CN1471981A - Surface treatment for SARS lungs bacteria infection - Google Patents
Surface treatment for SARS lungs bacteria infection Download PDFInfo
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- CN1471981A CN1471981A CNA031408257A CN03140825A CN1471981A CN 1471981 A CN1471981 A CN 1471981A CN A031408257 A CNA031408257 A CN A031408257A CN 03140825 A CN03140825 A CN 03140825A CN 1471981 A CN1471981 A CN 1471981A
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Abstract
A surface treating method for the lung infected with SARS virus is based on the theory that the SARS virus infection is a surface infectious ulcer disease, and features that the ozone is dissolved in the liquid-state perfluoro chemical (PFC) and the solution is used to wash lung for treating the SARS.
Description
One. preamble
Talk from the function of lungs earlier.
Thereby the major function of lung is the blood that will be penetrated by right ventricle and carries out gas exchange and be pressed into oxygen and the discharge carbon dioxide through a large amount of blood capillaries that pulmonary artery is redistributed to each pulmonary artery branch and wide and alveolar, the speed of returning the relevant again heart rate ratio of left atrium by pulmonary vein is mixed into right ventricle then, and the full circulation operation of human aortic just surge gush thus of fresh oxygen containing power source! (accompanying drawing 1.)
Because the media of gas exchange there is no special feature, also as us in breed fish, air is squeezed into the water-bed bubble that produces, airborne oxygen relies on the face that the touches friction of the bubble spherical outside surface that rises and dissolves in the water.Be as good as with the bubble in breeding fish, our alveolar is born to constitute the vast area that has possessed ingress of air, just inner owing to exist the alveolar pore organizational structure that collects close at those slight lungs, thereby makes contact surface vast in more than the 70m2! And the surface of these cell structures is covered with blood capillary, serving as the traffic mission of " changing oxygen " with regard to this youngest, air is also just finished pulmonary ventilation (Palmnary Veneilation) toward blood, interstitial lamella and iuntercellular diffusion, and this is the modern medicine understanding the most basic to lungs.
Passing, pneumonopathy of a great variety, tuberculosis once be the difficulty infectious disease of curing also because of the invention of multiple antibiotic medicine, cure rate is near absolutely! Infantile pneumonia also is a kind of main commonly encountered diseases, and for example Diplococcus pneumoniae (pneumococcus) is from needn't speaking more as typical bacteria for other, but not the therapy of the star SARS of typical bacteria pneumonia is only the theme of today.
At first be tcm therapy, only the pattern that is absorbed by the intestines and stomach will be the chains of traditional Chinese medical science development, and the prescription of the traditional Chinese medical science only assisting the intestines and stomach to go the pestilence detoxifcation to lower the painstaking degree of liver, improves the physical ability enhancing immunity not much else whereby.
Yet, the main flow of diagnosis and treatment SARS still is the opinion of doctor trained in Western medicine at present, in state-ownedly see antibiotic therapies such as advocate using tetracycline, erythromycin, Hong Kong adheres to that ribavirin (Ribavirin) and steroid (steroid) are the medicines of effective first-line treatment SARS, but uses Canada of Ribavirin to announce to stop with this medicine as the customary scheme of treatment SARS because the issuable serious side effects of this medicine always.
But howsoever, antibiotic absorbed by the intestines and stomach or all good by intravenous injection, all can not change the pattern of operation antimicrobial factors in blood, we can take this feature and classify as " hemotherapy ", the micro element of a lot of antimicrobial factorses is can't be absorbed by the intestines and stomach to transform, therefore, the opinion curative effect still is come out top by western medicine therapy!
Also therefore, today medical courses in general circle various forces none be not absorbedly the direction focusing of scientific research to be spinned in the drug effect whirlpool that improves " antimicrobial factors "!
Yet, can gain enlightenment from the icon of accompanying drawing .2, seek quiet or injection point as artery at lungs, the curative effect of " hemotherapy " will significantly improve, by the flow-rate ratio of aorta and pulmonary circulation will be that a considerable constant can obtain to confirm, the clinical curative effect that comprises SARS is put into practice Ying Kecong and obtained the chance that promotes here, but today, we will point out that but the drug effect striving direction that medical courses in general circle are absorbed in SARS antimicrobial factors " hemotherapy " is all wet at this.
