CN1453563A - Simulated measurement of heat field distribution in microwave solidification treatment of tumor - Google Patents
Simulated measurement of heat field distribution in microwave solidification treatment of tumor Download PDFInfo
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- CN1453563A CN1453563A CN02116888.1A CN02116888A CN1453563A CN 1453563 A CN1453563 A CN 1453563A CN 02116888 A CN02116888 A CN 02116888A CN 1453563 A CN1453563 A CN 1453563A
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- 238000005259 measurement Methods 0.000 title claims abstract description 20
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 19
- 238000007711 solidification Methods 0.000 title claims abstract description 19
- 230000008023 solidification Effects 0.000 title claims abstract description 19
- 238000009826 distribution Methods 0.000 title claims abstract description 17
- 230000005855 radiation Effects 0.000 claims abstract description 31
- 238000005315 distribution function Methods 0.000 claims description 21
- 238000000691 measurement method Methods 0.000 claims description 14
- 210000001519 tissue Anatomy 0.000 claims description 10
- 238000002474 experimental method Methods 0.000 claims description 8
- 239000011521 glass Substances 0.000 claims description 7
- 238000006467 substitution reaction Methods 0.000 claims description 7
- 238000012546 transfer Methods 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 6
- 210000003205 muscle Anatomy 0.000 claims description 6
- 239000006185 dispersion Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 description 13
- 210000004185 liver Anatomy 0.000 description 7
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- 206010019695 Hepatic neoplasm Diseases 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 235000015277 pork Nutrition 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000000015 thermotherapy Methods 0.000 description 2
- 229910001006 Constantan Inorganic materials 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000008636 Neoplastic Processes Diseases 0.000 description 1
- 241000531807 Psophiidae Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
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- 238000012544 monitoring process Methods 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
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- 230000007480 spreading Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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Abstract
The simulated measurement of heat field distribution in microwave solidification treatment of tumor includes the following steps: making microwave radiation field simulating measurer; setting microwave antenna inside the simulating measurer and setting measuring thermocouples connected via data collector to computer in proper positions; setting microwave body mold inside the simulating measurer; measuring temperature varying with time with the thermocouples, substituting the data into biological heat conducting equation to obtain the microwave radiation energy SAR per unit volume and per unit time, substituting SAR into dispersion function equations, solving the simultaneous equations in computer to obtain the coefficients of the dispersion function equations and the 3D heat field dispersion function of microwave radiation as well as the temperature in certain points in certain time.
Description
Technical field:
The present invention relates to a kind of measuring method of microwave radiation thermal field, particularly microwave and be used for the analog measurement method that solidification treatment of tumor process thermal field distributes.
Background technology:
Implanted microwave heat therapeutic method has been widely used in the interventional therapy of tumour.The effective temperature thermal field that microwave forms in cancerous issue is the key that influences result of treatment, and promptly therapeutic process is a process of judging treatment by the regulation and control in temperature field that microwave is formed.This effective temperature thermal field all is the method that adopts the some thermometric in therapeutic process at present, estimate and effective thermal field body of controlled microwave effect with 1,2 point, or infer the change of temperature by resistance variations, these are measured and determination methods can not obtain whole microwave radiation three-dimensional thermal field accurate and detailed data in the thermotherapy process, also just can not finely learn emittance and the variation of temperature situation that is absorbed by each position of tumour of thermotherapy.
Summary of the invention:
The objective of the invention is to solve the technical barrier that the temperature of microwave three-dimensional thermal field in the implanted micro-wave therapeutic neoplastic process can't be measured and know, a kind of analog measurement method that can obtain microwave three-dimensional thermal field DYNAMIC DISTRIBUTION in micro-wave therapeutic is provided, has solved the default difficult problem that reaches real-time monitoring in the treatment of the preceding effectively thermal field of oncotherapy.
