CN1444558A - 新的n－(2－苯基－3－氨基丙基)萘甲酰胺类化合物 - Google Patents

新的n－(2－苯基－3－氨基丙基)萘甲酰胺类化合物 Download PDF

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Publication number
CN1444558A
CN1444558A CN01813656A CN01813656A CN1444558A CN 1444558 A CN1444558 A CN 1444558A CN 01813656 A CN01813656 A CN 01813656A CN 01813656 A CN01813656 A CN 01813656A CN 1444558 A CN1444558 A CN 1444558A
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China
Prior art keywords
alkyl
halogen
anxiety
disorder
disease
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CN01813656A
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Chinese (zh)
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P·贝恩斯泰恩
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P7/10—Antioedematous agents; Diuretics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
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    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN01813656A 2000-08-04 2001-07-31 新的n－(2－苯基－3－氨基丙基)萘甲酰胺类化合物 Pending CN1444558A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0019008.2 2000-08-04
GBGB0019008.2A GB0019008D0 (en) 2000-08-04 2000-08-04 Therapeutic compounds

Publications (1)

Publication Number Publication Date
CN1444558A true CN1444558A (zh) 2003-09-24

Family

ID=9896866

Family Applications (1)

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CN01813656A Pending CN1444558A (zh) 2000-08-04 2001-07-31 新的n－(2－苯基－3－氨基丙基)萘甲酰胺类化合物

Country Status (17)

Country Link
US (1) US6963011B2 (cg-RX-API-DMAC10.html)
EP (1) EP1307425B1 (cg-RX-API-DMAC10.html)
JP (1) JP2004505940A (cg-RX-API-DMAC10.html)
KR (1) KR20030059089A (cg-RX-API-DMAC10.html)
CN (1) CN1444558A (cg-RX-API-DMAC10.html)
AT (1) ATE293591T1 (cg-RX-API-DMAC10.html)
AU (1) AU2001284568A1 (cg-RX-API-DMAC10.html)
BR (1) BR0112957A (cg-RX-API-DMAC10.html)
CA (1) CA2415467A1 (cg-RX-API-DMAC10.html)
DE (1) DE60110233T2 (cg-RX-API-DMAC10.html)
GB (1) GB0019008D0 (cg-RX-API-DMAC10.html)
IL (1) IL153784A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA03000977A (cg-RX-API-DMAC10.html)
NO (1) NO20030509L (cg-RX-API-DMAC10.html)
NZ (1) NZ523434A (cg-RX-API-DMAC10.html)
WO (1) WO2002012168A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200300218B (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE486842T1 (de) * 2002-03-12 2010-11-15 Merck Sharp & Dohme Substituierte amide
AU2003226149A1 (en) * 2002-04-05 2003-10-27 Merck & Co., Inc. Substituted aryl amides
SE0201938D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New process
WO2006013205A1 (en) * 2004-08-04 2006-02-09 Solvay Pharmaceuticals B.V. Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation
US8093268B2 (en) 2007-01-24 2012-01-10 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-)
CA2740970A1 (en) 2008-10-21 2010-04-29 Oregon Health & Science University Naphthamides as anticancer agents
CN116102514B (zh) * 2023-01-17 2024-03-15 河南省锐达医药科技有限公司 一类萘酰胺类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751327A (en) * 1985-06-28 1988-06-14 Xerox Corporation Photoconductive imaging members with unsymmetrical squaraine compounds
AU6578090A (en) * 1989-11-06 1991-05-09 Warner-Lambert Company Acat inhibitors
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
GB9922521D0 (en) * 1998-10-07 1999-11-24 Zeneca Ltd Compounds
GB9907571D0 (en) * 1999-04-06 1999-05-26 Zeneca Ltd Compounds
FR2792835B3 (fr) * 1999-04-27 2001-05-25 Sanofi Sa Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression

Also Published As

Publication number Publication date
NZ523434A (en) 2004-08-27
US6963011B2 (en) 2005-11-08
AU2001284568A1 (en) 2002-02-18
EP1307425A1 (en) 2003-05-07
IL153784A0 (en) 2003-07-31
BR0112957A (pt) 2003-07-08
US20040014809A1 (en) 2004-01-22
DE60110233T2 (de) 2006-03-09
DE60110233D1 (de) 2005-05-25
WO2002012168A1 (en) 2002-02-14
NO20030509D0 (no) 2003-01-31
MXPA03000977A (es) 2003-06-09
ZA200300218B (en) 2004-06-25
KR20030059089A (ko) 2003-07-07
CA2415467A1 (en) 2002-02-14
GB0019008D0 (en) 2000-09-27
ATE293591T1 (de) 2005-05-15
EP1307425B1 (en) 2005-04-20
JP2004505940A (ja) 2004-02-26
NO20030509L (no) 2003-03-24

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