CN1354010A - Shuangjinlian oral liquid for curing cold and influenza, and its preparing method - Google Patents
Shuangjinlian oral liquid for curing cold and influenza, and its preparing method Download PDFInfo
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- CN1354010A CN1354010A CN 01138245 CN01138245A CN1354010A CN 1354010 A CN1354010 A CN 1354010A CN 01138245 CN01138245 CN 01138245 CN 01138245 A CN01138245 A CN 01138245A CN 1354010 A CN1354010 A CN 1354010A
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Abstract
The present invention relates to a Chinese medicine Shuangjinlian oral liquor for curing common-cold and epidemic influenza and its preparation method. It is characterized by that the medicine is prepared by using (wt%) lonicera flower 10-40%, globeflower 10-25%, scutellaria root 10-25%, forsythia fruit 20-40% and bupleurum root 15-30%. The oral liquor possesses the advantages of high effective component contents, inhibiting several influenza viruses and several pathogenic bacteria, quick abatement of fever, stopping pain and relieving cough, etc.
Description
(1) technical field:
The present invention relates to field of medicaments, relate to a kind of Shuangjinlian oral liquid that is used for the treatment of flu, influenza and preparation method thereof specifically.
(2) background technology:
Influenza, flu are common, multiple and the epidemic disease very harmful to the mankind, and Zui Da once global influenza great outburst once caused more than 3,000 ten thousand people's death in history, was equivalent to the death toll of a world war.The generation of influenza is many because of due to the influenza virus, and it is few to be used for the treatment of the influenza virus specific medicament in the world today.Western medicine class medicine of the prior art mostly is the medicine that slows down disease, and the amantadine that can play therapeutical effect can not be applicable because of its cost is too high.Though generally the antipyretic-antalgic class medicine of Shi Yonging can play the malaise symptoms such as caused heating, pain, cough of falling ill and slow down effect, does not play therapeutical effect, as the saying goes: do not take medicine 7 days good, eaten medicine also need 7 days good.In the past few years, China approved several new drugs that are used for the treatment of influenza, flu, as SHUANGHUANGLIAN KOUFUYE, QINGRE JIEDU KOUFUYE etc., because this type of medicine has stronger inhibitory action to influenza virus, except that can slowing down the symptom, and can shorten healing time, play the effect for the treatment of both the principal and secondary aspects of a disease, and have no side effect, be subjected to patient and medical personnel's welcome deeply.But compare the weak point that also existence is brought down a fever, pain relieving is slower with Western medicine class medicine.Above-mentioned in addition oral liquid also exists the too much problem of bigger, the disposable oral consumption of dose in the prescription, makes troubles to the patient.
(3) summary of the invention:
Purpose of the present invention provides at above-mentioned weak point of the prior art just that a kind of active constituent content height and recipe quantity are little, fast, the analgesic effect of bringing down a fever significantly is used for the treatment of Shuangjinlian oral liquid of flu, influenza and preparation method thereof.
Purpose of the present invention can adopt following measure to realize:
The Shuangjinlian oral liquid that is used for the treatment of flu, influenza of the present invention, it is the medicine that is prepared from by following raw material (weight ratio), Flos Lonicerae 10-40% wherein, Flos Trollii 10-25%, Radix Scutellariae 10-25%, Fructus Forsythiae 20-40%, Radix Bupleuri 15-30%.
The preparation method of Shuangjinlian oral liquid of the present invention comprises following technical process:
A, filter with Flos Lonicerae, Flos Trollii, Fructus Forsythiae, the superfine grinding of Radix Bupleuri four Chinese medicine material and through＞300 purpose dusting covers, go into jar in temperature is 50-60 ℃ water, soak 1.5-2 hour after, medicinal liquid is through the pump dynamic low temperature extraction that circulates, it is that 50-60 ℃ hydrodynamic(al) attitude was soaked after 1.5-2 hour that the medicinal liquid that extracts adds temperature again, merges to decoct, filter; When being cooled to 50-60 ℃, after under vacuum condition, being concentrated into relative density and being 1.20-1.25 (surveying under the 70-80 ℃ of condition), treat slowly to add when medicinal liquid is cooled to 35-40 ℃ ethanol again, make to contain when the alcohol amount reaches 65-70% and fully stir, after leaving standstill 12-14 hour, get supernatant, decompression recycling ethanol is to there not being the alcohol flavor, and is standby;
B, with Radix Scutellariae section, decoct with water 1.5-2 hour for the first time three times, each 1-1.5 of second and third time hour, merging decoction liquor, filtration, concentrated filtrate, and in the time of 75-85 ℃, add hydrochloric acid solution, adjusting ph value to 1.0-2.0, be incubated 1-1.5 hour, left standstill 12-14 hour, inhale and remove supernatant, treat post precipitation, with 90-100 ℃ of washing, when ph value to 4, the ethanol of reuse 90%-95% is washed till neutrality, left standstill 12-14 hour, and inhaled and remove supernatant, standby behind the precipitate centrifuge dripping;
C, b is added among a, it is an amount of to add water, regulate the ph value to 6.5-7.0, back under 4-8 ℃ cryogenic conditions cold preservation 24-48 hour stirs, get supernatant afterwards, the filtration back adds correctives, essence is an amount of, and its ph value is adjusted to the setting of 6.5-7, add water to the full dose of required preparation, be finished product after the after-filtration that stirs, fill, the sterilization.
Shuangjinlian oral liquid of the present invention also can adopt following preparation method to produce, and it comprises following technical process:
A, Flos Lonicerae, Flos Trollii, Radix Scutellariae, Fructus Forsythiae four Chinese medicine are decocted with water 2-3 time, each 40-80 minute, filter, afterwards merging filtrate, left standstill 12-14 hour; Get the macroporous resin column absorption of the achromatism and clarity of filtrate supernatant through anticipating, discard cleanout fluid, the ethanol elution of reuse 80%-85% when yellow alcoholic solution flows out, begins to collect eluent to not containing till the baicalin; Reclaim ethanol afterwards, to be concentrated into fluid extract standby;
B, extract Radix Bupleuri volatile oil: Radix Bupleuri dry powder is dropped in the extraction kettle, to extraction kettle, extraction-container I, extraction-container II, storage tank heats respectively or cools off, when the extraction kettle temperature reaches 30-35 ℃, extraction-container I temperature reaches 60-65 ℃, when extraction-container II temperature reaches 40-45 ℃, opening dioxide bottle pressurizes to system, when extraction kettle pressure reaches 20-21Mpa, extraction-container I pressure reaches 12-12.5Mpa, when extraction-container II pressure reaches 6-6.5Mpa, close gas cylinder, cycling extraction 3-5 hour, carbon dioxide flow is 0.8-1kg/h, material flow is 10-20kg/h, keeps constant temperature and pressure; Extraction goes out raw material from extraction-container I, II discharging opening after finishing, and obtains Radix Bupleuri volatile oil;
C, extract the saikoside crude product: the Radix Bupleuri dry powder and the entrainer that will extract Radix Bupleuri volatile oil drop in the extraction kettle, entrainer is the ethanol of 55%-65%, to extraction kettle, extraction-container I, extraction-container II, storage tank heats respectively or cools off, when the extraction kettle temperature reaches 60-65 ℃, extraction-container I temperature reaches 55-60 ℃, when extraction-container II temperature reaches 40-45 ℃, opening dioxide bottle pressurizes to system, when extraction kettle pressure reaches 25-30Mpa, extraction-container I pressure reaches 12-12.5Mpa, when extraction-container II pressure reaches 6-6.5Mpa, close gas cylinder, cycling extraction 3-5 hour, carbon dioxide flow is 0.8-1kg/h, material flow is 10-20kg/h, keeps constant temperature and pressure; Extraction goes out raw material from extraction-container I, II discharging opening after finishing, and obtains containing the ethanol liquid of saikoside, and it is standby to reclaim ethanol;
D, the extract in a, the c technical process is merged, adds water and regulate the ph value to 6.5-7.0, the back under 4-8 ℃ cryogenic conditions cold preservation 8-12 hour of stirring, after the filtration filtrate; Mix with filtration back gained filtrate after again the extract in the b technical process being added an amount of cosolvent, add correctives, essence is an amount of, and its ph value is adjusted to the setting of 6.5-7, and add water to the full dose of required preparation, be finished product after the after-filtration that stirs, fill, the sterilization.
Be monarch drug with the strong Fructus Forsythiae of antipyretic and antidote functions in the prescription of the present invention, minister is with Flos Lonicerae (Flos Lonicerae), Radix Scutellariae two flavor heat-clearing and toxic substances removing medical materials again, make its heat-clearing and toxic substances removing effect better, modern medicine study proves, Fructus Forsythiae, Flos Lonicerae, Radix Scutellariae are except that having antipyretic and antidote functions, the effect that also has multiple virus of stronger inhibition and pathogenic bacteria, triplicity can make the effect that suppresses multiple virus and pathogenic bacteria stronger.The main effect of the Radix Bupleuri in the prescription is for the rate cold is induced sweat, heat-clearing and toxic substances removing, for treatment influenza, catch cold remove heat, analgesia is fast and effect is obvious; Flos Trollii also belongs to the antipyretic and antidotal type medical material, and modern medicine study proves that it is brought down a fever, the effect of cough-relieving, treatment pharyngalgia is quite outstanding, and famous pharmacologist professor Li Lianda finds that also it also has stronger antivirus action; In the prescription assistant can make with Radix Bupleuri and Flos Trollii bring down a fever, the effect of analgesia is more quick, definitely.
The present invention not only has the active constituent content height compared to existing technology, recipe quantity is little, can suppress the effect of multiple influenza virus and the multiple pathogenic bacteria of inhibition; The present invention simultaneously also have bring down a fever fast, analgesia, the tangible advantage of cough suppressing effect.One hour promptly begins to bring down a fever after the clinical trial patient takes medicine of the present invention, can reach normal body temperature after 7 hours, and analgesia, cough suppressing effect are obvious, can compare U.S. with the ntipyretic analgesic medicine in the Western medicine, and the effect for the treatment of both the principal and secondary aspects of a disease obviously are better than Western medicine.
(4) specific embodiment:
The present invention does with detailed description below with reference to embodiment:
Embodiment 1:
Present embodiment adopts following proportioning and processing step to realize:
A, by weight with Flos Lonicerae 30%, Flos Trollii 15%, Fructus Forsythiae 30%, Radix Bupleuri 15% four Chinese medicine material superfine grinding and warp＞300 purpose dusting covers filter, the water of putting into temperature and be 60 ℃ soaked after 2 hours, medicinal liquid is through the pump dynamic extraction that circulates, it is that 60 ℃ hydrodynamic(al) attitude is soaked to merge after 1.5 hours and decocted that the medicinal liquid that extracts adds temperature again, filter, after under vacuum condition, being concentrated into relative density when being cooled to 60 ℃ and being 1.20 (surveying under 80 ℃ of conditions), treat slowly to add when medicinal liquid is cooled to 40 ℃ ethanol again, making the alcohol amount of containing reach at 70% o'clock fully stirs, after leaving standstill 12 hours, get supernatant, decompression recycling ethanol is to there not being the alcohol flavor, and is standby;
B, with Radix Scutellariae 10% section, decoct with water 2 hours for the first time three times, second and third time each 1 hour, merging decoction liquor, filtration, concentrated filtrate, and in the time of 80 ℃, add hydrochloric acid solution, adjusting ph value to 1.5, be incubated 1 hour, left standstill 12 hours, inhale and remove supernatant, treat post precipitation, with 100 ℃ of washings, when ph value to 4, the ethanol of reuse 95% is washed till neutrality, left standstill 12 hours, and inhaled and remove supernatant, standby behind the precipitate centrifuge dripping;
C, b is added among a, it is an amount of to add water, regulate ph value to 6.7, back cold preservation 26 hours under 4 ℃ cryogenic conditions stirs, get supernatant afterwards, the filtration back adds correctives, essence is an amount of, and its ph value is adjusted to 6.7, add water to the full dose of required preparation, be finished product after the after-filtration that stirs, fill, the sterilization.
Embodiment 2:
Present embodiment adopts following proportioning and processing step to realize:
A, by weight with Flos Lonicerae 25%, Flos Trollii 15%, Fructus Forsythiae 25%, Radix Bupleuri 20% four Chinese medicine material superfine grinding and warp＞300 purpose dusting covers filter, the water of putting into temperature and be 55 ℃ soaked after 2 hours, medicinal liquid is through the pump dynamic extraction that circulates, it is that 60 ℃ hydrodynamic(al) attitude is soaked to merge after 1.5 hours and decocted that the medicinal liquid that extracts adds temperature again, filter, after under vacuum condition, being concentrated into relative density when being cooled to 60 ℃ and being 1.22 (surveying under 80 ℃ of conditions), treat slowly to add when medicinal liquid is cooled to 35 ℃ ethanol again, making the alcohol amount of containing reach at 70% o'clock fully stirs, after leaving standstill 14 hours, get supernatant, decompression recycling ethanol is to there not being the alcohol flavor, and is standby;
B, with Radix Scutellariae 15% section, decoct with water 2 hours for the first time three times, second and third time each 1 hour, merging decoction liquor, filtration, concentrated filtrate, and in the time of 80 ℃, add hydrochloric acid solution, adjusting ph value to 1.7, be incubated 1.5 hours, left standstill 10 hours, inhale and remove supernatant, treat post precipitation, with 100 ℃ of washings, when ph value to 4, the ethanol of reuse 95% is washed till neutrality, left standstill 12 hours, and inhaled and remove supernatant, standby behind the precipitate centrifuge dripping;
C, b is added among a, it is an amount of to add water, regulate ph value to 6.7, back cold preservation 36 hours under 6 ℃ cryogenic conditions stirs, get supernatant afterwards, the filtration back adds correctives, essence is an amount of, and its ph value is adjusted to 6.7, add water to the full dose of required preparation, be finished product after the after-filtration that stirs, fill, the sterilization.
Embodiment 3:
Present embodiment adopts following proportioning and processing step to realize: the advantage of this preparation method is effective ingredient purity height, and is easily in line with international standards, easy registration sales abroad, but cost is higher.
A, by weight Flos Lonicerae 25%, Flos Trollii 20%, Radix Scutellariae 20%, Fructus Forsythiae 20% four Chinese medicine are decocted with water 2 times, each 60 minutes, filter, afterwards merging filtrate, left standstill 12 hours; Get the macroporous resin column absorption (flow velocity 5ml/min) of the achromatism and clarity of filtrate supernatant through anticipating, discard cleanout fluid, the ethanol elution of reuse 85% when yellow alcoholic solution flows out, begins to collect eluent to not containing till the baicalin; Reclaim ethanol afterwards, to be concentrated into fluid extract standby;
B, extraction Radix Bupleuri volatile oil: Radix Bupleuri 15% (by weight) dry powder is dropped in the extraction kettle, to extraction kettle, extraction-container I, extraction-container II, storage tank heats respectively or cool off, reach 65 ℃ when the extraction kettle temperature reaches 30 ℃, extraction-container I temperature, when extraction-container II temperature reaches 40 ℃, opening dioxide bottle pressurizes to system, reach 12Mpa when extraction kettle pressure reaches 20Mpa, extraction-container I pressure, when extraction-container II pressure reaches 6Mpa, close gas cylinder, cycling extraction 4 hours, carbon dioxide flow is 1kg/h, material flow is 10-20kg/h, keeps constant temperature and pressure; Extraction goes out raw material from extraction-container I, II discharging opening after finishing, and obtains Radix Bupleuri volatile oil;
C, extract the saikoside crude product: the Radix Bupleuri dry powder and the entrainer that will extract Radix Bupleuri volatile oil drop in the extraction kettle, entrainer is 60% ethanol, to extraction kettle, extraction-container I, extraction-container II, storage tank heats respectively or cools off, when the extraction kettle temperature reaches 65 ℃, extraction-container I temperature reaches 55 ℃, when extraction-container II temperature reaches 43 ℃, opening dioxide bottle pressurizes to system, when extraction kettle pressure reaches 30Mpa, extraction-container I pressure reaches 12Mpa, when extraction-container II pressure reaches 6Mpa, close gas cylinder, cycling extraction 3 hours, carbon dioxide flow is 1kg/h, material flow is 10-20kg/h, keeps constant temperature and pressure; Extraction goes out raw material from extraction-container I, II discharging opening after finishing, and obtains containing the ethanol liquid of saikoside, and it is standby to reclaim ethanol;
D, the extract in a, the c technical process is merged, add water and regulate ph value to 7.0, the back cold preservation 10 hours under 4 ℃ cryogenic conditions that stirs must filtrate after the filtration; Mix with filtration back gained filtrate after again the extract in the b technical process being added an amount of cosolvent, add correctives, essence is an amount of, and its ph value is adjusted to 7.0 setting, and add water to the full dose of required preparation, be finished product after the after-filtration that stirs, fill, the sterilization.