Technical scheme of the present invention is such: it comprises the steps:
1, make microwave radiation field analogue measurement device, 2, microwave guide needle and microwave antenna are inserted in the described analogue measurement device, and the certain position apart from microwave antenna is provided with the measurement thermopair in the analogue measurement device, described thermopair links to each other with data acquisition unit, described data acquisition unit links to each other with computing machine, 3, base goes into to organize MICROWAVE PHANTOM MUSCLE TISSUE in described analogue measurement device, 4, the microwave radiation of measuring different-energy in the position temperature that described thermopair is set over time, with the biological heat transfer equation of data substitution, obtain unit volume and unit interval microwave radiation energy SAR, with its distribution function equation of SAR substitution, by these simultaneous equations of machine solution, can try to achieve every coefficient of distribution function equation, obtain the distribution function of microwave radiation three-dimensional thermal field, thereby can obtain the temperature of fixed time at specified point, described biological heat transfer equation is:
SAR=ρ CdT/dt-K Δ T+M
bC
b(T-T
b) wherein ρ be the (kg/m of tissue density
3), C is a specific heat, and T is a temperature, and t is the time, and K is the coefficient of heat conductivity (W/m ℃) of tissue, M
b, C
bBe respectively the filling rate (kg/m of blood
3S) and specific heat (J/kg ℃), T
bFor this regional arterial blood temperature (℃).
Described microwave radiation energy SAR distribution function equation:
SAR＝ρCe
-aZ[X
0r
3+X
1r
2+X
2r+X
3][cos(X
5θ)+X
4]
According to preliminary experiment microwave radiation energy SAR distribution function is the plane distribution function:
SAR＝ρCe
-aZ[X
0r
3+X
1r
2+X
2r+X
3]
Above-mentioned microwave radiation analogue means comprises the organic glass frame of a hollow and can shelve the support cover of this framework, be symmetrically arranged with a pair of diameter greater than 1 millimeter guid needle through hole at two opposite side of four frames of described framework, a side of described guid needle through hole at interval equidistance be provided with a pair or more of diameter less than 1 millimeter backguy through hole, described every pair of backguy through hole is provided with backguy, and described backguy is provided with thermopair.
Described support slot is made by organic glass.
Above-mentioned backguy through hole is 5 pairs, and its spacing is 5 millimeters.
The thermopair that is provided with in the above-mentioned backguy is 16.
A kind of device of realizing the analog measurement method that the microwave solidification treatment of tumor thermal field distributes, comprise the microwave radiation analogue means that to place microwave antenna, be provided with a plurality of thermopairs apart from the microwave antenna certain distance in the described analogue means, described thermopair links to each other with data acquisition unit, and described data acquisition unit links to each other with computing machine.
Technique effect:
The invention provides a kind of measuring method that can obtain microwave solidification treatment of tumor three-dimensional simulation thermal field DYNAMIC DISTRIBUTION, promptly set up an office by preset distance on MICROWAVE PHANTOM MUSCLE TISSUE, tissue temperature over time after measuring the relevant position phantom and being subjected to microwave radiation, distribution equation by microwave radiation energy SAR that biological heat transfer equation and finite element analysis are obtained combines, by computing machine to the system of equations simultaneous solution, obtain every coefficient of microwave radiation energy SAR distribution equation, thereby obtain microwave solidification treatment liver tumour three-dimensional simulation thermal field DYNAMIC DISTRIBUTION, before micro-wave therapeutic, can dynamically learn microwave in any one site, space on the temperature at the appointed time, obtain the information of three-dimensional temperature field with not having wound.Before concrete treatment,, only need the change partial parameters (as the blood perfusion rate by to the actual case analysis, temperature conductivity etc.), get final product the preceding predicted temperature field of art, micro-wave therapeutic is based upon on the basis with foresight, and when treatment, can obtain the real-time three-dimensional heat-transmission field distribution of treatment region.
Description of drawings:
Fig. 1 is the structural representation of microwave radiation analogue means of the present invention;
Fig. 2 measures the synoptic diagram of layouting;
Fig. 3 is the coordinate figure of Fig. 2 each point.
Embodiment:
At this microwave coagulation thermal field analogue measurement with liver tumour is example, and the neoplastic lesion analogue measurement step of other tissue is identical, just the liver phantom is changed to other and organizes phantom or the stripped pork liver of trial test is changed to other three-dimensional animal tissues.
Design philosophy of the present invention is for utilizing finite element method, find the solution unit (tumour) microwave radiation energy that tissue absorbed (SAR-Specific Absorption Rate) in the unit interval, by the dynamic 3 D thermal field of computer simulation implanted microwave solidification treatment liver tumour.
Desire to find the solution SAR, according to the Pennes equation of simplifying:
ρcdT/dt＝Qr+KΔT-M
bC
b(T-T
b)＝SAR+KΔT-M
bC
b(T-T
b)
Wherein: ρ is the (kg/m of tissue density
3), c is a specific heat, and T is a temperature, and t is the time, and K is the coefficient of heat conductivity (W/m ℃) of tissue, M
b, C
bBe respectively the filling rate (kg/m of blood
3S) and specific heat (J/kg ℃), T
bFor this regional arterial blood temperature (℃), the rate of temperature change that hence one can see that measures certain some place just can obtain the SAR value of this point.
Therefore, rule of thumb suppose the distribution function of SAR earlier along three coordinate axis, for example the r direction is an exponential damping, the z direction is that the cubic polynomial match is (if interested in the universe of z direction SAR distribution, SAR distributes usually complicated in this scope, can not come match with a simple cubic polynomial, can adopt piecewise fitting this moment), the θ direction is a cosine function.Then they are combined into the SAR distributed in three dimensions function of following equation form.
SAR＝ρce
-αz[x
0r
3+x
1r
2+x
2r+x
3][cos(x
5θ)+x
4]
The peak (central point) of temperature has carried out following preliminary experiment when seeking the antenna for radiating microwave emission simultaneously for checking microwave field whether to be symmetrically distributed.
Symmetry on checking r direction, the θ direction: on the pork liver that exsomatizes, select r＞0 respectively, r＜0, four symmetric points continuous temperature measurements on the different directions are carried out at different θ angles, and experiment cloth point diagram sees Table:
The preliminary experiment coordinates table
| Period | Coordinate (mm r θ z) |
| ????T1 | ??5????0???0 |
| ????T2 | ?-5????0???0 |
| ????T3 | ??5????45℃??0 |
| ????T4 | ?-5???45℃???0 |
Result's institute's thermometric on the different four directions of same radius rises rule and temperature value very close (Δ T＜3 ℃), liver specimens is cut along sagittal plane and coronal-plane in the effect back, its sex change district of visual inspection is that the center is symmetrically distributed with the antenna for radiating microwave, therefore can prove that one pole implanted microwave antenna is in the r direction, the θ direction is symmetrical distribution, thereby SAR can be found the solution and be used as the two-dimensional problems processing.Found by the method for layouting simultaneously and solidified the spheroid maximum transverse diameter pairing to be the microwave antenna central point, to be distance antenna pointed end 15mm place in the z direction.The result of r direction coordinate symmetric points thermometric shows that z＞0 temperature rise speed is very fast, and temperature is higher, z＜0 temperature rise is mild relatively, temperature is lower, so the thermal field right and wrong of microwave field on the z direction are symmetric, and formal measurement must be found the solution z＞0, z＜0 o'clock SAR attenuation law respectively.
