CN1257393C - Simulated measurement of heat field distribution in microwave solidification treatment of tumor - Google Patents
Simulated measurement of heat field distribution in microwave solidification treatment of tumor Download PDFInfo
- Publication number
- CN1257393C CN1257393C CN02116888.1A CN02116888A CN1257393C CN 1257393 C CN1257393 C CN 1257393C CN 02116888 A CN02116888 A CN 02116888A CN 1257393 C CN1257393 C CN 1257393C
- Authority
- CN
- China
- Prior art keywords
- microwave
- thermal field
- sar
- analog measurement
- solidification treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Surgical Instruments (AREA)
- Radiation-Therapy Devices (AREA)
- Radiation Pyrometers (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
The present invention relates to a simulated measurement method of heat field distribution in microwave solidification treatment of tumors, which is the simulated measurement method of heat field distribution in the process of using microwaves for the solidification treatment of tumors. The present invention comprises the following steps: step 1, a simulated measurement device of microwave radiation fields is manufactured; step 2, a microwave antenna is placed in the simulated measurement device, a measuring thermocouple is arranged in a relevant position, wherein the thermocouple is connected with a data acquisition device which is connected with a computer; step 3, a tissue microwave body mold is placed in the simulated measurement device; step 4, temperature history of microwave radiation of different energy at the position of the thermocouple is measured, the data is substituted in a bio-heat transfer equation to obtain radiation energy SAR of unit volume and unit time, SAR is substituted a distributed functional equation, the simultaneous equation is solved by the computer to obtain coefficients of the distributed functional equation, distribution functions of a microwave radiation three-dimensional thermal field can be obtained, and thereby, the temperature of scheduled time at a scheduled point can be obtained.
Description
Technical field:
The present invention relates to a kind of measuring method of microwave radiation thermal field, particularly microwave and be used for the analog measurement method that solidification treatment liver tumour process thermal field distributes.
Background technology:
Implanted microwave heat therapeutic method has been widely used in the interventional therapy of liver tumour.The effective temperature thermal field that microwave forms in cancerous issue is the key that influences result of treatment, and promptly therapeutic process is a process of judging treatment by the regulation and control in temperature field that microwave is formed.This effective temperature thermal field all is the method that adopts the some thermometric in therapeutic process at present, estimate and effective thermal field body of controlled microwave effect with 1,2 point, or infer the change of temperature by resistance variations, these are measured and determination methods can not obtain whole microwave radiation three-dimensional thermal field accurate and detailed data in the thermotherapy process, also just can not finely learn emittance and the variation of temperature situation that is absorbed by each position of liver tumour of thermotherapy.
" computer simulation in cervical carcinoma microwave heat therapeutic temperature field " in " Beijing University of Technology's journal " in Dec, 1999 number put down in writing by setting up the thermal model of cervix thermotherapy, utilize phantom measurement to go out specific absorption rate (SAR), and obtain the SAR distribution function by data fitting to radiation energy.Therefore the foundation of above-mentioned thermal model organize the difference in distribution of SAR bigger with actual lesion owing to be to measure acquisition under more assumed condition, can only be applicable to special small-sized canceration, can not be generalized to bigger cancerous issue.
Summary of the invention:
The objective of the invention is to solve the technical barrier that the temperature of microwave three-dimensional thermal field in the implanted micro-wave therapeutic liver tumour process can't be measured and know, a kind of analog measurement method that can more accurately obtain microwave three-dimensional thermal field DYNAMIC DISTRIBUTION in micro-wave therapeutic is provided, has solved the default difficult problem that reaches real-time monitoring in the treatment of the preceding effectively thermal field of liver tumour treatment.
Technical scheme of the present invention is such: it comprises the steps:
1, the pork liver that exsomatizes is carried out preliminary experiment, promptly on the pork liver that exsomatizes, select r＞0 respectively, r＜0, the symmetric points continuous temperature measurement at different θ angle, and be that the z direction is layouted at antenna direction, drawing single built-in type microwave antenna in the r direction, the θ direction is symmetrical distribution; 2, make microwave radiation field analogue measurement device, but the two-dimensional analog measurement mechanism that described analogue measurement device is the thermopair plane layouts; 3, microwave guide needle and microwave antenna are inserted in the described analogue measurement device of described two dimension, and in the two-dimensional analog measurement mechanism, locate galvanic couple apart from one of microwave antenna, described thermopair links to each other with data acquisition unit, described data acquisition unit links to each other with computing machine, 4, base goes into to organize MICROWAVE PHANTOM MUSCLE TISSUE in described two-dimensional analog measurement mechanism, 5, the microwave radiation of measuring different-energy in the position temperature that described thermopair is set over time, with the biological heat transfer equation of data substitution, obtain unit volume and unit interval microwave radiation energy SAR, with its distribution function equation of SAR substitution, by these simultaneous equations of machine solution, can try to achieve every coefficient of distribution function equation, obtain the distribution function of microwave radiation three-dimensional thermal field, thereby can obtain the temperature of fixed time at specified point, described biological heat transfer equation is:
SAR=ρ CdT/dt-K Δ T+M
bC
b(T-T
b) wherein ρ be the (kgm of tissue density
-3), C is a specific heat, and T is a temperature, and t is the time, and K is the coefficient of heat conductivity (Wm of tissue
-1℃
-1), M
b, C
bBe respectively the filling rate (kgm of blood
-3S
-1) and specific heat (Jkg
-1℃
-1), T
bFor this regional arterial blood temperature (℃),
Described microwave radiation energy SAR distribution function equation:
SAR＝ρCe
-αr[X
0z
3+X
1z
2+X
2z+X
3][cos(X
5θ)+X
4]，
According to preliminary experiment microwave radiation energy SAR distribution function is the plane distribution function:
SAR＝ρCe
-αr[X
0z
3+X
1z
2+X
2r+z
3]。
Above-mentioned microwave radiation two-dimensional analog device comprises the organic glass frame of a hollow and can shelve the support cover of this framework, be symmetrically arranged with a pair of diameter greater than 1 millimeter guid needle through hole at two opposite side of four frames of described framework, a side of described guid needle through hole at interval equidistance be provided with a pair or more of diameter less than 1 millimeter backguy through hole, described every pair of backguy through hole is provided with backguy, and described backguy is provided with thermopair.Described support slot is made by organic glass.Above-mentioned backguy through hole is 5 pairs, and its spacing is 5 millimeters.
The thermopair that is provided with in the above-mentioned backguy is 16.
A kind of device of realizing the analog measurement method that microwave solidification treatment liver tumour thermal field distributes, comprise the microwave radiation analogue measurement device that to place microwave antenna, but the two-dimensional analog measurement mechanism that described analogue measurement device is layouted for the plane, be provided with a plurality of thermopairs apart from the microwave antenna certain distance in the described two-dimensional analog measurement mechanism, described thermopair links to each other with data acquisition unit, and described data acquisition unit links to each other with computing machine.
Technique effect:
The invention provides a kind of measuring method that can obtain microwave solidification treatment liver tumour three-dimensional simulation thermal field DYNAMIC DISTRIBUTION, promptly at first by the pork liver that exsomatizes is carried out preliminary experiment, promptly select r＞0 respectively at stripped pork liver, r＜0, the symmetric points continuous temperature measurement at different θ angle, and be that the z direction is layouted at antenna direction, thereby know the regularity of distribution of hepatic tissue microwave field, set up an office by preset distance on MICROWAVE PHANTOM MUSCLE TISSUE then, tissue temperature over time after measuring the relevant position phantom and being subjected to microwave radiation, distribution equation by microwave radiation energy SAR that biological heat transfer equation and finite element analysis are obtained combines, by computing machine to the system of equations simultaneous solution, obtain every coefficient of microwave radiation energy SAR distribution equation, thereby obtain microwave solidification treatment liver liver tumour three-dimensional simulation thermal field DYNAMIC DISTRIBUTION, before micro-wave therapeutic, can dynamically learn microwave in any one site, space on the temperature at the appointed time, do not obtain the information of three-dimensional temperature field with having wound, owing to can more accurately obtain the thermal field distribution of hepatic tissue, thereby this temperature field energy is applicable to the micro-wave therapeutic of most liver tumour to microwave.Before concrete treatment,, only need the change partial parameters (as the blood perfusion rate by to the actual case analysis, temperature conductivity etc.), get final product the preceding predicted temperature field of art, micro-wave therapeutic is based upon on the basis with foresight, and when treatment, can obtain the real-time three-dimensional heat-transmission field distribution of treatment region.
Description of drawings:
Fig. 1 is the structural representation of microwave radiation analogue means of the present invention;
Fig. 2 measures the synoptic diagram of layouting;
Fig. 3 is the coordinate figure of Fig. 2 each point.
Embodiment:
Design philosophy of the present invention is for utilizing finite element method, find the solution unit (liver tumour) microwave radiation energy that tissue absorbed (SAR-Specific Absorption Rate) in the unit interval, by the dynamic 3 D thermal field of computer simulation implanted microwave solidification treatment liver liver tumour.
Desire to find the solution SAR, according to the Pennes equation of simplifying:
ρcdT/dt＝Qr+KΔT-M
bC
b(T-T
b)＝SAR+KΔT-M
bC
b(T-T
b)
Wherein: ρ is the (kgm of tissue density
-3), c is a specific heat, and T is a temperature, and t is the time, and K is the coefficient of heat conductivity (Wm of tissue
-1℃
-1), M
b, C
bBe respectively the filling rate (kgm of blood
-3S
-1) and specific heat (Jkg
-1℃
-1), T
bFor this regional arterial blood temperature (℃), the rate of temperature change that hence one can see that measures certain some place just can obtain the SAR value of this point.
Therefore, rule of thumb suppose the distribution function of SAR earlier along three coordinate axis, for example the r direction is an exponential damping, the z direction is that the cubic polynomial match is (if interested in the universe of z direction SAR distribution, SAR distributes usually complicated in this scope, can not come match with a simple cubic polynomial, can adopt piecewise fitting this moment), the θ direction is a cosine function.Then they are combined into the SAR distributed in three dimensions function of following equation form.
SAR＝ρce
-αr[x
0z
3+x
1z
2+x
2z+x
3][cos(x
5θ)+x
4]
The peak (central point) of temperature has carried out following preliminary experiment when seeking the antenna for radiating microwave emission simultaneously for checking microwave field whether to be symmetrically distributed.
Symmetry on checking r direction, the θ direction: on the pork liver that exsomatizes, select r＞0 respectively, r＜0, four symmetric points continuous temperature measurements on the different directions are carried out at different θ angles, and experiment cloth point diagram sees Table
The preliminary experiment coordinates table
| Period | Coordinate (mm r θ z) |
| | 5 0 0 |
| T2 | -5 0 0 |
| | 5 45℃ 0 |
| T4 | -5 45℃ 0 |
Result's institute's thermometric on the different four directions of same radius rises rule and temperature value very close (Δ T＜3 ℃), liver specimens is cut along sagittal plane and coronal-plane in the effect back, its sex change district of visual inspection is that the center is symmetrically distributed with the antenna for radiating microwave, therefore can prove that one pole implanted microwave antenna is in the r direction, the θ direction is symmetrical distribution, thereby SAR can be found the solution and be used as the two-dimensional problems processing.Found by the method for layouting simultaneously and solidified the spheroid maximum transverse diameter pairing to be the microwave antenna central point, to be distance antenna pointed end 15mm place in the z direction.The result of r direction coordinate symmetric points thermometric shows that z＞0 temperature rise speed is very fast, and temperature is higher, z＜0 temperature rise is mild relatively, temperature is lower, so the thermal field right and wrong of microwave field on the z direction are symmetric, and formal measurement must be found the solution z＞0, z＜0 o'clock SAR attenuation law respectively.
Result according to preliminary experiment, can make the simple two-dimensional test model measures, with the biological heat transfer equation of measurement result substitution, obtain microwave radiation energy SAR, with its distribution function equation of array SAR value substitution, solve the parameter value of distribution function equation by computing machine, obtain the real-time distribution of SAR three-dimensional thermal field.Concrete measuring process is as follows:
1, makes microwave radiation field analogue measurement device: see Fig. 1.With thick 1.5cm, 15 * 15cm is square, flat poly (methyl methacrylate) plate center hollows out, form the framework 20 of all hem width 1.5cm, this framework 20 is just put into the D=15.1cm that is used for adorning phantom, high 20cm is as in the organic glass cylinder barrel 21 of support cover, adopt organic glass to be because this kind material is noiseless to the microwave thermal field, and it is transparent, visual good, two opposite side at organic glass frame 20 are symmetrical arranged the guid needle through hole 22 that a pair of diameter is 1.7mm, just put into the microwave guide needle, each makes a call to the backguy through hole 24 of 5 D＜1mm up and down at two opposite side of its right side decentering 5mm, distance between borehole 5mm, pass last pull-down line through hole 24 with 1 trumpeter's art suture line, form 5 backguys 25 with microwave antenna parallel interval 5mm along framework 20;
2, insert in the framework 1 with described microwave guide needle guiding microwave antenna 26, take out the microwave guid needle again;
3, the certain position apart from microwave antenna 26 is provided with measurement thermopair 27 in framework 20, the diameter that described thermopair 27 adopts U.S. Ω company to produce is 0.003 inch an iron-constantan thermocouple silk, all thermopairs 27 are linked to each other with data acquisition unit, data acquisition unit links to each other with computing machine, by preliminary experiment as can be known, because thermal field is along the r direction, the θ direction is symmetrical distribution, thereby SAR can be found the solution and be used as the two-dimensional problems processing, thermopair 27 carries out the plane by Fig. 2 layouts, and Fig. 3 is the spatial value of Fig. 2 each point correspondence.And be separately fixed in the backguy 25 among Fig. 1 by this cloth point diagram, each 16 points of cloth are after cloth is better; together put into cylinder barrel 21 together with microwave antenna 26; the slow base of liver MICROWAVE PHANTOM MUSCLE TISSUE that has prepared is gone into, left standstill 12-24 hour, until phantom temperature and indoor temperature balance.Adopt Jiang-Han Area guarantor of Sichuan University to wait the MICROWAVE PHANTOM MUSCLE TISSUE prescription of development in this liver MICROWAVE PHANTOM MUSCLE TISSUE, the complex permittivity of this phantom is in the 300-2500MHz scope, with error≤5% of actual human body liver organization.
4, check cold junction temperature before measuring, and the temperature by the preceding measurement point of computer acquisition microwave action, with in the temperature fluctuation 5 minutes＜0.01 ℃ as the stable state index.
(60W300s, 50W10min 40W30min) divide above-mentioned 16 points to carry out 16-18 time and measure each energy group, and 3 energy groups are carried out 53 measurements altogether, and repeat 5-9 time in each site, calculates the mean value of getting each point at last.Energy gives 60W300s (every 100s is 10s at interval) respectively; 50W10min; 40W30min; data acquisition unit is with every 500ms (60W300s) or 1s (40W30min on; 50W10min) 16 passages of the continuous scanning of speed; the computer real-time record; shutting down the back observes continuously; with temperature drop to (initial temperature 21-24 ℃) below 43 ℃ and in 1 minute temperature variation＜1 ℃ be the index of shutdown; the 60W effect is organized general 15-20 minute and is reached stable, reaches stable state in 50W10 minute general 30-35 minute, and 40W30min organizes general 35-45 minute and reaches relative stable state; deposit resultant data in computing machine, use to do to analyze.
At least 7 some place variation of temperature are measured in experiment, notice that dT/dt is the slope of temperature variation curve, just can obtain SAR on these aspects from biological heat transfer equation, the distribution function equation of the coordinate of these points and SAR value difference substitution SAR, so just obtain the Simultaneous Equations formed by 7 equations, separate this Simultaneous Equations, just can obtain every coefficient.Obtain the distribution function of SAR/ ρ c, see the following form.
| 60W | Forward direction | 2.2667×2.9e -0.3164r(-0.0002z 3+0.0042z 2-0.0344z+0.4864) |
| The back to | 2.2667×2.9e -0.3164r(-0.00003z 3+0.0013z 2-0.0306z+0.4864) | |
| 50W | Forward direction | 1.4903×3.02e -0.3002r(8E-5z 3-0.003z 2+0.0091z+0.4152) |
| The back to | 1.4903×2.98e -0.3002r(4E-5z 3-0.0012z 2-0.0066z+0.4168) | |
| 40W | Forward direction | 1.1264×5.3e -0.2829r(0.00003z 3-0.0016z 2+0.0042z+0.3651) |
| The back to | 1.1264×5.2e -0.2829r(0.00003z 3-0.0009z 2-0.0117z+0.3692) |
Just can obtain the distribution function of whole microwave thermal field SAR when known density and specific heat.
Utilize U.S. ANSYS (V5.5 version) finite element analysis software can finish whole computation process and (comprise pre-treatment-----spatial spreading based on finite element method, the derivation of finite element equation and aftertreatment-----further calculation of parameter, data output, the drafting of form and curve map etc.), calculate the dynamic 3 D thermal field of implanted microwave solidification treatment liver tumour.
Claims (10)
1. the analog measurement method that distributes of a microwave solidification treatment liver tumour thermal field, it comprises the steps: 1), pork liver carries out preliminary experiment to exsomatizing, promptly on the pork liver that exsomatizes, select r＞0 respectively, r＜0, the symmetric points continuous temperature measurement at different θ angle, and be that the z direction is layouted at antenna direction, drawing single built-in type microwave antenna in the r direction, the θ direction is symmetrical distribution; 2), make microwave radiation field analogue measurement device, but the two-dimensional analog measurement mechanism that described analogue measurement device is the thermopair plane layouts; 3), microwave guide needle and microwave antenna are inserted in the described two-dimensional analog measurement mechanism, and the certain position apart from microwave antenna is provided with the measurement thermopair in the two-dimensional analog measurement mechanism, described thermopair links to each other with data acquisition unit, described data acquisition unit links to each other with computing machine, 4), base goes into to organize MICROWAVE PHANTOM MUSCLE TISSUE in the two-dimensional analog measurement mechanism, 5), the microwave radiation of measuring different-energy in the position temperature that described thermopair is set over time, with the biological heat transfer equation of data substitution, obtain unit volume and unit interval microwave radiation energy SAR, with its distribution function equation of SAR substitution, by these simultaneous equations of machine solution, can try to achieve every coefficient of distribution function equation, obtain the distribution function of microwave radiation three-dimensional thermal field, thereby can obtain the temperature of fixed time at specified point, described biological heat transfer equation is:
SAR=ρ CdT/dt-K Δ AT+M
bC
b(T-T
b) wherein ρ be the (kgm of tissue density
-3), C is a specific heat, and T is a temperature, and t is the time, and K is the coefficient of heat conductivity (Wm of tissue
-1℃
-1), M
b, C
bBe respectively the filling rate (kgm of blood
-3S
-1) and specific heat (Jkg
-1℃
-1), T
bFor this regional arterial blood temperature (℃),
Described microwave radiation energy SAR distribution function equation:
SAR＝ρCe
-αr[X
0z
3+X
1z
2+X
2z+X
3][cos(X
5θ)+X
4]，
According to preliminary experiment, microwave radiation energy SAR distribution function is the plane distribution function:
SAR＝ρCe
-αr[X
0z
3+X
1z
2+X
2z+X
3]。
2, the analog measurement method that distributes according to the described microwave solidification treatment liver tumour of claim 1 thermal field, it is characterized in that described thermal field distribution function is the distribution of solidifying thermal field emittance SAR/ ρ c of 60W microwave radiation for power, apart from the forward direction of antenna pointed end 15mm partly be at the microwave antenna central point:
2.2667×2.9e
-0.3164r(-0.0002z
3+0.0042z
2-0.0344z+0.4864)，
The microwave antenna central point is distributed as to part apart from the back of other end 12mm:
2.2667×2.9e
-0.3164r(-0.00003z
3+0.0013z
20.0306z+0.4864)。
3. the analog measurement method that distributes according to the described microwave solidification treatment liver tumour of claim 1 thermal field, it is characterized in that described thermal field distribution function is the distribution of solidifying thermal field emittance SAR/ ρ c of 50W microwave radiation for power, apart from the forward direction of antenna pointed end 15mm partly be at the microwave antenna central point:
1.4903×3.02e
-0.3002r(8E-5z
3-0.003z
2+0.0091z+0.4152)，
The microwave antenna central point is distributed as to part apart from the back of other end 12mm:
1.4903×2.98e
-0.3002r(4E-5z
3-0.0012z
2-0.0066z+0.4168)。
4. the analog measurement method that distributes according to the described microwave solidification treatment liver tumour of claim 1 thermal field, it is characterized in that described thermal field distribution function is the distribution of solidifying thermal field emittance SAR/ ρ c of 40W microwave radiation for power, apart from the forward direction of antenna pointed end 15mm partly be at the microwave antenna central point:
1.1264×5.3e
-0.2829r(0.00003z
3-0.0016z
2+0.0042z+0.3651)，
The microwave antenna central point is distributed as to part apart from the back of other end 12mm:
1.1264×5.2e
-0.2829r(0.00003z
3-0.0009z
20.0117z+0.3692)。
5. the analog measurement method that distributes according to the described microwave solidification treatment liver tumour of claim 1 thermal field, it is characterized in that described microwave radiation two-dimensional analog measurement mechanism comprises the organic glass frame of a hollow and can shelve the support cover of this framework, be symmetrically arranged with a pair of diameter greater than 1 millimeter guid needle through hole at two opposite side of four frames of described framework, a side of described guid needle through hole at interval equidistance be provided with a pair or more of diameter less than 1 millimeter backguy through hole, described every pair of backguy through hole is provided with backguy, and described backguy is provided with thermopair.
6. the analog measurement method that distributes according to the described microwave solidification treatment liver tumour of claim 5 thermal field is characterized in that described support cover made by organic glass.
7. the analog measurement method that distributes according to the described microwave solidification treatment liver tumour of claim 5 thermal field is characterized in that above-mentioned backguy through hole is 5 pairs, and its spacing is 5 millimeters.
8. the analog measurement method that distributes according to the described microwave solidification treatment liver tumour of claim 5 thermal field is characterized in that the thermopair that is provided with in the above-mentioned backguy is 16.
9. device of realizing the analog measurement method that microwave solidification treatment liver tumour thermal field distributes, comprise the microwave radiation analogue measurement device that to place microwave antenna, the two-dimensional analog measurement mechanism that but described analogue measurement device is the thermopair plane layouts, be provided with a plurality of thermopairs apart from the microwave antenna certain distance in the described two-dimensional analog measurement mechanism, described thermopair links to each other with data acquisition unit, and described data acquisition unit links to each other with computing machine.
10. the device of the analog measurement method that realization microwave solidification treatment liver tumour thermal field according to claim 9 distributes, it is characterized in that, but the two-dimensional analog measurement mechanism of layouting in described thermopair plane comprises the organic glass frame of a hollow and can shelve the support cover of this framework, be symmetrically arranged with a pair of diameter greater than 1 millimeter guid needle through hole at two opposite side of four frames of described framework, a side of described guid needle through hole at interval equidistance be provided with a pair or more of diameter less than 1 millimeter backguy through hole, described every pair of backguy through hole is provided with backguy, and described backguy is provided with thermopair.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02116888.1A CN1257393C (en) | 2002-04-24 | 2002-04-24 | Simulated measurement of heat field distribution in microwave solidification treatment of tumor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02116888.1A CN1257393C (en) | 2002-04-24 | 2002-04-24 | Simulated measurement of heat field distribution in microwave solidification treatment of tumor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1453563A CN1453563A (en) | 2003-11-05 |
| CN1257393C true CN1257393C (en) | 2006-05-24 |
Family
ID=29257032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN02116888.1A Expired - Fee Related CN1257393C (en) | 2002-04-24 | 2002-04-24 | Simulated measurement of heat field distribution in microwave solidification treatment of tumor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1257393C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940498A (en) * | 2010-09-10 | 2011-01-12 | 中山大学 | Model for evaluating tumor ablation safe boundary by virtual navigation |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9377367B2 (en) * | 2010-06-03 | 2016-06-28 | Covidien Lp | Specific absorption rate measurement and energy-delivery device characterization using thermal phantom and image analysis |
| CN104345068A (en) * | 2013-08-08 | 2015-02-11 | 广州医科大学附属肿瘤医院 | Medical electromagnetic wave energy ratio absorption rate measurement device |
