CN1344217A

CN1344217A - Valve

Info

Publication number: CN1344217A
Application number: CN00805382A
Authority: CN
Inventors: G·J·M·安德森; M·A·海利; D·J·鲁塞尔; J·W·戈德弗雷
Original assignee: Glaxo Group Ltd
Current assignee: Glaxo Group Ltd
Priority date: 1999-03-24
Filing date: 2000-02-23
Publication date: 2002-04-10
Also published as: ATE302151T1; EP1144272A2; WO2000056632A2; JP2002540017A; AU3656200A; CA2366958A1; BR0009227A; MXPA01009570A; DE60022007D1; DE60022007T2; HK1039602A1; EP1144272B1; ZA200106110B; WO2000056632A3; GB9906640D0

Abstract

There is provided a valve for an aerosol container. The valve comprises a valve body; within the valve body, a sealing ring and receivable by the sealing ring, a valve stem having a dispensing passage. The valve stem is slidably movable within the sealing ring from a valve-closed position to a valve-open position in which the interior of the valve body is in communication with the dispensing passage. The sealing ring is shaped such as to reduce the contact area between the sealing ring and the valve stem. Preferably, the valve is a metering valve.

Description

Valve

The present invention relates to the valve of aerosol container, utilize this valve can quantitatively send aerosol in the container.The present invention is specially adapted to send the drug dose of metering, generally is suitable for sending aerosol.

Aerosol ingredients container generally includes the bottle that is connected in valve.This valve comprises valve rod, sends this ingredients by this valve rod.Valve generally comprises the valve seal of rubber, makes valve rod reversibly to move, and can prevent that the volatilizer in the container from leaking simultaneously again.

Have been found that in some conventional equipment valve rod is during starts clinging easily, stopping or viscous motion, so the motion that valve rod can not be level and smooth, particularly during unclamping.This thing happens partly cause is in the drug volatilization agent magma medicine or generation sedimentation of solution ingredients or precipitation, and be deposited on the inner valve member.On slidingsurface, exist medicine to increase the friction force of operating period.

The prior art sealing member generally comprises rubber ring, and its method for making is to form rubber ring by die-cut elastomeric material plate.Therefore its annular distance has the die-cut seamed edge in right angle inevitably, and this seamed edge causes the area of contact between sealing member and the valve rod quite big.In addition, when valve rod moved in the die-cut sealing member in this right angle, deformation can take place in sealing member, thereby to cause face area between sealing member and the valve rod be that the wipe contact area increases.

The applicant has been found that if change the shape of valve seal and makes it reduce area of contact between sealing member and the valve rod, then can alleviate the problems referred to above and do not damage sealing property.When adopting the mechanography manufacturing process, just can produce a kind of its annular distance seamed edge and be down to become seal ring fillet or other shape.When making the seal ring of valve with the ring of this rounding or special-shaped seamed edge, the area of contact between sealing member and the valve rod is just less than the formed area of contact of the seal ring with the die-cut seamed edge in right angle of same thickness.When moving in this sealing member, valve rod also reduced to make the possibility that area of contact increases between sealing member and the valve rod because of sealing member deformation.

According to the present invention, a kind of valve of aerosol container is provided, this valve comprises: valve body; Be contained in the seal ring in the above-mentioned valve body; Insert the valve rod of above-mentioned seal ring, this valve rod has sendaisle, can slide into the valve open position from the valve closing position in above-mentioned seal ring, at this open position, valve inner communicates with sendaisle, and wherein seal ring is shaped as the area of contact that can reduce between seal ring and the valve rod.

Area of contact between seal ring and the valve rod is reasonable to be that the area of contact that forms when having the die-cut seamed edge in right angle of valve rod patchhole than seal ring is little by 90%, is little by 70% better, preferably little by 50%.

The most handy mechanography of seal ring is made.

Mechanography is injection-molded preferably.

Perhaps, mechanography is a compression molded.

Perhaps, mechanography is die casting (transfer molding).

Preferably not with respect to the valve body motion, promptly it is fixed on the valve body seal ring by some way.Seal ring more preferably is fixed in the groove of valve body.

In one aspect, the valve rod patchhole of seal ring has at least one rounded edge, and preferably all seamed edges that receive bar all are roundings.

On the other hand, the valve rod receiving unit of seal ring forms the surface with projection facing to valve rod.That is, the surface comprises one or more lug bosses.This has the surface of salient and the valve rod insertion portion of valve rod to form one or more wells.Preferably comprise lubricant in these one or more wells.

This valve is calibrate valve preferably, second seal ring that the valve body of this valve has masuring room, sampling hut and disposes betwixt, and valve rod can slide in this seal ring.This valve rod has the transmission passage, make valve sendaisle and masuring room when off position isolate, this masuring room is communicated with the sampling hut by above-mentioned transmission passage, when valve is positioned at open position, sendaisle is communicated with masuring room, and transmit passage and masuring room isolation, wherein second seal ring is shaped as the area of contact that can reduce between second seal ring and the valve rod.

Area of contact between second seal ring and the valve rod is reasonable to be that the area of contact that forms when having the die-cut seamed edge in right angle of valve rod patchhole than second seal ring is little by 90%, is little by 70% better, and best is little by 50%.

Preferably adopt molding process to make seal ring and the second any seal ring.

This molding process is injection-molded preferably.

Perhaps, molding process can be a compression molded.

Perhaps, molding process can be die casting.

Second seal ring does not preferably move with respect to valve body.Second seal ring preferably is fixed in the groove of valve body.

On the one hand, the valve rod receiving unit of second seal ring has at least one rounded edge, and it all is roundings that preferably all valve rods receive seamed edge.

On the other hand, the valve rod receiving unit of second seal ring forms the surface that salient is arranged facing to valve rod.There are the surface of salient and the valve rod insertion portion of valve rod to be preferably formed as one or more wells.Preferably include lubricant in these one or more wells.

The seal ring and/or second seal ring preferably are made of elastomeric material.The representative type elastic deformation can take place in this ring.

Elastomeric material or comprise thermoplastic elastomer (s) (TPE) or comprise can the selectivity interlinkage thermoset elastomeric material.Seal ring also comprises thermoplastic elastomer (s) compound or admixture, and in this compound, elastomeric material is dispersed in the thermoplastic matrix.Elastomeric material optionally additionally comprises for example for example an amount of mineral oil of processing aid, colorant, tackifier, lubricant, quartz, french talc or technical oil of conventional polymer additive.

The thermoset rubber that is fit to comprises butyl rubber, neoprene based rubber, brombutyl rubber, government rubber, silaatic, flurorosilicone rubber, fluorocarbon rubber, thiokol, polypropyleneoxide rubber, isoamyl ethylene rubber, isoprene-isobutene rubber, isobutene rubber or poly-chloroprene rubber ((co) polychloroprene rubber).

Suitable thermoplastic elastomer (s) comprises the copolymer that about 80%～85% mole ethene and one or more about 5%～20% mole comonomers of total amount form, and as known in this technology, these comonomers comprise 1-ethene, 1-hexene and 1-octene.Also can mix the formation thermoplastic polymer mixtures by the copolymer that two or more are such.

The thermoplastic elastomer of other suitable species is a styrene-ethylene/butylene-styrene block copolymer.These copolymers also additionally comprise polyolefin (routine polyethylene) and polyoxy alkane.

Thermoplastic elastomer (s) can be selected from following one or more materials: lactoprene, poly-urethane rubber, ethylene-vinylacetate rubber, buna-S, copolyether ester TPE, the TPE of alkene family, polyesteramide TPE and polyamide ether TPE.

Other suitable elasticity material comprises propylene diene rubber (EPDM).This EPDM can independently form thermoplastic elastomer (s) or as the part of thermoplastic elastomer (s), for example as the particulate matter that is dispersed in substantially in the continuous thermoplastic matrix (for example polypropylene or polyethylene).Commercially available thermoplastic elastomer (s) compound or admixture comprise that registered trade mark (RTM) is the elastomeric material of SANTOPRENE.Other suitable thermoplastic elastomer (s) comprises butyl polyethylene (for example its ratio is between about 2: 3 to 3: 2) and butyl polyethylene.

Above-mentioned elastomeric material is with method manufacturing known to the skilled.

The seal ring and/or second seal ring also comprise lubricant material.Seal ring preferably includes 5%～20% lubricant material or/and second seal ring can comprise the lubricant up to 30%.

Valve rod preferably includes lubricant material.Valve rod can comprise the lubricant up to 30%, preferably includes 5%～20% lubricant.

Term used herein " lubricant material " is meant any material that can reduce friction force between valve rod and the sealing member.The proper lubrication material comprises silicone oil or fluorocarbon polymer for example polytetrafluoroethylene (PTFE) or PVF propylene (PEP).

Lubricant material can be added on valve rod, seal ring or second seal ring with any suitable technology, and these technologies comprise coating and infiltration, for example with injection technique and filling technology.

According to another aspect of the present invention, provide a kind of aerosol container that comprises above-mentioned valve.

This aerosol container preferably includes the floating medicine that is suspended in the volatilizer.

HFA 134a or HFA-227 that this volatilizer preferably liquefies, or its compound.

Medicine preferably is selected from albuterol, salmeterol, Fluticasone Propionate, beclomethasone dipropionate, ipratropium bromide bromide, their salt and solvate and their any compound.

Further specify the present invention below with reference to accompanying drawing, these accompanying drawings are:

Fig. 1 is the section drawing of calibrate valve of the present invention;

Fig. 2 is the sealed section figure of sealing member in the valve of the present invention-valve rod contact area;

Fig. 3 is the sealed section figure of sealing member in the valve of the present invention-valve rod contact area;

Fig. 4 a is the sealed section figure of prior art valve sealing member-valve rod contact area when being positioned at dead position;

Fig. 4 b is the sealed section figure of the sealing member-valve rod contact area when operating position of valve shown in Fig. 4 a.

Valve of the present invention is shown in Fig. 1, comprises valve body 1, and this valve body utilizes the crimp crimping to be sealed in the sleeve 2, and this sleeve itself is contained in again on the neck of container (not shown), adopts known way to insert packing ring 3 therebetween.This container is equipped with floating outstanding medicine, for example the Salmeterol Xinafoate in liquefied propellant HFA134a.

The lower part of valve body 1 forms masuring room 4, and its top forms sampling hut 5, and the retracing spring shell also plays in this sampling hut.Speech " on " and D score be to be at container to use orientation, this moment, container neck and valve were positioned at the lower end of container, this use orientation is equivalent to the orientation of valve shown in Figure 1.Configuration valve rod 7 in valve body 1, its part 8 is stretched out valve through lower valve shaft seal 9 and sleeve 2.Valve stem part 8 has inner axial passage or vertical passage 10, this path 10 in the outer end of valve rod be open wide and be communicated with warp-wise passage 11.

Its diameter of the top of valve rod 7 is decided to be to slide and passes the perforate of upper valve shaft seal 12, and with the contacting fully of this perforate, so that sealing function to be provided.Valve rod sealing member 9 and 12 mechanography manufacturing, it is become fillet with the contact area of valve rod.Upper valve shaft seal 12 utilizes sleeve 14 to be pressed on the step 13 and fix in position, and this step is formed on the valve body 1, between above-mentioned lower part and top, and the masuring room 4 that this sleeve 14 forms between lower seal 9 and upper seal 12.Valve rod 7 has passage 15, and this passage makes masuring room 4 and sampling hut 5 be communicated with when valve rod is positioned at the inoperation position, and this sampling hut itself is communicated with internal tank by the through hole 16 that forms on valve body 1 sidewall again.

Valve rod 7 is biased into the inoperation position by retracing spring 6, and this valve rod has the shoulder 17 with 9 crimping of lower valve shaft seal.In inoperation position shown in Figure 1, shoulder 17 crimping lower valve shaft seal 9, so radial passage 11 is unlimited below lower valve shaft seal 9, thereby masuring room 4 and path 10 isolation, floating so outstanding medicine just can not be overflowed.

The annular element 18 that has the U-shaped plane of structure and radially extend is around the valve body configuration, be contained in through hole 16 below, make to form a groove 19 around valve body.As shown in Figure 1, this annular element can make independent have in the parts of annular contact opening, the diameter of this contact opening is suitable for forming frictional fit with the top of valve body 1, this annular element is pressed on the step 13 that is positioned at below the through hole 16.Yet annular element 18 also can make the Unitarily molded part of valve body 1.

For operative installations, at first shake container, shake up the floating outstanding medicine in the container.End user's elastic force of overcoming spring 6 is pressed into valve rod 7 then.When valve rod 7 was pressed into, the two ends of passage 15 just were positioned at the side away from the upper valve shaft seal 12 of masuring room 4.Therefore the drug dose in masuring room is measured.Be pressed into valve rod continuously and will make radial passage 11 enter masuring room 4, simultaneously upper valve shaft seal 12 is being pasted the valve rod main body and sealed.Like this Ji Liang medicine just through the radial passage 11 and delivery channel 10 penetrate.

Unclamping valve rod just makes it get back to graphic position under the effect of spring 6.Passage 15 makes masuring room 4 and sampling hut 5 be communicated with again subsequently.In this stage, fluid flows into masuring room 4, and is full of this masuring room from container via through holes 16, passage 15 under pressure.

Fig. 2 illustrate valve of the present invention sealing member-valve rod contact area clip details after the part.Cross-sectional plane is that circular upright valve rod 108 is contacted hermetically by seal ring 112.The annular distance 130 of seal ring 112 has rounded edge.Area of contact when the area of contact that should be understood that seal ring 112 and valve rod 108 has the die-cut seamed edge in right angle less than seal ring 112.When valve rod 108 moved up, the sealing ring trended towards in clearance envelope 140 crooked.

Fig. 3 illustrate the present invention's second valve sealing member-valve rod contact area cut details after the part.Upright valve rod 208 with circular cross section is contact seal ring 212 hermetically.The annular distance of sealing ring 112 makes the seamed edge with two rounding salients 230,232.Area of contact when the area of contact of sealing ring 212 and valve rod 208 has the die-cut seamed edge in right angle less than sealing ring 212.When valve rod 208 when seal ring 212 moves, sealing ring 212 tends to carry out bending in clearance envelope 240 and well 242.Can be entirely in this well 242 or partly charge into lubricant.

Fig. 4 a and 4b illustrate the prior art valve sealing member-valve rod contact area cut details after the part, wherein Fig. 4 a illustrates static structures, the structure when Fig. 4 b illustrates valve and is positioned at moving position.Upright valve rod 308 with round section is contact seal ring 312 hermetically.The annular distance 330 of seal ring 312 has the die-cut seamed edge in right angle 330.When valve rod during upward movement, just seal ring 312 deformation takes place and stretches, makes that the area of contact between seal ring 312 and the valve rod 308 increases shown in Fig. 4 b.Thereby the wipe contact between seal ring 312 and valve rod 308 also increases.

It should also be appreciated that seal ring can also have many different structures except that the structure shown in Fig. 2 and 3, these structures all can reduce the area of contact between seal ring and the valve rod.A kind of possible similar is in the structure of Fig. 3, but the seamed edge of annular distance is configured as the plural salient of tool.Its sealing annular distance of another kind of possible structure has the straight seamed edge to a some convergent (making that its cross-sectional plane is a triangle), compares with the die-cut seamed edge in right angle, and the area of contact of this seamed edge and valve rod reduces.This seal ring also can have the salient that changes shape, and two above salients wherein can be arranged, and wherein each salient all is tapered to a bit.The another kind of structure that can reduce to contact the valve rod area of contact has the top side partial sum bottom side portion of the annular distance of the part of cutting, stays less projection after cutting and forms sealing with valve rod.This projection can be die-cut seamed edge in right angle or special-shaped seamed edge.The space that the valve rod receiving unit of seal ring was moved into when one or more grooves that cut out on the non-valve rod receiving surface of seal ring or little raceway groove formed stem movement, the result has reduced the deformation and the friction force of the mating surfaces of contact valve rod.

It should also be appreciated that on any part of the floating outstanding medicine of calibrate valve contact and all can coat for example fluoropolymer material that this material can reduce medicine and stick to trend on these parts.Suitable fluoropolymer polymer comprises polytetrafluoroethylene (PTFE), PVF propylene (FEP).Also can be coated on any movable part, this can strengthen the motion characteristics of its requirement.Add lubricant in the time of also can adding friction coatings and need, the former can increase wipe contact, and the latter can reduce wipe contact.

Aerosol container of the present invention and valve are applicable to dispense medication, are specially adapted to treat RD example asthma and chronic asthma obstructive lung disease (COPD).

Can from following medicine for example, select the dispense medication that is fit to: sedative drugs, for example codeine, paramorphane, ergotamine, structure rafter acid fentanyl or morphine; The angina preparation, routine sulphur nitrogen ketone; Antiallergic, for example cromoglycate, ketotifen or nedocromil; Anti-infectious agent, for example cephaloridnum, penicillin, streptomycin, sulfanilamide (SN), tetracycline and pentylenetetrazol; Antihistamine, for example methapyrilene; Antiphlogistic, for example beclomethasone dipropionate, Fluticasone Propionate, 9-remove fluorine Topsyne, budesonide, Mometasone Furoate or Triamcinolone Acetonide; Anti-tussive agents, for example Nuo Jika product; Bronchodilator; For example albuterol, salmeterol, ephedrine, adrenaline, fenoterol, Formoterol, isoprel, alotec, phenylephrine, phenyl amino propyl alcohol, pyrrole butanols, reproterol, asmaten, terbutaline, Dilabron, fourth chlorine breathes heavily or (-)-4-amino-3,5-two chloro-α-[[[6-[2-(2-pyridine) ethylol] hexyl] methyl] phenmethylol; Diuretic, for example ammonia chlorine pyrrole rice; Anticholinergic, for example ipratropium bromide, tiotropium, atropine or oxitropine; Hormone, for example cortisone, hydrocortisone or prednisolone; Xanthine, for example aminophylline, choledyl, Paidomal salt (lysinetheophyllinate), Paidomal; Treatment protide and peptide, for example insulin or glucagons.Those skilled in the art can obviously find out, when appropriate, these medicines can be used the medicine of salt form (for example alkali metal salt or amine salt or acid blending salt (acid additionsalts)), ester-formin (for example lower alkyl ester) or flux thing form (for example hydrate), to optimize the active and/or stable of medicine.

Preferred medicine is to be selected from albuterol, salmeterol, Fluticasone Propionate and beclomeasone propionate, with and salt or solvate for example vulcanize salbutamol and Xinafoate ofSalmeterol.

The hybrid medicine of can providing and delivering, preferred prescription comprises the mixture that active component mixes with the anti-inflammatory type sterol, active component comprises salbutamol (for example as free radical or sulfate) or salmeterol (for example as Xinafoate salt), and the anti-inflammatory type sterol for example is beclomethasone dipropionate ester (for example dipropionate) or Fluticasone ester (for example propionic ester).

Should be understood that this explanation only makes illustrative purpose.The present invention can change, modification and improvement.

Illustrate that constituting its a part of the application with claims can be used as the basis of any application preference subsequently.These claims of applying for subsequently are at the feature of this paper explanation or the associating of feature.They can get the form that product, method or application rights require, and can comprise for example one or more following claims, but be not limited to these claims.

Claims

1. valve that is used for aerosol container, this valve comprises: valve body; Be contained in the seal ring in the above-mentioned valve body; Valve rod, insert in the above-mentioned seal ring, has the distribution passage, this valve rod can slide into the valve opening position from the valve closing position in seal ring, be on the open position at valve, valve inner and distribution channel connection is characterized in that seal ring is configured as the area of contact that can reduce between seal ring and the valve rod.

2. valve as claimed in claim 1 is characterized in that, the area of contact that the area of contact between seal ring and the valve rod is had when having rectangle cutting seamed edge than seal ring is little by 90%.

3. valve as claimed in claim 3 is characterized in that seal ring can be made of molding process.

4. valve as claimed in claim 3 is characterized in that this molding process is an injection-molded.

5. valve as claimed in claim 3 is characterized in that this molding process is a compression molded.

6. valve as claimed in claim 3 is characterized in that this molding process is die casting.

7. as each described valve in the claim 1～6, it is characterized in that seal ring does not move with respect to valve body.

8. valve as claimed in claim 7 is characterized in that, seal ring is fixed in the interior groove of valve body.

9. as the valve shown in the claim 1～8 each, it is characterized in that the valve rod receiving unit of seal ring has the seamed edge that at least one falls into fillet.

10. as each described valve in the claim 1～9, it is characterized in that the valve rod receiving unit of seal ring constitutes the surface that projection is arranged facing to valve rod.

11. valve as claimed in claim 10 is characterized in that, has the surface of projection and the bar insertion portion of valve rod to limit one or more wells.

12. valve as claimed in claim 11 is characterized in that, comprises lubricant material in above-mentioned one or more wells.

13. as each described valve in the claim 1～12, it is characterized in that, valve body has masuring room, sampling hut and second seal ring that is contained in the centre, valve rod can slippage in this second seal ring, this valve rod has transfer passage, thereby when valve is positioned at off position, this distributes passage and masuring room to isolate, and this masuring room is communicated with the sampling hut by transfer passage, and when valve was positioned at open position, this distributed passage to be communicated with masuring room, and transfer passage and masuring room are isolated, wherein, second seal ring is configured as the area of contact that can reduce between second seal ring and the valve rod.

14. valve as claimed in claim 13 is characterized in that, the contact area that the contact area between second seal ring and the valve rod is had when having rectangle cutting seamed edge than second seal ring is little by 90%.

15., it is characterized in that second seal ring adopts molding process to make as claim 13 or 14 described valves.

16. valve as claimed in claim 15 is characterized in that, this molding process is an injection-molded.

17. valve as claimed in claim 15 is characterized in that, this molding process is a compression molded.

18. valve as claimed in claim 15 is characterized in that, this molding process is die casting.

19., it is characterized in that second seal ring does not move with respect to valve body as each described valve in the claim 13～18.

20. valve as claimed in claim 19 is characterized in that, second seal ring is fixed in the interior groove of valve body.

21., it is characterized in that the valve rod receiving unit of second seal ring has at least one rounded edge as each described valve in the claim 13～20.

22., it is characterized in that the valve rod receiving unit of second seal ring constitutes the surface that projection is arranged facing to valve rod as each described valve in the claim 13～21.

23. valve as claimed in claim 22 is characterized in that, this has the surface of projection and the bar insertion portion of valve rod to limit one or more wells.

24. valve as claimed in claim 23 is characterized in that, comprises lubricant material in above-mentioned one or more wells.

25., it is characterized in that seal ring comprises elastomeric material as each described valve in the claim 1～24.

26., it is characterized in that second seal ring comprises elastomeric material as each described valve in the claim 13～25.

27., it is characterized in that this elastomeric material is selected from following one group of material as claim 25 and 26 described valves, this group material comprises:

(a) thermoplastic elastomer (s) comprises the copolymer of one or more alkene in ethene and 1-butylene, 1-hexene and the 1-octene, and the former accounts for 80～95% moles, and the latter accounts for 5～20% moles altogether

(b) styrene-ethylene/butylene-styrene block polymer;

(c) ethylene propylene ethylene rubber (EPDM);

(d) make EPDM be dispersed in thermoplastic elastomer (s) compound in polypropylene or the polyethylene matrix;

(e) butyl polyethylene;

(f) butyl polypropylene; With its any compound.

28., it is characterized in that seal ring also comprises lubricant material as each described valve in the claim 1～27.

29., it is characterized in that second seal ring also comprises lubricant material as each described valve in the claim 13～28.

30., it is characterized in that valve rod comprises lubricant material as each described valve in the claim 1～29.

31. an aerosol container comprises as each described valve in the claim 1～30.

32. aerosol container as claimed in claim 31 is characterized in that, also is included in floating outstanding medicine in the volatilizer.

33. aerosol container as claimed in claim 32 is characterized in that, this volatilizer is HFA134a and HFA-227 or its compound of liquefaction.

34. as claim 32 or 33 described aerosol containers, it is characterized in that this medicine is selected from one group of medicine, this group medicine comprises: albuterol, salmeterol, Fluticasone Propionate, beclomethasone dipropionate, ipratropium bromide bromide, with its salt and solvate, with and composition thereof.