Result according to preliminary experiment, can make the simple two-dimensional test model measures, with the biological heat transfer equation of measurement result substitution, obtain microwave radiation energy SAR, with its distribution function equation of array SAR value substitution, solve the parameter value of distribution function equation by computing machine, obtain the real-time distribution of SAR three-dimensional thermal field.Concrete measuring process is as follows:
1, makes microwave radiation field analogue measurement device: see Fig. 1.With thick 1.5cm, 15 * 15cm is square, flat poly (methyl methacrylate) plate center hollows out, form the framework 20 of all hem width 1.5cm, this framework 20 is just put into the D=15.1cm that is used for adorning phantom, high 20cm is as in the organic glass cylinder barrel 21 of support cover, adopt organic glass to be because this kind material is noiseless to the microwave thermal field, and it is transparent, visual good, two opposite side at organic glass frame 20 are symmetrical arranged the guid needle through hole 22 that a pair of diameter is 1.7mm, just put into the microwave guide needle, each makes a call to the backguy through hole 24 of 5 D＜1mm up and down at two opposite side of its right side decentering 5mm, distance between borehole 5mm, pass last pull-down line through hole 24 with 1 trumpeter's art suture line, form 5 backguys 25 with microwave antenna parallel interval 5mm along framework 20;
2, insert in the framework 1 with described microwave guide needle guiding microwave antenna 26, take out the microwave guid needle again;
3, the certain position apart from microwave antenna 26 is provided with measurement thermopair 27 in framework 20, the diameter that described thermopair 27 adopts U.S. Ω company to produce is 0.003 inch an iron-constantan thermocouple silk, all thermopairs 27 are linked to each other with data acquisition unit, data acquisition unit links to each other with computing machine, by preliminary experiment as can be known, because thermal field is along the r direction, the θ direction is symmetrical distribution, thereby SAR can be found the solution and be used as the two-dimensional problems processing, thermopair 27 carries out the plane by Fig. 2 layouts, and Fig. 3 is the spatial value of Fig. 2 each point correspondence.And be separately fixed in the backguy 25 among Fig. 1 by this cloth point diagram, each 16 points of cloth are after cloth is better; together put into cylinder barrel 21 together with microwave antenna 26; the slow base of liver MICROWAVE PHANTOM MUSCLE TISSUE that has prepared is gone into, left standstill 12-24 hour, until phantom temperature and indoor temperature balance.Adopt Jiang-Han Area guarantor of Sichuan University to wait the MICROWAVE PHANTOM MUSCLE TISSUE prescription of development in this liver MICROWAVE PHANTOM MUSCLE TISSUE, the complex permittivity of this phantom is in the 300-2500MHz scope, with error≤5% of actual human body liver organization.
4, check cold junction temperature before measuring, and the temperature by the preceding measurement point of computer acquisition microwave action, with in the temperature fluctuation 5 minutes＜0.01 ℃ as the stable state index.
(60W300s, 50W10min 40W30min) divide above-mentioned 16 points to carry out 16-18 time and measure each energy group, and 3 energy groups are carried out 53 measurements altogether, and repeat 5-9 time in each site, calculates the mean value of getting each point at last.Energy gives 60W300s (every 100s is 10s at interval) respectively; 50W10min; 40W30min; data acquisition unit is with every 500ms (60W300s) or 1s (40W30min on; 50W10min) 16 passages of the continuous scanning of speed; the computer real-time record; shutting down the back observes continuously; with temperature drop to (initial temperature 21-24 ℃) below 43 ℃ and in 1 minute temperature variation＜1 ℃ be the index of shutdown; the 60W effect is organized general 15-20 minute and is reached stable, reaches stable state in 50W10 minute general 30-35 minute, and 40W30min organizes general 35-45 minute and reaches relative stable state; deposit resultant data in computing machine, use to do to analyze.
At least 7 some place variation of temperature are measured in experiment, notice that dT/dt is the slope of temperature variation curve, just can obtain SAR on these aspects from biological heat transfer equation, the distribution function equation of the coordinate of these points and SAR value difference substitution SAR, so just obtain the Simultaneous Equations formed by 7 equations, separate this Simultaneous Equations, just can obtain every coefficient.Obtain the distribution function of SAR/ ρ c, see the following form.
Just can obtain the distribution function of whole microwave thermal field SAR when known density and specific heat.
Utilize U.S. ANSYS (V5.5 version) finite element analysis software can finish whole computation process and (comprise pre-treatment-----spatial spreading based on finite element method, the derivation of finite element equation and aftertreatment-----further calculation of parameter, data output, the drafting of form and curve map etc.), calculate the dynamic 3 D thermal field of implanted microwave solidification treatment liver tumour.
Claims (10)
1. the analog measurement method that distributes of a microwave solidification treatment of tumor thermal field, it comprises the steps: 1), make microwave radiation field analogue measurement device, 2), microwave guide needle and microwave antenna are inserted in the analogue measurement device, and the certain position apart from microwave antenna is provided with the measurement thermopair in analogue means, described thermopair links to each other with data acquisition unit, described data acquisition unit links to each other with computing machine, 3), base goes into to organize MICROWAVE PHANTOM MUSCLE TISSUE in the analogue measurement device, 4), the microwave radiation of measuring different-energy in the position temperature that described thermopair is set over time, with the biological heat transfer equation of data substitution, obtain unit volume and unit interval microwave radiation energy SAR, with its distribution function equation of SAR substitution, by these simultaneous equations of machine solution, can try to achieve every coefficient of distribution function equation, obtain the distribution function of microwave radiation three-dimensional thermal field, thereby can obtain the temperature of fixed time at specified point, described biological heat transfer equation is:
SAR=ρ CdT/dt-K Δ T+M
bC
b(T-T
b) wherein ρ be the (kg/m of tissue density
3), C is a specific heat, and T is a temperature, and t is the time, and K is the coefficient of heat conductivity (W/m ℃) of tissue, M
b, C
bBe respectively the filling rate (kg/m of blood
3S) and specific heat (J/kg ℃), T
bFor this regional arterial blood temperature (℃).
Described microwave radiation energy SAR distribution function equation:
SAR＝ρCe
-αZ[X
0r
3+X
1r
2+X
2r+X
3][cos(X
5θ)+X
4]
2. according to the analog measurement method of the described microwave solidification treatment of tumor thermal field distribution of claim 1, it is characterized in that according to preliminary experiment microwave radiation energy SAR distribution function is the plane distribution function:
SAR＝ρCe
-αZ[X
0r
3+X
1r
2+X
2r+X
3]
3 analog measurement methods according to claim 1 or 2 described microwave solidification treatment of tumor thermal fields distributions, it is characterized in that described thermal field distribution function is the distribution of solidifying thermal field emittance SAR/ ρ c of 40W microwave radiation for power, apart from the forward direction of antenna pointed end 15mm partly be at the microwave antenna central point:
2.2667×2.9e
-0.3164r(-0.0002z
3+0.0042z
2-0.0344z+0.4864)
The microwave antenna central point is distributed as to part apart from the back of other end 12mm:
2.2667×2.9e
-0.3164r(-0.00003z
3+0.0013z
2-0.0306z+0.4864)
4. the analog measurement method that distributes according to claim 1 or 2 described microwave solidification treatment of tumor thermal fields, it is characterized in that described thermal field distribution function is the distribution of solidifying thermal field emittance SAR/ ρ c of 50W microwave radiation for power, apart from the forward direction of antenna pointed end 15mm partly be at the microwave antenna central point:
1.4903×3.02e
-0.3002r(8E-5z
3-0.003z
2+0.0091z+0.4152)
The microwave antenna central point is distributed as to part apart from the back of other end 12mm:
1.4903×2.98e
-0.3002r(4E-5z
3-0.0012z
2-0.0066z+0.4168)
5. the analog measurement method that distributes according to claim 1 or 2 described microwave solidification treatment of tumor thermal fields, it is characterized in that described thermal field distribution function is the distribution of solidifying thermal field emittance SAR/ ρ c of 60W microwave radiation for power, apart from the forward direction of antenna pointed end l5mm partly be at the microwave antenna central point:
1.1264×5.3e
-0.2829r(0.00003z
3-0.0016z
2+0.0042z+0.3651)
The microwave antenna central point is distributed as to part apart from the back of other end 12mm:
1.1264×5.2e
-0.2829r(0.000003z
3-0.0009z
2-0.0117z+0.3692)
6. the analog measurement method that distributes according to claim 1 or 2 described microwave solidification treatment of tumor thermal fields, it is characterized in that described microwave radiation analogue measurement device comprises the organic glass frame of a hollow and can shelve the support cover of this framework, be symmetrically arranged with a pair of diameter greater than 1 millimeter guid needle through hole at two opposite side of four frames of described framework, a side of described guid needle through hole at interval equidistance be provided with a pair or more of diameter less than 1 millimeter backguy through hole, described every pair of backguy through hole is provided with backguy, and described backguy is provided with thermopair.
7. the analog measurement method that distributes according to the described microwave solidification treatment of tumor thermal field of claim 3 is characterized in that described support slot made by organic glass.
8. the analog measurement method that distributes according to the described microwave solidification treatment of tumor thermal field of claim 3 is characterized in that above-mentioned backguy through hole is 5 pairs, and its spacing is 5 millimeters.
9. the analog measurement method that distributes according to the described microwave solidification treatment of tumor thermal field of claim 3 is characterized in that the thermopair that is provided with in the above-mentioned backguy is 16.
10. device of realizing the analog measurement method that the microwave solidification treatment of tumor thermal field distributes, comprise the microwave radiation analogue means that to place microwave antenna, be provided with a plurality of thermopairs apart from the microwave antenna certain distance in the described analogue means, described thermopair links to each other with data acquisition unit, and described data acquisition unit links to each other with computing machine.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011202655A1 (en) * | 2010-06-03 | 2011-12-22 | Tyco Healthcare Group, Lp | Specific absorption rate measurement and energy-delivery device characterization using thermal phantom and image analysis |
| CN104345068A (en) * | 2013-08-08 | 2015-02-11 | 广州医科大学附属肿瘤医院 | Medical electromagnetic wave energy ratio absorption rate measurement device |
| CN105427725A (en) * | 2015-12-16 | 2016-03-23 | 中山大学附属第三医院 | Simulation model for evaluating tumor ablation range through ultrasonic mono-modal image fusion |
| CN117731390A (en) * | 2024-02-19 | 2024-03-22 | 南京康友医疗科技有限公司 | Radio frequency ablation control system |
Families Citing this family (1)
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| CN101940498B (en) * | 2010-09-10 | 2012-05-09 | 中山大学 | Model for evaluating tumor ablation safe boundary by virtual navigation |
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2002
- 2002-04-24 CN CN02116888.1A patent/CN1257393C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011202655A1 (en) * | 2010-06-03 | 2011-12-22 | Tyco Healthcare Group, Lp | Specific absorption rate measurement and energy-delivery device characterization using thermal phantom and image analysis |
| CN104345068A (en) * | 2013-08-08 | 2015-02-11 | 广州医科大学附属肿瘤医院 | Medical electromagnetic wave energy ratio absorption rate measurement device |
| CN105427725A (en) * | 2015-12-16 | 2016-03-23 | 中山大学附属第三医院 | Simulation model for evaluating tumor ablation range through ultrasonic mono-modal image fusion |
| CN105427725B (en) * | 2015-12-16 | 2019-06-04 | 中山大学附属第三医院 | A kind of imitative body Model for ultrasonic single mode image co-registration assessment tumour ablation range |
| CN117731390A (en) * | 2024-02-19 | 2024-03-22 | 南京康友医疗科技有限公司 | Radio frequency ablation control system |
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