CN1387883A - Chinese medicine extract and its application - Google Patents

Abstract

The Chinese medicine extract is prepared through mixing and extracting dahurian angelica root and peach kernel as two kinds of Chinese medicinal material materials. The extract may be used as medicine for preventing and treating hypertension, mgraine, chronic inflammation, pain and other reactive source diseases.

Description

Chinese medicine extract and application

The present invention relates to two kinds of mixed extracts of Chinese medicine and application thereof, particularly the application in the medicine of reaction source kinds diseases such as preparation prevention and treatment hypertension, migraine.

Diseases such as known hypertension, migraine are world today's medical science class diseases of the clear and definite cause of disease not as yet, due to illness because of not clear, can not carry out etiological treatment.The medicine that present world medicine is treated this class disease only can be done the treatment of suiting the medicine to the illness, make temporary alleviation of disease or improvement, but the cause of disease does not eliminate, the cause of disease has then continued pathogenic effects, cause disease to be shown effect repeatedly and can not cure fully, perhaps, can only alleviate to some extent and become lifelong disease, the health and lives of serious harm extensive patients even symptom can not be alleviated fully.For example the hypertension incidence rate is 11.26%, and is also higher the America and Europe.Hypertension is easy to cause arteriosclerosis, the serious even lethal complication of the harm of heart and brain kidneys such as heart failure and renal failure.Present common treatment is with expanding the blood pressure lowering treatment of suiting the medicine to the illness of blood vessel hypotensor, need take medicine every day, as if drug withdrawal then blood pressure raise once more, become patient's lifelong disease.Other problem as migraine, chronic bronchial class, coronary heart disease or the like disease also all exists.

The objective of the invention is to extract and a kind ofly can thoroughly cure and prevent diseases such as essential hypertension, migraine, the Chinese medicine extract that it is not recurred.

From medical history, symptom, (reaction source place local subcutaneous is injected low dose of procaine or lignocaine for sign and clinical trial treatment, medicinal liquid only can soak into the skin and the subcutaneous tissue of 2-3 cm diameter, the local anaesthetics permeates cell membranes, the gate of the sodium-ion channel of side blocking-up within it, make the cell at reaction source place can not produce action potential and conduction of impulse, injected about 2 minutes, symptom such as blood pressure or pain can take a turn for the better, disappearance along with local anesthetic action, symptom and sign recovers again, the pernicious stimulation of unusual bioenergy of reaction source is described, again cause the symptom and sign of reaction source kinds disease to recover) the middle discovery, the body local tissue is by physics, chemistry or the biological cytogene damage that causes, can make cytometaplasia, form and to discharge unusual bio electricity, bioenergy such as electromagnetic wave, directly or the pernicious stimulation target tissue in reflexive ground, produce pathological reaction, and the generation secondary disease, change the virulent unusual bioenergy that primary focus discharges behind this normal tissue injury into, this pernicious stimulus just is called the injury response source, is called for short reaction source.Cause that the reaction source that a certain disease takes place is called relevant reaction source, otherwise claim irrelevant reaction source.The disease that reaction source causes is called the reactinogenicity disease.For example, the hypertension that reaction source causes claims reactinogenicity hypertension, promptly present alleged hypertension or essential hypertension.In the clinical reaction source kinds disease of having found hypertension, migraine, chronic bronchitis, anaphylaxis or neurodermatitis, arrhythmia, coronary heart disease, ankylosing spondylitis are arranged, the dizzy pain of back limb muscle arthralgia, chronic gastritis, chronic colitis and cerebral concussion etc.This numerous reaction source kinds disease is that intensity, frequency and four parameters of target tissue of the unusual bioenergy that discharged by the different parts of reaction source, reaction source are determined.According to the principle of reaction, reaction source kinds diseases such as hypertension, migraine are checked, treated and prevent, be called the reaction source therapy and (draw certainly: Liu Jisheng, Liao Jianxian.The clinical observation of reaction source therapy for treating essential hypertension.The hypertension magazine.1995，3(3)：218～220)。The reaction source therapy is to treat in approach such as reaction source place local subcutaneous liquid medicine injection or quiet, oral drugs, and with control or eliminate reaction source, symptom and sign obtains taking a turn for the better or recovery from illness.

Preferably verifying repeatedly through 2 over thousands of kinds of medicines, having now found that the co-extracted thing of the Radix Angelicae Dahuricae (kind that does not contain angelicotoxin), Semen Persicae (can not each extract back mixing use separately, in order to avoid affect the treatment with clinical.This may be two medicines can generate trace in extraction a new chemical compound, and curative effect is better) can treat reactinogenicity diseases such as hypertension, migraine, and no longer recurrence.

The mechanism of action of this Chinese medicine extract is:

1, Radix Angelicae Dahuricae reducing swelling and alleviating pain in this prescription, the Semen Persicae blood circulation promoting and blood stasis dispelling, has antiinflammatory, anticoagulation, antithrombotic formation, antiallergic, the slight blood vessel that expands increases blood flow, the effect of microcirculation improvement (drawing from " China's book on Chinese herbal medicine "), and reaction source place nutrition supply is increased, promote the abnormal function of cell to transfer the energy that normally provides enough to.

2, this extract more important role is by clinical practice, and reaction source kinds diseases such as treatment hypertension, migraine obtain the curative effect of highly significant, and late result is preferably arranged.Illustrate that this extract has the effect of protection cell normal function, especially can repair cell gene unconventionality structure, change the effect of normal configuration into.The structures shape function.Because the cytogene at reaction source place is unusual, cause the dysfunction of cell, and the abnormal function with the unusual bioenergy of release, and constantly generations of duplicate splitted new cell also heredity anomalous structure, also all has the abnormal function that discharges unusual bioenergy, so, after the hypertension outbreak, just can long term maintenance hypertension.It is more and more to be that the reaction source injury region changes the cell of anomalous structure into again, and the amount that discharges unusual bioenergy is just big more, and again if textural anomaly is serious more, it is just strong more to discharge unusual bioenergy, and the effect of pernicious stimulation is just big more, and hypertension is also just serious more.Thereby long-term serious its children of hyperpietic are the genetic predisposition of the hereditary hypertension of possibility also.Though reaction source kinds diseases such as hypertension are can be not hereditary, but just be easier to the more sick reason reaction of sensitivity real estate after the region of interest local tissue damage, the gene structure that is damaging cells is easier to by normally changing into unusual, form reaction source, the intensity frequency that the also easier cell that makes the reaction source place discharges unusual bioenergy reaches and causes hypertensive scope, and hypertension takes place.Certainly, not having the local tissue damage of posteriori region of interest is can not get hypertension.For example, there are a lot of father and mother to suffer from its children of hypertension and do not suffer from hypertension.Hypertension that hence one can see that is not a hereditary.If be hereditary, constantly heredity from generation to generation, human nearly several thousand history hands down by heredity, and the sickness rate of middle national trouble hypertension has surpassed more than 60% for a long time, and far more than until now 11%.A lot of in addition his last three generations of patients with hypertension do not suffer from hypertension.Observe from this EPDML angle, illustrated that also hypertension is not a hereditary, but the reactinogenicity disease.So, at the clinical depressor of symptomatic treatment commonly used now, only when drug effect, just having temporary transient hypotensive effect, a drug withdrawal blood pressure raises again.Procaine or lignocaine can only the temporary interruption reaction source discharge the effect of unusual bioenergy, and blood pressure only can temporarily descend, and after local anesthetic action rapidly disappeared, blood pressure went up rapidly again.So, have this extract that can repair reaction source place cytogene structure only and could cure hypertension fully.This is because the unusual bioenergy of the release that the cell at reaction source place can continue for a long time stimulates cerebral cortex, and cause corticocerebral excitement and process of inhibition imbalance for a long time, cause vasomotor centre and the dysfunction of endocrine maincenter under the cortex, vasoconstrictor centre and sympathetic excitability are strengthened, cause the trickle tremulous pulse of whole body and continue spastic contraction for a long time, peripheral vascular resistance increases, and blood pressure is just along with rising.The participation that hypophysis endocrine and body fluid change has aggravated the rising of blood pressure, but blood pressure just continues rising for a long time, makes hypertension become lifelong disease.

Hypertension is thoroughly being treated through this extract, and the cytogene anomalous structure at reaction source place is all repaired, and transfers normal cell to, destroys and eliminate the cell that can not repair.And cell on the throne only has normal function, do not discharge virulent unusual bioenergy and stimulated cerebral cortex, cerebral cortex by excited with press down the process imbalance and transfer to normal, the subcortical center causes that producing hypertensive pathological reaction has disappeared, blood pressure just descends naturally, recover normal, long-term stability, hypertension has just been cured fully.Other reaction source kinds diseases too, because the thorough treatment of this extract, the cytogene anomalous structure at reaction source place is all repaired, transfer normal cell to, reaction source has not discharged the unusual bioenergy of pernicious stimulation, and the former secondary focus that is subjected to pernicious stimulation to produce pathological reaction just disappears gradually automatically, transfer normal structure to, symptom and sign disappears, no longer recurrence, and disease just has been completely recovered.And can cure relevant reaction source at premorbid, and can reach the purpose of prophylactic response source class disease.

The prescription of two Chinese medicine extract of indication of the present invention is: Radix Angelicae Dahuricae 100g, and Semen Persicae 15g makes the injection of 500ml achromatism and clarity, and every 1ml contains crude drug 0.23g.(prescription of long-acting sustained-release agent is Radix Angelicae Dahuricae 1000g, and Semen Persicae 200g extracts the 100ml medicinal liquid, and every 1ml contains crude drug 12g)

Manufacturing process: former medicine → each medicine pulverize separately, the Radix Angelicae Dahuricae such as Semen phaseoli radiati are big, Semen Persicae such as Semen Sesami are big, add Radix Angelicae Dahuricae in → the insoluble container in water-bath, add pure water 2500ml again, be heated to 80 ℃ and boil 30min earlier, adding Semen Persicae then boils together, distillation 120min gets liquid 1500ml → distillation medicinal liquid 1500ml redistillation 50min, gets concentrated solution 500ml.The still-process of secondary all must carry out → add lignocaine in full-sealing device, make the every 1ml of medicinal liquid contain lignocaine 1mg (vein use do not contain lignocaine) → filtration → embedding, and 2ml/ props up, and keeps in Dark Place in medicinal liquid achromatism and clarity → sterilization → place, cool place.

Usage and dosage: subcutaneous injection, every day 1～2 time, each 2ml～40ml.

Intravenous drip, every day 1～2 time, each 10ml～20ml.

The Chinese medicine extract that the present invention proposes both can have been treated reaction source kinds diseases such as hypertension, no longer recurrence after curing fully, and can cure relevant reaction source at premorbid, and can reach prophylactic response source class disease.

The following stated embodiment describes the present invention in detail.

Press random-blind method and front and back own control in clinical research, (9～21 times, once a day, three days one courses of treatment, rest is two days between the course of treatment to inject this two Chinese medicine extraction liquid do treatment in short-term in the relevant reaction source place of hypertension pain of patients with hypertension local subcutaneous.For fear of subjective error, the automatic display of blood pressure pulse instrument of Japanese CA-211 numeral that the blood pressure unification is checked and approved with mercury column is measured, and two people are observed and recorded simultaneously), observe 76 examples, effective 74 examples, effective percentage is 97.3%, produce effects 53 examples, obvious effective rate is 69.7%.Own control before and after procaine injection and normal saline solution and this extract medicinal liquid, matched group is all invalid, own control before and after FUFANG LUOBUMA PIAN and this extract medicinal liquid, this extract medicinal liquid matched group (P＜0.01) that is better than evident in efficacy.Blood pressure is reduced to normally, and stopping need not any depressor after the treatment, follows up a case by regular visits to 28 examples after 1 year, has 12 examples still to be stabilized in normal range, accounts for 43%; Follow up a case by regular visits to former normotensive 12 examples after 3 years, wherein 9 routine blood pressures are still stable normal, account for 75%; Former normal 9 examples in the time of 6 years have 3 examples still stable normal, account for 33%.

Clinical efficacy and late result one are with whether to have treated diseases induced whole relevant reaction source exactly relevant, if the injection hour offset, medicinal liquid fails to make reaction source all to soak into, and fails to make the cytogene anomalous structure reparation in total overall reaction source, then weak curative effect, also easily recurrence.The 2nd, treatment number of times deficiency, the cytogene anomalous structure of reaction source is not repaired fully, but can only weaken rather than eliminate the function that reaction source discharges unusual bioenergy, and then hypertension is not cured fully, yet very easy recurrence.

The possible related factors that reaction source kinds diseases such as hypertension are brought out or increased the weight of: head tan by the sun, catch a cold, consume oil bar, fry in shallow oil hot dry irritable foods such as meat, Rhizoma Zingiberis Recens, beef, cock, Carnis Canitis; Fatigue, insomnia, nutrition and dysthymia and wound etc.In treatment, remove inducement, then can quicken to take a turn for the better.After if relevant reaction source cures fully, the above-mentioned related factors fall out effect that do not recur.

Side effect: have the part patient to have slightly in the treatment and swell and ache, if can die away in 2-3 days in injection hot compress in 12 hours or prolongation shot to shot turnaround at injection site.If disappear, still need continue treatment, Sui's reaction source is transferred well to sell gradually and is lost.This reaction only appears at the reaction source place, and can play the ocular effect at favourable landmark identification reaction source place.Not finding has harmful effect to hepatic and renal function.

Claims (2)

1, a kind of Chinese medicine extract is characterized in that this extract is to mix the back extraction by two kinds of Chinese medicines of Radix Angelicae Dahuricae 10-1000g, Semen Persicae 1-200g to make.

2, the application in the medicine of hypertension, migraine that causes in preparation treatment and prophylactic response source by the described Chinese medicine extract of claim 1 and disease that chronic inflammatory disease, pain symptom sign are arranged.