CN1424074A - Capsule for constipation and its preparing method - Google Patents
Capsule for constipation and its preparing method Download PDFInfo
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Abstract
A Chinese medicine in the form of capsule for treating constipation is prepared from 4 Chinese-medicinal materials including capejasmine fruit, bupleurum root, areca seed and cistanche through extracting and mixing with microcrystal cellulose.
Description
Technical field:
The present invention relates to treat the medicine of constipation, a kind of Chinese patent medicine for the treatment of constipation be provided especially---the deciphering capsule.
Background technology:
Constipation is a common disease clinically, and its sickness rate is 3%～4%.Epidemiological study confirms that constipation is relevant with multiple factors such as age, sex, diet, occupation, heredity, medicine, schoolings.The sickness rate and the age of constipation are proportionate.The U.S. confirms that after deliberation the degeneration of intestinal smooth muscle dominating neural system is the major reason of old constipation occurred frequently.On sex, the women is more than the male, and is higher with 21～30 years old women's prevalence especially.Its origin cause of formation and menstrual phase or trimester of pregnancy Alfasone secretion suppressed the intestinal tube motion and intestinal tube relevant to the sensitivity that stimulates.Now clear and definite, the high-cellulose diet is difficult for taking place constipation.The constipation patient of daily drink amount＜1000ml is obviously more than 〉=1000ml person.Constipation is with to take some medicine for a long time relevant, as cholinolytic preparation, antacid, tranquilizer, muscle relaxant and zest medicine, particularly cathartic.
Prolonged constipation person can be because of painful defecation, companion's abdominal distention and malnutrition, and influence quality of life.With the passing of time then can cause colonic ulcer and cancerous protuberance.And it is relevant with the generation of diseases such as the old popular feeling, lung and brain.Therefore, actively cure constipation, the physical and mental health of suffering from the patient is had very important significance.
To the treatment of functional constipation, use the catharsis agent more.The irritant laxative life-time service can bring out or increases the weight of constipation because of enteric plexus damage.Phenolphthalein (phenolphthalein element) has proved carcinogenesis.Many 5 usefulness Radix Et Rhizoma Rhei, Folium Sennae, Aloe etc. whenever cause stomachache in the Chinese patent medicine.Contained anthraquinone component easily causes melanosis coli in the following Chinese medicine and rush down.
The technology contents of invention:
The object of the present invention is to provide a kind of determined curative effect and be difficult for producing the new preparation of drug dependence and untoward reaction.
The invention provides a kind of medicine for the treatment of constipation, it is characterized in that this medicine is formed parts by weight by following prepared from traditional Chinese medicines:
700～800 parts of Fructus Gardeniaes
400～500 parts of Radix Bupleuri
400～500 parts of Semen Arecaes
200～300 parts of Herba Cistanches.
The present invention provides a kind of medicine of treatment constipation of oral capsule dosage form especially---the deciphering capsule, it is the alcohol-extracted extract of Fructus Gardeniae, Radix Bupleuri and Semen Arecae and the mixture of Herba Cistanches powder, in 500 the gram, 1000, dry extract is 245 ± 5 grams, Herba Cistanches powder 250 ± 1 grams can add the microcrystalline Cellulose counterpoise.
The invention provides above-mentioned treatment constipation medicine---decipher capsular preparation method, it is characterized in that process is as follows:
Fructus Gardeniae, Radix Bupleuri, Semen Arecae medical material are added ethanol extraction respectively repeatedly, each 0.5～2 hour, filter merging filtrate, standing over night, 50～70 ℃ of fluid extracts that reclaim ethanol to relative density 1.20～1.25;
Get the Herba Cistanches medical material, be ground into fine powder;
With above-mentioned fluid extract, Herba Cistanches powder and auxiliary materials and mixing, be dried to driedly, pulverize, granulate.
The present invention is a monarch drug with the Fructus Gardeniae clearing away heat and loosing the bowels, and Semen Arecae circulation of qi promoting intestinal stasis relieving, the orderly and clearly mechanism of qi of Radix Bupleuri, Herba Cistanches loosening bowel to relieve constipation are adjuvant drug altogether.Have following advantage:
1. do not select Chinese medicine under the rushing down that Radix Et Rhizoma Rhei etc. can cause suffering from abdominal pain for use;
2. do not select Chinese medicine under the rushing down that contains anthraquinone component for use;
3. it is fewer but better to decipher capsular prescription composition, and the flavour of a drug number is limited to below 5 flavors;
4. it should be best deciphering that capsular curative effect compares with current listing herbal species.
The specific embodiment:
Embodiment 1 deciphering capsule preparation
750 gram Fructus Gardeniaes, 450 gram Radix Bupleuri, 450 gram Semen Arecae medical materials are added 6 times of amounts of 50% ethanol respectively extract 2 times, each 1 hour, filter, merge secondary filtrate, standing over night reclaims fluid extract 245 grams of ethanol (60 ℃) to relative density 1.20～1.25 (60 ℃), and device is preserved in addition; Get 250 gram Herba Cistanches medical materials, be ground into fine powder, merge with the ethanol extraction fluid extract, add 5 gram microcrystalline Cellulose, mixing is dried to driedly, pulverizes, and makes 1000, promptly.
Embodiment 2 deciphering capsule Pharmacodynamic test of active extract
Be subjected to the reagent thing:
The deciphering capsule, embodiment 1 preparation, clinical consumption is 3/time, every day 3 times.Specification: 0.5g/ grain, 1.9g crude drug/grain.Be that clinical consumption is 17.1g crude drug/day.
DAHUANG TONGBIAN JIAONANG (positive control drug), Jianjiang Pharmaceutical Factory produces, and authentication code: (98) are defended the accurate word Z-054 of medicine number, lot number: 990301, clinical consumption is 2/time, every day 1 time.Specification: the 0.45g/ grain, it is standby to be subjected to the reagent thing all to be made into the desired concn suspension with distilled water.
Animal subject:
Kunming kind white mice, the qualified laboratory animal of one-level is bought by Chinese Medical Sciences University's Experimental Animal Center, the quality certification number: No. 010, the real moving word of the Liao Dynasty; The Wistar rat is bought by the Shenyang Medical College Experimental Animal Center, the quality certification number: No. the 001st, the real moving word of the Liao Dynasty; Pellet is provided by people's animal feed factory before Shenyang City's Yuhong District.The quality certification number: distant real bar closes word No. 032.
Experimental situation:
Laboratory temperature 22-25 ℃, humidity 45-60%.
Reagent:
India ink, chemical plant in the west, Beijing, lot number: 980301; Compound diphenoxylate, Jiaozuo City Kang Li Pharmaceutical limited company, lot number: 99032726; Pentobarbital sodium, SERVA import packing, the chemical plant is known in last sea-run, lot number: 921019.
Instrument:
JJ-200 type precise electronic balance, the two outstanding test instrunment in Changshu factory.
Test method and result:
1, the deciphering capsule is to the defecation test of dryness accumulated in the stomach and intestine dehydration constipation model mice
Get body weight 24～26g healthy mice, male and female half and half are divided into six groups at random by body weight, blank group, model control group, the basic, normal, high dosage group of deciphering capsule and DAHUANG TONGBIAN JIAONANG group.Except that the blank group, other are respectively organized mice and prohibited the water non-fasting 72 hours, cause dryness accumulated in the stomach and intestine dehydration constipation model.The blank group is irritated stomach and is given 2% the india ink suspension that is configured to distilled water, the administration group is then irritated 2% the india ink suspension that stomach gives to replace in order to medicinal liquid distilled water, administration volume 1ml/20g, after the administration mice put into the mice box, 1 in every box, the clean filter paper of underlay white, every mice of observed and recorded are discharged the time (min) of melena and mice discharge melena sum in 4 hours first.T checks the significance of each group difference.The results are shown in Table 1.
Table 1 deciphering capsule is to the influence test of dryness accumulated in the stomach and intestine dehydration constipation model mice defecation
Group number of animals dosage is arranged row in the melena 4 hours first
(time of g crude drug/kg), (branch) melena was counted (only)
Blank group 10-190.9 ± 78.8 2.3 ± 1.6
Model control group 10-355.0 ± 15.8
△ △0.2 ± 0.6
△ △
The low group 10 2.22 335.0 ± 79.1 0.4 ± 1.3 of deciphering capsule
Group 10 4.44 266.0 ± 112.2 in the deciphering capsule
*1.8 ± 2.2
*
The high group 10 8.88 229.2 ± 84.3 of deciphering capsule
*2.7 ± 2.0
*
DAHUANG TONGBIAN JIAONANG group 10 0.47# 323.5 ± 66.8 0.9 ± 1.7
With the blank group than △ △ P＜0.01 and model control group ratio
*P＜0.05
*P＜0.01
The # dosage unit is g/kg
By table 1 as seen, model control group is obviously discharged the time lengthening of melena first than blank group mice, and excludes the minimizing of melena sum in 4 hours, and its difference has statistical significance, and mice dryness accumulated in the stomach and intestine dehydration constipation model moulding success is described.With the model control group ratio, the time that the middle and high dosage group of deciphering capsule mice is discharged melena first shortens, mice was discharged the melena sum and increases in 4 hours, its difference has statistical significance, showing that the deciphering capsule has dryness accumulated in the stomach and intestine dehydration constipation model mice shortens the mice defecation time more significantly, increases the discharge function of mice defecation frequency.
2, the deciphering capsule is to the defecation test of compound diphenoxylate (DC) model mice
Get body weight 22～24g healthy mice, male and female half and half are divided into six groups at random by body weight, blank group, model control group, the basic, normal, high dosage group of deciphering capsule and DAHUANG TONGBIAN JIAONANG group.Each is organized mice and prohibited the water non-fasting 12 hours, except that the blank group is given the equivalent distilled water, all the other each groups are irritated stomach and are given compound diphenoxylate (DC) suspension 50mg/kg, after 30 minutes, each treated animal is irritated stomach and is subjected to the reagent thing, administration volume 1ml/20g body weight, blank group and model control group are given the equivalent distilled water.The argol that every group of mice of observed and recorded discharged is counted, loose stool is counted and the number of animals of defecation not, observes continuously 12 hours, respectively organizes index, and t checks the significance of each group difference.The results are shown in Table 2.
Table 2 deciphering capsule is to the influence test of DC constipation model mice defecation
Group number of animals dosage argol loose stool is defecation not
(only) (number of animals of counting of g crude drug/kg)
Blank group 10-0.8 ± 4.12 0.0 ± 0.00 0
Model control group 10-2.4 ± 2.54
△ △0.0 ± 0.00 2
The low group 10 2.22 3.9 ± 3.24 0.2 ± 0.42 0 of deciphering capsule
Group 10 4.44 4.6 ± 2.46 in the deciphering capsule
*0.3 ± 0.48 0
The high group 10 8.88 9.4 ± 3.27 of deciphering capsule
*1.9 ± 1.97
*0
DAHUANG TONGBIAN JIAONANG group 10 0.47# 3.7 ± 1.57 0.0 ± .00 0
With the blank group than △ △ P＜0.01 and model control group ratio
*P＜0.05
*P＜0.01
The # dosage unit is g/kg
By table 2 as seen, the argol of discharging in the model control group mice 12 hours minimizings of counting, the number of animals of defecation does not increase, and with blank group ratio, its difference has statistical significance, illustrates that the moulding of mice DC constipation model is successfully.With the model control group ratio, the argol that dosage group mice was discharged in 12 hours in the deciphering capsule is counted and is increased, and the number of animals of defecation does not reduce, and its difference has statistical significance.The argol that deciphering capsule in high dose group mice was discharged in 12 hours is counted and is increased, loose stool is counted and is increased, and the number of animals of defecation does not reduce, with the model control group ratio, its difference also has statistical significance, shows that the deciphering capsule has significant discharge function to DC constipation model mice.
3, the deciphering capsule is to the defecation test of normal mouse
Get body weight 22～24g healthy mice, male and female half and half are divided into five groups at random by body weight, blank group, the deciphering basic, normal, high dosage group of capsule and DAHUANG TONGBIAN JIAONANG group.The blank group is irritated stomach and is given 2% the india ink suspension that is configured to distilled water, the administration group is then irritated stomach and is given 2% the india ink suspension that replaces in order to medicinal liquid that distilled water is configured to, the administration volume is 1ml/20g, after the administration mice put into the mice box, 1 in every box, the clean filter paper of underlay white, every mice of observed and recorded are discharged the time (min) of melena and mice discharge melena sum in 4 hours first.T checks the significance of each group difference.The results are shown in Table 3.
Table 3 deciphering capsule is to the influence test of normal mouse defecation
Group number of animals dosage is arranged row in the melena 4 hours first
(time of g crude drug/kg), (branch) melena was counted (only)
Blank group 10-148.6 ± 44.8 2.2 ± 2.15
The low group 10 2.22 138.6 ± 65.8 4.0 ± 1.90 of deciphering capsule
Group 10 4.44 110.0 ± 55.6 5.5 ± 3.27 in the deciphering capsule
*
The high group 10 8.88 93.0 ± 49.1 of deciphering capsule
*8.3 ± 2.71
*
DAHUANG TONGBIAN JIAONANG group 10 0.47# 116.7 ± 42.2 6.8 ± 2.39
*
With blank group ratio
*P＜0.05
*P＜0.01
The # dosage unit is g/kg
By table 3 as seen, with blank group ratio, the middle melena sum that dosage group mice was discharged in 4 hours in the deciphering capsule increases, the time that deciphering capsule in high dose group mice is discharged melena first shortens, mice is discharged the melena sum in 4 hours and increases, its difference has statistical significance, shows that the deciphering capsule has significant discharge function to normal mouse.
4, the deciphering capsule is tested the mouse small intestine ahead running
Get body weight 23～25g healthy mice, male and female half and half are divided into five groups at random by body weight, blank group, the deciphering basic, normal, high dosage group of capsule and DAHUANG TONGBIAN JIAONANG group.With the charcoal end is mark, the blank group is irritated stomach and is given 7% the carbon ink suspension that is configured to normal saline, the administration group is then irritated stomach and is given 7% the carbon ink suspension that replaces in order to medicinal liquid that distilled water is configured to, the administration volume is 0.4ml/20g, irritates behind the stomach 30 minutes, and mice is put to death in the cervical vertebra dislocation, the taking-up gastrointestinal of cutting open the belly immediately, be tiled on the glass plate, measure displacement and the small intestinal total length (from pylorus to ileum) of carbon ink head end in intestinal tube, calculate and advance percentage rate.T checks the significance of each group difference.The results are shown in Table 4.
Table 4 deciphering capsule is to the intestinal propulsion test of normal mouse
Group number of animals dosage small intestinal length carbon ink advance distance advances percentage rate
(only) (g crude drug/kg) (cm) is (%) (cm)
Blank group 10-51.7 ± 3.27 39.3 ± 3.65 76.13 ± 6.59
The low group 10 2.22 47.5 ± 6.39 36.4 ± 6.96 77.33 ± 9.03 of deciphering capsule
Group 10 4.44 49.3 ± 3.71 42.7 ± 6.38 86.46 ± 9.84 in the deciphering capsule
*
The high group 10 8.88 49.0 ± 5.35 46.0 ± 5.29 of deciphering capsule
*94.03 ± 6.58
*
DAHUANG TONGBIAN JIAONANG group 10 0.47# 48.0 ± 4.52 43.2 ± 6.36 90.04 ± 10.65
*
With blank group ratio
*P＜0.05
*P＜0.01
The # dosage unit is g/kg
By table 4 as seen, the middle and high dosage group of deciphering capsule mouse small intestine carbon ink advance distance is long with blank group ratio, advances percentage rate to increase, and its difference has statistical significance, shows that deciphering capsule has the effect that promotes the small intestine movement of mice ahead running.
5, the deciphering capsule is tested rat large intestine ahead running
Get body weight 250～350g healthy adult rat, all male, be divided into five groups at random by body weight, blank group, the deciphering basic, normal, high dosage group of capsule and DAHUANG TONGBIAN JIAONANG group.Anesthetized rat during test, abdominal part cropping then along the median line otch, is opened the abdominal cavity and is found caecum and colon junction.Blank group rat is injected the normal saline that contains 10% india ink in this one in colonic lumen, the administration group is then injected the medicinal liquid that contains 10% india ink, administration volume 2.5ml/kg body weight.5min after the administration opens the abdominal cavity immediately, separates and cuts large intestine, and it is straight to take out the nature pendulum, measures large intestine length and the propulsive distance of prepared Chinese ink with meter ruler, calculates to advance percentage rate.T checks the significance of each group difference.The results are shown in Table 5.
Table 5 deciphering capsule is to the large intestine propulsion trial of normal rat
Group number of animals dosage dosage large intestine length prepared Chinese ink advance distance advances percentage rate
(only) (g crude drug/kg) (cm) is (%) (cm)
Blank group 10-15.4 ± 1.3 5.7 ± 2.2 37.4 ± 15.3
The low group 10 1.54 15.5 ± 1.1 9.2 ± 4.3 of deciphering capsule
*58.7 ± 25.7
*
Group 10 2.08 15.2 ± 0.9 9.3 ± 3.7 in the deciphering capsule
*61.1 ± 22.4
*
The high group 10 6.16 15.3 ± 1.1 11.1 ± 2.5 of deciphering capsule
*73.3 ± 19.0
*
DAHUANG TONGBIAN JIAONANG group 10 0.3# 14.8 ± 0.6 7.7 ± 4.0 52.1 ± 27.0
*
With blank group ratio
*P＜0.05
*P＜0.01
The # dosage unit is g/kg
By table 5 as seen, the basic, normal, high dosage group of deciphering capsule rat large intestine prepared Chinese ink advance distance is long with blank group ratio, advances percentage rate to increase, and its difference has statistical significance, shows that deciphering capsule has the effect that promotes normal rat large intestine ahead running.
6, the deciphering capsule is to mice intestinal volume influence test
Get body weight 18～22g healthy mice, male and female half and half are divided into five groups at random by body weight, blank group, the deciphering basic, normal, high dosage group of capsule and DAHUANG TONGBIAN JIAONANG group.Fasting be can't help water after 12 hours, and each organizes gastric infusion according to dosage, and the blank group is given the equivalent distilled water, administration volume 1ml/20g body weight, administration after 2.5 hours is put to death the disconnected cervical vertebra of animal, cuts off the abdominal cavity, exposes intestinal tube, in pylorus lower end and ileocecus ligation, the place cuts intestinal tube from pylorus, carefully cuts mesentery with little shears downwards along intestinal tube, cuts off intestinal tube at ileocecus, accurate weighing intestinal tube weight on electronic balance, t checks the significance of each group difference.The results are shown in Table 6.
Table 6 deciphering capsule is tested normal mouse intestinal volume
Group number of animals dosage intestinal tube weight
(only) (g crude drug kg) (g)
Blank group 10-1.26 ± 0.13
The low group 10 2.22 1.42 ± 0.21 of deciphering capsule
Group 10 4.44 1.40 ± 0.14 in the deciphering capsule
*
The high group 10 8.88 1.53 ± 0.25 of deciphering capsule
*
DAHUANG TONGBIAN JIAONANG group 10 0.47# 1.50 ± 0.36
With blank group ratio
*P＜0.05
The # dosage unit is g/kg
By table 6 as seen, with blank group ratio, the middle and high dosage group of deciphering capsule mice intestinal tube weight increases, and its difference has statistical significance, shows that the deciphering capsule has the volumetrical effect of the mice intestinal tube of increasing.
7, the deciphering capsule is tested the mice functions of loosening bowel relieving constipation
Get body weight 18～22g healthy mice, male and female half and half are divided into five groups at random by body weight, blank group, the deciphering basic, normal, high dosage group of capsule and DAHUANG TONGBIAN JIAONANG group.Each organizes gastric infusion according to dosage, the blank group is given the equivalent distilled water, administration volume 1ml/20g body weight, after the administration mice is put into the mice box, 1 in every box, the clean filter paper of underlay white, write down the time and the character that occur soft stool, loose stool, loose stool in 4 hours for the first time, represent purging and intestine lubricating action with soft stool, represent defecating feces excretion, represent discharge function with loose stool with loose stool.Soft stool refers to that excrement is shaped, but softly expands that to contain moisture more, and loose stool slightly is shaped or is shapeless, scattered paste shape, loose stool scattered paste shape or water liquid.T checks the significance of each group difference.The results are shown in Table 7.
Table 7-1 deciphering capsule is to the loosening bowel to relieve constipation test of normal mouse
Loose stool time group number of animals dosage loose stool time soft stool time
(only) ((branch) (branch) (branch) of g crude drug/kg)
Blank group 10-135.8 ± 10.2 240.0 ± 0.0 240.0 ± 0.0
The low group 10 2.22 53.4 ± 73.2 180.4 ± 96.2 240.0 ± 0.0 of deciphering capsule
Group 10 4.44 34.6 ± 27.6 in the deciphering capsule
*126.3 ± 98.1
*202.2 ± 61.1
The high group 10 8.88 28.5 ± 29.7 of deciphering capsule
*130.6 ± 96.9
*172.6 ± 108.5
DAHUANG TONGBIAN JIAONANG group 10 0.47# 52.4 ± 66.8 183.3 ± 91.9 240.0 ± 0.0
Table 7-2 deciphering capsule is to the loosening bowel to relieve constipation test of normal mouse
Group number of animals dosage soft stool rate loose stool rate loose stool rate
(only) (g crude drug/kg) (%) is (%) (%)
Blank group 10-50 00
The low group 10 2.22 90 30 0 of deciphering capsule
Group 10 4.44 100 60 30 in the deciphering capsule
The high group 10 8.88 100 60 30 of deciphering capsule
DAHUANG TONGBIAN JIAONANG group 10 0.4# 90 30 0
With blank group ratio
*P＜0.05
*P＜0.01
The # dosage unit is g/kg
By table 7 as seen, with blank group ratio, deciphering capsule middle and high dosage group mice soft stool, loose stool time occur and obviously shortens, and soft stool rate, loose stool rate and loose stool rate obviously improve, its difference has statistical significance, shows that the deciphering capsule has significantly functions of loosening bowel relieving constipation.
8, separate capsule and align the stripped ileum influence of normal rabbit test
Get 10 of body weight 1.5～2.0kg rabbit, the male and female dual-purpose, fasting be can't help water after 24 hours, method is put to death with tapping the head, press the stripped duodenum specimen of document preparation, every section about 2cm of intestinal tube hangs in the isolated organ analyzer water bath that fills 30mL37 ℃ of tyrode's solution, in bath, slowly inject oxygen, tension load 1g.The curve movement of the normal duodenum smooth muscle that exsomatizes is write down in stable back, is recorded in to add acetylcholine (Ach), barium chloride (Bacl in the bath again
2), the curve movement of epinephrine (Adr) metaduodenum smooth muscle, the deciphering capsule medicinal liquid that in bath, adds various dose then successively, write down the curve movement of the duodenum smooth muscle that exsomatizes again, the each observation 15 minutes, measure the variation of its administration ideocolon muscular tension, calculate its tension variation percentage rate, t checks the significance of each group difference.The results are shown in Table 8.
Table 8 deciphering capsule is to the influence test of rabbit intestine in vitro motion
Group dosage muscular tension changes percentage rate
(g/0.2ml) normal intestinal tube Ach intestinal tube Bacl
2Intestinal tube Adr intestinal tube
(1×10
-40.1ml) (20％0.1ml) (1×10
-4?0.1ml)
Blank group-6.4 ± 13.09-2.4 ± 6.64-6.4 ± 10.72 3.9 ± 6.62
The low group 0.0042 48.6 ± 22.59 17.1 ± 17.80 of deciphering capsule
*23.7 ± 5.69
*135.9 ± 94.2
*
Group 0.0084 97.0 ± 29.60 in the deciphering capsule
*30.8 ± 19.96
*38.8 ± 18.29
*289.2 ± 122.01
*
The high group 0.0168 251.3 ± 76.22 of deciphering capsule
*56.2 ± 23.62
*634 ± 10.54
*600.0 ± 159.85
*
DAHUANG TONGBIAN JIAONANG group 0.00168 129.8 ± 58.87
*19.4 ± 16.70
*40.0 ± 14.92
*119.0 ± 82.02
*
With blank group ratio
*P＜0.05
*P＜0.01
By table 8 as seen, basic, normal, high three the dosage groups of deciphering capsule can make the stripped duodenal shrinkage amplitude of rabbit strengthen, and muscular hypertonia makes Ach, Bacl
2The stripped duodenal tetanic property contraction of the rabbit that causes recovers normal rhythm, shrinkage amplitude strengthens, muscular hypertonia, the stripped duodenal inhibition of the rabbit that antagonism Adr causes shrinks, with blank group ratio, its difference has 9 meanings of uniting, and shows that the deciphering capsule has the easypro active effect of contracting of the stripped duodenum of the rabbit of improvement.
In a word, the time that deciphering capsule 4.44g crude drug/kg, 8.88g crude drug/kg dosage can make dryness accumulated in the stomach and intestine dehydration constipation model mice discharge melena first shortens, and mice is discharged melena color dot sum and increases in 4 hours; The argol that deciphering capsule 4.44g crude drug/kg dosage can make DC constipation model mice discharge in 12 hours is counted and is increased, the number of animals of defecation does not reduce, 8.88g can making the argol of discharging in the DC constipation model mice 12 hours count, increases crude drug/kg dosage, loose stool is counted and is increased, and the number of animals of defecation does not reduce; With the model control group ratio, its difference all has statistical significance.Deciphering capsule 4.44g crude drug/kg dosage can make normal mouse discharge melena color dot sum in 4 hours to increase, 8.88g the time that crude drug/kg dosage can make normal mouse discharge melena first shortens, mice is discharged melena color dot sum and increases in 4 hours, with blank group ratio, its difference also has statistical significance, points out the deciphering capsule that dryness accumulated in the stomach and intestine dehydration constipation model mice, DC constipation model mice and normal mouse are all had and promotes the excretory discharge function of animal more significantly.
Deciphering capsule 4.44g crude drug/kg, 8.88g crude drug/kg dosage can promote mouse small intestine prepared Chinese ink 10 advance distances, make to advance percentage rate to increase; Deciphering capsule 2.22g crude drug/kg, 4.44g crude drug/kg, 8.88g crude drug/kg dosage can promote rat large intestine prepared Chinese ink advance distance, improve and advance percentage rate, with blank group ratio, its difference all has statistical significance, prompting deciphering capsule has the ahead running that promotes intact animal's small intestinal, large intestine, strengthens the function of enterokinesia.
Deciphering capsule 4.44g crude drug/kg, 8.88g crude drug/kg dosage can obviously increase the mouse small intestine moisture, and mice intestinal tube weight is increased, and it is big that the intestinal volume becomes; Deciphering capsule 4.44g crude drug/kg, 8.88g crude drug/kg dosage can make mice soft stool, loose stool time occur obviously to shorten, and soft stool rate, loose stool rate and loose stool rate obviously improve, and with blank group ratio, its difference all has statistical significance.Point out the deciphering capsule to have and more significantly reduce intestinal, make the remollescent functions of loosening bowel relieving constipation of stool moisture absorption.
Deciphering capsule 2.22g crude drug/kg, 4.44g crude drug/kg, 8.88g crude drug/kg dosage have excitation to the duodenum that exsomatizes, and shrinkage amplitude obviously increases, and the contractility of intestinal smooth muscle obviously strengthens; To Ach, Bacl
2The stripped duodenal tetanic property contraction of the rabbit that causes has its normal rhythm of recovery, strengthens the effect of shrinkage amplitude and muscular tension; The stripped duodenal inhibition contraction of rabbit that Adr is caused has antagonism, and with blank group ratio, its difference has statistical significance, and prompting deciphering capsule has the easypro active effect of contracting of the stripped duodenum of the rabbit of improvement.
Above result shows, the deciphering capsule has stronger promotion animal defecation, increases enterokinesia and functions of loosening bowel relieving constipation, and regulates and improve the active effect of the animal intestine rhythm and pace of moving things, these effects and this medicine purge heat clearly knot, intestinal stasis relieving relieving constipation, the effect for the treatment of habitual constipation is consistent.
Claims (4)
1, a kind of medicine for the treatment of constipation is characterized in that this medicine is formed parts by weight by following prepared from traditional Chinese medicines:
700～800 parts of Fructus Gardeniaes;
400～500 parts of Radix Bupleuri;
400～500 parts of Semen Arecaes;
200～300 parts of Herba Cistanches.
2, press the medicine of the described treatment constipation of claim 1, it is characterized in that described medicine is a capsule preparations, be the alcohol-extracted extract of Fructus Gardeniae, Radix Bupleuri and Semen Arecae and the mixture of Herba Cistanches powder, in 500 the gram, 1000, dry extract is 245 ± 5 grams, Herba Cistanches powder 250 ± 1 grams are used the microcrystalline Cellulose counterpoise.
3, the preparation method of the described treatment constipation of a kind of claim 2 medicine is characterized in that process is as follows:
Fructus Gardeniae, Radix Bupleuri, Semen Arecae medical material are added ethanol extraction respectively repeatedly, each 0.5～2 hour, filter merging filtrate, standing over night, 50～70 ℃ of fluid extracts that reclaim ethanol to relative density 1.20～1.25;
Get the Herba Cistanches medical material, be ground into fine powder;
With above-mentioned fluid extract, Herba Cistanches powder and auxiliary materials and mixing, be dried to driedly, pulverize, granulate packing.
4, by the preparation method of the described treatment constipation of claim 3 medicine, it is characterized in that process is as follows: described ethanol extraction process is to extract 2 times with 6 times of amounts of 50% ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02144940 CN1216627C (en) | 2002-12-18 | 2002-12-18 | Capsule for constipation and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02144940 CN1216627C (en) | 2002-12-18 | 2002-12-18 | Capsule for constipation and its preparing method |
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| CN1424074A true CN1424074A (en) | 2003-06-18 |
| CN1216627C CN1216627C (en) | 2005-08-31 |
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| CN 02144940 Expired - Fee Related CN1216627C (en) | 2002-12-18 | 2002-12-18 | Capsule for constipation and its preparing method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764364A (en) * | 2012-08-20 | 2012-11-07 | 广东丸美生物技术股份有限公司 | External medicine for curing constipation and method for preparing same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764364A (en) * | 2012-08-20 | 2012-11-07 | 广东丸美生物技术股份有限公司 | External medicine for curing constipation and method for preparing same |
| CN102764364B (en) * | 2012-08-20 | 2014-01-29 | 广东丸美生物技术股份有限公司 | External medicine for curing constipation and method for preparing same |
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| Publication number | Publication date |
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| CN1216627C (en) | 2005-08-31 |
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