CN1404880A - Porous calcium carbonate-hydroxy-apatite gradient material and its preparation method thereof - Google Patents
Porous calcium carbonate-hydroxy-apatite gradient material and its preparation method thereof Download PDFInfo
- Publication number
- CN1404880A CN1404880A CN 01126427 CN01126427A CN1404880A CN 1404880 A CN1404880 A CN 1404880A CN 01126427 CN01126427 CN 01126427 CN 01126427 A CN01126427 A CN 01126427A CN 1404880 A CN1404880 A CN 1404880A
- Authority
- CN
- China
- Prior art keywords
- calcium carbonate
- hydroxyapatite
- preparation
- gradient material
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of porous calcium carbonate-hydroxyapatite gradient material and its preparation method. Said material is made up by using calcium carbonate and hydroxyapatitis according to different ratio, its surface layer is made of hydroxyapatite and is core its calcium carbonate. It possesses good biological compatibility, bone leading property and controllable biological degradation speed, so that it can meat requirements for grafting bone in different position of human body and animal. Said invention also provides its preparation method.
Description
The invention belongs to the technical field of medical materials. In particular to a porous calcium carbonate-hydroxyapatite gradient material and a preparation method thereof.
The natural coral is highly porous and degradable, the main component of the coral is calcium carbonate, and the biocompatibility and the bone guiding activity are not ideal.
Hydroxyapatite is the main inorganic component of bone tissues, has good biocompatibility and bone guiding activity, and is widely applied clinically as a bone substitute material. However, the synthesized hydroxyapatite is not in a porous structure and is not beneficial to the growth of bone tissues, and the hydroxyapatite has little degradability due to extremely slow degradation speed and remains in the organism for the whole life after being implanted.
Foreign scholars convert natural corals into hydroxyapatite through hydrothermal exchange reaction, and can obtain completely converted hydroxyapatite (the conversion rate is 100%) while keeping the porous structure of the corals. The completely transformed hydroxyapatite is biocompatible, has good bone guiding activity and high porosity, but has no degradability, and remains in the organism for the whole life after being implanted.
Therefore, it has been the object of research to find a highly porous material with controlled biodegradation rate, which is highly biocompatible and osteoconductive, and to which the present invention is directed.
The invention provides a porous calcium carbonate-hydroxyapatite gradient material. The material is composed of calcium carbonate and hydroxyapatite according to different ratios of hydroxyapatite content of 0-100%, and under the condition that the hydroxyapatite content is not 0% or 100%, the surface layer of the material is hydroxyapatite, and the center of the material is calcium carbonate. The novel material has good biocompatibility and bone guiding property, is highly porous, and has different ratios of calcium carbonate to hydroxyapatite, namely different conversion rates (hydroxyapatite content), so that the material has in vivo degradation speeds suitable for different positions and different requirements. For example, for the repair of bone defects, it is desirable that the material be absorbable within 6-12 months after implantation. For implantation for the purpose of facial beauty and shaping, it is required not to degrade to keep the facial form stable. The porous calcium carbonate-hydroxyapatite gradient material is not reported in documents at present.
Besides the new material, the invention also aims to provide a preparationmethod of the porous calcium carbonate-hydroxyapatite gradient material. The invention is based on hydrothermal exchange reaction, and obtains biological materials with different conversion ratios by reaction for 1 day at different temperatures (180-. The basic principle is as follows:
the reaction rate of the hydrothermal exchange is very slow, and the high temperature and high pressure are aimed at increasing the reaction rate. During the reaction time of one day, materials with different conversion ratios can be obtained under different conditions of temperature (180 ℃) and pressure (2-28 MPa). However, the results of the invention can also be obtained by alternative techniques, such as by varying the reaction time under certain conditions of temperature and pressure (180 ℃ C., 2 MPa). Namely:
using the above method, the present invention produces gradient materials with conversion ratios of 5%, 15%, 25%, 50%, 75%, 100%, and confirmed by X-ray energy spectrum analysis.
Animal experiment results show that the material disclosed by the invention has the characteristics of high porosity, good biocompatibility and bone guiding activity and controllable degradation speed, and can meet the bone grafting requirements of different parts by preparing materials with different conversion ratios.
Example 1.
Preparation of porous calcium carbonate-hydroxyapatite gradient Material hydroxyapatite content 5% 15% 25% 50% 75% 100% pressure (Mpa) 2228152428 temperature (. degree. C.) 180195200215245260 example 2.
Three materials with transformation ratios of 5%, 15% and 100% are made into a disk shape with a diameterof 15mm and a thickness of 2mm, and are used for repairing a standard defect of a rabbit skull with a diameter of 15 mm. Three materials were shown to be effective in repairing the defect 3 months after implantation by histological examination. 7 months after implantation, the material with 5 percent conversion rate is completely absorbed, and the bone defect is completely filled by autologous bone tissue, and the material with 15 percent conversion rate is absorbed by about 50 percent; the 100% transformation ratio of the material was not absorbed and the bone defect was filled with bone tissue and material.
Claims (3)
1. A porous calcium carbonate-hydroxyapatite gradient material. The material is characterized in that the material is composed of calcium carbonate and hydroxyapatite with the hydroxyapatite content of 0-100%, and the surface layer of the material is the hydroxyapatite, and the center is the calcium carbonate.
2. The method for preparing a porous calcium carbonate-hydroxyapatite gradient material as claimed in claim 1, characterized in that the method comprises reacting calcium carbonate with hydroxyapatite at a temperature of 180-.
3. The method for preparing a gradient material of calcium porous carbonate-hydroxyapatite according to claim 2, wherein the gradient material with a hydroxyapatite content of 0-100% can be prepared by the method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01126427 CN1404880A (en) | 2001-08-09 | 2001-08-09 | Porous calcium carbonate-hydroxy-apatite gradient material and its preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01126427 CN1404880A (en) | 2001-08-09 | 2001-08-09 | Porous calcium carbonate-hydroxy-apatite gradient material and its preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1404880A true CN1404880A (en) | 2003-03-26 |
Family
ID=4666444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01126427 Pending CN1404880A (en) | 2001-08-09 | 2001-08-09 | Porous calcium carbonate-hydroxy-apatite gradient material and its preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1404880A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100371029C (en) * | 2003-06-24 | 2008-02-27 | 国立大学法人九州大学 | Medical bone prosthetic material and process for producing the same. |
| CN100421736C (en) * | 2006-11-01 | 2008-10-01 | 华中科技大学 | A gradient laminated composite supporting frame material based on bionic structures and its preparation method |
| CN101987208A (en) * | 2009-08-03 | 2011-03-23 | 宁波大学 | Multi-phase large-aperture bone regeneration bracket material transformed from cuttlebone and preparation method thereof |
| CN101444640B (en) * | 2008-07-29 | 2012-07-11 | 四川大学 | Doped bone repairing material and preparation method thereof |
| CN106007699A (en) * | 2016-05-23 | 2016-10-12 | 广州医科大学 | Beta-tricalcium phosphate (TCP)/calcium carbonate (CC) double-phase ceramic material and preparation method thereof |
| CN107021465A (en) * | 2017-04-19 | 2017-08-08 | 东南大学 | A kind of preparation method of the calcium salt admixture as biomaterial |
| CN110025406A (en) * | 2019-04-17 | 2019-07-19 | 上海黑焰医疗科技有限公司 | A kind of preparation method of 3D printing bone defect filler |
-
2001
- 2001-08-09 CN CN 01126427 patent/CN1404880A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100371029C (en) * | 2003-06-24 | 2008-02-27 | 国立大学法人九州大学 | Medical bone prosthetic material and process for producing the same. |
| CN100421736C (en) * | 2006-11-01 | 2008-10-01 | 华中科技大学 | A gradient laminated composite supporting frame material based on bionic structures and its preparation method |
| CN101444640B (en) * | 2008-07-29 | 2012-07-11 | 四川大学 | Doped bone repairing material and preparation method thereof |
| CN101987208A (en) * | 2009-08-03 | 2011-03-23 | 宁波大学 | Multi-phase large-aperture bone regeneration bracket material transformed from cuttlebone and preparation method thereof |
| CN106007699A (en) * | 2016-05-23 | 2016-10-12 | 广州医科大学 | Beta-tricalcium phosphate (TCP)/calcium carbonate (CC) double-phase ceramic material and preparation method thereof |
| CN106007699B (en) * | 2016-05-23 | 2019-01-11 | 广州医科大学 | Bata-tricalcium phosphate/calcium carbonate biphase ceramics material and preparation method thereof |
| CN107021465A (en) * | 2017-04-19 | 2017-08-08 | 东南大学 | A kind of preparation method of the calcium salt admixture as biomaterial |
| CN107021465B (en) * | 2017-04-19 | 2019-05-31 | 东南大学 | A kind of preparation method of the calcium salt admixture as biomaterial |
| CN110025406A (en) * | 2019-04-17 | 2019-07-19 | 上海黑焰医疗科技有限公司 | A kind of preparation method of 3D printing bone defect filler |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6139578A (en) | Preparation of cell seeded ceramic compositions | |
| CN108653809B (en) | Composite hydrogel based on black phosphorus and gelatin and application of composite hydrogel in bone tissue engineering | |
| CN101564553B (en) | Humanization active forging bone and preparation method thereof | |
| CN100536936C (en) | New-type of inorganic bone grafting material and its preparation and use | |
| CN109954167B (en) | Bone repair material and application thereof | |
| WO2015113482A1 (en) | Mineralized collagen composite bone cementing and filling material | |
| CN1644221A (en) | Composite material for porous material and gel use thereof | |
| Okazakl et al. | Insolubilized properties of UV-irradiated C03 apatite-collagen composites | |
| EP0868409B1 (en) | Bone graft substitute and its preparation | |
| CN101274108B (en) | Compound porous bracket and method of producing the same | |
| WO2007011172A1 (en) | Preparation method of porous beta tricalcium phosphate granules | |
| CN114504677B (en) | 3D printing skull repairing titanium mesh and preparation method thereof | |
| CN107032775B (en) | Nano-hydroxyapatite and dicalcium silicate composite bioceramic and preparation method and application thereof | |
| CN1404880A (en) | Porous calcium carbonate-hydroxy-apatite gradient material and its preparation method thereof | |
| CN101176798B (en) | Complex stephanoporate bracket of calcium sulphate and freeze drying bone as well as preparation method thereof | |
| CN111773432A (en) | Magnesium-based amorphous-calcium phosphate/calcium silicate composite filler and preparation and application thereof | |
| CN114601971B (en) | Natural composite bone filling material for inducing bone regeneration and preparation method and application thereof | |
| CN104436318A (en) | Method for preparing absorbable and antibacterial guided tissue regeneration membrane for bone-like structure | |
| CN110960726A (en) | Preparation method and application of borosilicate bioglass-based bone cement containing whitlockite | |
| CN114452441A (en) | Skull repairing polyether-ether-ketone material and preparation method thereof | |
| CN107670100A (en) | The medical synthesis bone grafting material of the biphasic calcium phosphate type dentistry of abalone shells synthesizing hydroxylapatite and β tricalcium phosphates and preparation method | |
| CN113117149B (en) | Bone-like hydroxyapatite-collagen composite scaffold and preparation method thereof | |
| CN115624654A (en) | Application of berberine hydrochloride in barrier repair integrated alveolar bone defect bone augmentation technology and composite material thereof | |
| CN108653821B (en) | Citric acid-bioactive glass organic-inorganic hybrid material and preparation method and application thereof | |
| CN2737357Y (en) | Porous high polymer composite implant for surgery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |