CN1392188A - Absorbable composite polymer/calcium sulfate biomaterial - Google Patents
Absorbable composite polymer/calcium sulfate biomaterial Download PDFInfo
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- CN1392188A CN1392188A CN 02125346 CN02125346A CN1392188A CN 1392188 A CN1392188 A CN 1392188A CN 02125346 CN02125346 CN 02125346 CN 02125346 A CN02125346 A CN 02125346A CN 1392188 A CN1392188 A CN 1392188A
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- calcium sulfate
- bone
- biological material
- biomaterial
- chitosan
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Abstract
The present invention provides a kind absorbable composite polymer/calcium sulfate biomaterial and aims at providing a kind of bone repairing material with good absorption effect, adjustable absorption rate and certain bone conductibility. The technological scheme of the present invention is that the composite biological material is prepared by using calcium sulfate as basic material and through adding one or more degradable polymer with the ratio between calcium sulfate and degradable polymer being 5-95 to 5-95 and casting or smelting formation. The biological material is used as bone repairing material and bone defection stuffing material. In extraneous experiment under simulating conditions, calcium sulfate is absorbed completely while porous skeleton remains for cell growth.
Description
Background technology
The home and abroad bone renovating material adopts calcium phosphate series or hydroxyapatite more at present, and wherein calcium phosphate bone cement has entered clinical application.The research report of the timbering material that calcium phosphate such as hydroxyapatite and polymkeric substance constitute is also a lot, and wherein the collagen/hydroxyapatite compound system has also entered the clinical application stage in the U.S..The calcium sulfate bone repair materials of U.S. WHIGHT company has also entered clinical application, and has applied for multinomial United States Patent (USP).The calcium sulfate bone repair materials of the said firm has two series, and first calcium sulfate bone is filled (reparation) material, and another is that the calcium sulfate bone that is loaded with tobramycin is filled (reparation) material.Domestic bone renovating material mainly contains hydroxyapatite and calcium phosphate bone cement two big series, and the subject matter that calcium phosphate bone cement exists is that uptake rate is slow, and hydroxyapatite absorbs in vivo hardly, and this can delay the formation of new bone, can cause some illnesss.
Technical field
The present invention relates to a kind of technical field of biological material, more particularly, relate to a kind of bone reparing biological material.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, but a kind of bone renovating material with osteoconductive rapid absorption is provided.
The present invention is achieved through the following technical solutions:
With calcium sulfate is basic material, add biodegradable polymer, wherein the weight ratio of calcium sulfate and degradable polymer is 5: 95～95: 5, degradable polymer can be a kind of, it also can be two or more mixture, adopt casting or melt molding method, make composite biological material.The good absorbing effect of beneficial effect 1. composite biological materials of the present invention, uptake rate is adjustable.2. composite biological material has osteoconductive.3. stay cancellated porous support after matrix material is absorbed, help the breeding of cell.
Embodiment
The present invention is to be basic material with calcium sulfate, add biodegradable polymer, wherein the weight ratio of calcium sulfate and degradable polymer is 5: 95～95: 5, degradable polymer can be a kind of, it also can be two or more mixture, adopt casting or melt molding method, with different moulds, can obtain having difform composite biological material according to the different mining of desired shape.Such biomaterial has osteoconductive, can be used as bone renovating material, the damaged packing material of bone.This matrix material is carried out external absorption experiment under in-vitro simulated condition, left and right sides calcium sulfate was absorbed fully in 40 days, stayed the porous support of network structure, helped the breeding of cell.Example 1 calcium sulfate/polylactic acid composite biological material
Poly(lactic acid) 1 gram is dissolved in the 3.5ml chloroform, makes the solution of about 20wt%, with in the calcium sulfate 9 gram adding solution and stir, ultrasonication 20 minutes, then mixed solution is poured in the mould, put into vacuum drying oven solvent evaporates is fallen, moulding obtains compound bone reparing biological material.Example 2 calcium sulfate/chitosan compound biological material
Chitosan 3 grams are dissolved in the acetic acid of 7.5ml 5wt%, make the chitosan solution about 40wt%, to also fully stir evenly in the calcium sulfate 7 gram adding solution, ultrasonication 10 minutes, then mixed solution is poured in the mould, put into vacuum drying oven solvent evaporates is fallen, moulding gets chitosan/calcium sulfate biomaterial.
Example 3 calcium sulfate/chitosan compound biological material
Chitosan 3 grams are dissolved in the acetic acid of 7.5ml 5wt%, make the chitosan solution of 40wt%, to also fully stir evenly in the calcium sulfate 7 gram adding solution, ultrasonication 10 minutes, the glutaraldehyde of 2ml 5wt% will be added then behind the mixed solution mixing, after crosslinking reaction, obtain crosslinked chitosan/calcium sulfate composite biological material.
Example 4 calcium sulfate/gelatin-compounded biomaterial
With gelatin 5 gram swelling, dissolvings in 10ml distilled water, obtain the aqueous gelatin solution of 50wt%.Calcium sulfate 5 grams are added in the aqueous gelatin solution, and fully stir, ultrasonication 10 minutes obtains homodisperse solution, and above-mentioned solution is poured on the polyester flake, obtains calcium sulfate/gelatin-compounded biomaterial film under the room temperature after the drying.Scanning electron microscope analysis finds that calcium sulfate is evenly dispersed in the gelatin.Example 5 calcium sulfate/chitosan/gelatin ternary composite biological material
Chitosan 3 gram is dissolved in the acetic acid of 7.5ml, is mixed with the chitosan solution of 20wt%, in solution, add 6 gram gelatin then, make and obtain chitosan and gelatin total content solution after gelatin swelling, the dissolving for about 60wt%.Calcium sulfate 1 gram is added in the solution, and stirring, ultrasonication 15 minutes, above-mentioned solution is poured on the polyester flake, dry under the room temperature, obtain calcium sulfate/chitosan ternary composite biological material film material or sheet material after the moulding.Example 6 calcium sulfate/polyoxyethylene glycol composite biological material
With molecular weight is that 5000 polyoxyethylene glycol, 4 grams are heated to 60 ℃ of thawings, adds calcium sulfate 3 grams then, behind the thorough mixing, ultrasonication 20 minutes, then above-mentioned solution is poured on the polyester flake, dry under the room temperature, obtain calcium sulfate/polyoxyethylene glycol composite biological material after the moulding.
Claims (2)
1. a polymkeric substance/calcium sulfate can absorb composite biological material, it is characterized in that, by weight be made of calcium sulfate following component: degradable polymer is 5～95: 95～5.
2. polymkeric substance/calcium sulfate according to claim 1 can absorb composite biological material, it is characterized in that, described biodegradable polymer is at least a in gelatin, chitosan, poly(lactic acid), the polyoxyethylene glycol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021253463A CN1181124C (en) | 2002-07-26 | 2002-07-26 | Absorbable composite polymer/calcium sulfate biomaterial |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021253463A CN1181124C (en) | 2002-07-26 | 2002-07-26 | Absorbable composite polymer/calcium sulfate biomaterial |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1392188A true CN1392188A (en) | 2003-01-22 |
| CN1181124C CN1181124C (en) | 2004-12-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021253463A Expired - Fee Related CN1181124C (en) | 2002-07-26 | 2002-07-26 | Absorbable composite polymer/calcium sulfate biomaterial |
Country Status (1)
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| CN (1) | CN1181124C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450555C (en) * | 2006-10-23 | 2009-01-14 | 天津大学 | Method for preparing chitosan or/and gelatin-polylacticacid polymer blend three-dimensional porous stent |
| CN101478997A (en) * | 2006-06-30 | 2009-07-08 | Scil技术有限公司 | Biomaterial containing degradation stabilized polymer |
| CN102153845A (en) * | 2011-05-23 | 2011-08-17 | 刘立文 | Calcium sulfate modified polylactic acid material and preparation method thereof |
| TWI380832B (en) * | 2007-09-28 | 2013-01-01 | Univ Nat Taiwan | Porous bio-material and method of preparation thereof |
| CN103251982A (en) * | 2013-05-06 | 2013-08-21 | 浙江大学 | Absorbable calcium dithiophosphate/polylactic acid composite material and preparation method thereof |
| CN104248479A (en) * | 2013-06-26 | 2014-12-31 | 贺利氏医疗有限公司 | Method for the production of spacers and device for same |
| CN108569717A (en) * | 2018-06-28 | 2018-09-25 | 湖北工业大学 | A kind of preparation method of Ag doped with nano calcium sulfate nanosphere for 3D printing organization bracket |
| CN109437805A (en) * | 2018-12-21 | 2019-03-08 | 中国科学院长春应用化学研究所 | Keep the temperature temperature adjustment plasterboard and preparation method thereof |
-
2002
- 2002-07-26 CN CNB021253463A patent/CN1181124C/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101478997A (en) * | 2006-06-30 | 2009-07-08 | Scil技术有限公司 | Biomaterial containing degradation stabilized polymer |
| CN101478997B (en) * | 2006-06-30 | 2014-03-26 | Scil技术有限公司 | Biomaterial containing degradation stabilized polymer |
| US8829072B2 (en) | 2006-06-30 | 2014-09-09 | Scil Technology Gmbh | Biomaterial containing degradation stabilized polymer |
| CN100450555C (en) * | 2006-10-23 | 2009-01-14 | 天津大学 | Method for preparing chitosan or/and gelatin-polylacticacid polymer blend three-dimensional porous stent |
| TWI380832B (en) * | 2007-09-28 | 2013-01-01 | Univ Nat Taiwan | Porous bio-material and method of preparation thereof |
| CN102153845A (en) * | 2011-05-23 | 2011-08-17 | 刘立文 | Calcium sulfate modified polylactic acid material and preparation method thereof |
| CN103251982A (en) * | 2013-05-06 | 2013-08-21 | 浙江大学 | Absorbable calcium dithiophosphate/polylactic acid composite material and preparation method thereof |
| CN103251982B (en) * | 2013-05-06 | 2014-12-31 | 浙江大学 | Absorbable calcium dithiophosphate/polylactic acid composite material and preparation method thereof |
| CN104248479A (en) * | 2013-06-26 | 2014-12-31 | 贺利氏医疗有限公司 | Method for the production of spacers and device for same |
| CN104248479B (en) * | 2013-06-26 | 2016-08-24 | 贺利氏医疗有限公司 | For producing the method and device of sept |
| CN108569717A (en) * | 2018-06-28 | 2018-09-25 | 湖北工业大学 | A kind of preparation method of Ag doped with nano calcium sulfate nanosphere for 3D printing organization bracket |
| CN109437805A (en) * | 2018-12-21 | 2019-03-08 | 中国科学院长春应用化学研究所 | Keep the temperature temperature adjustment plasterboard and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1181124C (en) | 2004-12-22 |
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