| CN105427725B (en) * | 2015-12-16 | 2019-06-04 | 中山大学附属第三医院 | A kind of imitative body Model for ultrasonic single mode image co-registration assessment tumour ablation range |
| CN117731390B (en) * | 2024-02-19 | 2024-06-25 | 南京康友医疗科技有限公司 | Radio frequency ablation control system |
-
2002
- 2002-04-24 CN CN02116888.1A patent/CN1257393C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940498A (en) * | 2010-09-10 | 2011-01-12 | 中山大学 | Model for evaluating tumor ablation safe boundary by virtual navigation |
| CN101940498B (en) * | 2010-09-10 | 2012-05-09 | 中山大学 | Model for evaluating tumor ablation safe boundary by virtual navigation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1453563A (en) | 2003-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Tompkinsn et al. | Temperature-dependent versus constant-rate blood perfusion modelling in ferromagnetic thermoseed hyperthermia: results with a model of the human prostate | |
| Bu-Lin et al. | A polyacrylamide gel phantom for radiofrequency ablation | |
| CN104837527A (en) | High-intensity focused ultrasound for heating a target zone larger than the electronic focusing zone | |
| CN103970929A (en) | High-order diffusion tensor mixture sparse imaging method for alba fiber tracking | |
| CN1257393C (en) | Simulated measurement of heat field distribution in microwave solidification treatment of tumor | |
| CN111743626B (en) | Tumor puncture path acquisition device and storage medium | |
| Gao et al. | Temperature simulation of microwave ablation based on improved specific absorption rate method compared to phantom measurements | |
| Wang et al. | A transformation-domain image reconstruction method for open electrical impedance tomography based on conformal mapping | |
| Schreier et al. | Preliminary studies of interstitial hyperthermia using hot water | |
| Wu et al. | A simulation-experiment method to characterize the heat transfer in ex-vivo porcine hepatic tissue with a realistic microwave ablation system | |
| Roemer | The local tissue cooling coefficient: a unified approach to thermal washout and steady-state ‘perfusion’calculations | |
| Van der Koijk et al. | The influence of vasculature on temperature distributions in MECS interstitial hyperthermia: importance of longitudinal control | |
| Nussbaum | Quality assessment and assurance in clinical hyperthermia: requirements and procedures | |
| Fang et al. | Optimization of a wearable device for core body temperature monitoring based on the dual-heat-flux model | |
| CN101088474A (en) | Heat field border displaying method ofr microwave interventional therapy of tumor | |
| Hossain et al. | One-dimensional steady-state analysis of bioheat transfer equation: tumour parameters assessment for medical diagnosis application | |
| Lee et al. | Influence of water bolus temperature on measured skin surface and intradermal temperatures | |
| CN1290472C (en) | Combined multiple-antenna and heat-field method for microwave intervention treatment of tumor | |
| Schooneveldt et al. | Experimental validation of a thermophysical fluid model for use in a hyperthermia treatment planning system | |
| Partovi et al. | Analytical and numerical temperature distribution in a 3-D triple-layer skin tissue subjected to a multi-point laser beam | |
| Nan et al. | Analysis to a critical state of thermal field in microwave ablation of liver cancer influenced by large vessels | |
| Gentili et al. | FDTD electromagnetic and thermal analysis of interstitial hyperthermic applicators | |
| Stauffer et al. | Using a conformal water bolus to adjust heating patterns of microwave waveguide applicators | |
| Van Wieringen et al. | Dose uniformity of ferromagnetic seed implants in tissue with discrete vasculature: a numerical study on the impact of seed characteristics and implantation techniques | |
| CN108261184B (en) | Fat temperature measuring method and device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: GUANGDONG WELL PHARMACEUTICAL TECHNOLOGY CO., LTD Free format text: FORMER OWNER: DONG BAOWEI Owner name: DONG BAOWEI Free format text: FORMER OWNER: NONE Effective date: 20040604 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20040604 Address after: 51906 Guangdong city of Zhuhai Province Nanping South Beishan Avenue on the west side of North office building will produce substation Applicant after: Guangdong Weier Meical Science & Technology Co., Ltd. Co-applicant after: Dong Baowei Address before: 1303, room 100853, West nine, PLA General Hospital, 28 Fuxing Road, Beijing, Haidian District Applicant before: Dong Baowei |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060524 Termination date: 20100424 |