CN1336237A - Low-density gastrointestinal contrast medium and its production process - Google Patents
Low-density gastrointestinal contrast medium and its production process Download PDFInfo
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- CN1336237A CN1336237A CN 00122432 CN00122432A CN1336237A CN 1336237 A CN1336237 A CN 1336237A CN 00122432 CN00122432 CN 00122432 CN 00122432 A CN00122432 A CN 00122432A CN 1336237 A CN1336237 A CN 1336237A
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- contrast medium
- water
- gastrointestinal contrast
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Abstract
The present invention relates to the production method of contrast agent for ttomach intestine use. It is prepared by mixing monoolein, oropanediol alginate and carboxymethyl cellulose sodium according to certain proportion, then by using 70-100 deg.c water to infuse. The invented product can raise the quality of CT radiographic image greatly. The product has no toxic side effect.
Description
The present invention relates to contrast agent, be specially adapted to the production method of gastrointestinal contrast agent.
Based on the gastrointestinal anatomical features; gastrointestinal tract provides ideal prerequisite can not for CT (Computerzedtomoyraphy-X ray CT scan) the equipment video picture of axle position; and due to the gastrointestinal motility " pseudo-shadow " also regular meeting bring difficulty to diagnosis, and a common difficult problem is abdominal cavity lump and stomach intestinal tissue should not be made discriminating in the CT examination.Owing to still there is not the ideal CT contrast agent that is used for gastrointestinal examination, a lot of hospitals do not make gastrointestinal CT, thereby have limited to the due diagnostic function of CT equipment.If be used as contrast medium, be difficult to obtain ideal image effect with high density contrast agent (comprising cardiografin and other iodine or barium class contrast agent) or water.
The CT value of high density contrast agent (comprising cardiografin and other iodine or barium class contrast agent) is up to hundreds of and even thousands of H μ, full behind gastrointestinal tract and CT value be about+the gastrointestinal wall soft tissue of 20--+40H μ between the great density contrast of generation, can produce serious pseudo-shadow at the video edge, destroy tonal value, bring difficulty to diagnosis.And some high density contrast agent (as iodine preparation) also might produce anaphylaxis to some patient, so water is migrated as full agent by some hospital.
The CT value of water is generally zero, produces the density contrast of the above CT value of 20H μ theoretically with soft tissue such as gastrointestinal wall.Yet the actual density difference on its CT sheet that detects by an unaided eye is very little, therefore also claims that water is " isodensity contrast agent ".Because the enhanced way of available vein increases the contrast between itself and the soft tissue clinically, thereby remedied the deficiency of its density contrast slightly.The density of water is lower than the density of soft tissue in addition, has eliminated pseudo-shadow phenomenon preferably, and the definition of CT video is made moderate progress again, so some hospital uses till today.But, the also not very big real difficulty of density contrast is clearly differentiated the trickle pathological changes in gastrointestinal wall and the adjacent tissue thereof between water and the gastrointestinal wall tissue, in addition the poor adhesive force of water, no viscosity, drain characteristics such as fast, be easy to produce filling defect in gastrointestinal, the diagnosis that reaches pathological changes to image quality brings interference.Therefore using water as gastrointestinal CT remains to belong to and is not still having " way of having no way " that adopts under the desirable contrast agent situation at present.But among the comparison of water and high density contrast agent, can draw a useful conclusion,, adopt low-density contrast medium more suitable for the CT diagnosis of gastrointestinal CT and even other cavity organ.
One of the object of the invention according to above-mentioned the deficiencies in the prior art, proposes a kind of low-density gastrointestinal contrast medium and production method thereof, and the present invention eliminates pseudo-shadow effectively, thereby improves the definition of CT image, gives and accurately diagnoses focus to bring benefit.
Two of the object of the invention is oleaginous tastes of having eliminated the lipid contrast agent trial product of once appearing, fundamentally improves mouthfeel.
Three of the object of the invention, " dry powderization " on the mode of production, thus solved the layering of liquid contrast agent trial product in the past, the mushroom pollution problem in the perishable and production process.
The object of the invention realizes being realized by following technical scheme:
The present invention is mainly mixed by glyceryl monooleate, propylene glycol alginate and sodium carboxymethyl cellulose, proportioning 8～12: 2～3: 0.5～1, and form is a powdered; Production method is after monoglyceride (glyceryl monooleate) and propylene glycol alginate and sodium carboxymethyl cellulose are mixed in proportion, and dashes with 70 ℃～100 ℃ water and infuses, and forms uniform emulsion through stirring, and leaves standstill more than 24 hours under 0 ℃～10 ℃ environment; When product volume of the present invention is 10～18 grams, dashes and infuse to 500ml～800ml; The present invention also can add 0.06～0.1 the stevioside or the suitable sugar of sugariness, to improve mouthfeel.
Advantage of the present invention is: the CT value of product of the present invention leave standstill stablize about more than 24 hours, its CT value can reach-40～-50H μ, extend to the time as quiet, the CT value continues to descend, minimum reaching-below the 300H μ, like this density contrast between soft tissue such as gastrointestinal wall and the full place of contrast agent has been expanded to more than the 300H μ from about the 20H μ of water, thereby the quality of radiography image is greatly improved, and fundamentally eliminated the oleaginous taste of lipid contrast agent trial product.Particularly since raw material sources in raw-food material, not only without any side effects, and have instant character, thereby on the mode of production, realized " dry powderization ", thereby solved the mushroom pollution problem in the layering of liquid contrast agent trial product in the past, the perishable and production process.If add the stevioside of trace, make that product mouthfeel of the present invention is fragrant and sweet, but belonging to the refinement of empty calory plant, its sweeting agent forms, do not hinder in sugared urea patient and take.
By the following examples feature of the present invention and other feature are described in further detail:
The present invention mainly is made up of glyceryl monooleate, propylene glycol alginate and sodium carboxymethyl cellulose, with powdery three components, glyceryl monooleate 8 grams, powdery propylene glycol alginate 2 grams, sodium carboxymethyl cellulose 1 gram physical method mix, add 0.06～0.1 the stevioside or the suitable sugar of sugariness again, purpose is to improve mouthfeel.
Production method of the present invention is, dash with 70 ℃～100 ℃ water and to infuse to 500ml, after stirring the uniform emulsion of formation, it is about more than 24 hours stable (also can shake between stable phase) to leave standstill shady and cool place (best 0 ℃～10 ℃), its CT value can reach-40～-50H μ, can guarantee the high-quality of gastrointestinal CT cross-sectional image completely.Peep three-dimensional image in the emulation as doing with spiral CT, can extend quietly makes its CT value continue to descend to stabilization time, as stablize 4 days then the CT value can reduce to-below the 200H μ; Stablize 7～10 days CT values can reduce to-below the 300H μ.To shaking up once more, drink on an empty stomach before the stable good contrast agent use.The general consumption 500ml that is grown up, one or two people need 800ml, and the child follows the doctor's advice and cuts down according to the circumstance.Do preferably to inject 654-2 before the CT,, improve image quality in order to slow down gastrointestinal peristalsis.
Claims (4)
1, low-density gastrointestinal contrast medium is characterized in that, is mainly mixed proportioning 8～12: 2～3 by glyceryl monooleate, propylene glycol alginate and sodium carboxymethyl cellulose: 0.5～1, and form is a powdered.
2, low-density gastrointestinal contrast medium according to claim 1, it is characterized in that, production method is after glyceryl monooleate, propylene glycol alginate and sodium carboxymethyl cellulose are mixed in proportion, dash with 70 ℃～100 ℃ water and to infuse, form uniform emulsion through stirring, under 0 ℃～10 ℃ environment, leave standstill more than 24 hours.
According to claim 1 and 2 described low-density gastrointestinal contrast mediums, it is characterized in that 3, when product volume of the present invention was 10～14 grams, water dashed and infuses to 500ml～800ml.
4, low-density gastrointestinal contrast medium according to claim 1 is characterized in that, also can add 0.06～0.1 stevioside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001224328A CN1162186C (en) | 2000-08-01 | 2000-08-01 | Low-density gastrointestinal contrast medium and its production process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001224328A CN1162186C (en) | 2000-08-01 | 2000-08-01 | Low-density gastrointestinal contrast medium and its production process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1336237A true CN1336237A (en) | 2002-02-20 |
| CN1162186C CN1162186C (en) | 2004-08-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001224328A Expired - Fee Related CN1162186C (en) | 2000-08-01 | 2000-08-01 | Low-density gastrointestinal contrast medium and its production process |
Country Status (1)
| Country | Link |
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| CN (1) | CN1162186C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400105C (en) * | 2006-05-11 | 2008-07-09 | 上海交通大学 | Aqueous matrix CT negative contrast medium for digestive tract and its preparation method |
| CN102139118A (en) * | 2010-01-28 | 2011-08-03 | 陈星荣 | Isosmotic gastrointestinal tract neutral filling liquid for CT (computed tomography), MR (magnetic resonance), PET (positron emission tomography)/CT |
-
2000
- 2000-08-01 CN CNB001224328A patent/CN1162186C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400105C (en) * | 2006-05-11 | 2008-07-09 | 上海交通大学 | Aqueous matrix CT negative contrast medium for digestive tract and its preparation method |
| CN102139118A (en) * | 2010-01-28 | 2011-08-03 | 陈星荣 | Isosmotic gastrointestinal tract neutral filling liquid for CT (computed tomography), MR (magnetic resonance), PET (positron emission tomography)/CT |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1162186C (en) | 2004-08-18 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| ASS | Succession or assignment of patent right |
Owner name: ZHOU KANGRONG; PENG WEIJUN Free format text: FORMER OWNER: NONE Effective date: 20020118 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT INVENTOR; FROM: ADI QINFU; TO: NONE |
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| TA01 | Transfer of patent application right |
Effective date of registration: 20020118 Applicant after: Adu Qinfu Co-applicant after: Zhou Kangrong Co-applicant after: Peng Weijun Address before: 010010 14-4-4, unity District, the Inner Mongolia Autonomous Region, Hohhot Applicant before: Adu Qinfu Inventor before: Adu Qinfu |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |