CN1355012A - Exterior-applied disinfecting liquid with disinfecting and antipruritic actions - Google Patents
Exterior-applied disinfecting liquid with disinfecting and antipruritic actions Download PDFInfo
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- CN1355012A CN1355012A CN 00134213 CN00134213A CN1355012A CN 1355012 A CN1355012 A CN 1355012A CN 00134213 CN00134213 CN 00134213 CN 00134213 A CN00134213 A CN 00134213A CN 1355012 A CN1355012 A CN 1355012A
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- disinfecting
- sterilization
- boric acid
- skin
- exterior
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An exterior-applied anutiseptic liquid "Huafu" for disinfecting, sterilizing and preventing infection is prepared from boric acid and glutaric dialdehyde. Its advantages include broad spectrum, high effect, no irritation to skin and low poison.
Description
The present invention relates to one group and have sterilization, sterilization and anti-infection effect skin sterilizing agent for external use.
Sterilization is to keep human health to human body skin, an important channel of protecting from infection, the preparation that is used at present skin degerming both at home and abroad is a lot, skin degerming is all had certain effect, these preparations such as Cidex-7: 3% boric acid, 0.1% ethacridine, 1: 5000 potassium permanganate, the benzoyl peroxide of 5%-10% etc. and antibiotic such as 0.5%-1% neomycin, 2% fusidinic acid, certain sterilization and bacteriostasis are all arranged during local topicals such as 1% clindamycin, but these disinfectant all act on more weak to pathogenic bacterium property fungus or do not have bactericidal action, that is to say, when use the part, exist defective such as pathogenic bacterium property fungus is invalid.And antifungal, as 2%-3% clotrimazole, 1% econazole, 2% miconazole, 2% ketoconazole, 1% bifonazole, 1% terbinafine, nystatin, amphotericin B; 10% cyclopropanone amine, 10% undecylenic acid, 5%-10% salicylic acid, 6%-12% benzoic acid, 10%-30% salicylic acid, 2.5% selenium sulfide etc., these preparations all have antifungic action preferably, some medicine is killed the effect of fungus in addition, but this class medicine is only effective to fungus, other antibacterials are not then had disinfective action, carry out the sterilization of broad-spectrum antiseptic antifungal, make its definite effect skin, easy to use, also need to study new preparation.
The research of this project addresses this problem in order to develop a kind of wide spectrum skin degerming biocide exactly, and this skin degerming biocide is made up of boric acid and glutaraldehyde, has broad-spectrum sterilization, sterilization and prevention infection effect, and this scheme is to form like this:
China's cottonrose hibiscus disinfectant solution mainly is made up of boric acid and two kinds of primary raw materials of glutaraldehyde, and boric acid content is 3%, and glutaraldehyde content is 0.1%.The prescription of said preparation and compound method are: get boric acid 3g, and 50% glutaraldehyde solution 0.2ml, distilled water adds to 100ml and gets final product.
Boric acid boric acid is the skin degerming medicine of using always, has weak antisepsis when using separately, and zest is little, can be used for the flushing in skin and eye, oral cavity, bladder and uterus, or is used for dermopathic soak.The bactericidal action of boric acid is imprecise, even saturated solution also can only suppress the growth of antibacterial.Antibacterial and fungus there is weak inhibitory action, major advantage is a nonirritant, can be used for tender and lovely position, glutaraldehyde Glularaldehyde then is a kind of wide spectrum, efficient and the less sterilization of corrosivity, biocide, be mainly used in the sterilization of expensive instrument, glutaraldehyde is all effective to all microorganisms, Gram-positive and gram negative bacteria all had bactericidal action, to spore, acid-fast bacilli, virus and fungus are also effective, its 2% solution is usually used in sterilization of instruments, the solution of 5-10% is embrocated and be can be used for treating verruca vulgaris, hyperhidrosis and tinea unguium, but this concentration more easily causes contact dermatitis, and its steam also can be to nose, eye, respiratory tract has stimulation, can cause cough, dysphagia, laryngospasm, tracheitis and pneumonia, suck repeatedly asthma can take place, can not be used for face, anus, genitals etc. partly close on mucosa in order to avoid stimulate.
This project seminar proves by the repeated multiple times experimentation, compound recipe China cottonrose hibiscus disinfectant solution with 3% boric acid and 0.1% glutaraldehyde composition, the action effect of this two medicine is strengthened and adverse reaction reduction, boric acid can make glutaraldehyde more stable, and antibacterial action significantly strengthens, and the glutaraldehyde consumption that we adopt only is 0.1%, hang down 20 times than its antibiotic concentration 2% commonly used, but its antibacterial effect is the same, and does not have local irritation, and the Disinfection Effect that is used for skin is better.
China's cottonrose hibiscus disinfectant solution bactericidal effect testing result shows, this product all reaches 99.99% to escherichia coli (ATCC 25922), staphylococcus aureus (ATCC 65389), bacillus subtilis black variety bud cell (ATCC 9372) sterilizing rate, Candida albicans is also had the killing action of highly significant, and sterilizing rate also reaches 99.99%.
China's cottonrose hibiscus disinfectant solution acute toxicity test, 20 healthy Kunming mouses (male and female half and half) are once irritated stomach and are given this product 0.2ml/20g, are equivalent to 10ml/kg, observe continuously 7 days, and white mice all survives, and shows that this product toxicity is lower.
China's cottonrose hibiscus disinfectant solution skin irritation test adopts new zealand rabbit to carry out the single-use skin stimulation test, and the average product score value is 0.2 as a result, and acute eye stimulates and separate index number is 2.0.
China's cottonrose hibiscus disinfectant solution is estimated by disinfectant acute oral toxicity test evaluation of result standard, and this product acute oral toxicity belongs to nontoxic level, to the skin nonirritant, eye is had atomic zest.
China's cottonrose hibiscus disinfectant solution stability study, this product is placed after three months naturally, and the assay of its Main Ingredients and Appearance does not have significant change, and antibacterial action does not reduce, and this product stability is described better, and longer research standing time is in progress.
Claims (2)
1, a kind of skin sterilizing agent for external use with sterilization, sterilization, anti-infectious function is characterized in that the prescription of this disinfectant solution is made up of boric acid and glutaraldehyde.
2, as claimed in claim 1 have a disinfection anti-infective skin sterilizing agent for external use, it is characterized in that the drug ratios of this prescription and compound method are as follows:
Boric acid 3g, 50% glutaraldehyde 0.2ml, distilled water add to 100ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00134213 CN1132570C (en) | 2000-11-24 | 2000-11-24 | Exterior-applied disinfecting liquid with disinfecting and antipruritic actions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00134213 CN1132570C (en) | 2000-11-24 | 2000-11-24 | Exterior-applied disinfecting liquid with disinfecting and antipruritic actions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1355012A true CN1355012A (en) | 2002-06-26 |
| CN1132570C CN1132570C (en) | 2003-12-31 |
Family
ID=4596122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00134213 Expired - Fee Related CN1132570C (en) | 2000-11-24 | 2000-11-24 | Exterior-applied disinfecting liquid with disinfecting and antipruritic actions |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1132570C (en) |
-
2000
- 2000-11-24 CN CN 00134213 patent/CN1132570C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1132570C (en) | 2003-12-31 |
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| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |