CN1328839A - Medicine for reducing blood pressure and cleaning fat and its production method - Google Patents
Medicine for reducing blood pressure and cleaning fat and its production method Download PDFInfo
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- CN1328839A CN1328839A CN 01114527 CN01114527A CN1328839A CN 1328839 A CN1328839 A CN 1328839A CN 01114527 CN01114527 CN 01114527 CN 01114527 A CN01114527 A CN 01114527A CN 1328839 A CN1328839 A CN 1328839A
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Abstract
A Chinese medicine for reducing blood pressure and regulating blood-lipid is made up by using 13 Chinese medicinal materials of shepherd's purse, pteridium excelsum root, prunella spike, malachium, siphonostegia chinensis, imperate and others through the process of removing impurity, cleaning, drying, pulverizing, extracting, filtering, concentrating, fine filtering, filling, disinfection by means of high-pressure steam and packaging. This invented Chinese medicine possesses the functions of boosting qi, strengthening kidney, fortifying brain, supplementing qi and blood, calming liver and subduing yang, etc. so that it can obtain obvious therapeutic effect for curing hypertension, coronary heart disease and cerebral arteriosclerosis, etc.
Description
The present invention relates to a kind of medicine for the treatment of hypertension, is to be the blood pressure lowering of feedstock production, the Chinese patent medicine of fat eliminating with the Chinese herbal medicine particularly, the invention still further relates to this medicine production method.
Hypertension is person in middle and old age's commonly encountered diseases, a frequently-occurring disease, undermines the heart, brain, kidney and blood vessel, jeopardizes healthy.The Western medicine of treatment hypertension has phenobarbital, verticil, reserpine etc. at present, adopts these western medicine hypertension to exist side effect, the defective that blood pressure can rebound again after the drug withdrawal, and can only take stopgap measures, can not effect a permanent cure.Though the report of some relevant adjust blood pressure, the hypertensive Chinese medicine health care product of control is also arranged, the visible pill of dosage form, tablet, capsule, medicated wine, electuary and oral liquid, health tea etc., its curative effect is also relatively slowly.
The object of the present invention is to provide a kind of blood pressure lowering, fat eliminating medicine for the treatment of hypertension, to solve the weak point that existing hypertension therapy disease exists.
Another goal of the invention of the present invention provides this blood pressure lowering, fat eliminating medicine production method.
Solution of the present invention is based on the traditional Chinese medical science and thinks that hypertension belongs to the traditional Chinese medical science " headache and dizzy " scope, for " hepatic and renal YIN deficiency, excessive rising of liver-YANG " cause all as the mechanism of symptom, theory according to Huangdi's Internal Classics " liver governing tendons, heart governing blood and vessels, the kidney generating marrow and dominating bone are filled out brain " is the basis, theory with " firm congenital, conditioning the day after tomorrow " be guidance, use modern medical theory " three falling and draw together (be blood fat reducing, blood viscosity lowering, bring high blood pressure down and expand little blood vessel) proposes for pointer.
Medicine of the present invention is made by following raw materials by weight percent: (%)
Herba Capsellae 5-30 Rhizoma pteridii latiusculi 5-15 Spica Prunellaes 7-40
NIUFANLOU 5-25 Herba Siphonostegiae 7-40 Rhizoma Imperataes 7-15
DINGFENGCAO 4-10 Semen Sesami Nigrums 4-15 Fructus Jujubaes 4-15
The Cortex Eucommiae 4-25 Fructus Lyciis 4-25 Salvia kiaometiensis Levl.f.pubescens Stib.s 5-35
Radix Curcumae 5-15.
The optimum weight percentage ratio of medicine of the present invention is (%):
Herba Capsellae 10 Rhizoma pteridii latiusculi 10 Spica Prunellaes 10
NIUFANLOU 10 Herba Siphonostegiae 10 Rhizoma Imperataes 10
DINGFENGCAO 5 Semen Sesami Nigrums 5 Fructus Jujubaes 5
The Cortex Eucommiae 5 Fructus Lyciis 5 Salvia kiaometiensis Levl.f.pubescens Stib.s 7.5
Radix Curcumae 7.5.
Above-mentioned each component is made medicine production method of the present invention is:
1, above-mentioned Chinese herbal medicine roguing of selecting for use, cleaning, oven dry, powder essence is standby to treat;
2, take by weighing a certain proportion of Chinese herbal medicine mixing and use steam extraction by above-mentioned prescription;
3, the admixing medical solutions that extracts is filtered with 200 mesh sieves;
Admixing medical solutions after 4 filtrations gets final product through concentrated, fine straining, fill, disinfection with high pressure steam, encapsulation.
The present invention with Fructus Lycii, Semen Sesami Nigrum nourishing the liver and kidney, beneficial blood, to fill out brains be monarch drug, plays " firm the congenital foundation " effect; Herba Capsellae, Rhizoma pteridii latiusculi liver heat removing, sharp liver, soothing the liver, removing heat from blood strengthening the spleen play harmonizing the liver and spleen function and " three fall an expansion " and act as ministerial drug, and assistant relaxes the property of medicine with Fructus Jujubae tonification vigour, the spleen invigorating of nourishing blood; All medicines share, and play QI invigorating, kidney tonifying, brain-strengthening, strong marrow, QI invigorating essence and blood, suppressing the hyperactive liver and subsiding YANG altogether, let out the effect of liver-fire, building body, treating both the principal and secondary aspects of a disease clearly.The hypertensive patient that the treatment Chinese medical discrimination is belonged to overabundant liver-fire, hyperactivity of YANG due to deficiency of YIN, deficiency of both YIN and YANG type has curative effect well, and hypertension, coronary heart disease and the cerebral arteriosclerosis of other type also had auxiliary curative effect.The present invention does not have other adverse side effect, and blood pressure is difficult for bounce-back after the drug withdrawal, so can take stopgap measures, can effect a permanent cure again.
For showing the therapeutic effect of medicine of the present invention to hypertension, the present invention is through the clinical observation of 60 routine systems of Xiyuan Hospital, Chinese Medicine Academy of China, and its result is as follows: 1, material and method: occasion star oral liquid (being the present invention), be dark brown liquid, and use for test-meal.1.2, study subject: 60 routine hypertension experimenters (women's 29 examples, male's 31 examples), the age is at 18-65 years old, complication such as no severe cardiac Liver and kidney are divided at random and are subjected to examination group and matched group.Each group adopts the own control design, is control design between group between two groups.1.2.1, diagnostic criteria: develop and publish " new Chinese medicine clinical research guideline " with reference to Ministry of Public Health: systolic pressure 〉=150mnHg or diastolic pressure 〉=90mmHg.1.2.2, the person's of including in standard
All hyperpietics who meets above-mentioned diagnostic criteria all can carry out test-meal and observe.1.2.3, eliminator's standard 1.2.3.1, age be under-18s or person more than 70 years old, gestation or women breast-feeding their children.1.2.3.2, complication such as severe cardiac, liver, kidney are arranged, or be associated with other serious primary disease, the psychotic.1.2.3.3, the noncooperationist, can't judge the full person of curative effect or data.1.3, test-meal method 60 routine hypertension experimenters, be divided into 2 groups at random, former take the medicine kind and dosage constant, occasion star group adds food occasion star oral liquid, every day 3 times, each 20ml, edible continuously 4 weeks.1.4, instrument and reagent: desk model sphygmomanometer (Shanghai Medical Equipment Factory's product), F-820 type blood count meter is urinated ten analysers (German Bao Ling Man produce), Olympus automatic clinical chemistry analyzer (Japan produces), model AU600, biochemical reagents box are all provided by middle living company.2, observation index:
