022-04-22 浙江大学 一种捕获颗粒物并测量其相态、形貌和化学组分的系统

Also Published As

Publication number Publication date
WO2002031484A3 (en) 2002-07-25
US20030219731A1 (en) 2003-11-27
JP2004511773A (ja) 2004-04-15
EP1327151A2 (en) 2003-07-16
WO2002031484A2 (en) 2002-04-18
AU1199501A (en) 2002-04-22
WO2002031484A8 (en) 2003-09-04
CA2425434A1 (en) 2002-04-18

Similar Documents

Publication Publication Date Title
US20020182649A1 (en) Methods for protein identification, characterization and sequencing by tandem mass spectrometry
Dong et al. Advances in mass spectrometry‐based glycomics
Kinter et al. Protein sequencing and identification using tandem mass spectrometry
EP1530721B1 (en) Method for characterizing biomolecules utilizing a result driven strategy
CN1474944A (zh) 利用亲和捕获串联质谱分析表征分子间作用的方法
US8633031B2 (en) Expression quantification using mass spectrometry
US20020195555A1 (en) Apparatus and methods for affinity capture tandem mass spectrometry
CN1675372A (zh) 用于检测卵巢癌的生物标记的用途
Barbosa et al. Proteomics: methodologies and applications to the study of human diseases
CN1449496A (zh) 癌症标记的鉴定方法及其在癌症诊断中的用途
CN1502116A (zh) 亲和捕获串联质谱分析设备和方法
CN1426536A (zh) 前列腺癌标记
US20060078960A1 (en) Expression quantification using mass spectrometry
CN1636068A (zh) 将基因表达谱与蛋白质表达谱相关联的方法
CN1149398C (zh) 多肽测序的方法和试剂盒
Ho Protein Characterisation Using Affinity Enrichment Techniques and Mass Spectrometry
Nuccio The effect of search accuracy on shotgun protemoics results using a validated protein database and high resolution fragment spectra
Era of the proteome essentially impossible. 14, 15 Unfractionated

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication