CN1413736A - Multi-hole granular type vascular suppasitory - Google Patents
Multi-hole granular type vascular suppasitory Download PDFInfo
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- CN1413736A CN1413736A CN 02135019 CN02135019A CN1413736A CN 1413736 A CN1413736 A CN 1413736A CN 02135019 CN02135019 CN 02135019 CN 02135019 A CN02135019 A CN 02135019A CN 1413736 A CN1413736 A CN 1413736A
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- suppasitory
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Abstract
A porous granular embolic agent for blood vessel features that the pores are diffused in it and it can be suspended in the blood vessel and not flow backward, so avoiding error embolism.
Description
The present invention relates to a kind of intervention vascular suppository material, particularly blood capillary or peripheral vessel embolism materials.
In the prior art, multiple intervention vascular suppository material has been arranged, mainly contain polyvinyl alcohol (Polyvinyl Alcohol, PVA), gelfoam, surgical thread, stainless steel spring circle, platinum microcoils, taking off property sacculus, alpha-cyanoacrylate (cyanoacrylates), dewatered ethanol, iodized oil, sodium morrhuate etc.At clinical use medi-spring steel ring, surgical thread, gelfoam good clinical effectiveness is arranged when bolt blocks up trunk, influence long-term efficacy but prop up circulation foundation because of side.The mistake bolt easily takes place in liquid suppository such as alpha-cyanoacrylate (cyanoacrylates), dewatered ethanol, iodized oil, sodium morrhuate when clinical manipulation, operation easier is big.PVA (polyvinyl alcohol Polyvinyl Alcohol) and gelfoam, surgical thread etc. are invisible under X-ray, are difficult to observe the thromboembolism position during check.
The objective of the invention is to provide a kind of comparatively ideal intervention vascular suppository material, particularly blood capillary or peripheral vessel embolism materials, its proportion is moderate, can suspend in blood, is convenient to the formation of thrombosis, is difficult for backflowing, and can effectively avoid the mistake bolt; And low price.
The object of the present invention is achieved like this:
Multi-hole granular type vascular suppasitory relates to a kind of novel vascular embolism materials, comprises embolism materials (1) and micropore (2), it is characterized in that micropore (2) disperse is distributed in the embolism materials (1), forms porous prilled structure.
---can be mixed with the material (3) of X-ray opaque in the above-mentioned multi-hole granular type vascular suppasitory, be formed on the porous prilled structure that can develop under the X-ray; The material of X-ray opaque (3) adopts titanium or titanium alloy, platinum or tantalum manufacturing usually, also can adopt other can be in the material manufacture of the medium-term and long-term X-ray opaque of implanting of human body.
---the embolism materials (1) of above-mentioned multi-hole granular type vascular suppasitory adopts politef or polyethylene or polyvinyl alcohol (Polyvinyl Alcohol usually, PVA) make, also can adopt other material manufacture that in human body, to implant, as the porous titanium alloy powder particle.
---the micropore (2) of above-mentioned multi-hole granular type vascular suppasitory can adsorb the material (3) of contrast agent (5) or other X-ray opaques that can implant in human body, be formed on the porous prilled structure that can develop under the X-ray.
---the micropore (2) of above-mentioned multi-hole granular type vascular suppasitory can adsorb medicine (6), as anticarcinogen, analgesic etc., obtains containing the multi-hole granular type vascular suppasitory of anticarcinogen or the multi-hole granular type vascular suppasitory of analgesic.
---when the embolism materials (1) of above-mentioned multi-hole granular type vascular suppasitory adopts the porous material manufacturing that can develop under the X-ray that can implant in human body, the macromolecular material (7) that absorption can be implanted in human body in the micropore (2), as the superfine powder of polytetrafluoroethylene end, form compound nutty structure.
---the embolism materials (1) that the X-ray of above-mentioned multi-hole granular type vascular suppasitory can develop down can be coated in the macromolecular material (7) that can implant in human body, as is coated in polyethylene or the politef.
---the proportion of the particulate proportion of above-mentioned multi-hole granular type vascular suppasitory and the blood of human body is approaching, or the proportion of the particulate proportion of multi-hole granular type vascular suppasitory and contrast solution is approaching.
The present invention's multi-hole granular type vascular suppasitory is owing to adopted porous prilled structure, make proportion adjustable, enlarged the range of choice of peripheral vessel embolism materials, even if the material that proportion is big slightly also can be by the micropore of disperse, make it that good suspension be arranged in blood, and use, not only be convenient in blood vessel, deposit as vascular suppository material, be difficult for backflowing, effectively avoided the mistake bolt; And low price.Mix the material of nonferromagnetic and X-ray opaque simultaneously, make this present invention's multi-hole granular type vascular suppasitory under X-ray, to develop, can carry out nuclear magnetic resonance, NMR (MRI) inspection, can easily observe the thromboembolism position under X-ray, be a comparatively ideal intervention vascular suppository material.
Concrete structure of the present invention and operation principle are provided by following examples:
The structural representation of Fig. 1 the present invention's multi-hole granular type vascular suppasitory.
The structural representation of Fig. 2 the present invention's the multi-hole granular type vascular suppasitory that is mixed with the metal dust that can develop under the X-ray.
The structural representation of the multi-hole granular type vascular suppasitory of Fig. 3 the present invention's micro-porous adsorption contrast agent.
The structural representation of the multi-hole granular type vascular suppasitory of Fig. 4 the present invention's micro-porous adsorption medicine.
When Fig. 5 the present invention's embolism materials is the POROUS TITANIUM metallic particles surface adsorption polytetrafluorethylepowder powder or the structural representation when being coated by polyethylene.
The fundamental diagram of Fig. 6 multi-hole granular type vascular suppasitory of the present invention.
Among the above-mentioned figure: 1 is embolism materials, and 2 is micropore, and 3 is metal dust, and 4 are the present invention's multi-hole granular type vascular suppasitory, and 5 is contrast agent, and 6 is medicine, and 7 is macromolecular material, and 8 is conduit, and 9 is blood vessel.
Selecting particle diameter for use is the medical grade politef of 0.1～60 μ M, in mould, cold pressing, form the nutty structure that has a large amount of disperse micropores that can in blood, suspend behind the sintering, particulate diameter is usually between 50 μ M～1200 μ M, according to clinical different requirements, sieve into different specifications,, promptly obtained the present invention's multi-hole granular type vascular suppasitory as specifications such as 250～450 μ M, 350～600 μ M, 450～750 μ M.Fig. 1.
Select politef or polyethylene superfines for use, particle diameter is the medical grade politef of 0.1～60 μ M, mix the superfines of an amount of medical metallic titanium or the powder that nano titanium gold belongs to powder or metal platinum, in mould, cold pressing, form the nutty structure that has a large amount of disperse micropores that can in blood, suspend behind the sintering, particulate diameter is usually between 50 μ M～1200 μ M, according to clinical different requirements, sieve into different specifications, as 80～200 μ M, 250～450 μ M, 350～600 μ M, specifications such as 450～750 μ M have promptly obtained being mixed with the multi-hole granular type vascular suppasitory of the metal dust that can develop under the X-ray.Fig. 2.
Also can adsorb contrast agent (5) in the micropore (2) of the present invention's porous composite material granular blood vessel embolism agent (4), strengthen development effect under the X-ray.Fig. 3.
Also can adsorb medicine (6) in the micropore (2) of the present invention's porous composite material granular blood vessel embolism agent (4), when absorption during anticarcinogen, along with the slow release of medicine can strengthen the treatment of cancer effect; As when adsorbing analgesic, can alleviate the pain that causes because of ischemia behind the thromboembolism.Fig. 4.
When the present invention selects the POROUS TITANIUM metallic particles for use as embolism materials (1) surface adsorption polytetrafluorethylepowder powder or coat to be formed with the POROUS TITANIUM metallic particles by polyethylene be core, polytetrafluorethylepowder powder or be outer field composite structure by polyethylene.Fig. 5.
During clinical use,, select the suitable the present invention's of particle diameter multi-hole granular type vascular suppasitory (4) according to the vessel size that will stop up and diseased region.In intervene operation, the present invention's multi-hole granular type vascular suppasitory (4) is injected the blood vessel (9) that will stop up by microtubular (8).Because the existence of suppository causes thrombosis and finally blocks the target blood vessel, reaches the purpose of vascular embolization treatment disease.Fig. 6.
Claims (8)
1, multi-hole granular type vascular suppasitory relates to a kind of novel vascular embolism materials, comprises embolism materials (1) and micropore (2), it is characterized in that micropore (2) disperse is distributed in the embolism materials (1), forms porous prilled structure.
2, according to the described multi-hole granular type vascular suppasitory of claim 1, it is characterized in that can being mixed with in the multi-hole granular type vascular suppasitory material (3) of X-ray opaque, be formed on the porous prilled structure that can develop under the X-ray; The material of X-ray opaque (3) adopts titanium or titanium alloy, platinum or tantalum manufacturing usually, also can adopt other can be in the material manufacture of the medium-term and long-term X-ray opaque of implanting of human body.
3, according to the described multi-hole granular type vascular suppasitory of claim 1, the embolism materials (1) that it is characterized in that multi-hole granular type vascular suppasitory adopts politef or polyethylene or polyvinyl alcohol (Polyvinyl Alcohol usually, PVA) make, also can adopt other material manufacture that in human body, to implant, as the porous titanium alloy powder particle.
4, according to the described multi-hole granular type vascular suppasitory of claim 1, it is characterized in that the micropore (2) of multi-hole granular type vascular suppasitory can adsorb the material (3) of contrast agent (5) or other X-ray opaques that can implant in human body, be formed on the porous prilled structure that can develop under the X-ray.
5,, it is characterized in that the micropore (2) of multi-hole granular type vascular suppasitory can adsorb medicine (6), as anticarcinogen, analgesic etc. according to the described multi-hole granular type vascular suppasitory of claim 1.
6, according to the described multi-hole granular type vascular suppasitory of claim 1, when the embolism materials (1) that it is characterized in that multi-hole granular type vascular suppasitory adopts the porous material manufacturing that can develop under the X-ray that can implant in human body, the macromolecular material (7) that absorption can be implanted in human body in the micropore (2), as the superfine powder of polytetrafluoroethylene end, form compound nutty structure.
7, according to the described multi-hole granular type vascular suppasitory of claim 1, it is characterized in that the embolism materials (1) that can develop under the X-ray of multi-hole granular type vascular suppasitory can be coated in the macromolecular material (7) that can implant in human body, as be coated in polyethylene or the politef.
8, according to the described multi-hole granular type vascular suppasitory of claim 1, the proportion of blood that it is characterized in that the particulate proportion of multi-hole granular type vascular suppasitory and human body is approaching, or the proportion of the particulate proportion of multi-hole granular type vascular suppasitory and contrast solution is approaching.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 02135019 CN1413736A (en) | 2002-10-25 | 2002-10-25 | Multi-hole granular type vascular suppasitory |
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| CN 02135019 CN1413736A (en) | 2002-10-25 | 2002-10-25 | Multi-hole granular type vascular suppasitory |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114344551A (en) * | 2021-12-31 | 2022-04-15 | 神泓医疗科技(上海)有限公司 | Liquid embolism composition and application thereof, medical intervention apparatus and intervention treatment medicine |
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2002
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114344551A (en) * | 2021-12-31 | 2022-04-15 | 神泓医疗科技(上海)有限公司 | Liquid embolism composition and application thereof, medical intervention apparatus and intervention treatment medicine |
| CN114344551B (en) * | 2021-12-31 | 2023-06-16 | 神泓医疗科技(上海)有限公司 | Liquid embolism composition and application thereof, medical intervention instrument and intervention therapeutic drug |
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