Regularly decide people's measuring blood pressure once weekly, had a rest 15-20 minutes before surveying, each test once when all other indexs began and finish in the test-meal experiment.2.1, clinical health check-up: 2.1.1, blood pressure, electrocardiogram, the fluoroscopy of chest of X line, Abdominal B type ultrasonography.2.1.2, the blood routine inspection:
Hematochrome, red-cell count, lencocyte count.2.1.3, routine urianlysis
Acid-base value, specific gravity of urine, glucose in urine, protein, occult blood, bilirubin, urobilinogen, ketoboidies, leukocyte, erythrocyte.2.1.4, biochemical indicator measures 2.1.4.1, blood fat (triglyceride, T-CHOL, HDL-C).2.1.4.2, blood glucose, total protein, albumin, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT, carbamide, inosine.2.1.5, observation of symptoms
Detailed medical history-taking is observed main clinic symptoms: dizzy, dizzy, cardiopalmus, agitation, soreness of the waist and knees etc.Before and after test-meal, add up integrated value by symptom weight (serious symptom 3 minutes, moderate 2 minutes, light disease 1 minute), and improve (each doing well,improving 2 is divided into produce effects, improves 1 and is divided into effectively), observation doing well,improving rate with regard to its cardinal symptom.3, blood pressure lowering effect is judged: develop and publish " new Chinese medicine clinical research guideline " with reference to Ministry of Public Health and formulate.3.1, produce effects: 3.1.1, diastolic pressure decline 〉=10mmHg, and reach normal range.3.1.2, diastolic pressure decline 〉=20mmHg.3.2, effectively: 3.2.1, diastolic pressure decline＜10mmHg, but reached normal range.3.2.2, the diastolic pressure 10-19mmHg that descends, but do not reach normal range.3.2.3, systolic pressure decline 〉=20mmHg.3.3, invalid:
Do not reach above standard person.4, result: 4.1, physical data: observe 60 examples altogether, occasion star group male 14 examples, women's 16 examples, minimum 31 years old of age, the oldest 64 years old, average 52.20 years old; Matched group male 17 examples, women's 13 examples, minimum 35 years old of age, the oldest 63 years old, average 52.27 years old.4.1.1, two groups observe last as the situation comparison sheet 1 ordinary circumstance example other course of disease of several years rheological properties (year) blood pressure (mmHg) that relatively divides into groups
Compare no significant difference between preceding two groups of men and women's systolic pressure diastolic pressure occasion star group 30 52.20 ± 8.49 14 16 9.94 ± 10.79 154.33 ± 17.53 100.77 ± 10.47 matched groups 30 52.27 ± 8.38 17 13 8.50 ± 5.82 155.00 ± 14.43 100.77 ± 11.63 test-meals, have comparability.4.2, the preceding two groups of blood pressure situation 4.2.1 of test-meal, two groups of systolic pressure situations of change
Table 2 systolic pressure changes relatively (mmHg, difference occasion star group 154.33 ± 17.53 146.80 ± 17.17** 7.53 ± 13.50 141.13 ± 13.71**, 13.20 ± 14.00 matched groups 155.00 ± 14.43 153.37 ± 14.80 1.63 ± 10.27 151.17 ± 15.74 3.83 ± 12.02# after the difference test-meal in the test-meal before the project test-meal of X ± SD)
Contrast #P＜0.05 occasion star group systolic pressure 13.20 ± 14.80mmHg that on average descends between own control * * P＜0.01***P＜0.001 group, the matched group 3.83 ± 12.02mmHg that on average descends, two groups compare variant obviously.4.2.2, two groups of diastolic pressure situations of change
Table 3 diastolic pressure situation of change (mmHg, contrast #P＜0.05 occasion star group diastolic pressure between difference occasion star group 100.77 ± 10.47 95.03 ± 9.96** 5.73 ± 9.57 91.47 ± 9.73***, 9.30 ± 10.25 matched groups 100.17 ± 11.63 97.43 ± 10.42* 2.73 ± 6.39 95.77 ± 9.37**, 4.40 ± 6.74# own control * P＜0.05 * * P＜0.01 * * * P after the difference test-meal in the test-meal before the project test-meal of X ± SD)＜0.001 group and flatten the 9.30 ± 10.25mmHg that all descends, matched group 4.40 ± the 6.74mmHg that on average descends, two groups compare variant obviously.4.3, effect evaluation
Relatively divide into groups routine digital display of table 4 blood pressure lowering effect is imitated enabledisable total effective rate (%) occasion star group 30 8 15 7 76.67 matched groups 30 5 12 13 56.674.4, doing well,improving situation
Table 5 doing well,improving is symptom example time produce effects enabledisable improvement rate (%) dizzy 27 4 15 8 62.96 relatively
(25) (2) (9) (14) (44.00) headache 21 3 10 8 61.90
(21) (2) (8) (11) (47.62) cardiopalmus 20 397 60.00
(18) (2) (7) (9) (50.00) irritated 24 2 13 9 62.50
(21) (1) (9) (11) (47.62) soreness of the waist and knees 24 48 12 50.00
(26) (3) (9) (14) (46.15)
() is matched group 4.5 clinical symptoms integrations statistics
Table 6 clinical symptoms integration is (occasion star group 30 9.07 ± 3.99 6.47 ± 3.98***, 4.50 ± 3.28*** matched groups 30 9.10 ± 3.46 7.78 ± 3.74**** 6.93 ± 3.89*** after the test-meal in the test-meal before the routine number test-meal of grouping of X ± SD) relatively
Own control * * * P＜0.0014.6, blood testing index 4.6.1, blood fat
The comparison of table 7 Blood Lipid (X ± SD)
Occasion star group, (n=30) matched group, (n=30) TC after the test-meal before the test-meal after the test-meal before the project test-meal, (mmol/L) 4.14 ± 0.31 4.02 ± 0.31 4.67 ± 1.46 4.51 ± 1.35TG, (mmol/L) 1.67 ± 0.72 1.66 ± 0.69 1.92 ± 1.05 2.07 ± 1.20HDL, (mmol/L) 1.36 ± 0.34 1.32 ± 0.26 1.27 ± 0.41 1.23 ± 0.31 occasion star groups and the matched group blood fat is every has no significant change.4.6.2, routine blood test
The variation of table 8 routine blood test (X ± SD)
Occasion star group, (n=30) matched group, (n=30) HGB after the test-meal before the test-meal after the test-meal before the project test-meal, (g/L) 159.90 ± 23.52 155.17 ± 21.55 149.10 ± 17.38 143.47 ± 31.16RBC, (*/be 5.65 ± 0.61 5.72 ± 0.60 4.91 ± 0.59 4.88 ± 0.50WBC L), (*/L) 6.06 ± 1.44 6.38 ± 1.45 6.38 ± 1.60 6.11 ± 1.17
Two groups of every detection indexs of routine blood test are all at normal range 4.6.3, blood biochemistry index
Table 9 blood biochemistry index changes the (ALB (g/L) 49.07 ± 9.57 48.67 ± 9.39 45.14 ± 6.27 46.56 ± 5.53 of X ± SD)
ALT (mmol/L) 31.90 ± 20.75 28.69 ± 16.26 28.73 ± 18.81 28.75 ± 13.03AST (mmol/L) 45.29 ± 12.83 45.11 ± 9.72 30.48 ± 15.14 30.85 ± 12.68UREA (mmol/L) 5.70 ± 1.65 5.46 ± 1.47 8.76 ± 5.09 8.25 ± 3.92CRE (mol/L) 81.69 ± 10.61 83.68 ± 15.56 93.27 ± 30.27 95.17 ± 19.75GLU (mmol/L) 5.4 3 ± 0.89 5.28 ± 0.94 5.29 ± 1.33 5.24 ± 1.16TP (g/L) 75.08 ± 5.97 74.63 ± 5.10 75.86 ± 4.90 76.74 ± 6.09 after the front test-meal of test-meal after the front test-meal of occasion star group (n=30) control group (n=30) project test-meal
Two groups of every detection indexs are all at normal range 4.6.4, two groups of examination trencherman electrocardiograms, Abdominal B type ultrasonography, and the X-ray Chest X-rays all belongs to normal range.5, conclusion 5.1,60 routine hypertension experimenters, 30 routine test-meal groups are taken 4 weeks of occasion star oral liquid on request continuously, the blood pressure 13.20 ± 14.00/9.30 ± 10.25mmHg that on average descends, produce effects 8 examples wherein, effective 15 examples, total effective rate 76.67%; 30 routine matched group blood pressures, the 3.83 ± 12.02/4.40 ± 6.74mmHg that on average descends, produce effects 5 examples wherein, effective 12 examples, total effective rate 56.67%; Compare for two groups, test-meal group systolic pressure and diastolic pressure descend all than matched group obvious difference (P＜0.05), illustrate that occasion star oral liquid tries the trencherman to hypertension, and blood pressure lowering has certain effect.5.2, occasion star oral liquid is to symptom effects of having clear improvement such as patients with hypertension dizziness, dizzy, cardiopalmus, agitation, soreness of the waist and knees.5.3, before and after the test-meal occasion star oral liquid, hemoglobin, erythrocyte, leukocyte, total serum protein, albumin, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT inosine, carbamide etc. illustrate that all in normal range the present invention has no adverse effects to health.5.4, occasion star oral liquid do not observe allergy and other untoward reaction in the test-meal process.
Embodiment: the described blood pressure lowering of present embodiment, fat eliminating medication medication are made by following raw materials by weight percent:
Herba Capsellae 10% (20g) Rhizoma pteridii latiusculi 10% (20g) Spica Prunellae 10% (20g)
NIUFANLOU 10% (20g) Herba Siphonostegiae 10% (20g) Rhizoma Imperatae 10% (20g)
DINGFENGCAO 5% (10g) Semen Sesami Nigrum 5% (10g) Fructus Jujubae 5% (10g)
The Cortex Eucommiae 5% (10g) Fructus Lycii 5% (10g) Salvia kiaometiensis Levl.f.pubescens Stib. 7.5% (15g)
Radix Curcumae 7.5% (15g).
Above-mentioned each component is made present embodiment medicine production method is:
1, above-mentioned Chinese herbal medicine roguing of selecting for use, cleaning, oven dry, powder essence is standby to treat;
2, take by weighing a certain proportion of Chinese herbal medicine mixing and use steam extraction by above-mentioned prescription;
3, the admixing medical solutions that extracts is filtered with 200 mesh sieves;
Admixing medical solutions after 4 filtrations gets final product through concentrated, fine straining, fill, disinfection with high pressure steam, encapsulation.
Claims (3)
1, blood pressure lowering, fat eliminating medicine is characterized in that being made by following raw materials by weight percent: (%)
Herba Capsellae 5-30 Rhizoma pteridii latiusculi 5-15 Spica Prunellaes 7-40
NIUFANLOU 5-25 Herba Siphonostegiae 7-40 Rhizoma Imperataes 7-15
DINGFENGCAO 4-10 Semen Sesami Nigrums 4-15 Fructus Jujubaes 4-15
The Cortex Eucommiae 4-25 Fructus Lyciis 4-25 Salvia kiaometiensis Levl.f.pubescens Stib.s 5-35
Radix Curcumae 5-15.
2, blood pressure lowering according to claim 1, fat eliminating medicine is characterized in that its optimum weight percentage ratio is (%):
Herba Capsellae 10 Rhizoma pteridii latiusculi 10 Spica Prunellaes 10
NIUFANLOU 10 Herba Siphonostegiae 10 Rhizoma Imperataes 10
DINGFENGCAO 5 Semen Sesami Nigrums 5 Fructus Jujubaes 5
The Cortex Eucommiae 5 Fructus Lyciis 5 Salvia kiaometiensis Levl.f.pubescens Stib.s 7.5
Radix Curcumae 7.5.
3, the described blood pressure lowering of a kind of claim 1, fat eliminating medicine production method is characterized in that being made up of following steps:
(1), Herba Capsellae, Rhizoma pteridii latiusculi, Spica Prunellae, NIUFANLOU, Herba Siphonostegiae, Rhizoma Imperatae, DINGFENGCAO, Semen Sesami Nigrum, Fructus Jujubae, the Cortex Eucommiae, Fructus Lycii, Salvia kiaometiensis Levl.f.pubescens Stib., Radix Curcumae roguing, cleaning, oven dry, the powder essence selected for use is standby to treat;
(2), take by weighing a certain proportion of Chinese herbal medicine mixing and use steam extraction by the described prescription of claim 1;
(3), the admixing medical solutions that extracts is filtered;
(4), the admixing medical solutions after the filtration gets final product through concentrated, fine straining, fill, disinfection with high pressure steam, encapsulation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1307909C (en) * | 2002-01-23 | 2007-04-04 | 黄昌柏 | Technological process for preparing beverage, oral liquor electuar, and antitoxic tablet from fern root |
| CN100346817C (en) * | 2004-11-08 | 2007-11-07 | 北京万邦医药投资有限公司 | Chinese medicine composition for preventing and treating hypertension, hyperlipemia and hyperglycemia |
| CN102973798A (en) * | 2012-11-28 | 2013-03-20 | 启东市大华电动工具有限公司 | Liver-calming and pressure-reducing medicament |
-
2001
- 2001-06-06 CN CN 01114527 patent/CN1328839A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1307909C (en) * | 2002-01-23 | 2007-04-04 | 黄昌柏 | Technological process for preparing beverage, oral liquor electuar, and antitoxic tablet from fern root |
| CN100346817C (en) * | 2004-11-08 | 2007-11-07 | 北京万邦医药投资有限公司 | Chinese medicine composition for preventing and treating hypertension, hyperlipemia and hyperglycemia |
| CN102973798A (en) * | 2012-11-28 | 2013-03-20 | 启东市大华电动工具有限公司 | Liver-calming and pressure-reducing medicament |
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