CN1452945A - Intelligent microwave cure instrument - Google Patents
Intelligent microwave cure instrument Download PDFInfo
- Publication number
- CN1452945A CN1452945A CN 02116889 CN02116889A CN1452945A CN 1452945 A CN1452945 A CN 1452945A CN 02116889 CN02116889 CN 02116889 CN 02116889 A CN02116889 A CN 02116889A CN 1452945 A CN1452945 A CN 1452945A
- Authority
- CN
- China
- Prior art keywords
- microwave
- thermal field
- tumor
- data
- computer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The present invention is one intelligent microwave cure instrument and provides one technological problem of taking proper treating scheme for different tumor sizes and conditions. The instrument includes one monochip computer, microwave unit connected to the monochip computer, and computer connected to the monochip computer and with effective microwave heat field data base to store the real-time microwave solidification heat field distribution data in different condition parameters. The optimized treating process includes: selecting one solidification heat field through comparing the treated tumor data and the said distribution data; and setting corresponding condition parameters on the monochip computer. The present invention is used in the microwave intervention treatment of tumor and other diseases.
Description
Technical field:
The present invention relates to a kind of medical treatment device, particularly a kind of intelligent microwave therapy equipment.
Background technology:
At present, being applied to the microwave instrument of clinical tumor interventional therapy, all is to utilize in the microwave antenna tissue to produce microwave, forms the thermocoagulation district of certain form in the part that is subjected to microwave radiation, causes the necrosis of tumor hyperpyrexia to treat tumor.But present microwave instrument interventional therapy can't accurately be estimated shape and the scope that microwave antenna solidifies, and can't take the corresponding treatment scheme at the different tumor size and the patient's condition, and solidification morphology and tumor shape do not match, and solidification morphology is little.Because can't carry out adaptability to treatment judges, selects and monitoring thereby kill tumor targetedly, the destruction of killing often or also causing a large amount of normal structures the part kill tumor time, the therapeutic effect of microwave can not be given full play to, particularly liver tumor of micro-wave therapeutic tumor can not be promoted the use of in a big way.
Summary of the invention:
The objective of the invention is to overcome the defective of prior art, a kind of intelligentized microwave thermal coagulating treatment instrument is provided, can be at different patient's condition optimized choice and determine to treat the therapeutic scheme of curing oncoma before treatment;
Another object of the present invention is on the basis of preferred therapeutic scheme, can effectively control the overall process of treatment, realizes killing whole tumor.
First purpose of the present invention is achieved in that it comprises a single-chip microcomputer that links to each other by serial ports with computer, and described single-chip microcomputer links to each other with microwave device; Described calculator memory has stored up effective microwave thermal field data storehouse, store the microwave coagulation thermal field real-time distribution data with different condition parameter in described effective microwave thermal field data storehouse, described computer is carried out and by carrying out the process of following preferred therapeutic scheme with single-chip data exchange control single chip computer:
To treat that the real-time distribution data in curing oncoma data and the effective microwave thermal field data storehouse compare, preferred one solidifies thermal field, according to this preferably solidifies the conditional parameter of thermal field correspondence in described effective microwave thermal field data storehouse, preset relevant parameter numerical value on single-chip microcomputer, this relevant parameter numerical value is exactly and treats the preferred therapeutic scheme that curing oncoma is complementary in the conditional parameter.Above-mentioned preferred process is to realize by preferred embodiment in the computer or software, when preferred embodiment optimize one solidify thermal field and corresponding conditional parameter thereof after, by exchanges data or directly by manually on single-chip microcomputer, presetting relevant parameter numerical value.
Also store the pairing three-dimensional collection of illustrative plates of thermal field real-time distribution that solidifies of microwave coagulation thermal field real-time distribution data in described effective microwave thermal field data storehouse, in the process of preferred embodiment preferred therapeutic scheme, can will treat that the real-time distribution data in curing oncoma data and the effective microwave thermal field data storehouse compare earlier, select the more approaching a plurality of thermal fields that solidify of data, the axonometric chart that to treat curing oncoma then covers with the corresponding three-dimensional collection of illustrative plates of the thermal field suitable shape of selecting in the display of computer of solidifying, preferred one directly perceived solidifies thermal field, according to this preferably solidifies the conditional parameter of thermal field correspondence in described effective microwave thermal field data storehouse, on single-chip microcomputer, preset relevant parameter numerical value;
Described conditional parameter comprises A), antenna condition B), power condition C), the time conditions .D of different capacity effect), tumor condition .E), the boundary temperature condition.Wherein the antenna condition comprises antenna type condition, antenna amount condition, antenna space locality condition, and the tumor condition comprises form class condition, size fractionation condition, the blood flow classification condition of tumor.
Described effective microwave thermal field data storehouse can be divided into following four data bases :) the thermal field data base: the thermal field distributed in three dimensions data that are suitable for the boundary temperature isothermal level of kill tumor under the different parameters condition, comprise that correspondence solidifies thermal field number, x, y, the z coordinate, temperature, the tumor blood flow filling rate, corresponding scheme number, include the corresponding described three-dimensional collection of illustrative plates 2 that solidifies thermal field in this thermal field data base) the therapeutic scheme data base: the therapeutic scheme storehouse of above-mentioned thermal field distributed in three dimensions data correspondence comprises scheme number, power, time, antenna number, antenna type, the locus of antenna.3) property data base: according to case statistics in the past tumor is done the form classification by certain sorting technique, size fractionation, the blood flow classification is convenient to sort out relatively contrast, comprises tumor form classification, big or small rank and blood perfusion rate rank.4) tumor data base, promptly the treatment before to behind the tumor examination to its description, comprise form, size, blood vessel and the blood flow of tumor.
Described single-chip microcomputer also can link to each other with thermometric needle by A/D converter.
Above-mentioned thermometric needle comprises guiding shank, guid needle medicated cap, it is characterized in that described guiding shank is a cavity structure, the head seal of guiding shank, head at guiding shank cavity is provided with pick off, the inwall of guid needle medicated cap is provided with junction point, connect sensor lead and cable, cable extends to the outside of guid needle medicated cap, the earthing of casing of guid needle needle body.
The head of described guiding shank seals with epoxy resin.
Above-mentioned microwave device comprises the magnetron as microwave source of at least one cover high-pressure control device and control thereof, described each magnetron links to each other with sample circuit with permutator respectively, two microwave antennas of described permutator control, described permutator links to each other with single-chip microcomputer respectively with sample circuit.
Above-mentioned microwave device comprises the magnetron as microwave source of two cover high-pressure control devices and control thereof.
Described permutator comprises the automatically controlled microwave ferrite coaxial switch of a high power.
Above-mentioned microwave antenna comprises outer conductor and the inner wire that links to each other with microwave source by fixed support and socket, described outer conductor is one to be the hollow cylinder in axle center with the inner wire, the free end of described inner wire extends outer conductor, the periphery of described inner wire is enclosed with dielectric layer, and the length that described inner wire extends to the outer part of outer conductor is the 9-30 millimeter.
An adherent layer also can be wrapped up in the outside of described outer conductor.
The process of described particularly preferred therapeutic scheme is promptly as follows by the preferred process that the preferred embodiment in the computer is carried out:
(1), the tumor conditions such as form, size, blood vessel and blood flow of computer input tumor are in computer tumor data base;
(2), computer extracts eigenvalue according to classification regulation in the property data base to the tumor situation of input, comprises tumor form classification, big or small rank, blood perfusion rate rank;
(3), computer retrieves the therapeutic scheme of some suitable tumor features from the treatment scheme database;
(4), computer takes out the three-dimensional data and the collection of illustrative plates of the thermal field that therapeutic scheme can form from the thermal field data base, the three-dimensional collection of illustrative plates that will solidify thermal field fit shape with the 3D shape for the treatment of curing oncoma and is covered, and relatively selects definite therapeutic scheme for the doctor;
(5), according to the therapeutic scheme of determining by setting output, power and the action time of microwave source on the single-chip microcomputer, determine the number and the locus of antenna.
Second purpose of the present invention is achieved in that it comprises a single-chip microcomputer that links to each other by serial ports with computer, described single-chip microcomputer and microwave device; Described calculator memory has stored up effective microwave thermal field data storehouse, store microwave coagulation thermal field real-time distribution data with different condition parameter and the corresponding three-dimensional collection of illustrative plates of thermal field real-time distribution that solidifies in described effective microwave thermal field data storehouse, described computer is carried out and by carrying out following preferred therapeutic scheme with single-chip data exchange control single chip computer and treating the process of control:
1) will treat that the real-time distribution data in curing oncoma data and the effective microwave thermal field data storehouse compare, select the more approaching thermal field that solidifies, the axonometric chart for the treatment of curing oncoma is covered mutually with the three-dimensional collection of illustrative plates of selecting that solidifies thermal field, preferred one solidifies thermal field, according to this preferably solidifies the conditional parameter of thermal field correspondence in described effective microwave thermal field data storehouse, on single-chip microcomputer, preset relevant parameter numerical value.This preferred process is to realize by the preferred embodiment in the computer, when preferred embodiment optimize one solidify thermal field and corresponding conditional parameter thereof after, by exchanges data or directly by manually on single-chip microcomputer, presetting relevant parameter numerical value.
2) after the treatment beginning, carry out the micro-wave therapeutic monitoring, write down whole therapeutic process, monitor the variations in temperature of cancerous issue in microwave source duty and the therapeutic process, realize control automatically.This process is to realize by the monitoring programme in the computer.
Particularly, step 2) described micro-wave therapeutic monitor procedure is that supervising device is carried out following process:
1, gathers microwave source state, thermometric, and data are sent in the computer by single-chip microcomputer;
If 2 greater than rated temperature, check the microwave source state, as undesired, can stop microwave radiation, also can adjust the microwave source state and continue treatment; Normal as microwave source, and reach the time-delay of presetting, can continue gatherer process;
If 3 less than rated temperature, prolong a period of time, whether decision revises therapeutic scheme, if do not revise, micro-wave therapeutic can be finished,, thermometric mode and microwave radiation scheme can be revised as revising, after the modification, as not continuing thermometric, can stop thermometric, as continuing thermometric, can further see whether reach the time-delay of presetting, to continue gatherer process.
The present invention is owing to stored up effective microwave thermal field data storehouse at calculator memory, before operation, just can the related data of curing oncoma such as the form of tumor will be treated, size, solidifying thermal field real-time distribution data in blood vessel and blood flow etc. and the effective microwave thermal field data storehouse compares, select an immediate thermal field that solidifies of data, or more approaching several thermal fields that solidify are selected by elder generation, the 3 dimensional drawing for the treatment of curing oncoma is fitted shape with the more approaching three-dimensional collection of illustrative plates that solidifies thermal field to be covered, optimize one and solidify thermal field, from effective microwave thermal field data storehouse, extract the relevant parameter numerical value that this solidifies the thermal field correspondence then, with the duty of setting single-chip microcomputer and the inserting needle scheme of microwave antenna.Therefore the present invention is based upon oncotherapy on the foreseeable basis, can treat the therapeutic scheme of curing oncoma at the different patient's condition definite also optimized choice before operation.
The present invention can also be on the basis of preferred therapeutic scheme, effectively controls the overall process of treatment by the supervising device that is provided with in the computer according to the therapeutic scheme of setting, and realizes killing whole tumor, simultaneously to the less infringement of normal structure.
Adopt the above microwave device of at least one cover and two above microwave antennas, can be at the shape of solidifying the zone of different case combinations matches microwave radiations formation, make simultaneously and solidify regional diameter and greatly increase, particularly adopt the structure of two cover microwave devices and microwave antenna, by reasonable combination to microwave antenna, maximum is once solidified the zone can be greater than 5 centimetres, are not more than 2 centimetres limitation considerably beyond prior art.
Adopt microwave antenna of the present invention, formed microwave coagulation is shaped as and more is similar to the circular or oval of tumor shape, rather than the imitative capitate of prior art, this aerial radiation shape can reduce the damage to tumor perienchyma, improves the efficient of solidifying the deactivation tumor.
The present invention is widely used in the microwave interventional therapy that various tumors and other can adopt the disease that microwave treats.
Description of drawings:
Fig. 1 is a structural representation of the present invention;
Fig. 2 is a fundamental diagram of the present invention;
Fig. 3 is a micro-wave therapeutic monitoring programme block diagram of the present invention;
Fig. 4 is the change-over switch arrangement sketch map;
Fig. 5 is the structural representation of microwave antenna of the present invention;
Fig. 6 is the structural representation of thermometric needle of the present invention;
The preferred embodiments of the present invention are provided below, but the invention is not restricted to the embodiment that narrated:
Computer 1 links to each other with single-chip microcomputer 2 by serial ports 1 ' among Fig. 1, single-chip microcomputer 2 links to each other with microwave device, at this, microwave device is two cover high-pressure control devices 3,3 ' and control the magnetron 4 as microwave source, 4 ', each magnetron 4 or 4 ' respectively also with permutator 5,5 ' and sample circuit 6,6 ' links to each other, permutator 5,5 ' controls two microwave antenna A1 respectively, A2 and B1, B2, permutator 5,5 ' is subjected to single-chip microcomputer 2 controls respectively, sample circuit 6,6 ' also links to each other with single-chip microcomputer 2 respectively, described permutator 5,5 ' structure is identical, see Fig. 4, comprise the automatically controlled microwave ferrite coaxial switch 7 of a high power, the automatically controlled microwave ferrite coaxial switch 7 of high power is subjected to the control of high power trigger 8, and high power trigger 8 is worked by the electric pulse that the pulse generator 9 that is subjected to single-chip microcomputer 2 controls sends, single-chip microcomputer 2 provides power supply by dc source 10, the model of the automatically controlled microwave ferrite coaxial switch 8 of high power is KTS0191, adopt the permutator 5 of said structure, 5 ' can be to two antenna A1 that control separately, A2 and B1, B2 carries out the switching and the regulation and control of microwave output power size, therefore, four compound modes that antenna can have various space forms and power to export.Microwave antenna A1, A2 and B1, B2 is efficient microwave interventional therapy antenna, its structure is seen Fig. 5, comprise the outer conductor 15 and the inner wire 14 that link to each other with microwave source by fixed support 12 and socket 11, outer conductor 15 be one with inner wire 14 be the hollow circular tube in axle center, the free end of inner wire 14 extends outer conductor 15, the part of extending outer conductor 15 forms aerial radiation part 17, the periphery of inner wire 14 is enclosed with dielectric layer 16, inner wire 14 extends to the outer part of outer conductor and forms the aerial radiation part, its length is the 9-30 millimeter, an adherent layer 18 is wrapped up in the outside of outer conductor 15, adherent layer 18 thickness are 0.1 millimeter, mainly constitute, also have a chromium coating 13 between outer conductor 15 and the adherent layer 18 by politef.This structure of treatment antenna not only can make it form bigger solidification morphology in treatment, the radiation efficiency height, and the single antenna solidification morphology is improved, form with the similar sphere of tumor shape and solidify thermal field, it is sticking that adherent layer 18 can make antenna not take place in tissue, and chromium coating can make fine antenna eye-catching.Adopt permutator and four efficient microwave interventional therapy antennas of unique texture, can be at the different cases shape of solidifying the zone that forms of combinations matches microwave radiation better, make simultaneously and solidify regional diameter and greatly increase, adopt microwave combination of the present invention, maximum is once solidified the zone can be greater than 5 centimetres, are not more than 2 centimetres limitation considerably beyond prior art.
Single-chip microcomputer 1 also links to each other with thermometric needle 20 by A/D converter 19 among Fig. 1.The structure of thermometric needle 20 is seen accompanying drawing 6, comprise guiding shank 24, guid needle medicated cap 23, guiding shank 24 is a cavity structure, head 27 sealings of guiding shank, the guiding shank is the 20G guid needle of 0.9, head at guiding shank cavity is provided with pick off 25, and at this, pick off 25 is a critesistor, the inwall of guid needle medicated cap 23 is provided with pad 22, connect sensor lead 26 and cable 21, cable 21 extends to the outside of guid needle medicated cap 23,24 earthings of casing of guiding shank.Because therefore 24 earthings of casing of guiding shank can guarantee that critesistor 25 is not subjected to the interference of microwave field when thermometric, more accurate and uninterrupted microwave radiation is measured the temperature of measured point in the therapeutic process.
Stored effective microwave thermal field data storehouse in the computer 1, effectively microwave thermal field data storehouse is just set up before treatment, microwave coagulation thermal field with treatment hepatocarcinoma is an example, its method for building up is: the microwave radiation experimental provision of at first setting up the hepatic tissue phantom, measure the variations in temperature of different capacity, time and position under the single antenna microwave field by the method for analogue measurement, with the composite equation of the distribution function equation of biological heat transfer equation of experimental data substitution and microwave radiation energy SAR: described biological heat transfer equation is:
ρcdT/dt＝Qr+KΔT-M
bC
b(T-T
b)＝SAR+KΔT-M
bC
b(T-T
b)
Wherein: ρ is the (kg/m of tissue density
3), c is a specific heat, and T is a temperature, and t is the time, and K is the heat conductivity (W/m ℃) of tissue, M
b, C
bBe respectively the filling rate (kg/m of blood
3S) and specific heat (J/kg ℃), T
bFor this regional arterial blood temperature (℃).
The distribution function equation of described microwave radiation energy SAR is:
SAR＝ρce
-az[x
0r
3+x
1r
2+x
2r+x
3][cos(x
5θ)+x
4]
Learn that through preliminary experiment the SAR distribution function is the plane distribution function:
SAR＝ρCe
-aZ[X
0r
3+X
1r
2+X
2r+X
3]
It is that the thermal field emittance SAR/ ρ c that solidifies of 60W microwave radiation partly is distributed as at the forward direction of microwave antenna central point apart from antenna pointed end 15mm that above-mentioned real-time three-dimensional thermal field distributes for power:
2.2667×2.9e
-0.3164r(-0.0002z
3+0.0042z
2-0.0344z+0.4864)
The microwave antenna central point is distributed as to part apart from the back of other end 12mm:
2.2667×2.9e
-0.3164r(-0.00003z
3+0.0013z
2-0.0306z+0.4864)
It is that the thermal field emittance SAR/ ρ c that solidifies of 50W microwave radiation partly is distributed as at the forward direction of microwave antenna central point apart from antenna pointed end 15mm that above-mentioned real-time three-dimensional thermal field distributes for power:
1.4903×3.02e
-0.3002r(8E-5z
3-0.003z
2+0.0091z+0.4152)
The microwave antenna central point is distributed as to part apart from the back of other end 12mm:
1.4903×2.98e
-03002r(4E-5z
3-0.0012z
2-0.0066z+0.4168)
When known density and specific heat, just can obtain the distribution function of whole microwave thermal field SAR.
Utilize U.S. ANSYS (V5.5 version) finite element analysis software to finish whole computational process and (comprise pre-treatment-----spatial spreading based on FInite Element, the derivation of finite element equation and post processing-----further calculation of parameter, data output, the drafting of form and curve chart etc.), calculate the dynamic 3 D thermal field of single antenna implanted microwave solidification treatment liver tumor.
Then, after trying to achieve the radiation thermal field of singly leading, can make up, try to achieve the distributed data base of combination thermal field by following six conditions and value thereof.
(1) power condition: adopt 40W, 50W, three kinds of microwave powers of 60W.
(2) be used for the antenna amount condition of hepatocarcinoma solidification treatment: according to the size of different tumors, applicable antenna amount is: 1,2,3,4, be respectively singly and lead, twoly lead, three lead, four lead.
(3) hepatocarcinoma local organization blood perfusion rate (Mb) condition is divided into 10 grades:
Mb is respectively: 1.5,2.5,3.0,3.5,4.0,4.5,5.0,6.0,7.0,8.0 (units: kg/m
3S).
(4) used time conditions:, adopt the different time corresponding to different capacity.
40W——600、900、1200、1800s
50W——300、400、500、600、700、800、900s
60W——300、400、500、600s
(5) antenna space locality condition: singly lead situation slightly.
Under two leading (timesharing is two to be led and the two simultaneously leading) situation, two antenna distances adopt 1.0cm, 1.2cm, 1.5cm, 1.6cm, 2.0cm.(annotate: two the leading of timesharing all adopted 20s: the timesharing ratio of 20s, i.e. and antenna effect 20s, another root antenna remakes uses 20s).
Three lead under the situation, can be in two kinds of situation, and promptly wherein two electrodes are that timesharing double electrode or three electrodes act on simultaneously.When two electrodes wherein are that the two of same microwave source lead the timesharing electrode, promptly two electrodes can act on different time respectively, and being increases thermocoagulation efficient, and another single electrode adopts continuous action.For obtaining better therapeutic effect, adopt the classification of big freezing range: two timesharing electrodes of leading are with spacing 1.5cm, 2.0cm, make another single electrode be positioned among above two electrode connecting lines on the vertical line spacing 1.5cm or 2.0cm.
Four lead under the situation, can divide three kinds of situations, and promptly wherein having only two electrodes is that timesharing double electrode or four electrodes are respectively two timesharing double electrodes or four electrodes are effect simultaneously.When solidification mode for two when leading the effect of timesharing electrode and forming in twos, can be with four electrodes by square arrangement, the adjacent electrode spacing is 1.0cm, 1.2cm, 1.5cm, 1.6cm, 2.0cm.And the mode that adopts adjacent electrode to act on simultaneously.
(6) antenna type condition: refer to that antenna produces difformity and solidifies the dissimilar antennas of thermal field correspondence, the antenna or the sphere of solidifying thermal field such as the generation spindle-type are solidified the thermal field antenna.
Above 6 kinds of situations are carried out permutation and combination, set up computer model, and utilize finite element analysis software to obtain microwave coagulation thermal field under the different condition parameter.
To treat required boundary condition at last carries out adding among the thermal field data base of the three-dimensional heat of solidification field distribution under the described different condition parameter behind the three-dimensional reconstruction, the preferred temperature boundary condition of rule of thumb learning treatment hepatocarcinoma is 54 ℃ and/or 60 ℃, the temperature boundary condition determines that the back just can form effective microwave thermal field data storehouse of satisfying the said temperature boundary condition under six kinds of conditions respectively in computer, this data base comprises the three-dimensional real-time distribution data of solidifying thermal field and the corresponding thermal field graphics spectrum of solidifying, the real-time distribution data of this thermal field are the temperature profile data of each point of space on different time points, just form many 54 and 60 isothermal surfaces of spending two temperature spots at one time.Like this, only need before operation, to have measured the size of tumor, obtain the space coordinates and the three-dimensional collection of illustrative plates of form at tumor edge, record its blood perfusion rate again, solidify the real-time distribution data of thermal field and corresponding known isothermal surface data compare with above-mentioned, just obtain several and the close thermal field of space coordinates its edge, and the three-dimensional collection of illustrative plates of the three-dimensional collection of illustrative plates of the form of tumor and several approximate thermal fields covered contrast, determine preferred thermal field at last, the quantity term of other conditions of this thermal field such as power condition, antenna and type and locus condition are just directly as can be known.
Further, effective microwave thermal field data storehouse that combinations thereof is tried to achieve can be divided into following plurality of data storehouse: 1) thermal field data base: the distributed in three dimensions data of following 54 degrees centigrade and the 60 degrees centigrade isothermal levels of different parameters condition, comprise corresponding thermal field number, x, y, z coordinate, temperature, tumor blood flow filling rate, corresponding scheme number.Include the corresponding described thermal field graphics spectrum 2 of solidifying in this thermal field data base) the therapeutic scheme data base: the therapeutic scheme storehouse of thermal field distributed in three dimensions data correspondence comprises the locus of scheme number, power, time, antenna number, antenna.3) property data base: according to case statistics in the past tumor is done the form classification by certain sorting technique, size fractionation, the blood flow classification is convenient to sort out relatively contrast, comprises tumor form classification, big or small rank and blood perfusion rate rank.4) tumor data base, promptly the treatment before to behind the tumor examination to its description, comprise form, size, blood vessel and the blood flow of tumor.
For the tumor of other types, only need when analogue measurement, to select for use the phantom of corresponding tissue to carry out analogue measurement, other programs of setting up effective microwave thermal field are identical with hepatocarcinoma with step.
After trying to achieve effective microwave thermal field data storehouse, optimization software in the computer of the present invention and monitoring software just can be finished preferred therapeutic scheme and treatment control procedure according to flow process shown in Figure 2:
1, the tumor situations such as form, size, blood vessel and blood flow of computer 1 input tumor are in tumor data base 30;
2, the tumor situation of 1 pair of input of computer is extracted the characteristic of correspondence value in property data base 31, comprises tumor form classification, big or small rank, blood perfusion rate rank;
3, computer 1 retrieves the therapeutic scheme that is fit to the tumor feature from treatment scheme database 32, promptly selects antenna type, antenna number, antenna space position, microwave source power, action time;
4, computer 1 takes out the three-dimensional data and the three-dimensional collection of illustrative plates of the thermal field that therapeutic scheme can form from thermal field data base 33, and the three-dimensional collection of illustrative plates that will solidify thermal field fit shape with the 3D shape for the treatment of curing oncoma and is covered, and relatively selects definite therapeutic scheme 34 for the doctor;
5, on single-chip microcomputer, set output, power and the action time of microwave source according to therapeutic scheme, determine microwave antenna number and locus;
6, after the treatment beginning, carry out the micro-wave therapeutic monitoring, write down whole therapeutic process, monitor the variations in temperature that thermometric needle is measured cancerous issue in microwave device duty and the therapeutic process, realize control automatically by single-chip microcomputer 2.
The following (see figure 3) of its flow process of micro-wave therapeutic monitoring software of storage in the computer 1:
1, gathers microwave source state, thermometric, and data are sent in the computer by single-chip microcomputer;
If 2 greater than rated temperature, check the microwave source state, as undesired, can stop microwave radiation, also can adjust the microwave source state and continue treatment; Normal as microwave source, and reach the time-delay of presetting, can continue gatherer process;
If 3 less than rated temperature, prolong a period of time, whether decision revises therapeutic scheme, if do not revise, micro-wave therapeutic can be finished,, thermometric mode and microwave radiation scheme can be revised as revising, after the modification, as not continuing thermometric, can stop thermometric, as continuing thermometric, can further see whether reach the time-delay of presetting, to continue gatherer process.
The present invention is widely used in the microwave interventional therapy that various tumors and other can adopt the disease that microwave treats.
Claims (14)
1. intelligent microwave cure instrument is characterized in that it comprises a single-chip microcomputer that links to each other by serial ports with computer, and described single-chip microcomputer links to each other with microwave device; Described calculator memory has stored up effective microwave thermal field data storehouse, store the microwave coagulation thermal field real-time distribution data with different condition parameter in described effective microwave thermal field data storehouse, described computer is carried out and by carrying out the process of following preferred therapeutic scheme with single-chip data exchange control single chip computer:
To treat that the real-time distribution data in curing oncoma data and the effective microwave thermal field data storehouse compare, preferred one solidifies thermal field, according to this preferably solidifies the conditional parameter of thermal field correspondence in described effective microwave thermal field data storehouse, presets relevant parameter numerical value on single-chip microcomputer.
2. intelligent microwave cure instrument according to claim 1, it is characterized in that also storing in described effective microwave thermal field data storehouse the pairing three-dimensional collection of illustrative plates of thermal field real-time distribution that solidifies of microwave coagulation thermal field real-time distribution data, in the process of preferred therapeutic scheme, can will treat that the real-time distribution data in curing oncoma data and the effective microwave thermal field data storehouse compare earlier, select the more approaching a plurality of thermal fields that solidify of data, the axonometric chart that to treat curing oncoma then covers with the corresponding three-dimensional collection of illustrative plates of the thermal field suitable shape of selecting in the display of computer of solidifying, preferred one directly perceived solidifies thermal field, according to this preferably solidifies the conditional parameter of thermal field correspondence in described effective microwave thermal field data storehouse, on single-chip microcomputer, preset relevant parameter numerical value.
3. intelligent microwave cure instrument according to claim 1 and 2 is characterized in that described conditional parameter comprises A), antenna condition B), power condition C), the time conditions .D of different capacity effect), tumor condition .E), the boundary temperature condition.
4. intelligent microwave cure instrument according to claim 1 and 2, it is characterized in that described effective microwave thermal field data storehouse can be divided into following four data bases: 1) thermal field data base: the thermal field distributed in three dimensions data that are suitable for the boundary temperature isothermal level of kill tumor under the different parameters condition, comprise corresponding thermal field number, x, y, z coordinate, temperature, tumor blood flow filling rate, corresponding scheme number include the corresponding described thermal field graphics spectrum of solidifying in this thermal field data base; 2) therapeutic scheme data base: the therapeutic scheme storehouse of above-mentioned thermal field distributed in three dimensions data correspondence comprises the locus of scheme number, power, time, antenna type, antenna number, antenna; 3) property data base: according to case statistics in the past tumor is done the form classification by certain sorting technique, size fractionation, the blood flow classification is convenient to sort out relatively contrast, comprises tumor form classification, big or small rank and blood perfusion rate rank; 4) tumor data base, promptly the treatment before to behind the tumor examination to its description, comprise form, size, blood vessel and the blood flow of tumor.
5. intelligent microwave cure instrument according to claim 1 and 2 is characterized in that described single-chip microcomputer also can link to each other with thermometric needle by A/D converter.
6. intelligent microwave cure instrument according to claim 5, it is characterized in that described thermometric needle comprises guiding shank, guid needle medicated cap, described guiding shank is a cavity structure, the head seal of guiding shank, head at guiding shank cavity is provided with pick off, and the inwall of guid needle medicated cap is provided with junction point, connects sensor lead and cable, cable extends to the outside of guid needle medicated cap, the earthing of casing of guid needle needle body.
7. intelligent microwave cure instrument according to claim 1 and 2, it is characterized in that described microwave device comprises the magnetron as microwave source of at least one cover high-pressure control device and control thereof, described each magnetron links to each other with sample circuit with permutator respectively, two microwave antennas of described permutator control, described permutator links to each other with single-chip microcomputer respectively with sample circuit, and described permutator comprises the automatically controlled microwave ferrite coaxial switch of a high power.
8. intelligent microwave cure instrument according to claim 1 and 2, it is characterized in that described microwave antenna comprises outer conductor and the inner wire that links to each other with the microwave source magnetron by fixed support and socket, described outer conductor is one to be the hollow cylinder in axle center with the inner wire, the free end of described inner wire extends outer conductor, the periphery of described inner wire is enclosed with dielectric layer, the length that described inner wire extends to the outer part of outer conductor is the 9-30 millimeter, and an adherent layer is also wrapped up in the outside of described outer conductor.
9. intelligent microwave cure instrument according to claim 4 is characterized in that described preferred therapeutic scheme comprises following process:
(1), the tumor conditions such as form, size, blood vessel and blood flow of computer input tumor are in computer tumor data base;
(2), computer extracts eigenvalue according to classification regulation in the property data base to the tumor situation of input, comprises tumor form classification, big or small rank, blood perfusion rate rank;
(3), computer retrieves the therapeutic scheme of some suitable tumor features from the treatment scheme database;
(4), computer takes out the three-dimensional data and the collection of illustrative plates of the thermal field that therapeutic scheme can form from the thermal field data base, the three-dimensional collection of illustrative plates that will solidify thermal field fit shape with the 3D shape for the treatment of curing oncoma and is covered, and relatively selects definite therapeutic scheme for the doctor;
(5), according to the therapeutic scheme of determining by setting output, power and the action time of microwave source on the single-chip microcomputer, determine the number and the locus of antenna.
10. intelligent microwave cure instrument is characterized in that it comprises a single-chip microcomputer that links to each other by serial ports with computer, and described single-chip microcomputer links to each other with microwave device; Described calculator memory has stored up effective microwave thermal field data storehouse, store microwave coagulation thermal field real-time distribution data with different condition parameter and the corresponding three-dimensional collection of illustrative plates of thermal field real-time distribution that solidifies in described effective microwave thermal field data storehouse, described computer is carried out and by carrying out following preferred therapeutic scheme with single-chip data exchange control single chip computer and treating the process of control:
1) will treat that the real-time distribution data in curing oncoma data and the effective microwave thermal field data storehouse compare, select the more approaching thermal field that solidifies, the axonometric chart for the treatment of curing oncoma is covered mutually with the three-dimensional collection of illustrative plates of selecting that solidifies thermal field, preferred one solidifies thermal field, according to this preferably solidifies the conditional parameter of thermal field correspondence in described effective microwave thermal field data storehouse, on single-chip microcomputer, preset relevant parameter numerical value;
2) after the treatment beginning, carry out the micro-wave therapeutic monitoring, write down whole therapeutic process, monitor the variations in temperature of cancerous issue in microwave device duty and the therapeutic process, realize control automatically.
11. intelligent microwave cure instrument according to claim 10 is characterized in that described single-chip microcomputer also links to each other with thermometric needle by A/D converter.
12. intelligent microwave cure instrument according to claim 10, it is characterized in that described microwave device is the magnetron as microwave source of two cover high-pressure control devices and control thereof, described each magnetron also links to each other with sample circuit with permutator respectively, described permutator is controlled two microwave antennas respectively, described permutator links to each other with single-chip microcomputer, described sample circuit links to each other with single-chip microcomputer, and described permutator comprises the automatically controlled microwave ferrite coaxial switch of a high power.
13. intelligent microwave cure instrument according to claim 10, it is characterized in that described microwave antenna comprises outer conductor and the inner wire that links to each other with the microwave source magnetron by fixed support and socket, described outer conductor is one to be the hollow cylinder in axle center with the inner wire, the free end of described inner wire extends outer conductor, the periphery of described inner wire is enclosed with dielectric layer, the length that described inner wire extends to the outer part of outer conductor is the 9-30 millimeter, and an adherent layer is also wrapped up in the outside of described outer conductor.
14. intelligent microwave cure instrument according to claim 10 is characterized in that described step 2) monitoring of described micro-wave therapeutic comprises following process:
(1) gathers microwave source state, thermometric, and data are sent in the computer by single-chip microcomputer;
(2) if greater than rated temperature, check the microwave source state, as undesired, can stop microwave radiation, also can adjust the microwave source state and continue treatment; Normal as microwave source, and reach the time-delay of presetting, can continue gatherer process;
(3) if less than rated temperature, prolong a period of time, whether decision revises therapeutic scheme, if do not revise, micro-wave therapeutic can be finished,, thermometric mode and microwave radiation scheme can be revised as revising, after the modification, as not continuing thermometric, can stop thermometric, as continuing thermometric, can further see whether reach the time-delay of presetting, to continue gatherer process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02116889 CN1233301C (en) | 2002-04-24 | 2002-04-24 | Intelligent microwave cure instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02116889 CN1233301C (en) | 2002-04-24 | 2002-04-24 | Intelligent microwave cure instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1452945A true CN1452945A (en) | 2003-11-05 |
| CN1233301C CN1233301C (en) | 2005-12-28 |
Family
ID=29257033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02116889 Expired - Fee Related CN1233301C (en) | 2002-04-24 | 2002-04-24 | Intelligent microwave cure instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1233301C (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100458805C (en) * | 2006-01-20 | 2009-02-04 | 上海西门子医疗器械有限公司 | Management system and method for scan protocols |
| CN1748815B (en) * | 2005-09-16 | 2010-05-05 | 何申戌 | Method for quantizing data |
| CN103271769A (en) * | 2013-06-18 | 2013-09-04 | 刘中一 | High-power 2450MHz solid-state-source microwave therapy apparatus |
| CN103656865A (en) * | 2012-09-25 | 2014-03-26 | 郭运斌 | Device and method for transmitting microwave energy by using phased array antenna |
| CN108853661A (en) * | 2018-05-17 | 2018-11-23 | 苏州贝舒医疗科技有限公司 | A kind of interactive system of compression atomizer operational data |
| CN109481013A (en) * | 2018-12-19 | 2019-03-19 | 南京康友医疗科技有限公司 | A kind of microwave ablation device with thermal field monitoring function |
| CN109682489A (en) * | 2018-12-10 | 2019-04-26 | 国网冀北电力有限公司电力科学研究院 | Thermistor selection method and device based on electric energy meter protection feature |
| CN110547866A (en) * | 2018-06-01 | 2019-12-10 | 福美生技有限公司 | feedback energy release system and method of operation thereof |
| CN111012484A (en) * | 2020-01-06 | 2020-04-17 | 南京康友医疗科技有限公司 | Real-time ablation area imaging system |
| CN111700678A (en) * | 2020-06-23 | 2020-09-25 | 南京诺源医疗器械有限公司 | Control method of microwave ablation treatment dosage for liver tumor |
| WO2021258640A1 (en) * | 2020-06-23 | 2021-12-30 | 南京诺源医疗器械有限公司 | Microwave ablation carbonization control method for liver |
-
2002
- 2002-04-24 CN CN 02116889 patent/CN1233301C/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1748815B (en) * | 2005-09-16 | 2010-05-05 | 何申戌 | Method for quantizing data |
| CN100458805C (en) * | 2006-01-20 | 2009-02-04 | 上海西门子医疗器械有限公司 | Management system and method for scan protocols |
| CN103656865A (en) * | 2012-09-25 | 2014-03-26 | 郭运斌 | Device and method for transmitting microwave energy by using phased array antenna |
| CN103271769A (en) * | 2013-06-18 | 2013-09-04 | 刘中一 | High-power 2450MHz solid-state-source microwave therapy apparatus |
| CN103271769B (en) * | 2013-06-18 | 2016-09-14 | 刘中一 | High-power 2450MHz Solid Source microwave therapy apparatus |
| CN108853661A (en) * | 2018-05-17 | 2018-11-23 | 苏州贝舒医疗科技有限公司 | A kind of interactive system of compression atomizer operational data |
| CN110547866A (en) * | 2018-06-01 | 2019-12-10 | 福美生技有限公司 | feedback energy release system and method of operation thereof |
| CN109682489A (en) * | 2018-12-10 | 2019-04-26 | 国网冀北电力有限公司电力科学研究院 | Thermistor selection method and device based on electric energy meter protection feature |
| CN109481013A (en) * | 2018-12-19 | 2019-03-19 | 南京康友医疗科技有限公司 | A kind of microwave ablation device with thermal field monitoring function |
| CN109481013B (en) * | 2018-12-19 | 2021-05-28 | 南京康友医疗科技有限公司 | Microwave ablation device with thermal field monitoring function |
| CN111012484A (en) * | 2020-01-06 | 2020-04-17 | 南京康友医疗科技有限公司 | Real-time ablation area imaging system |
| CN111700678A (en) * | 2020-06-23 | 2020-09-25 | 南京诺源医疗器械有限公司 | Control method of microwave ablation treatment dosage for liver tumor |
| WO2021258640A1 (en) * | 2020-06-23 | 2021-12-30 | 南京诺源医疗器械有限公司 | Microwave ablation carbonization control method for liver |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1233301C (en) | 2005-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1233301C (en) | Intelligent microwave cure instrument | |
| Stea et al. | Treatment of malignant gliomas with interstitial irradiation and hyperthermia | |
| CN87100574A (en) | The method and apparatus of the fever therapy of tumor | |
| CN206239499U (en) | Radiofrequency ablation work station | |
| TW201233406A (en) | Scalar laser therapy apparatus | |
| CN104524698A (en) | Cell repair apparatus used for vagina of woman | |
| CN1961987A (en) | Pole plate array heating device for general or local tumor thermotherapy | |
| CN205832397U (en) | A kind of microwave therapy apparatus | |
| CN2910139Y (en) | Cold circulation electrode | |
| CN104836112B (en) | A kind of insulation heat radiator of single-tube semiconductor laser cascaded structure | |
| CN103990228B (en) | A kind of can the multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus of focused electromagnetic | |
| CN1290472C (en) | Combined multiple-antenna and heat-field method for microwave intervention treatment of tumor | |
| CN2568134Y (en) | Fully automatic pulse microwave thermotherapy machine | |
| CN106693210A (en) | Hair-growing helmet | |
| CN200957108Y (en) | Active injection heat therapeutic needle for tumour target therapy | |
| CN204972710U (en) | Microwave underarm odour therapeutic instrument | |
| CN2831921Y (en) | Far-infrared health-care mattress with loess | |
| CN203417255U (en) | Locking maxillofacial reconstruction type bone plate | |
| CN208943272U (en) | Animal model making apparatus packet is lighted in epilepsy electro photoluminescence | |
| CN202191597U (en) | High-voltage pulse electric field therapy device based on multiple needle electrodes | |
| CN207286459U (en) | The square treatment head of laser therapeutic apparantus | |
| Gaffoglio et al. | Impact of different modeling approaches in field focusing predictions of hyperthermia cancer therapy | |
| CN201150719Y (en) | Microwave therapy for treating finger and toes osteomyelitis | |
| CN105381547A (en) | LED chest protection device | |
| CN201481998U (en) | Digitally controlled electromagnetic therapeutic apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: GUANGDONG WELL PHARMACEUTICAL TECHNOLOGY CO., LTD Free format text: FORMER OWNER: DONG BAOWEI Owner name: DONG BAOWEI; Free format text: FORMER OWNER: NONE |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20040611 Address after: 519060 Guangdong city of Zhuhai Province Nanping South Beishan Avenue on the west side of North office building will produce substation Applicant after: Guangdong Weier Meical Science & Technology Co., Ltd. Co-applicant after: Dong Baowei Address before: 1303, room 100853, West nine, PLA General Hospital, 28 Fuxing Road, Beijing, Haidian District Applicant before: Dong Baowei |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20051228 |