Because must be the interface definition with the air, SARS courses of infection (SARS) remains a kind of usur and infects, and this is the medical definition of an innovation, will cause lungs medical treatment revolution! Therefore, we more have used very mixed ripe being commonly called as of industrial quarters, promptly introduce more direct " surface treatment " technology that lungs infect, and that is to say and will will introduce the sonic cleaning technology in treatment! Talk about later, also can simply come this youngest to say, such as outer skin bacterial infection ulcer, as long as gentian voiet one wiping will be better than the wonder drug of any antibiotic " hemotherapy "!
In this connection, we can point out fully optimistically further, in case obtaining medical circle relay developing at the lungs " surface treatment " of subject recommending today studies carefully and sends out and enter clinical practice, that is one years old, for the preliminary the infected of SARS, wash a lung to hospital, and the bacterial virus of its kind is not being talked about more to the infection of pulmonary, SARS just no longer exists the danger side of body of life from now on to the mankind!
Today, curing the SARS infection is the theme that we will discuss, and we also must have a general understanding to the physical property of SARS:
1. accompanying drawing 3. is online pictures of downloading, and SARS is the ultra micro pathogenic bacteria less than 50 nanometers, and SARS is gained the name by the bodily form of many hats, yet is many
The physics ecologic structure of hat has determined its adsorptivity! And " surface treatment " infection emphasized at this chapter that overcomes of this adsorptivity has the utmost point
Its significance.From the inspiration of this viewpoint, in the measure of respiratory tract prevention infection, make the author expect the permeability of strong brine, be
Traditional disinfecting anti inflammatory is a treasured in the cupboard especially, should be easily society admit prevention block SARS from the oral cavity, the propagation of throat period
And lung, as long as wet one's whistle for the people of the pharyngolaryngitis of bacterial infection drink some saline, the pain perception of pharyngolaryngitis can obtain well at once
Releive, the micro-of fujinon electronic video endoscope can be told us truth easily, is that the position antibacterial that infects the ulcer inflammation " is washed away " by saline and subtracts
Few.
2. ultra micro, extra light pathogenic bacteria can only could show shape under ultramicroscope, and the filtration limit nominal of N95 is 75 nanometers, make ultra micro,
Extra light physical property can make SARS along with the moisture content pearl in the moving air, dust microparticle are propagated, and at this specific character, we can
To formulate effective specific aim measure of a sequence, in case comprise into " surface treatment " method of pulmonary of wafing.
Two. lungs " surface treatment " will have five modes the present and the past
1. antibiotic gasification anapnotherapy;
2. massage and sneeze cough therapy;
3. the lobe of the lung is taken out external sterilization treatment;
4. the lobe of the lung does not excise, the local anxious sterilization treatment of freezing;
5. the lobe of the lung injects the biocide processing.
Discuss one.
Antibiotic gasification anapnotherapy exists for a long time, at the initial stage of infecting positive role is arranged, if transfer the anti-epidemic measure before and after the high-risk medical care operation period to, may have good effect, the chemistry of antibiotics characteristic of gasification must have both with respect to 37 ℃ has good molten aqueous just to have Development Prospect.
Discuss two.
Massage sneeze cough therapy also belongs in " surface treatment " series, claims physiotherapy or can be more suitable.Use and pulmonary is applied rubbing power push alveolar, make pathogenic bacteria break away from the cell wall of alveolar, the patient can stimulate the nostril sneeze and by the expectoration of lung depths, looks forward to only in initial stage of infecting or the decision of the individual in the defence measure towards sunlight,
Therefore light sneeze device has the large market,, sneeze three of every days and can not underestimate the lifting of old people's health preserving art because this also is a kind of best mode of breast, lobe of the lung portion motion! The benefit of this motion mode is temporarily rare is excavated understanding by people, will be good news to patient a little less than the lung, but confirm to infect this pathogenic bacteria that powerful absorption affinity is arranged of SARS that it is unpractical that attempt alleviates condition of illness with this.
Discuss three.
