CN1394591A - Menthanol and menthanol lactic acid ester composite and its preparation method and application - Google Patents
Menthanol and menthanol lactic acid ester composite and its preparation method and application Download PDFInfo
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- CN1394591A CN1394591A CN 02138077 CN02138077A CN1394591A CN 1394591 A CN1394591 A CN 1394591A CN 02138077 CN02138077 CN 02138077 CN 02138077 A CN02138077 A CN 02138077A CN 1394591 A CN1394591 A CN 1394591A
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- Prior art keywords
- menthol
- lactic acid
- acid ester
- menthanol lactic
- menthanol
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- -1 menthanol lactic acid ester Chemical class 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims description 5
- 239000002131 composite material Substances 0.000 title abstract 3
- UODXCYZDMHPIJE-UHFFFAOYSA-N menthanol Chemical compound CC1CCC(C(C)(C)O)CC1 UODXCYZDMHPIJE-UHFFFAOYSA-N 0.000 title 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 77
- 229940041616 menthol Drugs 0.000 claims abstract description 77
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract 18
- 239000000203 mixture Substances 0.000 claims description 50
- 230000002159 abnormal effect Effects 0.000 claims description 15
- 238000007710 freezing Methods 0.000 claims description 15
- 230000008014 freezing Effects 0.000 claims description 15
- 230000035943 smell Effects 0.000 claims description 15
- 235000013599 spices Nutrition 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 7
- 230000003287 optical effect Effects 0.000 claims description 6
- 238000005352 clarification Methods 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 abstract description 11
- 235000013361 beverage Nutrition 0.000 abstract description 3
- 239000002304 perfume Substances 0.000 abstract description 3
- 239000002453 shampoo Substances 0.000 abstract description 3
- 235000019505 tobacco product Nutrition 0.000 abstract description 3
- 239000000606 toothpaste Substances 0.000 abstract description 3
- 229940034610 toothpaste Drugs 0.000 abstract description 3
- 229940112822 chewing gum Drugs 0.000 abstract description 2
- 235000015218 chewing gum Nutrition 0.000 abstract description 2
- 239000006210 lotion Substances 0.000 abstract description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 239000002781 deodorant agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 61
- 239000003921 oil Substances 0.000 description 7
- 239000003507 refrigerant Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- UJNOLBSYLSYIBM-SGUBAKSOSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] 2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C(C)O UJNOLBSYLSYIBM-SGUBAKSOSA-N 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 235000019615 sensations Nutrition 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229940116871 l-lactate Drugs 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 125000001755 (-)-menthol group Chemical group 0.000 description 1
- JKXYOQDLERSFPT-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO JKXYOQDLERSFPT-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical class C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000003924 oil dispersant Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 239000008257 shaving cream Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a composite of menthol and menthol lactate, their weight ratio is 2:8-8:2 and the solidifying point of said composite is lower than 25 deg.C. Under the condition of room temp. is a liquid form, can be used as freshener, smell regualting agent and perfume in the various products of toothpaste, gargle, perfume, lotion, shave cream, shampoo, deodorant, beverage, chewing gum, tobacco product and medicine product, etc.
Description
Technical field
The present invention relates to the application of a kind of menthol and ester thereof as freshener, abnormal smells from the patient regulator, spice, the compositions of menthol and menthanol lactic acid ester specifically, this compositions freezing point is lower than room temperature, and is liquid form.
Background technology
Menthol is well-known physiological cooling agents, be applied to analgesia is arranged in skin and the oral cavity, salubrious and regulate the effect of abnormal smells from the patient.As the Herba Menthae main body of oil, menthol has been widely applied in food, beverage, toothpaste, collutory, cosmetics, detergent, confection, tobacco product and the medicinal product.But menthol exists intensive mint flavored and coarse sensation has limited its use.
Therefore, it has long lasting cooling effect to need a kind of freshener, and does not have the coarse and offending abnormal smells from the patient of similar menthol.
For improving these shortcomings of menthol, people have prepared the ester of a variety of menthols, but most ester has bad abnormal smells from the patient, and can not be employed.Menthanol lactic acid ester is successful one, and it is German Haarman ﹠amp; The freshener that Reimer GmBH company releases, commodity are called Frescolat ML.Manufacturer's data shows that Frescolat ML is an effective active component and being used in cosmetics and the food, and it is the oil-soluble product, and is very stable in the scope of pH value 4-8, adds in the prescription and needs to maintain the temperature at 40-45 ℃.For this reason, Frescolat ML must perhaps be dissolved in it perfumery oil, cosmetic oil, alcohols solvent as 1, in 2-propylene glycol, the dipropylene glycol 50-60 ℃ of fusing.When menthanol lactic acid ester is used for shampoo, gel, foam bath, it is not suitable for being dissolved in these materials.
Menthanol lactic acid ester, its general structure is as follows:
Compare with menthol, it is of a specified duration that menthanol lactic acid ester has little, the refrigerant persistent period of stimulation, and therefore not volatile advantage obtains the market approval.But, there be refrigerant effect of the moment shortcoming low than menthol in it, and the field of its application still is restricted, particularly for oral cavity, skin articles for use, user uses the back to wish that very strong refrigerant impression is just arranged immediately, and menthanol lactic acid ester can not be accomplished this point.
The report that menthol and menthanol lactic acid ester is added, is used in jointly some product is respectively also arranged in some technical literatures.Be to mention a kind of cosmetics that contain menthol and menthanol lactic acid ester in the patent of WO00/42983 as the patent No., its zest and abnormal smells from the patient are all very little.Contain the menthol of 0.01-2% and the menthanol lactic acid ester of 0.1-10% in the patent report prescription, the application percentage of menthol and menthanol lactic acid ester is 1: 1-1: 10 scopes, the abnormal smells from the patient and the zest of menthol is very little in the prescription like this, and the effect of menthol is retained again simultaneously.Also having the patent No. is also to mention menthol and menthanol lactic acid ester in the patent of JP06329528 and JP10231238 to separate the application example that makes an addition to product with the ratio of 1: 1 and 2: 1.In patent JP06329528 embodiment, the concentration of menthol and menthanol lactic acid ester from 0.1%: 0.1% (1: 1) to 0.2%: 0.2% (1: 1), the working concentration of menthol is 0.001%-10% (w/w) in its claim, and the working concentration of menthanol lactic acid ester is 0.001%-10% (w/w).In patent JP10231238, menthol and menthanol lactic acid ester are applied in the same prescription with 0.2% and 0.1% concentration respectively.
More than invention is mentioned is that interpolation respectively with menthol and menthanol lactic acid ester is used in same prescription, and uses concentration less than 15%, does not also mention mixture.The shortcoming of doing like this is: menthol and menthanol lactic acid ester must be heated to 50-60 ℃ of fusing earlier, or it is dissolved in perfumery oil, cosmetic oil, alcohols solvent, could add in the prescription easily.Above-mentioned Haarman ﹠amp; The menthanol lactic acid ester of Reimer GmBH company has two kinds of forms, crystallization and non-crystalline types.Non-crystalline type product, freezing point are solid-state at 40 ℃, do not have other additives; Crystal type product freezing point is at 42 ℃, and white powder contains 0.1% sodium bicarbonate simultaneously.The shortcoming of non-crystalline type product is that inconvenience is handled, because product will be poured out from pail pack, must be heated to the product fusing together with pail pack.And the crystal type product though good the processing wherein has other additive, and may cause consistency problem with formula material.
It is inconvenient that above-mentioned menthol and menthanol lactic acid ester add under solid-state situation, is very disadvantageous for industrialized great production particularly, need provide Special Equipment and heating equipment to come heat fused menthol and menthanol lactic acid ester on the one hand; Can only use cold treatment process for some product, also be inappropriate, and this technology is a kind of development trend, and it can be saved the energy, enhance productivity.On the other hand, menthol volatile, very strong pungent taste of when heating has negative effect to operator ' s health.
Summary of the invention
The purpose of this invention is to provide under a kind of room temperature liquid state, can directly use, lowly stimulate, low flavor, low volatilization the compositions that combines by menthol and menthanol lactic acid ester, and do not contain solvent and solubilising composition.
Another object of the present invention provides a kind of this menthol and menthanol lactic acid ester preparation of compositions method.
The present invention also aims to provide a kind of said composition is made moment refrigerant sensation and all well application of the application of freshener and abnormal smells from the patient regulator, spice of refrigerant persistency.
Purpose of the present invention can reach by following measure:
Menthol is to extract or synthetic chemical compound from Oleum menthae.Exist three chiral carbon atoies in the menthol molecular structure, 12 kinds of optical isomers are arranged in theory, but widely used have only the L-menthol, its fusing point is 42-43 ℃, menthanol lactic acid ester is by menthol and lactic acid esterification and obtain, have 4 chiral carbon atoies in its molecular structure, have 16 kinds of optical isomers in theory, what application was arranged at present is L-menthol and L or D-lactic acid derivative.The market extensive use then be L-menthol-L-lactate, its fusing point is 43-45 ℃.
The menthol component of mentioning in the compositions provided by the invention has comprised all optical isomers of menthol, and the menthanol lactic acid ester component of mentioning has comprised all optical isomers of menthanol lactic acid ester.And for convenience, below will be with widely used L-menthol and L-menthol-L-lactate as description object.
The inventor considers, menthol is a kind ofly knownly can form the chemical compound that melts system altogether, and the fusing point that forms the mixture that melts altogether will be lower than single component, but the fusing point of the fused matter of having reported is generally in room temperature or be higher than room temperature.Menthol and menthanol lactic acid ester form mixture and yet there are no report.The present invention has disclosed menthol and menthanol lactic acid ester for the first time and has formed and melt system altogether, and the fusing point of its fused matter can subambient phenomenon.For reaching menthol and menthanol lactic acid ester fused matter freezing point is reduced to below the room temperature, in addition lower, and it is important controlling both suitable ratios.
Menthol provided by the invention and menthanol lactic acid ester compositions are characterized in: the weight ratio of menthol and menthanol lactic acid ester is in 2: 8～8: 2 scope, and its freezing point is lower than 25 ℃ of room temperatures;
Menthol provided by the invention and menthanol lactic acid ester compositions, more suitably ratio be the weight ratio of menthol and menthanol lactic acid ester in 3.5: 6.5～6.5: 3.5 scopes, its freezing point is lower than 15 ℃;
Menthol provided by the invention and menthanol lactic acid ester compositions, best component is: the part by weight of menthol and menthanol lactic acid ester is 1: 1, its freezing point is not higher than 8.5 ℃.
According to the present invention, menthol and menthanol lactic acid ester compositions at room temperature are in a liquid state.
The concrete operations technology that realizes the object of the invention is as follows:
Menthol and menthanol lactic acid ester compositions can make by following steps as freshener, abnormal smells from the patient regulator, spice:
A. menthol and menthanol lactic acid ester part by weight are set in 1: 4-4: 1, and both add in the container,
B. stirring at low speed under the room temperature,
C. mixture stops to stir to transparent clarification,
D. the said mixture suitable containers of packing into can be used as freshener, abnormal smells from the patient regulator, spice,
E. repeat the a-c step as required.
Menthol provided by the present invention and menthanol lactic acid ester compositions, its advantage is: said composition at room temperature promptly is in a liquid state, and makes freshener with it and uses very conveniently in product, does not need heat fused, both save the cost that equipment drops into, saved the energy again.And simplified production technology, saved the operating time, can be used at room temperature, cold technology manufacture process, thereby make produce convenient and economical.
Menthol provided by the invention and menthanol lactic acid ester compositions are done the application of freshener, abnormal smells from the patient regulator, spice, also can be made of said composition and other adjuvant.Adjuvant can be liquids such as the water dispersant of menthol and menthanol lactic acid ester, pure system, oils and fats, silicone oil, esters or quintessence oil; These liquids can not satisfy the requirement of product to activity concentration to the dissolubility deficiency of menthol and menthanol lactic acid ester, but can be used as the liquid dispersion carrier of compositions.The dispersion form of this compositions can provide freshener, abnormal smells from the patient regulator, the spice of the high concentration of other form for practical application, has expanded the range of application of compositions greatly.In prescription, because the fused matter of menthol and menthanol lactic acid ester exists, can be prescription provides than the higher concentration of other possibility modes as freshener, abnormal smells from the patient regulator, fragrance applications for menthol provided by the invention and menthanol lactic acid ester compositions.
The concrete operations that the compositions of above-mentioned dispersion form realizes are as follows: the compositions of menthol and menthanol lactic acid ester is added suitable surfactant, mix with above-mentioned materials of mentioning such as water, oil, fat, carry out homogenizing.Can obtain the said composition dispersion.
Compositions provided by the invention and dispersion thereof can be used in the multiple product that influences mucosa and skin, as toothpaste, collut, perfume, lotion, shaving cream, back preparation, shampoo, antiperspirant, deodorizer, beverage, chewing gum, tobacco product and medicinal product etc. shave.
Compositions provided by the invention is as freshener, has moment refrigerant sensation and refrigerant persistency good advantage all.
Description of drawings
Fig. 1 is in the present invention's the compositions, the graph of a relation of menthol content and said composition freezing point.
The specific embodiment
Embodiment 1:
Be under 23 ℃ the condition, 50g solid menthol and 50g solid menthanol lactic acid ester to be dropped in the beaker in indoor temperature, with agitator stirring at low speed 20 minutes, compositions became complete clarifying liquid.Freezing point to said composition detects, and measuring its freezing point is 8.2 ℃.
Embodiment 2:
Be under 23 ℃ the condition, 25g solid menthol and 75g solid menthanol lactic acid ester to be dropped in the flask in indoor temperature, use the agitator stirring at low speed, after 20 minutes, compositions becomes complete clarifying liquid.The freezing point of measuring said composition is 20.5 ℃.
Embodiment 3:
Be under 23 ℃ the condition, 75g solid menthol and 25g solid menthanol lactic acid ester to be dropped in the flask in indoor temperature, use the agitator stirring at low speed, after 20 minutes, compositions becomes complete clarifying liquid.The freezing point of measuring said composition is 21.1 ℃.
Embodiment 4:
With the compositions 10g among the embodiment 1, add 3g polysorbate60 and 87g water, homogenizing at room temperature, the homogenizer rotating speed is 5000rpm, makes 10% stable menthol of milky and menthanol lactic acid ester water dispersant.
Embodiment 5:
With the compositions 10g among the embodiment 1, add 3.6g Phospholipid SV (hard ester acyl ammonium propyl group propylene glycol list phospholipid base alkyl dimethyl ammonium chloride), 3.6g Brij72 (polyoxyethylene-2-monostearate), and add entry to total amount 100g, at room temperature use common homogenizer homogenizing, at high pressure high-shear emulsion machine homogenizing, make milky stable 10% nanometer menthol and menthanol lactic acid ester water dispersant again.
Embodiment 6:
With the compositions 20g among the embodiment 1, add 5g department classes 80 and 75g diformazan silicone, homogenizing at room temperature, the homogenizer rotating speed is 5000rpm, makes the 20% stable menthol of milky and the oil dispersant of menthanol lactic acid ester.
Claims (10)
1, menthol and menthanol lactic acid ester compositions is characterized in that: the weight ratio of menthol and menthanol lactic acid ester is in 2: 8～8: 2 scope, and its freezing point is lower than 25 ℃ of room temperatures.
2, menthol according to claim 1 and menthanol lactic acid ester compositions, more suitably ratio be the weight ratio of menthol and menthanol lactic acid ester in 3.5: 6.5～6.5: 3.5 scopes, its freezing point is lower than 15 ℃.
3, menthol according to claim 1 and menthanol lactic acid ester compositions, best component is: the part by weight of menthol and menthanol lactic acid ester is 1: 1, its freezing point is not higher than 8.5 ℃.
4, menthol according to claim 1 and menthanol lactic acid ester compositions, the menthol component comprises all optical isomers of menthol, the menthanol lactic acid ester component comprises all optical isomers of menthanol lactic acid ester.
5, make freshener according to claim 3 and 4 described compositionss, be applied in the prescription, the fused matter of menthol and menthanol lactic acid ester exists, and can be prescription provides than the higher concentration of other possibility modes.
6, make the abnormal smells from the patient regulator according to claim 3 and 4 described compositionss, be applied in the prescription, the fused matter of menthol and menthanol lactic acid ester exists, and can be prescription provides than the higher concentration of other possibility modes.
7, make spice according to claim 3 and 4 described compositionss, the fused matter of menthol and menthanol lactic acid ester exists, and can be prescription provides than the higher concentration of other possibility modes.
8, menthol and menthanol lactic acid ester compositions can make by following steps as freshener, abnormal smells from the patient regulator, spice:
A. menthol and menthanol lactic acid ester part by weight are set in 1: 4-4: 1, and both add in the container;
B. stirring at low speed under the room temperature;
C. mixture stops to stir to transparent clarification;
D. the said mixture suitable containers of packing into can be used as freshener, abnormal smells from the patient regulator, spice;
E. repeat the a-c step as required.
9, preparation method according to claim 8, menthol and menthanol lactic acid ester weight ratio preferably are 3.5: 6.5-6.5: 3.5.
10, preparation method according to claim 8, the best weight ratio of menthol and menthanol lactic acid ester is 1: 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021380775A CN1158987C (en) | 2002-08-07 | 2002-08-07 | Menthanol and menthanol lactic acid ester composite and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021380775A CN1158987C (en) | 2002-08-07 | 2002-08-07 | Menthanol and menthanol lactic acid ester composite and its preparation method and application |
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| Publication Number | Publication Date |
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| CN1394591A true CN1394591A (en) | 2003-02-05 |
| CN1158987C CN1158987C (en) | 2004-07-28 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491092A (en) * | 2014-12-12 | 2015-04-08 | 湖南天龙制药有限公司 | Composition for refreshing brain and regaining consciousness and preparation method thereof |
| CN108360256A (en) * | 2017-09-29 | 2018-08-03 | 上海大学 | A kind of interim curable type material of liquid and its preparation method and application |
| CN112245317A (en) * | 2020-09-07 | 2021-01-22 | 广州雨晓生物制品有限公司 | Mouthwash |
-
2002
- 2002-08-07 CN CNB021380775A patent/CN1158987C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491092A (en) * | 2014-12-12 | 2015-04-08 | 湖南天龙制药有限公司 | Composition for refreshing brain and regaining consciousness and preparation method thereof |
| CN108360256A (en) * | 2017-09-29 | 2018-08-03 | 上海大学 | A kind of interim curable type material of liquid and its preparation method and application |
| WO2019062216A1 (en) * | 2017-09-29 | 2019-04-04 | 上海大学 | Liquid-state temporary reinforcing material, preparation method therefor and application thereof |
| US11873605B2 (en) | 2017-09-29 | 2024-01-16 | Shanghai University | Liquid-state temporary reinforcing material, preparation method therefor and application thereof |
| CN112245317A (en) * | 2020-09-07 | 2021-01-22 | 广州雨晓生物制品有限公司 | Mouthwash |
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| Publication number | Publication date |
|---|---|
| CN1158987C (en) | 2004-07-28 |
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