Embodiment 4:
Present embodiment adopts following proportioning and processing step to realize: the advantage of this preparation method is effective ingredient purity height, and is easily in line with international standards, easy registration sales abroad, but cost is higher.
A, by weight Flos Lonicerae 25%, Flos Trollii 15%, Radix Scutellariae 15%, Fructus Forsythiae 25% four Chinese medicine are decocted with water 2 times, each 80 minutes, filter, afterwards merging filtrate, left standstill 13 hours; Get the macroporous resin column absorption (flow velocity 5ml/min) of the achromatism and clarity of filtrate supernatant through anticipating, discard cleanout fluid, the ethanol elution of reuse 85% when yellow alcoholic solution flows out, begins to collect eluent to not containing till the baicalin; Reclaim ethanol afterwards, to be concentrated into fluid extract standby;
B, extraction Radix Bupleuri volatile oil: Radix Bupleuri 20% (by weight) dry powder is dropped in the extraction kettle, to extraction kettle, extraction-container I, extraction-container II, storage tank heats respectively or cool off, reach 65 ℃ when the extraction kettle temperature reaches 35 ℃, extraction-container I temperature, when extraction-container II temperature reaches 40 ℃, opening dioxide bottle pressurizes to system, reach 12Mpa when extraction kettle pressure reaches 21Mpa, extraction-container I pressure, when extraction-container II pressure reaches 6Mpa, close gas cylinder, cycling extraction 5 hours, carbon dioxide flow is 1kg/h, material flow is 10-20kg/h, keeps constant temperature and pressure; Extraction goes out raw material from extraction-container I, II discharging opening after finishing, and obtains Radix Bupleuri volatile oil;
C, extract the saikoside crude product: the Radix Bupleuri dry powder and the entrainer that will extract Radix Bupleuri volatile oil drop in the extraction kettle, entrainer is 60% ethanol, to extraction kettle, extraction-container I, extraction-container II, storage tank heats respectively or cools off, when the extraction kettle temperature reaches 60 ℃, extraction-container I temperature reaches 55 ℃, when extraction-container II temperature reaches 43 ℃, opening dioxide bottle pressurizes to system, when extraction kettle pressure reaches 27Mpa, extraction-container I pressure reaches 12Mpa, when extraction-container II pressure reaches 6Mpa, close gas cylinder, cycling extraction 3 hours, carbon dioxide flow is 1kg/h, material flow is 10-20kg/h, keeps constant temperature and pressure; Extraction goes out raw material from extraction-container I, II discharging opening after finishing, and obtains containing the ethanol liquid of saikoside, and it is standby to reclaim ethanol;
D, the extract in a, the c technical process is merged, add water and regulate ph value to 7.0, the back cold preservation 12 hours under 5 ℃ cryogenic conditions that stirs must filtrate after the filtration; Mix with filtration back gained filtrate after again the extract in the b technical process being added an amount of cosolvent, add correctives, essence is an amount of, and its ph value is adjusted to 7.0 setting, and add water to the full dose of required preparation, be finished product after the after-filtration that stirs, fill, the sterilization.
Macroporous resin column described in the embodiment 3,4 adopts following method to handle: macroporous resin is placed container, with soak with ethanol 24 hours, use the distilled water thorough washing to achromatism and clarity afterwards, the hydrochloric acid of reuse 5% and 5% sodium hydroxide alternate treatment 2 times, each water washes to neutrality, and is standby in the resin column of packing into.
Medicine of the present invention has heat-clearing and toxic substances removing, the analgesia effect of bringing down a fever, and is mainly used in treatment is caught a cold, influenza causes fever, pain, cough.
Medicine of the present invention proves through clinical trial:
1, Diplococcus pneumoniae, streptococcus, bacillus pyocyaneus, micrococcus catarrhalis, alpha streptococcus, dysentery bacterium, Bao Shi dysentery bacterium, sonne bacillus, shigella flexneri, gram negative bacteria, gram positive bacteria, escherichia coli, enterocolitis yersinia enterocolitica, staphylococcus aureus all there is the obvious suppression effect;
2, to influenza virus A, B and become strain, respiratory syncytial virus, adenovirus, Sa Keqiai can virus, viral, the prevailing type herpes zoster virus of infectious parotitis etc., tangible antiviral and inhibitory action are all arranged;
3, the rat fever that is caused by 2% dinitro benzene ethanol pyrogenicity agent there is tangible refrigeration function; Swelling to Ovum Gallus domesticus album injection rat paw causes has tangible Chinese People's Anti-Japanese Military and Political College Mus pedal swelling;
4, has good analgesic activity.
Claims (3)
1, a kind of Shuangjinlian oral liquid that is used for the treatment of flu, influenza is characterized in that: it is the medicine that is prepared from by following raw material (weight ratio), wherein Flos Lonicerae 10-40%, Flos Trollii 10-25%, Radix Scutellariae 10-25%, Fructus Forsythiae 20-40%, Radix Bupleuri 15-30%.
2, the preparation method of Shuangjinlian oral liquid according to claim 1 is characterized in that: it comprises following technical process:
A, filter with Flos Lonicerae, Flos Trollii, Fructus Forsythiae, the superfine grinding of Radix Bupleuri four Chinese medicine material and through＞300 purpose dusting covers, go into jar in temperature is 50-60 ℃ water, soak 1.5-2 hour after, medicinal liquid is through the pump dynamic low temperature extraction that circulates, it is that 50-60 ℃ hydrodynamic(al) attitude was soaked after 1.5-2 hour that the medicinal liquid that extracts adds temperature again, merges to decoct, filter; When being cooled to 50-60 ℃, after under vacuum condition, being concentrated into relative density and being 1.20-1.25 (surveying under the 70-80 ℃ of condition), treat slowly to add when medicinal liquid is cooled to 35-40 ℃ ethanol again, make to contain when the alcohol amount reaches 65-70% and fully stir, after leaving standstill 12-14 hour, get supernatant, decompression recycling ethanol is to there not being the alcohol flavor, and is standby;
B, with Radix Scutellariae section, decoct with water 1.5-2 hour for the first time three times, each 1-1.5 of second and third time hour, merging decoction liquor, filtration, concentrated filtrate, and in the time of 75-85 ℃, add hydrochloric acid solution, adjusting ph value to 1.0-2.0, be incubated 1-1.5 hour, left standstill 12-14 hour, inhale and remove supernatant, treat post precipitation, with 90-100 ℃ of washing, when ph value to 4, the ethanol of reuse 90%-95% is washed till neutrality, left standstill 12-14 hour, and inhaled and remove supernatant, standby behind the precipitate centrifuge dripping;
C, b is added among a, it is an amount of to add water, regulate the ph value to 6.5-7.0, back under 4-8 ℃ cryogenic conditions cold preservation 24-48 hour stirs, get supernatant afterwards, the filtration back adds correctives, essence is an amount of, and its ph value is adjusted to the setting of 6.5-7, add water to the full dose of required preparation, be finished product after the after-filtration that stirs, fill, the sterilization.
