CN1332009C - Plant linolic acid purifying method - Google Patents
Plant linolic acid purifying method Download PDFInfo
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- CN1332009C CN1332009C CNB2005101189793A CN200510118979A CN1332009C CN 1332009 C CN1332009 C CN 1332009C CN B2005101189793 A CNB2005101189793 A CN B2005101189793A CN 200510118979 A CN200510118979 A CN 200510118979A CN 1332009 C CN1332009 C CN 1332009C
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- linolic acid
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- paper mulberry
- seed oil
- mulberry fruit
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Abstract
The present invention discloses a purification method of plant linoleic acid, which comprises the steps: paper mulberry oil at a certain temperature is added into a molecular distiller at a certain temperature and with a certain vacuum degree from a feeding opening, rotor scraping speed and coarse linolic acid flow rate are regulated, and the paper mulberry oil is distilled to obtain refined linolic acid; vapor chromatograophic measurement shows the linolic acid content in the refined linolic acid is from 78 to 82 %, and the linolic acid yield is from 36 to 41 %.
Description
Technical field
The present invention relates to a kind of linoleic purification process of herbal medicine paper mulberry fruit seed oil, this fatty oil is mainly used in industries such as medicine, food, makeup.
Background technology
Papermulberry Fruit is the dry mature fruit of moraceae plants paper mulberry [Broussonetia papyrifera (L.) Vent.], is distributed in China North China, northwest, East China, Central-South, southwest and Liaoning.Have the kidney tonifying clearing liver, make eye bright, the effect of diuresis is used for the treatment of soreness of the waist and knees clinically, the consumptive disease hectic fever due to yin, and dizzy blurred vision, order is given birth to film, and the oedema turgor can also be treated tetter such as stubborn dermatitis, neurodermatitis, eczema." Mingyi Bielu " carries to top grade: sweet, cold, nontoxic.The real son of the many records of ancient book on Chinese herbal medicine Chu is a tonic, carries to top grade as " Mingyi Bielu ": sweet, cold, nontoxic.The big help of function, clothes are not hungry, not old for a long time, make light of one's life by commiting suicide.Modern document shows that also it has anti-senile dementia or delays senile dementia, improves the effect of cognitive function, and is effective to chronic hepatitis C by the Chinese medicine preparation liver relieving capsule that Chu Shizi etc. forms in addition, and alanine aminotransferase is had clear improvement.The treatment Jaundice Jaundice there is special efficacy.Chu's reality, Root of coastal Glehnia, give birth to compatibility such as cultivated land and use and to improve the hepatic and renal YIN deficiency and be used for the treatment of type hepatitis special efficacy is arranged.Compatibility uses such as Chu's reality, Root of coastal Glehnia, living cultivated land can improve the hepatic and renal YIN deficiency and be used for the treatment of posthepatitic cirrhosis, and total effective rate 88%, HBsAg negative conversion rate are 67.7%.Can improve liver function to yellow subcutaneous ulcer companion hepatomegaly patients with ascites, recover serum bilirubin." setting upright disappears makes soup " formed with the real compatibility of Chu is to tangible hepatic ascites 65 examples of the deficiency of Yin, total effective rate 90.7%.Papermulberry Fruit can be treated ephrosis, real with Chu, obtain treatment chronic nephritis such as tongue and deficiency of kidney-QI type patient effective.With depleted double oedema person of treatment chronic renal merits such as the luxuriant 5 usefulness Chu Shizi of Huang and urinary system calculus certain effect is arranged all also.Papermulberry Fruit also can be used to treat ophthalmic diseases and gynaecology's infertility, with Papermulberry Fruit is the medicine that main ingredient is made, energy therapeutic community's property retinitis, can promote infertility women ovulation, male sterility is comprised all kinds of patients of impotence, premature ejaculation, involuntary emission, anejaculation and cacospermia also produce effect more.In addition, to treating bald class, senile morning, Baldo had curative effect preferably.Prospect application prospect, Papermulberry Fruit not only have the potentiality of exploitation treatment geriatric disease new drug, can also make the product of beauty and health care class.
Paper mulberry fruit seed oil tradition is extracted and partition method: promptly with organic solvent extraction such as sherwood oils, through crushing screening Papermulberry Fruit fruit, with sherwood oil cold-maceration or seepage method, with cold soaking or the solution suction filtration that leaks out, concentrate and reclaim solvent and promptly get brown paper mulberry fruit seed oil.Comprise pigment or the like owing to contain the impurity of other property in the grease, also need to make with extra care.Extract must be added on the silicagel column, the solvent of using opposed polarity respectively is as flushing such as sherwood oil, ether, acetone pillar.Reclaim solvent and obtain elaboration.More than these methods exist that complex process, cycle are long, extraction yield is lower, poor selectivity, effective constituent destructible, production efficiency be low.
Summary of the invention
The object of the present invention is to provide a kind of linoleic purification process of separating plant paper mulberry fruit seed oil, this method cost is low, good separating effect, and the paper mulberry fruit seed oil separates by molecular distillation equipment, obtains highly purified unsaturated fatty acids.Can more be widely used for industries such as medicine, food, makeup.
The linoleic purification process of one kind of plant Papermulberry Fruit oil, its step is as follows:
1, system is prepared and charging: when molecular distillation apparatus is heated to 50-70 ℃, opens vacuum pump and vacuumize, when vacuum tightness is 2-3Pa, the paper mulberry fruit seed oil is heated to 55-65 ℃ adds from opening for feed.
2, low boiling component is removed in distillation: the rotating speed of regulating the rotor knifing is 150-180r/ minute, paper mulberry fruit seed oil flow velocity 1500-2000ml/ hour, under the high speed rotating effect of blade applicator, be uniformly distributed on the heating evaporation face, the paper mulberry fruit seed oil is heated on generating surface, and under high vacuum condition, volatiles is through intermediate condenser and be condensed into liquid, flow into collecting chamber along condenser, get low boiling component respectively and take off the paper mulberry fruit seed oil of low boiling component from two discharge ports.
3, prepare thick linolic acid: when molecular distillation apparatus is heated to 105-110 ℃, open vacuum pump when vacuum tightness is 1.5-1.7Pa, the paper mulberry fruit seed oil that will take off low boiling component is heated to 75-85 ℃ and adds from opening for feed, the rotating speed of regulating the rotor knifing is 220-240r/ minute, flow velocity 1800-2000ml/ hour, from two discharge ports respectively thick linolic acid and residue.
4, prepare smart linolic acid: when molecular distillation apparatus is heated to 115-120 ℃, open vacuum pump when vacuum tightness is 0.3-0.4Pa, thick linolic acid is heated to 85-95 ℃ to add from opening for feed, the rotating speed of regulating the rotor knifing is 240-260r/ minute, flow velocity 1800-2200ml/ hour, from two discharge ports respectively smart linolic acid and residue, containing linolic acid in the smart linolic acid of gas chromatography determination is 78-82%, recovery rate is 36-41%.
The present invention compared with prior art has the following advantages and effect:
1. molecular distillation technique improves traditional purifying technique as the gentleest a kind of fractionation by distillation means, has improved quality product.Conventional distillation procedure temperature height, the long shortcoming of heated time have been overcome, can solve the insurmountable difficult problem of conventional distillation, the loss of, heat-sensitive substance clean etc. as impure, a large amount of dissolvent residual of smell, contaminant removal, and be suitable for the system that similar substance forms and the separation and the purification of highly difficult separate substance, help changing the situation that China's product innovation purifying technique falls behind, can improve the pre-treatment and the purifying technique of product, enrich the product innovation of China, improve the quality and the grade of product, reduced production cost.
2. characteristics such as separation degree and product yield height, nontoxic, harmless, pollution-free, noresidue, can obtain pure safe natural product, be applicable to comparatively complicated mixture, to the purification that separates of the high viscous material of thermo-responsive and added value, can carry out multiple-grade molecular distillation, be used with supercritical liquid extraction technique.Molecular distillation technique on industrial applications than other conventional distillation have the product quality height, energy consumption is little, cost is low, be easy to amplify remarkable advantages such as application.
Embodiment
The linoleic purification process of one kind of plant Papermulberry Fruit oil, its step is as follows:
(1) system is prepared and charging: when molecular distillation apparatus is heated to 50 or 60 or 70 ℃, opens vacuum pump and vacuumize, when vacuum tightness is 2.5Pa, the paper mulberry fruit seed oil is heated to 55 or 60 or 65 ℃ adds from opening for feed.
(2) low boiling component is removed in distillation: the rotating speed of regulating the rotor knifing is 150 or 165 or 180r/ minute, paper mulberry fruit seed oil flow velocity 1500 or 1800 or 2000ml/ hour, under the high speed rotating effect of blade applicator, be uniformly distributed on the heating evaporation face, the paper mulberry fruit seed oil is heated on generating surface, and at high vacuum condition, volatiles is through intermediate condenser and be condensed into liquid, flow into collecting chamber along condenser, get low boiling component respectively and take off the paper mulberry fruit seed oil of low boiling component from two discharge ports.
(3) prepare thick linolic acid: when molecular distillation apparatus is heated to 105 or 108 or 110 ℃, opening vacuum pump is 1.5 or 1.6 or during 1.7Pa to vacuum tightness, the paper mulberry fruit seed oil that will take off low boiling component is heated to 75 or 80 or 85 ℃ and adds from opening for feed, the rotating speed of regulating the rotor knifing is 220 or 230 or 240r/ minute, flow velocity 1800 or 1900 or 2000ml/ hour, from two discharge ports respectively thick linolic acid and residue.
(4) prepare smart linolic acid: when molecular distillation apparatus is heated to 115 or 117 or 120 ℃, opening vacuum pump is 0.3 or 0.35 or during 0.4Pa to vacuum tightness, thick linolic acid is heated to 85 or 90 or 95 ℃ to add from opening for feed, the rotating speed of regulating the rotor knifing is 240 or 250 or 260r/ minute, flow velocity 1800 or 1900 or 2200ml/ hour, from two discharge ports respectively smart linolic acid and residue, containing linolic acid in the smart linolic acid of gas chromatography determination is 78 or 80 or 82%, and recovery rate is 36 or 38 or 41%.
Claims (1)
1, the linoleic purification process of a kind of plant Papermulberry Fruit oil, its step is as follows:
A, system prepare and charging: when molecular distillation apparatus is heated to 50-70 ℃, opens vacuum pump and vacuumize, when vacuum tightness is 2-3Pa, the paper mulberry fruit seed oil is heated to 55-65 ℃ adds from opening for feed;
Low boiling component is removed in B, distillation: the rotating speed of regulating the rotor knifing is 150-180r/ minute, paper mulberry fruit seed oil flow velocity 1500-2000ml/ hour, under the high speed rotating effect of blade applicator, the paper mulberry fruit seed oil is heated on generating surface, under vacuum condition, volatiles is through intermediate condenser and be condensed into liquid, flows into collecting chamber along condenser, gets low boiling component respectively and takes off the paper mulberry fruit seed oil of low boiling component from two discharge ports;
C, prepare thick linolic acid: when molecular distillation apparatus is heated to 105-110 ℃, open vacuum pump when vacuum tightness is 1.5-1.7Pa, the paper mulberry fruit seed oil that will take off low boiling component is heated to 75-85 ℃ and adds from opening for feed, the rotating speed of regulating the rotor knifing is 220-240r/ minute, flow velocity 1800-2000ml/ hour, from two discharge ports respectively thick linolic acid and residue;
D, prepare smart linolic acid: when molecular distillation apparatus is heated to 115-120 ℃, open vacuum pump when vacuum tightness is 0.3-0.4Pa, thick linolic acid is heated to 85-95 ℃ to add from opening for feed, the rotating speed of regulating the rotor knifing is 240-260r/ minute, flow velocity 1800-2200ml/ hour, from two discharge ports respectively smart linolic acid and residue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101189793A CN1332009C (en) | 2004-09-07 | 2004-09-07 | Plant linolic acid purifying method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101189793A CN1332009C (en) | 2004-09-07 | 2004-09-07 | Plant linolic acid purifying method |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100608066A Division CN1332010C (en) | 2004-09-07 | 2004-09-07 | Preparation and purification method for plant linoleic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1772857A CN1772857A (en) | 2006-05-17 |
| CN1332009C true CN1332009C (en) | 2007-08-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005101189793A Expired - Fee Related CN1332009C (en) | 2004-09-07 | 2004-09-07 | Plant linolic acid purifying method |
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| Country | Link |
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| CN (1) | CN1332009C (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5387705A (en) * | 1993-08-13 | 1995-02-07 | The Procter & Gamble Company | Fatty acid anhydride process |
| CN1438211A (en) * | 2000-09-14 | 2003-08-27 | 国家海洋局第一海洋研究所 | Method for preparing conjugate linoleic acid |
-
2004
- 2004-09-07 CN CNB2005101189793A patent/CN1332009C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5387705A (en) * | 1993-08-13 | 1995-02-07 | The Procter & Gamble Company | Fatty acid anhydride process |
| CN1438211A (en) * | 2000-09-14 | 2003-08-27 | 国家海洋局第一海洋研究所 | Method for preparing conjugate linoleic acid |
Non-Patent Citations (3)
| Title |
|---|
| 楮实子的氨基酸及脂肪油成分分析 黄宝康等，第二军医大学学报，第02期 2003 * |
| 超临界CO2萃取-分子蒸馏对白术挥发油的提取分离和GC-MS分析 张忠义等，分析测试学报，第22卷第4期 2003 * |
| 超临界CO2萃取-分子蒸馏对白术挥发油的提取分离和GC-MS分析 张忠义等，分析测试学报，第22卷第4期 2003;楮实子的氨基酸及脂肪油成分分析 黄宝康等，第二军医大学学报，第02期 2003 * |
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| Publication number | Publication date |
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| CN1772857A (en) | 2006-05-17 |
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