CN1376460A - Fat emulsion for injection and its preparing process - Google Patents
Fat emulsion for injection and its preparing process Download PDFInfo
- Publication number
- CN1376460A CN1376460A CN02112860A CN02112860A CN1376460A CN 1376460 A CN1376460 A CN 1376460A CN 02112860 A CN02112860 A CN 02112860A CN 02112860 A CN02112860 A CN 02112860A CN 1376460 A CN1376460 A CN 1376460A
- Authority
- CN
- China
- Prior art keywords
- injection
- grams per
- water
- homogenize
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A fatty emulsion for injection is prepared from purified soybean oil, refined lecithin, anhydrous glycerine, sodium hydroxide and water for injection through heating said purified soybean oil to 70-90 deg.C, dissolving refined lecithin in it while stirring to obtain oil phase, dissolving anhydrous glycerine in the water for injection while stirring to obtain water phase, slowly adding said oil phase to said water phase while stirring, and stirring for 10 mins to obtain early emulsion. Its advantages are high safety and high energy density.
Description
Technical field
The invention belongs to a kind of lipomul of injection.
Background technology
Lipomul is a kind of comparatively ideal intravenous injection that energy, biosynthesis carbon atom and necessary fatty acid are provided.Its osmotic pressure is similar to blood, and is non-stimulated to wall of vein, can import through PeV, has the heat height, do not need insulin to participate in metabolism, advantages such as no hypertonicity diuresis.In clinical parenteral nutrition, it can provide the double energy supply to the patient with glucose infusion liquid together, prevents single a series of complication that produce with glucose.10% and 20% Intralipid has the clinical use experience of three more than ten years, and after patent expired, existing many enterprises are imitated to produce.Although 10% and 20% Intralipid clinical side effects incidence rate is very low, discover life-time service the said goods, patient's plasma cholesterol, phospholipid and triglyceride levels have the rising phenomenon.Animal and clinical research surface, the rising of this blood lipid level is relevant with the ratio of phospholipid/triglyceride (PL/TG) in the lipomul.The ratio of PL/TG is high more, and blood lipid level raises obvious more, illustrates that the metabolism of fat in the blood is slow more.When blood lipid level is elevated to unusual degree, just tangible clinical side effects may take place.
Summary of the invention
The objective of the invention is to produce a kind of brand-new fat emulsion for injection and manufacture method thereof.So that provide safer to extensive patients, energy density is higher, more is applicable to the lipomul of patient's use of confined liquid input quantity.Its main technical schemes is that the composition of this lipomul is a purification soybean oil 270-330 grams per liter, refined lecithin 11-13 grams per liter, and anhydrous glycerol 15-18 grams per liter, sodium hydroxide is an amount of, and all the other are water for injection.
A kind of manufacture method of fat emulsion for injection is characterized in that: a, in preparing tank, purification soybean oil 270-330 grams per liter is heated to about 70～90 ℃, and add refined lecithin 11-13 grams per liter under the strong agitation, continue to stir until dissolving, form oil phase;
B, in preparing tank, add water for injection, add 15-18 grams per liter anhydrous glycerol again, stirring and dissolving, the container of 2～4 drip washing of reuse injection moisture dress glycerol, merge leacheate to glycerite, form water, wherein water for injection is 25～29 to 1 with the ratio of anhydrous glycerol;
C, oil phase is slowly added intensively stirred water, continued strong agitation 8～12 minutes, form colostrum;
D, use proper amount of sodium hydroxide solution, regulate the pH to 7.5-8.5 of colostrum;
E, use two steps high pressure homogenize machine, the first step is regulated homogenize pressure to 520～600kg/cm
2, second step re-adjustment to 100～140kg/cm
2,, obtain uniform Emulsion with colostrum homogenize repeatedly;
F, again the Emulsion after the homogenize is poured in the infusion bottle through filter, jump a queue gland behind the inflated with nitrogen.
G, place the rotary steam Sterilization Kettle to sterilize this product again, sterilising temp 117-121 ℃, time 12-30 minute, F
0Be worth 11-16 minute, and promptly got this product.
Described preparing tank is a kind of preparing tank with heating jacket and mixing plant; Or only be a kind of preparing tank with mixing plant.
In order to provide safer to extensive patients, energy density is higher, more is applicable to the lipomul of patient's use of confined liquid input quantity, and our company is after carrying out great change to production technology, formula for a product, released 30% brand-new fat emulsion for injection, trade name 30% Intralipid.Providing soybean oil (main component the is a triglyceride) concentration of energy to reach 30% in this product, make energy that unit volume provides up to 3kcal/ml, is 3 times and 1.5 times of 10%, 20% product; Phospholipid concentration is identical with 10%, 20% product, thereby makes the PL/TG value reduce to 0.04.Be test group with this product, 20% Intralipid is that the clinical trial of matched group proves: test group is after input this product, blood triglyceride levels, the basic no change of blood total cholesterol concentration or decline to some extent, and matched group blood total cholesterol level has remarkable rising; Unusual lipoprotein LPX obviously raises than test group in the matched group, proves because new product has lower PL/TG ratio, can reduce the generation of unusual lipoprotein LPX and the generation of hyperlipemia.Two groups of patients are at total protein and albumin content, liver function, and the equal no significant difference in various vital signs aspect illustrates that new product is better than reference substance aspect safety on the whole.Simultaneously, high-energy-density can make provides the amount of infusion of identical heat to reduce significantly, to the patient of the heart of need confined liquid input, lung, renal dysfunction, more good energy source beyond doubt.These clinical trials illustrate that all the scope of application of new product is more extensive and safer.
Compare with 10%, 20% lipomul, its prescription characteristics see the following form:
| 10% Intralipid | 20% Intralipid | 30% Intralipid | |
| Purification soybean oil (gram) | 100 | ?200 | ?300 |
| Lecithin (gram) | 12 | ?12 | ?12 |
| Glycerol (gram) | 22 | ?22 | ?16.7 |
| Cumulative volume | 1000ml | ?1000ml | ?1000ml |
| Energy density kcal/ml | 1.0 | ?2.0 | ?3.0 |
| Phospholipid/triglyceride ratio | 0.12 | ?0.06 | ?0.04 |
As seen from the table, 30% product is when increasing purification Semen sojae atricolor oil mass to 300 gram, and the amount of keeping lecithin is constant, thereby makes phospholipid/triglyceride ratio be reduced to 0.04, and energy density is increased to 3.0kcal/ml.
Fat emulsion for injection is the emulsion of a kind of oil/water type.Soybean oil is an oil phase, and lecithin is emulsifying agent.Oil phase is dispersed in aqueous phase under the effect of lecithin, form stable Emulsion.For guaranteeing the safety of clinical use, two primary conditions are arranged: the one, for preventing blood vessel embolism, the diameter that must guarantee all breast grains is less than 5 microns; The 2nd, breast grain particle size distribution should be identical as far as possible with natural chyle, and mean diameter should be at the 0.34-0.38 micron.And must keep stable in the effect duration in 2 years at product.Angle from manufacturing process and maintenance emulsion stability is the bigger the better as the lecithin of emulsifying agent and the ratio of decentralized photo soybean oil (triglyceride).So after 10%, 20% lipomul is invented more than 30 year, be limited to the never product appearance of lower PL/TG ratio of reason of technology.Hua Rui company is on the basis that produces 10%, 20% Intralipid for many years, through research for many years, numerous technical barriers have been solved, finally invent out triglyceride concentration and reach 30%, the PL/TG value only is 0.04 lipomul, and the every technical specification of product and stability are all very desirable.
In R﹠D process, many new discoveries are arranged:
Lecithin is dispersed in the purification soybean oil can obtain colostrum preferably.
The temperature of oil phase heating is answered strict span of control, if low excessively, then the lecithin dispersion effect is poor; Too high, the then easy oxidation of soybean oil and lecithin, the emulsifying effectiveness of reduction lecithin.
Oil phase is transferred to water an optimum speed.Simultaneously to the stirring of oil water mixture should be appropriately to acquire the good and colostrum of entrained air not of dispersion effect.
Utilize the import high pressure homogenizer, product is carried out homogenize, strict control homogenize pressure and number of times are obtained best, the most stable emulsifying effectiveness.
During fill, spatial oxygen content in the strict control bottle makes the stability of product in the storage life be effectively guaranteed.
The rotation Sterilization Kettle that the product sterilization is used makes that product by heating, insulation, the influence of refrigerative each stage to product are uniformly, guarantee that Emulsion is not damaged because of hot-spot makes the Emulsion structure in sterilization process in the whole sterilization process.
The effect of each composition is as follows:
The purification soybean oil: soybean oil obtains behind refining purification.The main active of this product.For human body provides fat, satisfy the physiological need of human body as energy, essential fatty acid is provided simultaneously.In this product, soybean oil is dispersed in the water with about 0.35 micron tiny oil droplets, is fitly arranging the molecule of lecithin around the oil droplet, thereby the assurance oil droplet can not assembled the phenomenon that produces oil-water separation.
Lecithin: from egg yolk, obtain behind the refining refinement.One of main component of this product.Be a kind of natural emulsifying agent, play emulsification in this product.Oil droplet is disperseed the molecule of back lecithin can fitly be arranged in around the oil droplet, forms barrier one, prevents that oil droplet from reassembling.Therefore must there be the lecithin of q.s to have the stability that could guarantee emulsifying effectiveness and Emulsion in the product.Lecithin has the important physical effect in human body, human body self can synthesize lecithin, and as mentioned before, exceedingly taking in lecithin can influence the normal physiological metabolism activity of human body on the contrary.The content that as far as possible reduces lecithin under the stay-in-grade prerequisite of assurance Emulsion is starting point of the present invention, also is meaning of the present invention certainly.
Anhydrous glycerol: the osmotic pressure that is used to regulate this product.The osmotic pressure of solution is a basic physical parameters.The transfusion series products is pressed with and must asks infiltration.The product that osmotic pressure is low excessively can produce molten ware phenomenon after importing human body, and osmotic pressure is too high to have very large stimulation to blood vessel, to such an extent as to be difficult to stand.The liquid identical with colloidal osmotic pressure is called isosmotic solution, can directly import blood vessel and does not have discomfort.This product adds an amount of glycerol and oozes with the osmotic pressure of regulating this product and blood etc.
Sodium hydroxide: the pH value that is used to regulate this product.Blood has relatively-stationary pH value, and the pH value of transfusion should be approaching with blood as far as possible, in order to avoid influence the human physiological activity.
Water for injection: all infusion products all are carrier and solvent with water for injection.Oil droplet is evenly dispersed in the water for injection in this product.
The comparison of this product and old product
| 10% Intralipid | 20% Intralipid | 30% Intralipid | |
| Purification soybean oil (gram) | 100 | ?200 | ?300 |
| Lecithin (gram) | 12 | ?12 | ?12 |
| Glycerol (gram) | 22 | ?22 | ?16.7 |
| Sodium hydroxide | In right amount | In right amount | In right amount |
| Water for injection adds to | 1000ml | ?1000ml | ?1000ml |
| Energy density kcal/ml | 1.0 | ?2.0 | ?3.0 |
| Phospholipid/triglyceride ratio | 0.12 | ?0.06 | ?0.04 |
Mainly is that purification soybean oil content different with old product from the difference on the prescription from the visible this product of last table, and glycerol is variant slightly, therefore causes the more different of energy density and phospholipid/triglyceride ratio.The difference of the clinical practice that these differences bring, safety and curative effect is existing the description in first.
The specific embodiment
Example one
Composition is purification soybean oil 330 grams per liters, refined lecithin 3 grams per liters, and anhydrous glycerol 18 grams per liters, sodium hydroxide is an amount of, and all the other are water for injection.
Manufacture method: a, in a kind of preparing tank with heating jacket and mixing plant, purification soybean oil 330 grams per liters are heated to about 90 ℃, add refined lecithin 13 grams per liters under the strong agitation, continue to stir until dissolving, form oil phase;
B, in a kind of preparing tank, add water for injection, add 18 grams per liter anhydrous glycerols again, stirring and dissolving with mixing plant, the container of 4 drip washing of reuse injection moisture dress glycerol, merge leacheate to glycerite, form water, wherein water for injection is 29 to 1 with the ratio of anhydrous glycerol;
C, oil phase is slowly added intensively stirred aqueous phase, continued strong agitation 12 minutes, form colostrum;
D, use proper amount of sodium hydroxide solution, regulate the pH to 8.5 of colostrum;
E, use two steps high pressure homogenize machine, the first step is regulated homogenize pressure to 600kg/cm
2, the second step re-adjustment is to 140kg/cm
2,, obtain uniform Emulsion with colostrum homogenize repeatedly;
F, again the Emulsion after the homogenize is poured in the infusion bottle through filter, jump a queue gland behind the inflated with nitrogen.
G, place the rotary steam Sterilization Kettle to sterilize this product again, 121 ℃ of sterilising temps, 30 minutes time, F
0Be worth 16 minutes, and promptly got this product.
Example two
Composition is purification soybean oil 290 grams per liters, refined lecithin 12.5 grams per liters, and anhydrous glycerol 17 grams per liters, sodium hydroxide is an amount of, and all the other are water for injection.
Manufacture method: a, in a kind of preparing tank with heating jacket and mixing plant, purification soybean oil 290 grams per liters are heated to about 85 ℃, add refined lecithin 12.5 grams per liters under the strong agitation, continue to stir until dissolving, form oil phase;
B, in a kind of preparing tank, add water for injection, add 17 grams per liter anhydrous glycerols again, stirring and dissolving with mixing plant, the container of 3 drip washing of reuse injection moisture dress glycerol, merge leacheate to glycerite, form water, wherein water for injection is 27 to 1 with the ratio of anhydrous glycerol;
C, oil phase is slowly added intensively stirred aqueous phase, continued strong agitation 11 minutes, form colostrum;
D, use proper amount of sodium hydroxide solution, regulate the pH to 8.5 of colostrum;
E, use two steps high pressure homogenize machine, the first step is regulated homogenize pressure to 590kg/cm
2, the second step re-adjustment is to 115kg/cm
2,, obtain uniform Emulsion with colostrum homogenize repeatedly;
F, again the Emulsion after the homogenize is poured in the infusion bottle through filter, jump a queue gland behind the inflated with nitrogen.
G, place the rotary steam Sterilization Kettle to sterilize this product again, 121 ℃ of sterilising temps, 28 minutes time, F
0Be worth 15 minutes, and promptly got this product.
Product appearance: uniform milky white liquid, the surface does not have showy oil droplet
0.38 micron of breast grain mean diameter does not contain the breast grain greater than 5 microns.Room temperature storage is rechecked 0.38 micron of breast grain mean diameter after 24 months, do not contain the breast grain greater than 5 microns.
Discussion of results: compare with standard recipe, a breast grain mean diameter increases to some extent, and the upper limit of the mean diameter of approaching lipomul usually acceptance if improve the concentration of soybean oil again, may cause the stability decreases of Emulsion, and a breast grain diameter further strengthens.This prescription can be the limit of actual enforcement prescription.
Example three
Composition is purification soybean oil 320 grams per liters, refined lecithin 12.5 grams per liters, and anhydrous glycerol 17 grams per liters, sodium hydroxide is an amount of, and all the other are water for injection.
Manufacture method: a, in a kind of preparing tank with heating jacket and mixing plant, purification soybean oil 320 grams per liters are heated to about 75 ℃, add refined lecithin 12.5 grams per liters under the strong agitation, continue to stir until dissolving, form oil phase;
B, in a kind of preparing tank, add water for injection, add 17 grams per liter anhydrous glycerols again, stirring and dissolving with mixing plant, the container of 4 drip washing of reuse injection moisture dress glycerol, merge leacheate to glycerite, form water, wherein water for injection is 28 to 1 with the ratio of anhydrous glycerol;
C, oil phase is slowly added intensively stirred aqueous phase, continued strong agitation 11 minutes, form colostrum;
D, use proper amount of sodium hydroxide solution, regulate the pH to 7.5 of colostrum;
E, use two steps high pressure homogenize machine, the first step is regulated homogenize pressure to 580kg/cm
2, the second step re-adjustment is to 135kg/cm
2,, obtain uniform Emulsion with colostrum homogenize repeatedly;
F, again the Emulsion after the homogenize is poured in the infusion bottle through filter, jump a queue gland behind the inflated with nitrogen.
G, place the rotary steam Sterilization Kettle to sterilize this product again, 120 ℃ of sterilising temps, 16 minutes time, F
0Be worth 14 minutes, and promptly got this product.
Example four
Composition is purification soybean oil 300 grams per liters, refined lecithin 11.5 grams per liters, and anhydrous glycerol 17 grams per liters, sodium hydroxide is an amount of, and all the other are water for injection.
Manufacture method a, in a kind of preparing tank with heating jacket and mixing plant, purification soybean oil 300 grams per liters are heated to about 85 ℃, add refined lecithin 11.5 grams per liters under the strong agitation, continue to stir until dissolving, form oil phase;
B, in a kind of preparing tank, add water for injection, add 17 grams per liter anhydrous glycerols again, stirring and dissolving with mixing plant, the container of 3 drip washing of reuse injection moisture dress glycerol, merge leacheate to glycerite, form water, wherein water for injection is 27 to 1 with the ratio of anhydrous glycerol;
C, oil phase is slowly added intensively stirred aqueous phase, continued strong agitation 10 minutes, form colostrum;
D, use proper amount of sodium hydroxide solution, regulate the pH to 8.0 of colostrum;
E, use two steps high pressure homogenize machine, the first step is regulated homogenize pressure to 550kg/cm
2, the second step re-adjustment is to 120kg/cm
2,, obtain uniform Emulsion with colostrum homogenize repeatedly;
F, again the Emulsion after the homogenize is poured in the infusion bottle through filter, jump a queue gland behind the inflated with nitrogen.
G, place the rotary steam Sterilization Kettle to sterilize this product again, 119 ℃ of sterilising temps, 15 minutes time, F
0Be worth 13 minutes, and promptly got this product.
Example five
Composition is purification soybean oil 280 grams per liters, refined lecithin 12 grams per liters, and anhydrous glycerol 16 grams per liters, sodium hydroxide is an amount of, and all the other are water for injection.
Manufacture method: a, in a kind of preparing tank with heating jacket and mixing plant, purification soybean oil 280 grams per liters are heated to about 80 ℃, add refined lecithin 12 grams per liters under the strong agitation, continue to stir until dissolving, form oil phase;
B, in a kind of preparing tank, add water for injection, add 16 grams per liter anhydrous glycerols again, stirring and dissolving with mixing plant, the container of 3 drip washing of reuse injection moisture dress glycerol, merge leacheate to glycerite, form water, wherein water for injection is 26 to 1 with the ratio of anhydrous glycerol;
C, oil phase is slowly added intensively stirred aqueous phase, continued strong agitation 9 minutes, form colostrum;
D, use proper amount of sodium hydroxide solution, regulate the pH to 8.5 of colostrum;
E, use two steps high pressure homogenize machine, the first step is regulated homogenize pressure to 540kg/cm
2, the second step re-adjustment is to 120kg/cm
2,, obtain uniform Emulsion with colostrum homogenize repeatedly;
F, again the Emulsion after the homogenize is poured in the infusion bottle through filter, jump a queue gland behind the inflated with nitrogen.
G, place the rotary steam Sterilization Kettle to sterilize this product again, 118 ℃ of sterilising temps, 18 minutes time, F
0Be worth 12 minutes, and promptly got this product.
Example six
Composition is purification soybean oil 270 grams per liters, refined lecithin 13 grams per liters, and anhydrous glycerol 18 grams per liters, sodium hydroxide is an amount of, and all the other are water for injection.
Manufacture method: a, in a kind of preparing tank with heating jacket and mixing plant, purification soybean oil 270 grams per liters are heated to about 90 ℃, add refined lecithin 13 grams per liters under the strong agitation, continue to stir until dissolving, form oil phase;
B, in a kind of preparing tank, add water for injection, add 18 grams per liter anhydrous glycerols again, stirring and dissolving with mixing plant, the container of 4 drip washing of reuse injection moisture dress glycerol, merge leacheate to glycerite, form water, wherein water for injection is 29 to 1 with the ratio of anhydrous glycerol;
C, oil phase is slowly added intensively stirred aqueous phase, continued strong agitation 12 minutes, form colostrum;
D, use proper amount of sodium hydroxide solution, regulate the pH to 8.0 of colostrum;
E, use two steps high pressure homogenize machine, the first step is regulated homogenize pressure to 520～600kg/cm
2, second step re-adjustment to 100～140kg/cm
2,, obtain uniform Emulsion with colostrum homogenize repeatedly;
F, again the Emulsion after the homogenize is poured in the infusion bottle through filter, jump a queue gland behind the inflated with nitrogen.
G, place the rotary steam Sterilization Kettle to sterilize this product again, 121 ℃ of sterilising temps, 12 minutes time, F
0Be worth 16 minutes, and promptly got this product.
Example seven
Composition is purification soybean oil 330 grams per liters, refined lecithin 11 grams per liters, and anhydrous glycerol 15 grams per liters, sodium hydroxide is an amount of, and all the other are water for injection.
Manufacture method: a, in the preparing tank of band heating jacket and mixing plant, purification soybean oil 330 grams per liters are heated to about 90 ℃, add refined lecithin 11 grams per liters under the strong agitation, continue to stir until dissolving the formation oil phase;
B, the band mixing plant preparing tank in add water for injection, add 15 grams per liter anhydrous glycerols again, stirring and dissolving, the container of 2 drip washing of reuse injection moisture dress glycerol, merge leacheate to glycerite, form water, wherein water for injection is 25 to 1 with the ratio of anhydrous glycerol;
C, oil phase is slowly added intensively stirred aqueous phase, continued strong agitation 8 minutes, form colostrum;
D, use proper amount of sodium hydroxide solution, regulate the pH to 7.5 of colostrum;
E, use two steps high pressure homogenize machine, the first step is regulated homogenize pressure to 520kg/cm
2, the second step re-adjustment is to 100kg/cm
2,, obtain uniform Emulsion with colostrum homogenize repeatedly;
F, again the Emulsion after the homogenize is poured in the infusion bottle through filter, jump a queue gland behind the inflated with nitrogen.
G, place the rotary steam Sterilization Kettle to sterilize this product again, 117 ℃ of sterilising temps, 30 minutes time, F
0Be worth 11 minutes, and promptly got this product.
Claims (6)
1, fat emulsion for injection, the composition that it is characterized in that this lipomul are purification soybean oil 270-330 grams per liter, refined lecithin 11-13 grams per liter, and anhydrous glycerol 15-18 grams per liter, sodium hydroxide is an amount of, and all the other are water for injection.
2, a kind of manufacture method of fat emulsion for injection is characterized in that: a, in preparing tank, purification soybean oil 270-330 grams per liter is heated to about 70～90 ℃, and add refined lecithin 11-13 grams per liter under the strong agitation, continue to stir until dissolving, form oil phase;
B, in preparing tank, add water for injection, add 15-18 grams per liter anhydrous glycerol again, stirring and dissolving, the container of 2～4 drip washing of reuse injection moisture dress glycerol, merge leacheate to glycerite, form water, wherein water for injection is 25～29 to 1 with the ratio of anhydrous glycerol;
C, oil phase is slowly added intensively stirred aqueous phase, continued strong agitation 8～12 minutes, form colostrum;
D, use proper amount of sodium hydroxide solution, regulate the pH to 7.5-8.5 of colostrum;
E, use two steps high pressure homogenize machine, the first step is regulated homogenize pressure to 520～600kg/cm
2, second step re-adjustment to 100～140kg/cm
2,, obtain uniform Emulsion with colostrum homogenize repeatedly;
3, method according to claim 2 is characterized in that the Emulsion after the homogenize being poured in the infusion bottle through filter again, jumps a queue gland behind the inflated with nitrogen.
4, method according to claim 3 is characterized in that placing the rotary steam Sterilization Kettle to sterilize this product again, and sterilising temp 117-121 ℃, time 12-30 minute, F
0Be worth 11-16 minute, and promptly got this product.
5, method according to claim 2 is characterized in that preparing tank is a kind of preparing tank with heating jacket and mixing plant.
