CN1420121A - Mtehod for microwave extracting nimbin from nim kernel - Google Patents
Mtehod for microwave extracting nimbin from nim kernel Download PDFInfo
- Publication number
- CN1420121A CN1420121A CN 02122306 CN02122306A CN1420121A CN 1420121 A CN1420121 A CN 1420121A CN 02122306 CN02122306 CN 02122306 CN 02122306 A CN02122306 A CN 02122306A CN 1420121 A CN1420121 A CN 1420121A
- Authority
- CN
- China
- Prior art keywords
- microwave
- extracting method
- nimbin
- solvent
- kernel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NHOIBRJOQAYBJT-IMGVWCFESA-N nimbin Chemical compound C=1([C@@H]2C[C@H]3O[C@H]4[C@](C3=C2C)(C)[C@@H]([C@]2(C(=O)C=C[C@](C)([C@@H]2[C@H]4OC(C)=O)C(=O)OC)C)CC(=O)OC)C=COC=1 NHOIBRJOQAYBJT-IMGVWCFESA-N 0.000 title claims abstract description 15
- ZQIYJHBQRBBBRZ-UHFFFAOYSA-N nimbin Natural products COC(=O)CC1C2C(C(OC(=O)C)C3OC4CC(C(=C4C13C)C)c5cocc5)C(C)(C=CC2=O)C(=O)OC ZQIYJHBQRBBBRZ-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 23
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 15
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 12
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims abstract description 9
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960001701 chloroform Drugs 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000013500 Melia azadirachta Nutrition 0.000 claims description 16
- 240000005343 Azadirachta indica Species 0.000 claims description 13
- 230000005855 radiation Effects 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 238000010025 steaming Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 229940093499 ethyl acetate Drugs 0.000 abstract 1
- 235000019439 ethyl acetate Nutrition 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 4
- 244000237986 Melia azadirachta Species 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000010298 pulverizing process Methods 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- 240000000233 Melia azedarach Species 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A microwave process for extracting nimbin from the kernel of nim seed is characterized by that the microwave (245 MHz and 100-850 w) are used to extract nimbin from the kernels of nim seeds in the solvent which is the mixture of petroleum ether, methanol, ethanol, acetone, ethylacetate, dichloromethane, trichloromethane and water. Its advantages are high speed and effect, low cost, and high purity of product.
Description
Technical field
The present invention relates to adopt microwave technology from neem kernel, to extract the method for nimbin.
Background technology
The seal chinaberry, as a kind of " can solve the tree of global problems ", more and more be subjected to people's attention, and the nimbin that extracts from the seal chinaberry kind benevolence of bearing fruit has superior efficacy such as anti-inflammatory, sterilization, antipruritic, insect protected as the most effective activeconstituents wherein, is applied to fields such as agricultural chemicals, medicine, daily-use chemical industry more and more.Not only technical process is long, solvent consumption is big, yield is low, cost is high but traditional solvent method extracts nimbin, and environment is polluted harm humans health.
Summary of the invention
The object of the present invention is to provide a kind of method that adopts microwave technology from neem kernel, to extract nimbin.The microwave that it utilizes is a kind of high-frequency hertzian wave, along with hertzian wave is constantly changed direction at spatial, make the polar molecule of material inside, with the more than one hundred million inferior speed vibration at high speed of per second, intermolecular owing to the friction and Extrusion effect produces heat, thereby material is heated up rapidly, quickened simultaneously this ultimate principle of exchange of material inside and outside molecule greatly, with frequency is 2450MHz, power be the microwave of 100～850W to neem kernel at methyl alcohol, ethanol, acetone, ethyl acetate, methylene dichloride, trichloromethane, carry out microwave treatment in the solvent of water or its mixture, obtain the higher nimbin of content.
The present invention is that the employing frequency is 2450MHz, and power is that the microwave of 100～850W is handled in solvent neem kernel, extracts the novel method of nimbin from neem kernel.
Particularly, the present invention includes following aspect:
With frequency is 2450MHz, and power is the microwave of 100～850W carries out microwave treatment in sherwood oil to neem kernel step.
On the other hand, extracting method of the present invention, also be included in after the described microwave treatment step of the solids of microwave extraction gained being extracted once more with the solvent that is selected from methyl alcohol, ethanol, acetone, ethyl acetate, methylene dichloride, trichloromethane, water or its mixture.
In the said extracted method, the frequency of used microwave is 2450MHz, and microwave treatment time is 0.1～10min.
In the said extracted method, the amount of described solvent and neem kernel counts 1: 3 by weight～and 12.
In above-mentioned extracting method, described microwave treatment is divided and is carried out each 0.1～5min for 1～3 time.
In above-mentioned extracting method, described microwave treatment temperature is no more than 65 ℃.
In above-mentioned extracting method, described neem kernel is to grind form in small, broken bits.
Compared with prior art the present invention adopts microwave technology to extract nimbin from neem kernel, replace traditional solvent extration, micro-wave energy is penetrated into the deep layer of raw material, so the percentage extraction height, and reduced raw material long-time operation at high temperature, help the raising of quality product.The a large amount of uses and the consequent defective of organic solvent have been avoided, as toxicity, pollution, inflammable, leakage etc.Through the extraction of 10min, obtain effective constituent.Enforcement of the present invention has improved production efficiency greatly, has characteristics such as flow process weak point, less energy consumption, the product purity height that does not pollute, produces, economic worth height, and positive effect has been played in environment protection.
Embodiment:
Embodiment 1.
Neem kernel 15g after pulverizing being put into the 250ml round-bottomed flask, add the 150ml sherwood oil, is 300w with power, and frequency is that the microwave of 2450MHz carries out microwave radiation to it, divides and carries out for 3 times, each 1min.After the filtration, filter residue is put into the 250ml round-bottomed flask, adding 150ml methyl alcohol, is 300w with power once more, and frequency is that the microwave of 2450MHz carries out microwave radiation to it, divide and carry out for 3 times, each 2min filters, and filtrate is through underpressure distillation, drying obtains pale yellow powder shape solid phase prod 0.63g, and the content that records nimbin with high performance liquid chromatography is 9.5%.
Embodiment 2.
Neem kernel 15g after pulverizing being put into the 250ml round-bottomed flask, add the 150ml sherwood oil, is 300w with power, and frequency is that the microwave of 2450MHz carries out microwave radiation to it, divides and carries out for 3 times, each 1min.After the filtration, filter residue is put into the 250ml round-bottomed flask, adding 150ml acetone, is 300w with power once more, and frequency is that the microwave of 2450MHz carries out microwave radiation to it, divide and carry out for 3 times, each 2min filters, and filtrate is through underpressure distillation, drying obtains pale yellow powder shape solid phase prod 0.68g, and the content that records nimbin with high performance liquid chromatography is 8.8%.
Embodiment 3.
Neem kernel 15g after pulverizing being put into the 250ml round-bottomed flask, add the 150ml sherwood oil, is 300w with power, and frequency is that the microwave of 2450MHz carries out microwave radiation to it, divides and carries out for 3 times, each 1min.After the filtration, filter residue is put into the 250ml round-bottomed flask, adding the 150ml trichloromethane, is 300w with power once more, and frequency is that the microwave of 2450MHz carries out microwave radiation to it, divide and carry out for 3 times, each 2min filters, and filtrate is through underpressure distillation, drying obtains pale yellow powder shape solid phase prod 0.67g, and the content that records nimbin with high performance liquid chromatography is 9.0%.
Claims (8)
1, a kind of extracting method of nimbin, this method comprises:
With frequency is 2450MHz, and power is that the microwave of 100～850W carries out microwave radiation extraction to neem kernel in solvent, desolventizes through steaming, obtains containing the step of the powder of 2～50% nimbins after the drying.
2, the described extracting method of claim 1, comprise that also the solids of gained after solvent with methyl alcohol, ethanol, acetone, ethyl acetate, methylene dichloride, trichloromethane, water or its mixture is to microwave extraction carries out the step of microwave treatment, wherein said solids with extract solvent for use once more and count 1: 3 by volume～12.
3, the described extracting method of claim 1, wherein used microwave frequency is 2450MHz, and power is 100～850W, and microwave treatment time is 0.1～10min.
4, the described extracting method of claim 1, the amount of wherein said neem kernel and solvent count 1: 3 by weight～and 12.
5, claim 1,2 described extracting method, wherein the temperature of being controlled is no more than 65 ℃.
6, the described extracting method of claim 1～5, wherein said microwave treatment repeats 1～3 time, each 0.1～5min.
7, the described extracting method of claim 1～5, wherein said neem kernel are to grind form in small, broken bits.
8, the described extracting method of claim 2, the described frequency of extracting employing once more is 2450MHz, power is that the microwave of 100～850W carries out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02122306 CN1199980C (en) | 2002-05-31 | 2002-05-31 | Mtehod for microwave extracting nimbin from nim kernel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02122306 CN1199980C (en) | 2002-05-31 | 2002-05-31 | Mtehod for microwave extracting nimbin from nim kernel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1420121A true CN1420121A (en) | 2003-05-28 |
| CN1199980C CN1199980C (en) | 2005-05-04 |
Family
ID=4745031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02122306 Expired - Fee Related CN1199980C (en) | 2002-05-31 | 2002-05-31 | Mtehod for microwave extracting nimbin from nim kernel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1199980C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101818098A (en) * | 2010-04-21 | 2010-09-01 | 广东汇香源生物科技股份有限公司 | Method for preparing cardamon oil resin through microwave assistance |
| CN103238809A (en) * | 2013-05-23 | 2013-08-14 | 天宁香料（江苏）有限公司 | Red onion extractive and application thereof |
| CN104031073A (en) * | 2014-06-19 | 2014-09-10 | 中国林业科学研究院资源昆虫研究所 | Preparation method of azadirachtin dry powder |
-
2002
- 2002-05-31 CN CN 02122306 patent/CN1199980C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101818098A (en) * | 2010-04-21 | 2010-09-01 | 广东汇香源生物科技股份有限公司 | Method for preparing cardamon oil resin through microwave assistance |
| CN103238809A (en) * | 2013-05-23 | 2013-08-14 | 天宁香料（江苏）有限公司 | Red onion extractive and application thereof |
| CN104031073A (en) * | 2014-06-19 | 2014-09-10 | 中国林业科学研究院资源昆虫研究所 | Preparation method of azadirachtin dry powder |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1199980C (en) | 2005-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| de Hoyos-Martínez et al. | Tannins extraction: A key point for their valorization and cleaner production | |
| Sahne et al. | Enzyme-assisted ionic liquid extraction of bioactive compound from turmeric (Curcuma longa L.): Isolation, purification and analysis of curcumin | |
| Inoue et al. | Isolation of hesperidin from peels of thinned Citrus unshiu fruits by microwave-assisted extraction | |
| Ragasa et al. | Acetogenins from Annona muricata | |
| Kobus et al. | Effect of the duty cycle of the ultrasonic processor on the efficiency of extraction of phenolic compounds from Sorbus intermedia | |
| Abosede et al. | Biomass valorization: Agricultural waste in environmental protection, phytomedicine and biofuel production | |
| CN102166230B (en) | Microwave-assisted extraction method of seaweed polyphenol | |
| CN1212320C (en) | Resin process of extracting proanthocyanidin from graup seed | |
| CN108002982B (en) | Menthol extraction method | |
| CN1199980C (en) | Mtehod for microwave extracting nimbin from nim kernel | |
| Köse et al. | Valorization of citrus peel waste | |
| CN101735093A (en) | New method for extracting capsaicine | |
| Gu et al. | Characterization and potential utilization of extracts and pyrolyzates from Jasminum nudiflorum Lindl. Bark | |
| CN105503843A (en) | Preparation method of silymarin | |
| CN112846220A (en) | Method for synthesizing nano-silver based on alfalfa extract | |
| CN1273573C (en) | Method for extracting sun choke essential oil and sun choke brain by enzymolysis-vapor distillation process | |
| Yang et al. | Investigation of cascade valorization of Pistia stratiotes L. by hydrothermal treatment | |
| CN102342304B (en) | Production method for extracting pyrethrin from pyrethrum | |
| Kartika et al. | Evon Ph., Trisunaryanti W., Mukti RR, Hartati, Yuliana ND, Sailah I.(2021): Optimisation of concurrent Calophyllum oil-resin extraction and separation. Res | |
| CN112358526A (en) | Method for preparing citrus seed limonin from citrus seeds | |
| KR100511802B1 (en) | Extraction Method of Resveratrol from Grape | |
| CN112174925A (en) | Method for microwave-assisted extraction of grape seed procyanidine | |
| CN1158928C (en) | Process for supercritical extracting nimbin | |
| CN104069178A (en) | Extracting method for machilus salicina volatile oil | |
| CN111733017A (en) | Preparation process of cinnamomum camphora essential oil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Document name: Deemed as a notice of withdrawal |
|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| DD01 | Delivery of document by public notice |
Addressee: Yunnan Zhongke Biological Industry Co.,Ltd. mahongbing Document name: Notification to Pay the Fees |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050504 Termination date: 20120531 |