CN1336157A

CN1336157A - Double-wavelength image subtracting method and equipment for diagnosing mastosis

Info

Publication number: CN1336157A
Application number: CN 00119537
Authority: CN
Inventors: 杨森
Original assignee: Individual
Current assignee: Individual
Priority date: 2000-08-01
Filing date: 2000-08-01
Publication date: 2002-02-20
Anticipated expiration: 2020-08-01
Also published as: CN1190166C

Abstract

In the invention utilized is the property that variable rate of absorption in wave length 400 to 1100 nm is high for blood and low for skin, so that two different semi-conductor lasers at 700 nm with the lowest absorption for blood and a wave length that is away from 700 nm are chosen as light sources to penetrate the tested tissue, and computer is used to control camera and obtain clear picture showing the change of blood distribution density, thereby it raises the diagnostic effect.

Description

Dual wavelength image subtract breast disease diagnosis method and device

The present invention relates to the optical diagnostic method and the corresponding device thereof of cystic hyperplasia of breast, belong to the medical diagnosis field.

In the prior art, the HRJ of the LEO-1201 breast disease diagnosis instrument family of thunderous armarium company limited difficult to understand, Daheng Co., China of Chinese Academy of Sciences series breast examination instrument.Its instrument operation principle is denser than other normal structures according to its blood capillary distribution density of tumor locus (especially at the borderline tumor position), blood flow is bigger, and blood has absorption to the light of certain wavelength, when light passes tested breast, through shooting, demonstration, on picture, obtain the image that intensity changes thereupon, for the doctor provides diagnostic means.Shown in figure one, power supply 1 is lighted halogen tungsten lamp, the input 5 of light focusing in optical fibers 4, is transmitted to outfan 6 by 4 through reflection shield 2, passes tested tissue 9, obtains the image that changes with interior tissue through camera system 7, display system 8.

Shown in Figure 2, the luminescent spectrum of halogen tungsten lamp 3 is distributed as shown in the curve a, and spectrum extends to a far part near ultraviolet, is polychromatic light.Because 4 pairs of spectrum of optical fibers also are partly to absorb, the curve of spectrum that arrives at 9 o'clock is still quite wide spectrum shown in b, be still polychromatic light.

Shown in Figure 3 is that tissue comprises the curve to spectrographic absorption and scattering such as skin, blood.Wherein curve A e-epidermis is to spectrographic absorption, and the Se-epidermis is to spectrographic scattering, and Ab-blood is to spectrographic absorption, and Sb-blood is to spectrographic scattering, and Ad-corium is to spectrographic absorption, and Sd-corium is to spectrographic scattering, and the Ap-pigment is to spectrographic absorption.As can be seen from Figure 3, the human body most tissues is to spectrographic absorption and be scattered in the 400-1100nm scope and change not very bigly, and alters a great deal in the absorption of this scope inner blood.In technology in the past, pass tissue and be the wide spectrum shown in the curve b among Fig. 2.If as measuring-signal, other scattering and absorption just become noise so the signal of blood absorption.Be regardless of simultaneously the height of absorbance in curve b scope, photograph simultaneously, in fact only get its total value, its characteristic is not effectively utilized.Therefore its image is undesirable, brings difficulty to doctor's identification.

The present invention is directed to the deficiency of conventional art, design new method and apparatus.

Trend according to curve A b among Fig. 3, selecting the light about wavelength 700nm for use is witness mark light, away from the light of a certain wavelength among 760～1000nm or the 500～635nm in the light of wavelength 700nm as measuring light, pass tested tissue respectively, by computer control camera system record respectively, and two images are subtracted each other, show by display again, what obtain is the image of eliminating after the background that changes with the blood distribution density, as image subtract in the x-ray technology, improved contrast, for the doctor provides image clearly.

As one of embodiments of the invention, as shown in Figure 4,12,13 for launching the semiconductor laser tube and the

corresponding power supply

10,11 of different wave length among the figure, if 12 for measuring light, 13 is reference ray,, light is exported from outfan 17

input

14,15 of light focusing by condenser lens 19, passed 9 through 16 in Y type light 16.Optical fiber two

inputs

14,15 should guarantee uniform mixing at outfan 17 places after making up, handle through 7 receptions, computer 18, and display 8 shows.18 controls, 12,13 fluorescent lifetimes, intensity and sampling time of 7, and subtract each other processing as image, make the background trend minimum.

As a kind of conversion, when laser power is too little, can increase the quantity and the corresponding power supply of laser tube, y-type optical fiber also correspondingly increases bifurcated quantity.Need only keep uniform mixing at outfan 17.

Two of the embodiment of the invention, as shown in Figure 5, spectroscope 20 has such characteristic among the figure, and it has very high transmitance to the light of 12 emissions, and the light to 13 emission wavelengths has high reflectance simultaneously.Before entering optical fiber 21, just be merged into coaxial light path like this, have very high coupling efficiency simultaneously.21 input need not to be designed to the Y type.All the other get final product as one of embodiment.

As a kind of conversion, as shown in Figure 6, illuminator 22 is designed to two reflective surfaces among the figure, and the light source of 12,13 positions is transmitted in the optical fiber 21 respectively.

Three of the embodiment of the invention, as shown in Figure 6,

light source

12,13 can substitute or part alternative semiconductors laser tube the combination that can obtain to measure light and reference ray with light emitting diode.

Four of the embodiment of the invention, as shown in Figure 7, the light source of two kinds of different wave lengths is made into a kind of integrated optical source 23, under the control of computer, can be luminous respectively, finish shooting, subtract shadow, demonstration work.

Claims

1, diagnosis of dual wavelength image subtract and device, ABSORPTION AND SCATTERING in this scope such as skin changes little feature to 1100nm scope absorption variations is big at wavelength 400nm to it is characterized in that utilizing blood, selects the 700nm left and right sides light of blood absorption minimum to make witness mark light.Away from the light of a certain wavelength among the light about wavelength 700nm 760～1000 or the 500～635nm as measuring light, pass tested tissue respectively, make a video recording record, subtract shadow and handle, reach the method for eliminating background light, obtaining the image that changes with the blood distribution density.

2, according to claims 1, the dual wavelength of design subtracts image device, it is characterized in that this device is made up of two emission quasiconductors of different wave lengths or light emitting diode, power supply, y-type optical fiber, camera system, computer, display etc., two wavelength are in blood respectively it are had low absorption and high absorption position, and the time that luminous time, intensity, the video camera of computer control sampled is also made to subtract shadow to image and handles.

3, as a kind of conversion, when luminous power too hour, increase the quantity of laser tube (or light emitting diode), the corresponding increase bifurcated of optical fiber quantity, outfan only need keep uniform mixing.

4, according to claims 1,2, the dual wavelength of design subtracts image device.As another kind of conversion, it is characterized in that a spectroscope is arranged in the light path, have that light to transmission peak wavelength has high permeability, the light to reflection wavelength has high reflectance and is combined into coaxial light path simultaneously.

5, according to claims 4, as embodiment in another, it is characterized in that having in the light path two reflective surfaces, two light sources are formed the axis light roads.

6, according to claims 1,2, the device of design, its feature can also be made into integrated optical source with the light source of two kinds of different wave lengths, obtains to measure the combination of light and reference ray.