The lobe of the lung is taken out external sterilization treatment, is not an illusion, has related to the invention of great significance and the clinical practice of extracorporeal blood oxygenating machine.External sterilization treatment could have medicinal liquid to soak and the temperature difference is handled two kinds of classification, and it also is a brand-new medical concept so far that the temperature difference is handled! Not only can be used in pulmonary's bacterial infection, also can be used for patients such as cancer, the surface treatment model that has surmounted the lungs infection is raised, and if can develop better, can more effectively replace antibiotic hemotherapy in certain class treatment of diseases:
A. external medicinal liquid soaks compared with intravital medicinal liquid and soaks more all motilities, can select not injure the immersion of alveolar tissue at present
Medicinal liquid is rare or blank, is a successful face but can germ-resistant soaking medicated liquid can give full play to the highest curative effect by ultrasound wave
Temptation;
B. what makes the temperature difference handle? the ecological temperature curve that processed lungs organ and pathogenic bacteria are had nothing in common with each other is at processed device
Choose in the revivable IQF temperature range of official can complete various pathogenic bacterias death point, the processing hands of Here it is altitude temperature difference effect
Section; Whether this processing means are unimportant first in the proposition of medical literature, facts have proved not complicatedly, and key is
About the speed of IQF the resurrection rate this point of organ can not neglect, be the item that is worth to the positive recommendation of medical circle
Order.
Discuss four.
The lobe of the lung does not excise and local anxious freezes sterilization treatment, also is all the theory from altitude temperature difference effect, is that pro-is discussed on four the hierarchy of skill and further promoted.Take out external and do not excise pulmonary artery and vein and can reduce restorative injury and reduce contact between organ and make and locally suddenly freeze sterilization treatment and possess feasibility, be worthy of consideration with regard to lungs are difficult, can " half isolated organ " anxious to freeze the sterilization art be feasible as kidney etc. but for other, but problem is thorny is that anxious to freeze DeviceMode be not to be that the liquefied ammonia circulating cooling is so simple, clinical requirement is the organ of about 1kgs quality can be cooled in second at 5-10-chilling unit of 30-50 ℃ and be contact, and medical breakthrough will be known no measure and take this and be claimed to scientific and technological circle.
Discuss five.
The lobe of the lung injects the surface-treated theme of sterilization for lungs infection today, the author is not the specialized personnel that studies medicine, only by taking too many supplementary lessons for medical science general knowledge, and be derived from the notion inspiration of strong brine to oral cavity, throat surface treatment antiinflammatory, and also find comparatively suitable solvent and biocide, suddenly must be subjected to Clinical Laboratory, but the author be sure of, perhaps as long as the solvent teacher and the pharmacists of specialty just display in the world, make the more again selection in solvent and biocide aspect, the harm to life of SARS pathogenic bacteria will be so far!
Three. the singlet oxygen therapy of lungs " surface treatment "
In lung, inject and dissolved the liquid of disinfectant, the surface treatment liquid of Here it is lungs singlet oxygen therapy.This liquid formal name used at school is liquid perfluorochemical (Per fluoro chemicals.PFC), and disinfectant then is an ozone.
Importing ultrasound wave when treat liquid is conveyed into the lobe of the lung can improve the adsorptivity that overcomes SARS and clear up pathogenic bacteria in the lung hole fast, this is brand-new practical medical scheme, it is directly that drug effect produces, launch clever cruise missile facing to SARS pathogenic bacteria cell, therefore and single oxygen → O1 that the title of this guided missile is separated out by ozone just could order and is " singlet oxygen therapy "/" O1 → Therapy "!
And at present conventional antibiotic through the therapy of blood exchange effect by restricted rib, it for example is the restriction of haemoconcentration, again for example the alveolar blood capillary stretch and less than interstitial lamella all be enough to shelter volume 50 nanometers less than the SARS pathogenic bacteria, therefore " hemotherapy " stayed the historical eternal regret of 10% above mortality rate, so " hemotherapy " of doctor trained in Western medicine is near the limit.Opposite, " singlet oxygen therapy " produced powerful pharmacodynamics effect, and the mortality rate of expection will reduce to zero.
1.PFE selecting for use of solvent;
2. the characteristic of ozone sterilization agent;
3. lungs " surface treatment " design cycle;
4. the animal lungs are handled checking;
5. operating-table designs main points.
1.PFE selecting for use of solvent
When selecting the liquid medium of cleaning alveolar, we have at first expected a kind of perfluorochemical (Per fluoro chemicals.PFC) of liquid state, PFC breathes art in liquid state has the ready-made clinical medicine can reference, we can use the infection that this breathing liquid dissolves in effective biocide or antibiotic cleaning alveolar SARS fully, and PFC has following excellent properties:
1. PFC itself is a kind of liquid of colourless, tasteless, odorless, does not have toxicity;
2. the PFC surface tension is low, and is water insoluble or fatty;
3. PFC has the characteristic of high density and low solubility for the dissolubility height of oxygen and carbon dioxide, has higher for ozone
Dissolubility;
4. PFC can volatilize by nature under room temperature and body temperature, can not be transformed into other material because of metabolism;
Making a general survey of above-mentioned characteristic, is fully qualified as the lungs surface treatment liquid, and one side oxygen can penetrate it makes the gas exchange of alveolar not stop, so PFC can be described as the power liquid state; Person in addition, the permeability of liquid perfluorochemical can guarantee in alveolar all-pervasive, the single oxygen atom during ozone dissolve in PFC just like benefit can pursue the trace of SARS; The volatility of the nature of PFC must be in guaranteeing can not produce any sequela to lungs; In addition the person is more valuable is perfusion and drain with fresh PFC liquid, the damaged cell in the pulmonary and cell debris that inflammatory response causes and the lavation of SARS dead body remains can be come out!
2. the characteristic of ozone sterilization agent
1. the molecular formula of ozone is that O3 is the distortion of high-energy oxygen, is dissolved in water and various liquefied compound;
2. be a kind of colourless under the low concentration state, the gas of special careless fishy taste is arranged, be tangible blue gas under high concentration, proportion is empty
1.5 times of gas;
3. the sterilization base of ozone reason is to discharge the cyton of antozone deoxidation virus, destroys its nucleus, and remaining is pure just
O2 oxygen is the sweet spring water of pulmonary just also;
4. ozone has stronger, sterilizing effect faster after soluble in water, and it is PFC that ozone can be dissolved in liquid perfluorochemical simultaneously;
5. after the concentration of ozone surpasses certain numerical value, disinfection even can finish moment;
The above-mentioned characteristic of ozone is rational selection as the alveolar biocide, and figure below is the ozone sterilization disinfectant experimental data of generally acknowledging in the world by online download:
| Ozonization | Add concentration | Add the time | Virus, pathogen kind | Kill efficiency |
| ????10mg/m3 | 20 minutes | Hbs antigen (HbsAg) | ????99.99％ | |
| ????0.5ppm | 5 minutes | Influenza A virus | ????99％ | |
| ????0.13mg/L | 30 seconds | Poliovirus I type (PVI) | ????100％ | |
| ????40μg/L | 20 seconds | Coliphage ms2 | ????98％ | |
| ????0.25mg/L | 1 minute | Ape rotavirus SA-H and Human reoviruslike agent 2 types | ????99.60％ | |
| ??? *12.6mg/L | 4 minutes | Coronavirus (Coronaviridae) | ????100％ | |
| ????4mg/L | 3 minutes | HIV (human immunodeficiency virus) (HIV) | ????100％ | |
| ????8mg/m3 | 10 minutes | Mycoplasma (Mycoplasma), chlamydia pathogen such as (Chlamydia) | ????99.85％ |
*The concentration content that indicates the liquid 12.6mg of every liter of pulmonary " surface treatment " can be the preferred mid point of reference to us.
3. lungs " surface treatment " flow process
Handling process is handled demonstration with right lung, the left pulmonary respiration of temporary transient reservation, target is to handle two lung times spent, this program three. before human clinical's actual practice, after at first necessary animal lungs processing checking through program four is errorless, the animal lungs are handled checking and are used for reference human body handling process three, and the inversion benefit on the read-me is to save time, sincerely in explanation.
A. surface treatment clinical (except the anaesthetist's specialty, physical ability biochemical measurement) sketch map:
See accompanying drawing 4.
B. the clinical practice square frame of surface treatment
See accompanying drawing 5.
4. the animal lungs are handled checking
The animal lungs are handled checking and are reached two lungs more simultaneously the processing stage with the single lung of piglets, and animal is handled simulated program three. scheme, following arrangement is arranged:
A. pure PFC injects checking
| Head | After pure PFC injects 10mins | After pure PFC injects 30mins | After pure PFC injects 120mins | ||||||
| Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | |
| ????1 | |||||||||
| ????2 | |||||||||
| ????3 | |||||||||
B.12.6mg/L dissolve in PFC and inject the reaction of aseptic pig checking high-concentrated ozone
| Head | After pure PFC injects 10mins | After pure PFC injects 30mins | After pure PFC injects 120mins | ||||||
| Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | |
| ????1 | |||||||||
| ????2 | |||||||||
| ????3 | |||||||||
C.25.2mg/L dissolve in PFC and inject the reaction of aseptic pig checking high-concentrated ozone
| Head | After pure PFC injects 10mins | After pure PFC injects 30mins | After pure PFC injects 120mins | ||||||
| Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | |
| ????1 | |||||||||
| ????2 | |||||||||
| ????3 | |||||||||
D.12.6mg/L dissolve in PFC and inject the reaction of SARS pig checking high-concentrated ozone
| Head | Pure PFC injects 10mins | Pure PFC injects 30mins | Pure PFC injects 120mins | ||||||
| Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | Blood oxygen quantitative changeization | Heart pulse momentum | Show little description | |
| ????1 | |||||||||
| ????2 | |||||||||
| ????3 | |||||||||
The test of annotating 1. above a-c for the checking molten Ji of PEC and the property of medicine of the treatment fluid after dissolving in antibacterial ozone whether to lungs have deny bad instead
Should, the test of c should further improve the concentration of ozone, till the curve chart that a reliable Pulmonis Sus domestica reaction is arranged,
It is for referencial use in human body treatment formulations delimitation forbidden zone that this curve chart can be the pharmacists.
The check of putting into effect of the test SARS pathogenic bacteria inflammation of annotating 2. d. need be cultivated and be infected sick pig, the test of various concentration doses by that analogy, but
The premunition of experiment piglets should be much larger than the mankind, but in general, after drug reaction test by 1-3, sterilization dose
Test also can draw proximate result in test tube, and can see under ultramicroscope and obtain, and biochemical laboratory should be in short-term
Between within guide report for the pharmacists makes.This planning experiment is sincerely for referencial use.
5. the design main points of operating-table
The design main points key of operating-table is to rotate the horizontal plane of operating-table, makes people on the operating-table minimum 45 degree of leaning to one side about can be respectively, the convenient left and right sides pulmonary that handles in turn.
6. Figure of description explanation
1. Fig. 1. be the human body blood vessels diagrams that flow.
2. Fig. 2. be human body, the pulmonary's blood vessels contrast diagram that flows.
3. Fig. 3. be the micro-diagram of coronavirus (SARS).
4. Fig. 4. for the clinical sketch map of surface treatment and be appointed as Figure of abstract.
5. Fig. 5. be the clinical practice square frame of surface treatment.
Claims (5)
1. with liquid be surface treatment that vehicle is injected lungs cure at the therapy of pneumonopathy.
2. the disease of lungs comprises the infection of lungs atypia pathogenic bacteria.
The class of liquids of surface preparation comprise formal name used at school be liquid perfluorochemical (Per fluoro chemicals, PFC).
4. be that vectorial surface treatment liquid adds the factor of murdering or suppress pathogenic bacteria at liquid, comprise the mode that any antibiotic injects.
5. sterilization factor comprises the interpolation application of ozone (O3).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031408257A CN1471981A (en) | 2003-06-07 | 2003-06-07 | Surface treatment for SARS lungs bacteria infection |
| HK04103353A HK1060833A2 (en) | 2003-06-07 | 2004-05-13 | Surface treatment of sars-infected lungs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031408257A CN1471981A (en) | 2003-06-07 | 2003-06-07 | Surface treatment for SARS lungs bacteria infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1471981A true CN1471981A (en) | 2004-02-04 |
Family
ID=30122961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031408257A Pending CN1471981A (en) | 2003-06-07 | 2003-06-07 | Surface treatment for SARS lungs bacteria infection |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN1471981A (en) |
| HK (1) | HK1060833A2 (en) |
-
2003
- 2003-06-07 CN CNA031408257A patent/CN1471981A/en active Pending
-
2004
- 2004-05-13 HK HK04103353A patent/HK1060833A2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1060833A2 (en) | 2004-07-23 |
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