CN1354021A - Disposable fluid treatment pipeline and separation system - Google Patents
Disposable fluid treatment pipeline and separation system Download PDFInfo
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- CN1354021A CN1354021A CN 01120426 CN01120426A CN1354021A CN 1354021 A CN1354021 A CN 1354021A CN 01120426 CN01120426 CN 01120426 CN 01120426 A CN01120426 A CN 01120426A CN 1354021 A CN1354021 A CN 1354021A
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Abstract
The present invention relates to a separation system of disposable fluid treatment pipeline, which comprises a weighing balance with collecting containers on its arm, one of the container is used for collecting or removing the air bubble in the pipeline.
Description
Invention field
The present invention relates to be used for equipment and the method that biofluid is handled.More particularly, relate to the improved biofluid that is used to handle, as whole blood, equipment and method, comprise separation of whole blood is become several parts or be separated into the equipment and the method for each ingredient of blood.
Background technology
In patient's emergency treatment and/or long-term treatment, the component of blood transfusion or blood usually plays crucial effect.For treating various diseases, patient can import blood or the independent part and/or the component (for example platelet, blood plasma, erythrocyte etc.) of blood.
For example, patient can import whole blood or Red Blood Cells Concentrate, and replenishing losing blood that wound causes, and other blood component or part can be defeated by the patient who suffers from cancer or other relevant hematologic disease and be carried out long-term treatment as additament.Be defeated by patients'blood, blood component or part and come from the blood of before having gathered from donor usually, these blood have been separated into special component or part.
Blood collection procedure (comprising separation) and system have manual or automatic two kinds usually.In automatic blood collection procedure, donor is directly connected on the blood sampling apparatus, extracts whole blood out from it.Separation is also collected wherein required component or part, and remaining component or part are returned in the donor body.
The equipment that is used for automatic blood collection procedure, for example those foregoing descriptions generally include reusable hardware components and are used for disposable, disposable tubular portion or fluid circuit.Hardware components generally includes pump, and for example peristaltic pump is used for (1) and takes out whole blood on one's body from donor or patient; (2) anticoagulant is added in the whole blood; (3) blood transport is used for blood separation is become various components or part to segregation apparatus; (4) from segregation apparatus, extract out one or more blood components or part in order to it with or turn back to donor or patient.Hardware components and single use portion can comprise segregation apparatus, for example, can be the rotating rooms of describing in the rotating centrifugal device described in the United States Patent (USP) 4146172 or the United States Patent (USP) 5738792 with film.
Disposable tubular portion generally includes venipuncture needle and plastic tube, venipuncture needle is used to thrust in the donor body and by it extracts whole blood out, plastic tube is used for blood and/or blood component being input to donor or patient and exporting on one's body from them, and is input to separation equipment and from wherein output.If gather required blood component or part, disposable tubular portion also comprises the plastic containers that are used to collect required blood component or part.Pin, pipe, container and other relevant portion gather together and are sometimes referred to as " disposable fluid treatment pipeline ".
Usually, exist a certain section to cooperate with the peristaltic pump of equipment on the pipe, the function of peristaltic pump is to pass through from pipe to force fluid by extruded tube gradually.Peristaltic pump generally includes the spinner member (rotor) that is driven by motor.The rotation of pump motor drives the rotor extruded tube, and the result extracts and promote blood or blood partly flows through pipe and flows through system.
The automatic blood of market sale separates and the example of gathering system is CS3000 Plus separator and Amicus separator, and the Baxter health care company (Baxter Healthcare Corporation) that these two kinds of separators all are Illinois Deerfield sells.CS3000 Plus separator all is the automatic system of separating and collecting blood component and/or part (as blood plasma, platelet and similar component) with Amicus separator.
The automatic blood of market sale separates and another example of collecting device is an Autopheresis-C separator, and this also is that Baxter health care company sells.Autopheresis-C separator is to be mainly used in to collect hematoblastic automatic system.United States Patent (USP) 5112298 has been described the use automatic system, as Autopheresis-C separator, comprises relevant disposable processing pipeline, and blood separation is become component or method partly, and this patent is as a reference whole at this.
The system of describing in the United States Patent (USP) 5112298 comprises segregation apparatus and the disposable processing pipeline that is contained on this equipment.In this system, extract whole blood by incidental venipuncture needle from the person of donating blood, and be transported to segregation apparatus, whole blood is separated into two parts at this: blood plasma and hemocyte concentrated solution (mixture of erythrocyte, leukocyte and some remaining blood plasma).Isolated blood plasma partly is extracted and is transported to the blood plasma hold-up vessel by a flow channel, and this flow channel is the part of disposable processing pipeline.The hemocyte concentrated solution equally also extracts and is transported to by a flow channel container of independent preserved blood cell concentration liquid from segregation apparatus.Hemocyte concentrate container and blood plasma container all hang on the incidental weigh scale of equipment, are used to measure the gross weight of separating component.
More particularly, weigh scale is used for measuring the weight of (1) empty blood component container (collecting before the component); The weight of container when (2) collecting the blood component; The weight of (when for example, the hemocyte concentrated solution re-enters back donor) container when (3) the hemocyte concentrated solution is discharged from container and after the emptying.Then, the control system of equipment is utilized the various weight of weigh scale record, is used to calculate the flow velocity of pump.When the weight change of the calculating flow velocity of pump and expection is inconsistent, produce alarm signal.
Because the weight of weigh scale record is used to calculate the flow velocity of pump by equipment, therefore to reach required degree of accuracy and accuracy be very important to the weight of record.If container is suspended on the weigh scale, on weigh scale, produce significantly imbalance, will produce the error of weight measurement.Like this, the central vertical shaft complete matching of container and balance is very important.
Moreover with described, disposable processing pipeline also comprises additional in advance fluid container, as saline (electrolyte solution) and anticoagulant as shown in United States Patent (USP) 5112298.Disposable processing pipeline also is included in filter and the bubble trap in the flow channel between segregation apparatus and the cell concentration liquid collection container.
Blood filter and bubble trap are little plastic containers, and an end of this container has an inlet, at the other end of small container two outlets are arranged." filtration " feature of this container is round intake section and extends to internal tank mesh pouch or filter bag are arranged, filter filters out small aggregation and other unwanted material, thus the probability that stops these granules to enter the cell concentration liquid container and turn back to donor.
" bubble is caught " of this container is characterised in that " stand pipe " that extends upward into small container inside, it and outlet fluid communication, and the cell concentration liquid container is led in outlet.Flow through the bottom of the cell concentration drop of " filter ", before flowing into the erythrocyte container downwards, be elevated to the position at stand pipe top to small container.This structure can prevent fully that unusual air bubble (if re-entering the potential very big hazardness of the internal energy generation of donor body) from entering the cell concentration liquid container.
Though said system generally can both be worked satisfactorily, but still need further to improve and further simplified system, fluid circuit and method.For example, although above-mentioned blood filter/bubble container for capturing can be removed fully or the air bubble of catching exception, overflow or the air bubble that forms bubble trap can be trapped on the fragment of handling pipeline from catcher sometimes.Air bubble finally may enter into the defeated again intravital pipeline of donor of getting back to of a kind of separating part (for example cell concentration liquid).This will trigger audio alarm, cause the termination of separation process.
Summary of the invention
Piece-rate system of the present invention and disposable processing pipeline have been done the improvement of several aspects to existing systems and fluid treatment pipeline.Piece-rate system of the present invention is more economical with relevant disposable processing pipeline manufacturing, and has reduced operator's installation time.In addition, piece-rate system of the present invention, disposable processing pipeline and method have higher degree of accuracy and feasibility aspect weighing, and have reduced the danger that has air bubble in the system.
Therefore, a feature of the present invention is, a kind of disposable fluid treatment pipeline is provided, and it comprises the pin that inserts the biofluid source, fluid is separated into the segregation apparatus of two or more parts and connects pin and segregation apparatus is used for fluid is transported to from the source flow channel of segregation apparatus.Disposable processing pipeline also comprises first and second fluid collecting containers and first and second flow channels that connect the segregation apparatus and first and second containers.A container in these containers includes an inlet and an outlet, and the filter that links to each other with inlet.
The present invention another more particularly feature be that entrance and exit all is positioned at the same end of container, and the two distance of leaving the container center vertical axis equates.According to another feature, entrance and exit is positioned at the relative end of container, and preferably the two all is positioned on the central vertical axis of container.
The invention still further relates to biofluid is separated into two-part at least piece-rate system.Piece-rate system comprises the disposable fluid treatment pipeline that links to each other with segregation apparatus.As mentioned above, disposable fluid treatment pipeline comprises the pin that inserts the biofluid source and connects pin and segregation apparatus is used for fluid is transported to from the source flow channel of segregation apparatus.One of them container comprises independent entrance and exit, and the filter that links to each other with inlet.Separation equipment comprises the weigh scale that keeps container.Container is suspended on the weigh scale, and container is positioned on the central vertical axis of weigh scale.
According to a feature of the present invention, container can hang on the same arm of weigh scale.According to another feature, container interconnects, one of them container by adapter directly hang over another container below.
According to a feature of the present invention, container is positioned on the same central vertical axis of weigh scale.According to another feature, the central axis of following surface vessel aligns with the central axis of last surface vessel.
The invention still further relates to biofluid is separated into two-part at least method.The biofluid source that provides is provided the method, and the biofluid source is connected to segregation apparatus, makes biofluid from the source inflow separation device.The method also is included in and biofluid is separated into first and second parts in the segregation apparatus, and first part is shifted out and collect first first container from segregation apparatus.First container comprises inlet, outlet and the filter that links to each other with inlet.In addition, the method also comprises second portion is shifted out and collect second portion second container from segregation apparatus.The method comprises the weight of first and second parts of measurement collection in container, then first component is shifted out and it is turned back to the biofluid source from first container.
According to a feature of the present invention, the biofluid source is the people that donates blood, and blood partly comprises erythrocyte and blood plasma.According to another feature, the present invention includes first and second containers are suspended on the weigh scale, container is positioned on the vertical axis of weigh scale.
Description of drawings
Fig. 1 is the sketch map of piece-rate system of the present invention;
Fig. 2 is the plane graph of disposable fluid treatment pipeline of the present invention;
Fig. 2 A is the enlarged drawing that disposable fluid treatment pipeline connects the venipuncture needle part;
Fig. 3 is the axonometric chart of system of the present invention, comprises separation equipment that disposable fluid treatment pipeline is housed and the container that is suspended on the equipment;
Fig. 3 A is the partial perspective view that is suspended on another embodiment of the container on the separation equipment weigh scale;
Fig. 3 B is the partial perspective view that is suspended on another embodiment of the container on the separation equipment weigh scale;
Fig. 4 is the axonometric chart of container, comprises inlet, exports and be contained in the filter on the inlet;
Fig. 5 is another axonometric chart that has inlet, exports and be contained in the container embodiments of the filter on the inlet.
Embodiment
Referring to accompanying drawing, Fig. 1 is the sketch map of piece-rate system of the present invention.Piece-rate system comprises disposable processing pipeline 10 shown in Figure 2, and it is only as disposable use, and is contained on the reusable separation equipment 60, as shown in Figure 3.
Usually, as shown in Figure 1, disposable processing pipeline 10 comprises venipuncture needle 12, and it is connecting the pipe 13 of certain-length.Venipuncture needle 12 also can be connected to pipe 13 with standard road Er Shi joint 13a (as shown in Figure 2) or other removable joint, and is the same as well known in the skilled person.The operator can be connected to disposable processing pipeline to pin by road Er Shi joint 13a with cooperating of venipuncture needle 12 ends before separation process just will begin.In addition, venipuncture needle 12 also can when assembling by needle tubing 13 directly " pre-in conjunction with " to managing 18 joint (as " Y " shape joint) upward (Fig. 3) and permanently be connected on the pipe.This embodiment has simplified the user and has used the processing pipeline, has also reduced and relevant assembling, packing and the disinfectant cost of manufacturing processing pipeline.In addition, by usually eliminating and the relevant stagnant wake of Er Shi joint, road, the pin of " pre-in conjunction with " also can improve anticoagulation and the blood flow by pipe.By using solvent combination or other combination technology known in those skilled in the art of Ketohexamethylene, can realize the combination of pin 12.
This disposable fluid treatment pipeline 10 generally includes the source of anticoagulant, and for example the anticoagulant container 16.Pipe 17 provides anticoagulant has been transported to the flow channel of Y point 14 (being sometimes referred to as mixing chamber) from container 16, mixes with the whole blood of taking out on one's body from donor by venipuncture needle 12 at this anticoagulant.The pipe 18 of certain-length provides the whole blood that is mixed with anticoagulant by 21 flow channels that are transported to segregation apparatus 20 that enter the mouth.
In the inside of segregation apparatus 20, separation of whole blood is become required part.In one embodiment, segregation apparatus becomes blood plasma and hemocyte concentrated solution to the separation of whole blood that is mixed with anticoagulant, and the hemocyte concentrated solution comprises erythrocyte, leukocyte and platelet.Segregation apparatus 20 can be according to centrifugal principle, and the power that wherein centrifugal rotation produces is separated the less part of bigger part of density and density; Perhaps according to membrance separation, such a device comprises the film of rotating room and separating part or component.Provided the isolating example that uses this chamber and film in the United States Patent (USP) 5738792, this patent at this as a reference.
Illustrated segregation apparatus 20 comprises the outlet 22 of flowing out isolating blood plasma.Outlet 22 and pipeline 24 fluid communication are used for isolating blood plasma is transported to plasma collection container 26.Plasma collection container 26 can be connected to pipeline 10 in advance, perhaps also can, be connected to road Er Shi joint 27 in use, generally as shown in Figure 2.Segregation apparatus 20 can comprise another one outlet 28, links to each other with pipeline 30, is used for isolating hemocyte concentrated solution is transported to cell concentration liquid collection container 32 from segregation apparatus 20.
Disposable fluid treatment pipeline shown in Figure 2 also comprises prong 19 and 53, is used for setting up the fluid passage with anticoagulant container 16 and selectable saline container 50 (being described below).Disposable fluid treatment pipeline also comprises disinfection protection cover 19a and 53a (lid), takes from prong 19 and 53 before using.Pipe 41 and 43 in addition ends at road Er Shi joint 47 and 49, can be used for measuring the pressure in the pipeline 10.The details of vein pressure reformer line 41 and transmembrane reformer line 43 has been described in the United States Patent (USP) 5112298.
As schematically (more conventional see Fig. 3) shown in Figure 1, piece-rate system of the present invention, the use that combines of particularly disposable processing pipeline 10 and separation equipment 60.Separation equipment 60 comprises that three or more peristaltic pumps is transported to segregation apparatus 20 to whole blood and/or separated portions, or from segregation apparatus 20 outputs.Pump 34 is transported to segregation apparatus 20 to the whole blood that is mixed with anticoagulant from donor.Pump 36 is transported to mixing point or chamber 14 to anticoagulant from container 16, and anticoagulant mixes with the whole blood of taking out on one's body from donor at this.Pump 38 is extracted the isolated cells concentrated solution out and it is transported to collection container 32 from segregation apparatus 20.
Except the peristaltic pump of pumping fluid, piece-rate system also comprises valve, is used for optionally opening or closing the flow channel between disposable processing pipeline 10 each several parts.Valve is connected on the reusable separation equipment 60 (Fig. 3), and it acts on and is used to close (for example by clamping) on the pipe or opens (by discharging) pipe.As shown in figures 1 and 3, blood valve 40 is positioned on the pipe 18, is used for optionally making when needed blood to flow through or limit blood therefrom flows through from managing 18.Same, valve 62 optionally opens or closes, so that blood flows to donor from container 32 (by managing 33).Blood plasma valve 44 is positioned on the pipe 24, optionally makes blood flow to blood plasma container 26.The work of computer based apparatus control system autocontrol valve and pump, control system are generally by reference number 100 expressions.
Disposable fluid treatment pipeline of the present invention does not use the type of the blood filter that separates/bubble container for capturing of describing in the United States Patent (USP) 5112298.As mentioned above, to catch air bubble before the hemocyte collection container generally be effectively though this structure arrives for bubble, and air bubble is trapped in the flow channel between bubble trap and the collection container sometimes.When the hemocyte concentrated solution is defeated again when getting back in the donor body, in hemocyte concentrated solution flow process, must flow through identical flow channel and reach pipeline, get back in the donor body by this pipeline hemocyte concentrated solution is defeated again.Like this, these air bubbles can be forced to and enter into the pipeline of failing back again.Equipment 60 can detect the existence of air bubble, triggers audible alarm, and ends the blood transfusion process fully before air bubble arrives donor.
According to the present invention, comprise the independently hemocyte concentrated solution collection container 32 of entrance and exit by providing, and have the blood component to turn back to donor be not the fluid circuit of feature that flows into the pipeline of container by the hemocyte concentrated solution by providing, this problem can be avoided fully.Like this, container 32 not only is used to adorn isolating hemocyte concentrated solution as collection container, and as blood filter/bubble trap.Therefore, the air bubble that enters in the pipeline can not be imported in the donor body again.Inlet 80 and, more particularly, outlet 82 " bottoms " that are placed on container also can guarantee can not be input to donor at the inner air bubbles that form of container 32 (blood enter turbulent flow that internal tank forms cause).
The method according to this invention is extracted whole blood by venipuncture needle 12 out from donor, mixes at mixing chamber 14 with anticoagulant in the container 16.Open valve 40, pump 34 the whole blood that is mixed with anticoagulant by managing 18 inlets that are transported to segregation apparatus 20.If used saline source, valve 48 is in closed condition at this moment.
Along with whole blood enters segregation apparatus 20, it is separated into its ingredient: blood plasma and hemocyte concentrated solution.Isolating blood plasma flows out from segregation apparatus 20 by outlet 22, by manage 24 and inlet 27 be transported to container 26 (this moment, valve 44 was in open mode); On the other hand, blood plasma flows out segregation apparatus 20 from exporting 28, pumps to container 32 with pump 38 by managing 20.Valve 62 keeps closed condition (as shown in Figure 1).When container 32 was full of the hemocyte concentrated solution, its weight reached a specific preset value, and control system 100 is opened valve 62, made pump 34 reverse rotations, extracted the hemocyte concentrated solution from container 32 out by pipe 33, turned back in the donor body by pin 12.
Shown in Fig. 3 A and 3B, separation equipment 60 comprises weigh scale 64.Weigh scale 64 comprises balance arm 61, and container 32 and 26 is suspended on above it.As described in detail in the United States Patent (USP) 5112298, the weight of container is measured and monitored to separable programming, to guarantee the suitable extracorporeal blood volume that flows through disposable processing pipeline and keep permission.
Briefly, the work of weigh scale and separator control system is as described below: weighing for the first time is the weight of measuring empty, writes down and store this weight.After blood component in container 32 and 26 had been collected, record also stored the value of weighing for the second time.When the hemocyte concentrated solution when container 32 is taken away, weigh again (being the weight of container 32 and the weight of container 26) of record weigh scale.These weigh value record in the control system of equipment, and according to the expection weight contrast of the velocity variations of pump and be used to calculate the flowing velocity of new pump.Also can regulate the speed of pump according to the flowing velocity of new calculating.
The weight of weighing device record can be continuously or is used to monitor blood component mobile by disposable processing pipeline periodically.The gravimetric value contrast of weight that is monitored or weight change and expection, the gravimetric value of expection is to make according to the desired flow of used pump.For example, when the hemocyte concentrated solution is defeated again when getting back to donor,, then trigger warning devices, the indication mechanism fault if when finding that the weight that monitored or weight change exceed so-called expection weight permissible value.In this case, stop separation process.
In one embodiment of the invention, as shown in Figure 3, container 32 and 26 is hung on weigh scale arm 68 and 66.Weigh scale arm 66 and 68 generally can make the weight of two containers be applied on the balance on fulcrum 70.
Shown in Fig. 3 B, container 32 is suspended on the container 26, and vice versa, and the container on top directly hangs on the balance arm 61.By placing the otch on adapter 76 and the container edge, container 32 hangs on the container 26.As the embodiment shown in Fig. 3 A, this arrangement guarantees that also container is on the central vertical axis of weigh scale.
Fig. 4 and Fig. 5 show hemocyte container 32 additional embodiments.Container 32 (also can be container 26) can be made by traditional material, and these materials normally are used to make the medical bag that stores biofluid. Container 32 and 26 also can be made by that be fit to, flexible thermoplastic thin slice, and these materials can use radio frequency (RF) to seal along the periphery of thin slice.The polrvinyl chloride (PVC) that is combined with plasticizer such as DEHP, TEHTM, citrate, epoxidised oil or their mixture is exactly a kind of such a material.In one embodiment, container 32 and 26 is to use by main plasticizer such as DEHP and less important plasticizer such as the plastifying PVC of epoxidised oil to make. Container 32 and 26 should have enough deformabilities, so that container can expand when being full of.Such container can obtain from Baxter health care company, and its material trademark is PL-1813.Entrance and exit is made by same material.
As shown in Figure 4 and Figure 5, container 32 is used to collect the hemocyte concentrated solution, and it comprises two openings: inlet 80 and outlet 82.As shown in Figure 4, the end that inlet 80 and outlet 82 all are positioned at container 32, the distance of leaving the centrage of container 32 or central vertical axis is identical.As shown in Figure 3, outlet 82 links to each other with the pipe 33 of fluid treatment pipeline and to be used to return donor.Opening 80 is identical with the material of making container 32 and 26 with 82 manufactured materials.
According to a principal character of the present invention, inlet 80 also comprises filter, is used for removing undesired material such as little aggregation from the hemocyte concentrated solution.Here employed term " filter " is meant traditional screen cloth, fiber or non-fibrous membrane and removes material or the materials similar of not wanting material by absorbing.In a preferred embodiment, filter is the mesh bag of being made by polyester, nylon or other fine fibre material 90.The mesh size of mesh bag 90 is about 220 microns.This polyester material can obtain from the Sefar AG company of Sweden Ruschlikon.
The making of mesh bag 90 can allow end 90d open wide earlier with two selected materials along side 90a-c seal perimeter.In addition, the making of mesh bag also can be used one piece material, folds earlier and seals side 90b and 90c again, allows end 90d open wide earlier.Under any circumstance, opening end is enclosed within on the inlet 80.Periphery sealing 95 sealings and maintenance opening end 90d by container 32.
Fig. 5 represents another embodiment of container 32.In this embodiment, inlet 80 is positioned at the relative two ends of container with outlet 82.For example, inlet 80 is placed on " top " of container, and mesh bag 90 surrounds inlet.Outlet 82 is placed on " bottom " of container.Can be used for the hemocyte concentrated solution is failed back donor again with managing the pipe 33 that the outlet among Fig. 5 82 is connected to disposable processing pipeline.
As mentioned above, except as the collection container dress hemocyte concentrated solution, according to the present invention, container 32 also can guarantee the hemocyte concentrated solution or manage unusual air bubble in 30 and can not fail again and get back to donor.For example, in the container 32 of Fig. 4, " bottom " that inlet 80 and outlet 82 all are positioned at container 32 do not have turbulent flow here, so the hemocyte concentrated solution does not splash when entering container.So, can not form air bubble.Under any circumstance because buoyancy, any air bubble will on float to the hemocyte concentrated solution collected in the container 32 above, before entering outlet 82, dissipate or explosion.
In Fig. 5, although the hemocyte concentrated solution drops onto in the container 32, in fact air bubble also will on float to blood in the container 32 above, can guarantee that also air bubble can not import or carry back donor.In addition, no matter be to use container among Fig. 4, the still container among Fig. 5, because the hemocyte concentrated solution flows out (directly with pipe 30 fluid communication) from independent outlet and independent pipe 33, the unusual air bubble of managing in 30 has no chance to be input to donor.
Like this, when collection container 32 is removed air bubble as container dress hemocyte concentrated solution and catcher, just no longer need independent bubble trap/filter in the pipe of disposable processing pipeline 10, for example shown in the United States Patent (USP) 5112298.Remove independent bubble trap/filter, between separator 20 and container 32, set up direct flow channel, for example, just easy deaeration during being full of pipe.This also makes disposable processing pipeline simpler, more economical when assembling.
With other existing piece-rate system ratio, use the container 32 of collecting the hemocyte concentrated solution to also have additional advantage: can reach the different volume of control.At present, some piece-rate system comprises the hemocyte concentrated solution bin of fixed volume, is used to adorn the hemocyte concentrated solution.Have and depend on the bin that begins to fail back certain the volumetrical fixed volume that reaches, if the body weight of donor is low or the hemocyte capacity is low, reach target volume just needs big extracorporeal blood volume, and this is undesirable.Therefore, preferably, should as body weight or hemocyte capacity, change the total extracorporeal blood volume that is allowed according to the feature of certain donor, and the container that adapts to different donors is provided.Use container 32, can adjust the extracorporeal blood volume for different donors.Therefore, container 32 can be the maximum volume (as 300ml) that allows, in control software, can stipulate any less than greater than or comprise this peaked volume.According to the feature of each donor,, rather than, regulate the extracorporeal blood volume of each donor according to target volume as body weight and hemocyte capacity.
Invention has been described according to the preferred embodiment of the invention, just, and the disposable processing pipeline that the present invention relates to piece-rate system and in separation, use.But the present invention is not limited to foregoing description, and comprises all modifications in the claims scope.
Claims (28)
1. disposable fluid treatment pipeline comprises:
Insert the pin in biofluid source, described fluid is separated into the segregation apparatus of two or more components and connects described pin and described segregation apparatus is used for described fluid is transported to from the source flow channel of described segregation apparatus;
First and second fluid collecting containers and connect described segregation apparatus and first and second flow channels of described first and second containers;
It is characterized in that at least one described container includes an inlet and an outlet, and the filter that links to each other with described inlet.
2. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that described inlet and described outlet are positioned at the relative end of described container.
3. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that described inlet and described outlet are positioned at the same end of described container, and the two distance of leaving described container center vertical axis equates.
4. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that described filter comprises mesh bag.
5. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that when described container connects the central axis of described first and second containers being alignd substantially.
6. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that also comprising the 3rd container of adorning electrolyte solution and the flow channel that described the 3rd container is connected with the described flow channel that is connected described pin and described segregation apparatus.
7. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that described pin can be connected on the described flow channel.
8. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that described pin can not be connected on the described flow channel with removing.
9. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that described segregation apparatus comprises rotatable chamber and the semipermeable membrane relevant with described chamber.
10. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that also comprising the flow channel that connects described container outlet and described pin.
11. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that described outlet is connected with a flow channel, is not direct flow communication between this flow channel and the described flow channel that is connected described segregation apparatus and described collection container.
12. disposable fluid treatment pipeline as claimed in claim 1 is characterized in that described collection container comprises the catcher of catching air bubble.
13. one kind is separated into the piece-rate system of at least two kinds of components to biofluid, it comprises the disposable fluid treatment pipeline that is connected with separation equipment:
(a) described disposable fluid treatment pipeline comprises:
Insert the pin in biofluid source, described fluid is separated into the segregation apparatus of two or more components and connects described pin and described segregation apparatus is used for described fluid is transported to from the source flow channel of described segregation apparatus;
It is characterized in that at least one described container includes an inlet and an outlet, and the filter that links to each other with described inlet;
(b) described separation equipment comprises the weigh scale that keeps described container, it is characterized in that described container is suspended on the described weigh scale, and described container is alignd with the central vertical axis of described weigh scale substantially.
14. piece-rate system as claimed in claim 13 is characterized in that described weigh scale comprises two arms that are supported on the fulcrum, each described container is suspended on respectively on the described arm.
15. piece-rate system as claimed in claim 13 is characterized in that two described containers all are suspended on the same arm of described weigh scale.
16. piece-rate system as claimed in claim 13 is characterized in that described container interconnects.
17. piece-rate system as claimed in claim 16 is characterized in that a described container is suspended on the below of another described container by adapter.
18. piece-rate system as claimed in claim 17 is characterized in that the described container that is suspended on another described container below comprises described inlet, outlet and described filter.
19. piece-rate system as claimed in claim 17 is characterized in that the central axis of the container of described below aligns with the central axis of the container of described top.
20. piece-rate system as claimed in claim 13 is characterized in that described disposable fluid circuit also comprises the flow channel that connects described container outlet and described pin.
21. piece-rate system as claimed in claim 13 is characterized in that described separation equipment comprises the device that rotates described segregation apparatus.
22. one kind is separated into two-part at least method to biofluid, comprising:
(a) provide described biofluid source;
(b) the described source of described biofluid is connected to segregation apparatus;
(c) described biofluid is communicated with into described segregation apparatus from described source;
(d) in described segregation apparatus, described biofluid is separated into first and second portion;
(e) described first component is shifted out and collect described first from described segregation apparatus first container, described first container comprises inlet, outlet and the filter that links to each other with described inlet;
(f) described second portion is shifted out and collects described second portion from described segregation apparatus second container;
(g) weight of first and second parts of measurement collection in described container; And
(h) described first is shifted out and it is turned back to described biofluid source from described first container.
23. method as claimed in claim 22 is characterized in that described biofluid source comprises the people that donates blood.
24. method as claimed in claim 22 is characterized in that described biofluid comprises whole blood, described first comprises erythrocyte, and described second portion comprises blood plasma.
25. method as claimed in claim 22 is characterized in that comprising the weight of measuring described blood part by weighing.
26. method as claimed in claim 22 is characterized in that comprising described first and second containers are suspended on the weigh scale.
27. method as claimed in claim 26 is characterized in that comprising described first container is hung on described second container.
28. method as claimed in claim 26 is characterized in that comprising when hanging described first and second containers it is alignd with the central vertical axis of described weigh scale substantially.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71827000A | 2000-11-22 | 2000-11-22 | |
| US09/718,270 | 2000-11-22 |
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| Publication Number | Publication Date |
|---|---|
| CN1354021A true CN1354021A (en) | 2002-06-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01120426 Pending CN1354021A (en) | 2000-11-22 | 2001-07-12 | Disposable fluid treatment pipeline and separation system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105120912A (en) * | 2013-04-05 | 2015-12-02 | 泰尔茂株式会社 | Blood bag system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105120912A (en) * | 2013-04-05 | 2015-12-02 | 泰尔茂株式会社 | Blood bag system |
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