CN1162186C - Low-density gastrointestinal contrast medium and its production process - Google Patents

Low-density gastrointestinal contrast medium and its production process Download PDF

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Publication number
CN1162186C
CN1162186C CNB001224328A CN00122432A CN1162186C CN 1162186 C CN1162186 C CN 1162186C CN B001224328 A CNB001224328 A CN B001224328A CN 00122432 A CN00122432 A CN 00122432A CN 1162186 C CN1162186 C CN 1162186C
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China
Prior art keywords
contrast agent
present
gastrointestinal
density
low
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Expired - Fee Related
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CNB001224328A
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Chinese (zh)
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CN1336237A (en
Inventor
阿都沁夫
周康荣
彭卫军
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Adu Qinfu
Peng Weijun
Zhou Kangrong
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Individual
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Abstract

The present invention relates to a low-density gastrointestinal contrast agent and a production method. The present invention relates to the contrast agent, particularly to the production method of the gastrointestinal contrast agent. The present invention comprises the steps that glycerol alpha-monooleate, propylene glycol alginate and sodium carboxymethyl cellulose are mixed proportionally and flushed with water of which the temperature is 70 to 100 DEG C. The product of the present invention can make the quality of CT visualization images improved largely, and the contrast agent does not have any toxic side effect. The contrast agent has quick dissolving quality, so that dry pulverization of production modes can be realized, and thereby, the present invention solves the problems of delamination of the durables of original liquid contrast agents, easy deterioration and fungus pollution in a production process.

Description

Low-density gastrointestinal contrast medium and production method
Technical field
The present invention relates to contrast agent, be specially adapted to the production method of gastrointestinal contrast agent.
Background technology
Based on the gastrointestinal anatomical features; gastrointestinal tract provides ideal prerequisite can not for CT (Computerized tomoyraphy-X ray CT scan) the equipment video picture of axle position; and due to the gastrointestinal motility " pseudo-shadow " also regular meeting bring difficulty to diagnosis, and a common difficult problem is abdominal cavity lump and stomach intestinal tissue should not be made discriminating in the CT examination.Owing to still there is not the ideal CT contrast agent that is used for gastrointestinal examination, a lot of hospitals do not make gastrointestinal CT, thereby have limited to the due diagnostic function of CT equipment.If be used as contrast medium, be difficult to obtain ideal image effect with high density contrast agent (comprising cardiografin and other iodine or barium class contrast agent) or water.
The CT value of high density contrast agent (comprising cardiografin and other iodine or barium class contrast agent) is up to hundreds of and even thousands of H μ, full behind gastrointestinal tract and CT value be about+the gastrointestinal wall soft tissue of 20--+40H μ between the great density contrast of generation, can produce serious pseudo-shadow at the video edge, destroy tonal value, bring difficulty to diagnosis.And some high density contrast agent (as iodine preparation) also might produce anaphylaxis to some patient, so water is migrated as full agent by some hospital.
The CT value of water is generally zero, produces the density contrast of the above CT value of 20H μ theoretically with soft tissue such as gastrointestinal wall.Yet the actual density difference on its CT sheet that detects by an unaided eye is very little, therefore also claims that water is " isodensity contrast agent ".Because the enhanced way of available vein increases the contrast between itself and the soft tissue clinically, thereby remedied the deficiency of its density contrast slightly.The density of water is lower than the density of soft tissue in addition, has eliminated pseudo-shadow phenomenon preferably, and the definition of CT video is made moderate progress again, so some hospital uses till today.But, the also not very big real difficulty of density contrast is clearly differentiated the trickle pathological changes in gastrointestinal wall and the adjacent tissue thereof between water and the gastrointestinal wall tissue, in addition the poor adhesive force of water, no viscosity, drain characteristics such as fast, be easy to produce filling defect in gastrointestinal, the diagnosis that reaches pathological changes to image quality brings interference.Therefore using water as gastrointestinal CT remains to belong to and is not still having " way of having no way " that adopts under the desirable contrast agent situation at present.But among the comparison of water and high density contrast agent, can draw a useful conclusion,, adopt low-density contrast medium more suitable for the CT diagnosis of gastrointestinal CT and even other cavity organ.
One of the object of the invention according to above-mentioned the deficiencies in the prior art, proposes a kind of low-density gastrointestinal contrast medium and production method thereof, and the present invention eliminates pseudo-shadow effectively, thereby improves the definition of CT image, gives and accurately diagnoses focus to bring benefit.
Two of the object of the invention is oleaginous tastes of having eliminated the lipid contrast agent trial product of once appearing, fundamentally improves mouthfeel.
Three of the object of the invention, " dry powderization " on the mode of production, thus solved the layering of liquid contrast agent trial product in the past, the mushroom pollution problem in the perishable and production process.
Summary of the invention
The object of the invention realizes being realized by following technical scheme:
The present invention is mainly mixed by glyceryl monooleate, propylene glycol alginate and sodium carboxymethyl cellulose, proportioning 8~12: 2~3: 0.5~1, and form is a powdered; Using method is after monoglyceride (glyceryl monooleate) and propylene glycol alginate and sodium carboxymethyl cellulose are mixed in proportion, dash with 70 ℃~100 ℃ water and to infuse, form uniform emulsion through stirring, under 0 ℃~10 ℃ environment, leave standstill more than 24 hours, when the weight of product of the present invention is 10~18 grams, dashes and infuse to 500ml~800ml.
Advantage of the present invention is: the CT value of product of the present invention leave standstill stablize about more than 24 hours, its CT value can reach-40~-50H μ, extend to the time as quiet, the CT value continues to descend, minimum reaching-below the 300H μ, like this density contrast between soft tissue such as gastrointestinal wall and the full place of contrast agent has been expanded to more than the 300H μ from about the 20H μ of water, thereby the quality of radiography image is greatly improved, and fundamentally eliminated the oleaginous taste of lipid contrast agent trial product.Particularly since raw material sources in raw-food material, not only without any side effects, and have instant character, thereby on the mode of production, realized " dry powderization ", thereby solved the mushroom pollution problem in the layering of liquid contrast agent trial product in the past, the perishable and production process.
The specific embodiment
By the following examples feature of the present invention and other feature are described in further detail:
The present invention mainly is made up of glyceryl monooleate, propylene glycol alginate and sodium carboxymethyl cellulose, with powdery three components, glyceryl monooleate 8 grams, powdery propylene glycol alginate 2 grams, sodium carboxymethyl cellulose 1 gram physical method mix, if add trace (adding 0.06~0.1) stevioside, can also make that product mouthfeel of the present invention is fragrant and sweet, but its sweeting agent belongs to the refinement of empty calory plant to form, and does not hinder in diabetics and takes, and purpose is to improve mouthfeel.
Using method of the present invention is, dash with 70 ℃~100 ℃ water and to infuse to 500ml, after stirring the uniform emulsion of formation, it is about more than 24 hours stable (also can shake between stable phase) to leave standstill shady and cool place (best 0 ℃~10 ℃), its CT value can reach-40~-50H μ, can guarantee the high-quality of gastrointestinal CT cross-sectional image completely.Peep three-dimensional image in the emulation as doing with spiral CT, can extend quietly makes its CT value continue to descend to stabilization time, as stablize 4 days then the CT value can reduce to-below the 200H μ; Stablize 7~10 days CT values can reduce to-below the 300H μ.To shaking up once more, drink on an empty stomach before the stable good contrast agent use.The general consumption 500ml that is grown up, one or two people need 800ml, and the child follows the doctor's advice and cuts down according to the circumstance.Do preferably to inject 654-2 before the CT,, improve image quality in order to slow down gastrointestinal peristalsis.

Claims (2)

1, low-density gastrointestinal contrast medium is characterized in that, mainly mixes by glyceryl monooleate, propylene glycol alginate and sodium carboxymethyl cellulose, and proportioning (weight) 8~12: 2~3: 0.5~1, form is a powdered.
2, the preparation method of low-density gastrointestinal contrast medium according to claim 1 is characterized in that, glyceryl monooleate, propylene glycol alginate and sodium carboxymethyl cellulose is mixed in proportion get final product.
CNB001224328A 2000-08-01 2000-08-01 Low-density gastrointestinal contrast medium and its production process Expired - Fee Related CN1162186C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CNB001224328A CN1162186C (en) 2000-08-01 2000-08-01 Low-density gastrointestinal contrast medium and its production process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB001224328A CN1162186C (en) 2000-08-01 2000-08-01 Low-density gastrointestinal contrast medium and its production process

Publications (2)

Publication Number Publication Date
CN1336237A CN1336237A (en) 2002-02-20
CN1162186C true CN1162186C (en) 2004-08-18

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100400105C (en) * 2006-05-11 2008-07-09 上海交通大学 Aqueous matrix CT negative contrast medium for digestive tract and its preparation method
CN102139118A (en) * 2010-01-28 2011-08-03 陈星荣 Isosmotic gastrointestinal tract neutral filling liquid for CT (computed tomography), MR (magnetic resonance), PET (positron emission tomography)/CT

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CN1336237A (en) 2002-02-20

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