3, the preparation method of Shuangjinlian oral liquid according to claim 1 is characterized in that: it comprises following technical process:
A, Flos Lonicerae, Flos Trollii, Radix Scutellariae, Fructus Forsythiae four Chinese medicine are decocted with water 2-3 time, each 40-80 minute, filter, afterwards merging filtrate, left standstill 12-14 hour; Get the macroporous resin column absorption of the achromatism and clarity of filtrate supernatant through anticipating, discard cleanout fluid, the ethanol elution of reuse 80%-85% when yellow alcoholic solution flows out, begins to collect eluent to not containing till the baicalin; Reclaim ethanol afterwards, to be concentrated into fluid extract standby;
B, extract Radix Bupleuri volatile oil: Radix Bupleuri dry powder is dropped in the extraction kettle, to extraction kettle, extraction-container I, extraction-container II, storage tank heats respectively or cools off, when the extraction kettle temperature reaches 30-35 ℃, extraction-container I temperature reaches 60-65 ℃, when extraction-container II temperature reaches 40-45 ℃, opening dioxide bottle pressurizes to system, when extraction kettle pressure reaches 20-21Mpa, extraction-container I pressure reaches 12-12.5Mpa, when extraction-container II pressure reaches 6-6.5Mpa, close gas cylinder, cycling extraction 3-5 hour, carbon dioxide flow is 0.8-1kg/h, material flow is 10-20kg/h, keeps constant temperature and pressure; Extraction goes out raw material from extraction-container I, II discharging opening after finishing, and obtains Radix Bupleuri volatile oil;
C, extract the saikoside crude product: the Radix Bupleuri dry powder and the entrainer that will extract Radix Bupleuri volatile oil drop in the extraction kettle, entrainer is the ethanol of 55%-65%, to extraction kettle, extraction-container I, extraction-container II, storage tank heats respectively or cools off, when the extraction kettle temperature reaches 60-65 ℃, extraction-container I temperature reaches 55-60 ℃, when extraction-container II temperature reaches 40-45 ℃, opening dioxide bottle pressurizes to system, when extraction kettle pressure reaches 25-30Mpa, extraction-container I pressure reaches 12-12.5Mpa, when extraction-container II pressure reaches 6-6.5Mpa, close gas cylinder, cycling extraction 3-5 hour, carbon dioxide flow is 0.8-1kg/h, material flow is 10-20kg/h, keeps constant temperature and pressure; Extraction goes out raw material from extraction-container I, II discharging opening after finishing, and obtains containing the ethanol liquid of saikoside, and it is standby to reclaim ethanol;
D, the extract in a, the c technical process is merged, adds water and regulate the ph value to 6.5-7.0, the back under 4-8 ℃ cryogenic conditions cold preservation 8-12 hour of stirring, after the filtration filtrate; Mix with filtration back gained filtrate after again the extract in the b technical process being added an amount of cosolvent, add correctives, essence is an amount of, and its ph value is adjusted to the setting of 6.5-7, and add water to the full dose of required preparation, be finished product after the after-filtration that stirs, fill, the sterilization.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011382457A CN1150931C (en) | 2001-12-01 | 2001-12-01 | Shuangjinlian oral liquid for curing cold and influenza, and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB011382457A CN1150931C (en) | 2001-12-01 | 2001-12-01 | Shuangjinlian oral liquid for curing cold and influenza, and its preparing method |
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| CN1150931C CN1150931C (en) | 2004-05-26 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100335095C (en) * | 2003-12-13 | 2007-09-05 | 喜新 | Jierening Granule for abating fever and its preparation |
| CN102100752A (en) * | 2011-01-24 | 2011-06-22 | 四川国康药业有限公司 | Medicinal composition for resisting influenza virus, preparation method thereof and application thereof |
| CN101698005B (en) * | 2009-11-25 | 2011-12-14 | 河南太龙药业股份有限公司 | Gold granules used for treating cold and influenza and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107243024B (en) * | 2017-06-06 | 2018-05-29 | 河南太龙药业股份有限公司 | A kind of double golden pharmaceutical compositions connected, a kind of Neulized inhalation solution of double gold even and its preparation method and application |
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2001
- 2001-12-01 CN CNB011382457A patent/CN1150931C/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100335095C (en) * | 2003-12-13 | 2007-09-05 | 喜新 | Jierening Granule for abating fever and its preparation |
| CN101698005B (en) * | 2009-11-25 | 2011-12-14 | 河南太龙药业股份有限公司 | Gold granules used for treating cold and influenza and preparation method thereof |
| CN102100752A (en) * | 2011-01-24 | 2011-06-22 | 四川国康药业有限公司 | Medicinal composition for resisting influenza virus, preparation method thereof and application thereof |
| CN102100752B (en) * | 2011-01-24 | 2012-05-30 | 四川国康药业有限公司 | Medicinal composition for resisting influenza virus, preparation method thereof and application thereof |
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| CN1150931C (en) | 2004-05-26 |
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