6, method according to claim 2 is characterized in that preparing tank is a kind of preparing tank with mixing plant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02112860A CN1376460A (en) | 2002-04-05 | 2002-04-05 | Fat emulsion for injection and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02112860A CN1376460A (en) | 2002-04-05 | 2002-04-05 | Fat emulsion for injection and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1376460A true CN1376460A (en) | 2002-10-30 |
Family
ID=4742304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN02112860A Pending CN1376460A (en) | 2002-04-05 | 2002-04-05 | Fat emulsion for injection and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1376460A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331467C (en) * | 2004-10-09 | 2007-08-15 | 中国药品生物制品检定所 | Ursine fat injection emulsion, and its prepn. method |
| CN101926763A (en) * | 2009-06-22 | 2010-12-29 | 哈药集团生物工程有限公司 | Method for preparing lipoalprostadil sterile preparation |
| CN102302099A (en) * | 2011-07-13 | 2012-01-04 | 智卫华 | Soy glyceride and preparation method thereof |
| CN101015501B (en) * | 2007-02-28 | 2012-03-07 | 华瑞制药有限公司 | Injection composition of fat milk, amino acid and glucose packed with three-cavity bag and preparing method thereof |
| CN104490775A (en) * | 2014-12-20 | 2015-04-08 | 长沙佰顺生物科技有限公司 | Anacetrapib fat emulsion and preparation method thereof |
| WO2015180486A1 (en) * | 2014-05-26 | 2015-12-03 | 中国人民解放军第二军医大学 | Anti-inflammatory and analgesic drug and preparation thereof |
| WO2022147962A1 (en) * | 2021-01-05 | 2022-07-14 | 上海交通大学医学院附属第九人民医院 | Fat emulsion dialysate, and preparation method therefor and use thereof |
-
2002
- 2002-04-05 CN CN02112860A patent/CN1376460A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331467C (en) * | 2004-10-09 | 2007-08-15 | 中国药品生物制品检定所 | Ursine fat injection emulsion, and its prepn. method |
| CN101015501B (en) * | 2007-02-28 | 2012-03-07 | 华瑞制药有限公司 | Injection composition of fat milk, amino acid and glucose packed with three-cavity bag and preparing method thereof |
| CN101926763A (en) * | 2009-06-22 | 2010-12-29 | 哈药集团生物工程有限公司 | Method for preparing lipoalprostadil sterile preparation |
| CN102302099A (en) * | 2011-07-13 | 2012-01-04 | 智卫华 | Soy glyceride and preparation method thereof |
| WO2015180486A1 (en) * | 2014-05-26 | 2015-12-03 | 中国人民解放军第二军医大学 | Anti-inflammatory and analgesic drug and preparation thereof |
| CN104490775A (en) * | 2014-12-20 | 2015-04-08 | 长沙佰顺生物科技有限公司 | Anacetrapib fat emulsion and preparation method thereof |
| WO2022147962A1 (en) * | 2021-01-05 | 2022-07-14 | 上海交通大学医学院附属第九人民医院 | Fat emulsion dialysate, and preparation method therefor and use thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1965806A (en) | Fat emulsion injection liquid containing soybean oil, medium chain triglyceride, olive oil and fish oil and method for preparing the same | |
| CN1203864C (en) | Spray formulation of providone iodine | |
| CN105476020B (en) | A kind of vitamin D3Soft capsule and preparation method thereof | |
| CN101032467A (en) | Superregulated long-cycled lipid emulsion carrying medicine reagent for mainline | |
| CN1732969A (en) | Ointment with clindamycin and metronidazole and method for preparing the same | |
| CN1376460A (en) | Fat emulsion for injection and its preparing process | |
| CN101062025A (en) | Compound anget for reducing weight, fat, sugar, pressure and for preventing and treating osteoporosis | |
| CN101045042A (en) | Propofol injection and its preparing method | |
| CN107142289B (en) | Method for rapidly and stably preparing phosphatidylserine for food | |
| CN1204238C (en) | Kenrel oil composite extracted from plant kernel and its extraction process and application | |
| CN1709236A (en) | Fat emulsion containing docetaxel and its preparing method | |
| CN101167793A (en) | Walnut oil fat emulsion and manufacturing method thereof | |
| WO2004075878A1 (en) | Fatty emulsion injection of seal oil, method for preparation and the use in manufacturing intravenous injection | |
| CN111743996A (en) | Oral emulsion for improving memory and senile dementia and preparation method thereof | |
| CN1813733A (en) | Vitamin E nicotinate lipide microsphere injection and its preparing method | |
| CN1973826A (en) | Injection containing lipoid microsphere of etoposide and its prepn process | |
| CN1720948A (en) | Dripping pills of lllicium henryi dripping pills and method for preparing the same | |
| CN110038018B (en) | A method for preparing brain neurotrophic therapeutic composition | |
| CN1830485A (en) | Preparation method of anti-inflammation analgesia medicine compound bone peptide injection | |
| CN1561970A (en) | Fat soluble vitamin freeze-drying emulsion and its preparing method | |
| CN1788723A (en) | Liposome microsphere injection liquid containing demethylate disodium cantharidinate and its preparation method | |
| CN1686362A (en) | Hairy holly root drip pill and its preparation method | |
| CN1176655C (en) | Refapentine or rifampin liposome perfusate, injection and preparation process thereof | |
| CN1107501C (en) | Albendazole emulsion | |
| CN105707568A (en) | Alpha-linolenic acid soft capsule with function of auxiliarily lowering blood lipids and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |