CN1403059A - Extracorporeal ultrasonic capsule-locating system for non-injurious whole digestive tract detection - Google Patents

Abstract

In the extracorporeal ultrasonic capsule-locating system, the monochip computer control circuit controls via multiway switch and electromagnetic relay the 12 ultrasonic probes, which are distributed in the key points of body surface in the positions corresponding to the whole digestive tract and are connected to the amplifier circuit and the monochip computer control circuit via shaping and filtering circuit, comparator circuit and delay. The ultrasonic generator circuit produces exciting pulse to drive the probes to emit ultrasonic wave, the capsule produces echo signal and the echo signal is processed for timing and strobe of the probes. The present invention locates the capsule based on the echo signal accurately and has clinical application value.

Description

The all-digestive tract minisize non-invasive is got involved detecting capsule external supersonic navigation system

Technical field:

The present invention relates to a kind of all-digestive tract minisize non-invasive and get involved detecting capsule external supersonic navigation system, belong to Micro Electro Mechanical System or biomedical engineering technology field.

Background technology:

Along with people's rhythm of life is accelerated constantly to change with dietary structure, the sickness rate of digestive tract function disease is elevated to first day by day.Modern science thinks that there is substantial connection in the pressure variation in digestive tract disease and the people's intestinal, since both at home and abroad medical circle for the unknown of healthy people's intestinal internal pressure correct value and to enteric cavity under the physiological status intrinsic pressure various variations do not understand, therefore lack fixedly objective indicator to the digestive tract disease diagnosis.Thereby at no pain, do not have wound, need not to reflect under bowel relieving and the fasted conditions human body alimentary canal normal physiological, monitoring human all-digestive tract internal pressure, temperature, pH value and variation thereof in promptly 24 hours and food by the research of process, have become one of emphasis of international biomedical engineering field concern in digestive tract.System gets involved detecting capsule, portable external reception and storage device, vitro data treating stations, external supersonic navigation system by minisize non-invasive and forms.In system's diagnosis and treatment process, determining the correspondence of position, realization monitoring numerical value and the digestive tract position of " minisize non-invasive intervention detecting capsule " each time period in digestive tract, is an essential condition of later data analysis, correct diagnosis.The location of foreign body in vivo is generally adopted X line diascopy, B-mode ultrasonography method, radiosiotope photograph location, magnetic track and localization etc. at present clinically, above method all requires the subjects to carry out having in the hospital of certain condition, thereby bring a lot of inconvenience for subjects's daily life, work, limited its freedom of movement.The Smart Pill gastrointestinal tract that Smart Pill company produces detects capsule, utilization is through patient's pick off underwear on one's body and positions, and the reception antenna, electromagnetism excitation antenna, resonance magnetic test coil and the Radio Frequency Subsystem that are used for following the tracks of the capsule position are arranged in the pick off underwear.According to the signal that the pick off underwear receives, adopt neural network method to calculate capsule coordinate position in vivo and sensing angle.Because the particularity of positioning principle and human body alimentary canal, problems such as localized reliability, accuracy still exist, and this method also exists needs to obtain the problem of aspects such as great deal of experiment data, system structure complexity in advance.

Summary of the invention:

The objective of the invention is at the deficiencies in the prior art, provide a kind of all-digestive tract minisize non-invasive to get involved detecting capsule external supersonic navigation system, not only accurate positioning, reliable operation, and to not infringement of human body, easy to use.

For realizing such purpose, in the technical scheme of the present invention, change positive location into Passive Positioning, several miniature ultrasonic probe of design are separately positioned on the body surface position corresponding with each key point of human body all-digestive tract in the ultrasound positioning system.Because ultrasound wave has the characteristic of reflection, transmission, decay, absorption when propagating in medium, when ultrasound wave by having big acoustic impedance difference tissue and during the interface of " minisize non-invasive intervention detecting capsule ", will produce stronger ultrasonic reflections, can determine by the detection of reflected ripple whether " minisize non-invasive intervention detecting capsule " passes through this key point constantly by this key point and what, thereby realized detecting the correspondence of data and digestive tract position, provide essential condition for the follow-up data analysis reaches correct diagnosis.

So-called key point is exactly the adhesion owing to intracavity physiological tissue, the point that digestive tract changes with physiological process hardly in the position of this point.

The present invention comprises that mainly power module, miniature ultrasonic probe, ultrasonic output circuit, ultrasonic signal receive amplifying circuit, comparison and non-heavy trigger delayer, single chip machine controlling circuit.During system works: select several key points on all-digestive tract, corresponding body surface place arranges a miniature ultrasonic probe respectively, and is wired on the device body.Ultrasonic probe is controlled jointly by single-chip microcomputer, multicircuit switch, electromagnetic relay, the order gating work of passing through by capsule successively.But synchronization has only a probe job, in case last probe stops, next probe promptly begins to start.It is the driving pulse of the 2.5MHz of 1000Hz that ultrasonic output circuit produces repetition rate, probe emission ultrasound wave through power amplification rear drive gating, in case capsule is through this pairing key point of popping one's head in, just receive by receiving circuit from its surperficial return echo signal, compare with comparator behind voltage follower, amplifier, detection filter loop, the trigger impulse of generation is sent to single chip machine controlling circuit.Control circuit is then realized the functions such as order gating of timing, probe.

The present invention compares with additive method, transfers its time by the digestive tract fixed position of determining to from calculating each time point capsule particular location coordinate in vivo, transfers the thinking of Passive Positioning to by positive location, is a kind of brand-new localization method.The present invention utilizes hyperacoustic propagation characteristic as detecting medium, be better than physical mediums such as ray or magnetic field, system structure is simplified greatly, accurate positioning, reliability height, avoid the necessary complicated calculations of additive method, experiment and possible erroneous judgement in a large number, provide convenience for the patient simultaneously.Ultrasonic locating is a kind of therefore the complete undamaged method of human body, to be had more clinical value in addition, is easy to be accepted by patient, doctor.

Description of drawings:

Fig. 1 ultrasound positioning system structure of the present invention connected mode sketch map.

The sketch map of key point on the defined all-digestive tract of Fig. 2 the present invention.

As shown in Figure 2, among the navigation system embodiment of the present invention, define 12 key points that miniature detecting capsule 13 successively passes through and be respectively: cardia 1, pylorus 2, umbilicus 3, ileocecus 4, ascending colon mid point 5, hepatic flexure of colon 6, horizontal joint intestinal mid point 7, splenic flexure 8, descending colon mid point 9, second descending colon interconnecting part 10, straight second colon interconnecting part 11, rectum 12.

Fig. 3 is a fundamental diagram of the present invention.

The specific embodiment:

Below in conjunction with drawings and Examples technical scheme of the present invention is further described.

As Fig. 1, shown in Figure 3, navigation system of the present invention mainly receives amplifying circuit, plastic filter circuit, comparison and non-heavy trigger delayer and single chip machine controlling circuit etc. by miniature ultrasonic probe, ultrasonic output circuit, ultrasonic signal and forms.Ultrasonic probe is arranged in and the corresponding body surface of each key point of human body all-digestive tract, is connected to the body apparatus of navigation system through variable connector, and resonant frequency is that 2.5MHz, volume are Φ 6 * 6mm ³

Ultrasonic output circuit comprises phaselocked loop 4046 and power amplification, producing repetition rate by Single-chip Controlling phaselocked loop 4046 is the 2.5MHz pumping signal of 1000Hz, can drive ultrasonic probe emission ultrasound wave through the field effect transistor power amplification again, ultrasound wave receives amplifying circuit and is made up of forward voltage follower, two-stage calculation amplifier, detection, filtering link.Relatively the effect with non-time-delay trigger is to produce single trigger impulse.Single-chip microcomputer is selected the 87C51 cake core for use.System's connected mode is: single chip machine controlling circuit links to each other with multicircuit switch, multicircuit switch connects No. 12 electromagnetic relays, No. 12 electromagnetic relays are controlled 12 ultrasonic probes respectively, ultrasonic probe is connected with ultrasonic output circuit through relay, ultrasonic probe is connected to the reception amplifying circuit, and through plastic filter circuit with relatively be connected with non-heavy trigger delayer, non-heavy trigger delayer connects single chip machine controlling circuit.Single-chip microcomputer, ultrasonic output circuit, reception amplifying circuit, comparison and non-heavy trigger delayer are all by the power module power supply, with the normal operation of safeguards system.

It is as follows that the all-digestive tract minisize non-invasive is got involved the concrete work process of detecting capsule external supersonic navigation system: (1) determines 12 key point positions of digestive tract of patient by the doctor, and fixed resonant frequency is 2.5MHz, volume Φ 6 * 6mm respectively at corresponding body surface place ³Miniature ultrasonic probe.12 key points of the invention process are respectively as shown in Figure 2: cardia 1, pylorus 2, umbilicus 3, ileocecus 4, ascending colon mid point 5, hepatic flexure of colon 6, horizontal joint intestinal mid point 7, splenic flexure 8, descending colon mid point 9, second descending colon interconnecting part 10, straight second colon interconnecting part 11, rectum 12.(2) minisize non-invasive intervention detecting capsule enters from the oral cavity, presses system reset switch, and gating signal and enabling counting device that single-chip microcomputer sends first probe pick up counting; (3) driving pulse that produces of radiating circuit is added to first probe it is started working, the emission ultrasound wave; When (4) capsule is by first position, received echo-signal, behind amplification, shaping filter, send comparison and non-heavy trigger delayer by the probe of gating; (5) relatively export single trigger impulse and cause singlechip interruption, thereby record leads to the out of date moment, reads timer value, send memorizer to preserve with non-heavy trigger delayer; (6) stop first probe, second probe of gating works on.

Claims (3)

1, a kind of all-digestive tract minisize non-invasive is got involved detecting capsule external supersonic navigation system, it is characterized in that mainly by miniature ultrasonic probe, ultrasonic output circuit, ultrasonic signal receives amplifying circuit, plastic filter circuit, relatively with compositions such as non-heavy trigger delayer and single chip machine controlling circuits, single chip machine controlling circuit links to each other with multicircuit switch, multicircuit switch is controlled corresponding ultrasonic probe respectively by electromagnetic relay, ultrasonic probe is connected with ultrasonic output circuit through relay, ultrasonic probe is connected to the reception amplifying circuit, and through plastic filter circuit with relatively be connected with non-heavy trigger delayer, non-heavy trigger delayer connects single chip machine controlling circuit.

2, get involved detecting capsule external supersonic navigation system as the said all-digestive tract minisize non-invasive of claim 1, it is characterized in that arranging 12 ultrasonic probes at the body surface place corresponding with human body all-digestive tract key point, resonant frequency is that 2.5MHz, volume are Φ 6 * 6mm ³

3, get involved detecting capsule external supersonic navigation system as the said all-digestive tract minisize non-invasive of claim 1, it is characterized in that ultrasonic output circuit comprises phaselocked loop 4046 and power amplification, ultrasound wave receives amplifying circuit to be made up of forward voltage follower, two-stage calculation amplifier, detection, filtering link, and single-chip microcomputer is selected the 87C51 cake core for use.

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