CN105169372A - Functional food for increasing bone density and improving osteoporosis and preparation method of functional food - Google Patents
Functional food for increasing bone density and improving osteoporosis and preparation method of functional food Download PDFInfo
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- CN105169372A CN105169372A CN201510553097.3A CN201510553097A CN105169372A CN 105169372 A CN105169372 A CN 105169372A CN 201510553097 A CN201510553097 A CN 201510553097A CN 105169372 A CN105169372 A CN 105169372A
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Abstract
The invention belongs to the technical field of production of a food, and in particular relates to a functional food for increasing bone density and improving osteoporosis and a preparation method of the functional food. The functional food for increasing bone density and improving osteoporosis consists of the following raw materials in a formula in parts by weight: 18-23 parts of calcium lactate, 8-12 parts of chondroitin sulfate, 15-20 parts of an extract from kudzu vine root, 15-20 parts of collagen, 10-15 parts of gynura root powder, 8-14 parts of glucosamine, 0.001-0.005 parts of vitamin K and 0.002-0.004 parts of vitamin D. The functional food disclosed by the invention can promote calcium precipitation in bone and increase bone density; and the ingredients in the formula are combined to take a synergistic effect, so that osteoporosis in old people can be fundamentally improved.
Description
Technical field
The invention belongs to technical field of food production, be specifically related to a kind of bone density that increases and improve osteoporotic functional food and preparation method thereof.
Background technology
Osteoporosis is commonly encountered diseases and the frequently-occurring disease of aging society, and be a kind of low with bone amount, bone micro-structure destroys, and causes bone fragility to increase, and the systemic disease of fracture easily occurs.Cause osteoporotic reason to have multiple, main cause has: 1, inherited genetic factors.Sclerotin may be multigenic disease, these genes may participate in the acquisition of bone amount and the regulation and control of bone conversion, have obvious race difference, World Health Organization (WHO) predicts and occurs whole year the year two thousand fifty, in the middle aged and aged women of Hip Fracture, the case had more than 50% to be occurred in Asia.2, trophic factor.Calcium is mineral composition the most basic in sclerotin, and calcium Deficiency of Intake, malabsorption all can cause osteoporosis, and with advancing age, human body to the picked-up of calcium, absorb and reduce, and outdoor activity also reduces gradually, vitamin D synthesis is not enough, all can promote osteoporotic generation.3, hormonal change.After entering old age, great changes will take place for human endocrine, and thyroxin rising, calcitonin and growth hormone reduce, and the molten bone of osteoclast and Absorption significantly strengthen, and osteocyte osteogenic ability declines.In addition osteoporosis is also relevant with the impact of living habit and medicine, and inactive people is easier than movable people, and osteoporosis occurred, and old people often muscle does not get enough athletic exercise, and the circulation of skeleton inner blood is slowed down, and metabolic function reduces, and impels osteoporotic generation.In addition, glucocorticoid, antuepileptic, anticoagulant on long-term taking kidney, carry out chemotherapy containing aluminum antacid, diuretic, thyroxin etc. and cancer patient and all can affect calcium absorption and metabolism, cause osteoporosis.
It is inconvenient and painful greatly that osteoporosis is brought to patient; treatment is produced effects very slow; senile osteoporosis is except calcium loss acceleration, bone density decline; usually also along with the swelling of diseased region, pain, weak; easy initiation osteoporotic fracture; As time goes on the muscle of diseased region also has atrophy in various degree, occurs figure shortening, deformation of spinal column etc.Current osteoporotic control is mainly started with from replenishing the calcium, but simple replenishing the calcium can not improve senile osteoporosis often with pain, weak, and middle-aged and elderly people quantity of motion is low, and outdoor activity reduces, limited to the absorbability of calcium, improve osteoporotic effect so can not reach.The present invention is directed to the physiological feature of old people and many-sided symptom of senile osteoporosis, a kind of functional food provided, pass through scientific matching, play the synergism of formula, can reducing swelling and alleviating pain, remove osteoarticular inflammation, and mend with nutrient substance such as osteoarthrosis desirable proteins, calcium, then with vitamin D
3, vitamin K
3promote that human body is to the absorption of calcium, and help calcium to precipitate in skeleton.
Summary of the invention
The present invention solves the multiple osteoporosis of middle-aged and elderly people and with the problem of diseased region pain, the symptom such as weak, provides a kind of bone density that increases and improve osteoporotic functional food and preparation method thereof.
Increase bone density of the present invention improves osteoporotic functional food, and its formula material and shared number are: calcium lactate 18 ~ 23 parts, chondroitin sulfate 8 ~ 12 parts, Radix Puerariae extract 15 ~ 20 parts, collagen protein 15 ~ 20 parts, 10 ~ 15 parts, Radix gynurae segeti powder, glucosamine 8 ~ 14 parts, vitamin K
30.001 ~ 0.005 part of vitamin D
30.002 ~ 0.004 part.The present invention's Radix Puerariae used is purchased from Zheng Liyuan Industrial Co., Ltd. of Chongqing City, and Radix gynurae segeti is purchased from Bozhou City Teng Wang Pharmaceutical Co., Ltd of Anhui Province.
The preparation method that increase bone density of the present invention improves osteoporotic functional food comprises the following steps:
1, Radix Puerariae extract preparation: pulverized by Radix puerariae root, crosses 60 mesh sieves, adds the ethanol of 70%, 60 DEG C of-70 DEG C of ultrasonic assistant extract twice, each 30min, for the first time 10 times amount ethanol, second time 8 times amount ethanol, centrifuging and taking supernatant, sucking filtration, merging filtrate, filtrate reduced in volume is to extractum shape, lyophilization, pulverizing, for subsequent use.
2, Radix gynurae segeti powder preparation: by dry Radix gynurae segeti tuber, superfine grinding, for subsequent use.
3, calcium lactate, vitamin D is taken by formulation ratio
3, vitamin K
3, chondroitin sulfate, Radix Puerariae extract, collagen protein, Radix gynurae segeti powder, glucosamine, mix homogeneously, tabletting, film coating, to obtain final product.
Effect of the present invention is illustrated below in conjunction with raw material:
Radix Puerariae extract: Radix Puerariae is a kind of medicinal and edible plant, effective ingredient is osajin, there is the effect of oestrogen-like hormone, the osteoporosis caused because of estrogen deficiency can be acted on, research shows to have during Radix Puerariae and associated extraction thing are tested in vivo and in vitro increases the function that bone amount improves bone metabolism, the people such as He Zhipeng have studied the effect of Radix Puerariae to osteoporosis in ovariectomized rats, and result shows that Radix Puerariae can significantly improve the bone density of osteoporosis rat femur.Clinical research finds, Radix Puerariae can improve the bone metabolism growth indexes of osteoporosis patients, and improves the clinical symptoms of patient.
Radix gynurae segeti powder: Radix gynurae segeti is the On behalf of plant of Gynura Cass, complex chemical composition, main containing the abundant composition such as alkaloid volatile oil, terpenes, aminoacid, flavonoid, have and regulate the effect such as blood glucose blood pressure, promotion union of fracture, anti-inflammation detumescence, antitumor.All medicinal in the Dong nationality, Zhuang, the She, the Lahu, the Yi nationality, distributed over Yunnan, Sichuan and Guizhou, Achang nationality of Miao ethnic group, Tujia.Compendium of Material Medica is in " seven " bar cloud: " a kind of grass of nearly biography, spring raw Seedling, summer high three or four chis.Strength is thick like chrysanthemum Chinese mugwort for leaf, has discrimination point.Stem has red rib.Xia Qiukai Hemerocallis citrina Baroni, stamen is as spun gold, and dish knob is lovely, and gas is not fragrant, spends dryly then to tell stamen such as gutweed and wad a quilt with cotton.Root leaf sweet in the mouth, control the hemorrhage and upper and lower disorders of blood of incised wound injured, very imitate, cloud is Radix Notoginseng, and root is large as Radix Arctii "." Yunnan Chinese herbal medicine ": " sweet, bitter, warm, poisonous.Hemostasis dissipating blood stasis, reducing swelling and alleviating pain.Cure mainly traumatic injury, rheumatalgia, carbuncle, dermatitis, innominate toxic swelling, traumatic hemorrhage "
Chondroitin sulfate: be lenitive product common on market.It is as one of the composition of cartilage structure, the reparation in joint can be accelerated, retain moisture, make nutritional labeling rapid osmotic in cartilage, also be proteoglycan molecule, there is hydrophilic, larger viscosity, be attached to tissue surface, mass exchange between maintenance connective tissue moisture and tissue is all played an important role, there is the ability regulating Growth of Cells, growth and propagation.It can remove a large amount of Na+ absorbed in synovial membrane, promotes that sclerotin increases, repairs damaged joints, increase cartilage density in osteoarthrosis chamber.It also has the effect of suppression NK cytoactive, is conducive to the reparation of tissue.It concentrates in the cartilage in joint in a large number, can strengthen the absorption of articular cartilage to nutrition, chondrocyte also can be made to possess enough moisture, thus can reach the effect of damping vibration and lubrication.
Glucosamine: the main nutrient composition being composition articular cartilage, can form Chitosan in cartilaginous tissue, helps the cartilage development increasing articular cavity, and increases the lubricating fluid of articular cavity.It can stimulate the growth of chondrocyte by synthetic proteins polysaccharide, promotes to form articular cartilage tissue, reaches the arthritic generation of prevention.
Collagen protein: bone collagen is tectine again, accounts for the 30%-40% of human body protein total amount, be distributed in human muscle connect tendon in, joint connect cartilaginous tissue and connective tissue and skin skin corium in.It can eliminate arthralgia, and prevent, alleviate arthroncus, distortion, stiff, accelerating union of bone fracture, improves skeleton toughness, prevent calcium loss, improves calcium absorptivity, repairs osseous tissue, improves osteoporosis.
Calcium, vitamin D
3, vitamin K
3: calcium is the abundantest mineral of human body, it participates in the whole life process of human body, the calcium of human body 99% is present in tooth and skeleton, the calcium of 1% is only had to be present in blood, but when blood calcium reduces, the calcium in skeleton can be discharged into maintain blood calcium balance in blood by body automatically, and the content of bone calcium will reduce, calcium Deficiency of Intake affects obviously on old people, and the risk that osteoporosis and fracture occur is higher.Calcium lactate dissolubility is high, mouthfeel good, calcium content is higher, bioavailability is high, good stability, calcium ion effect are obvious, is conventional calcium complement agent.Vitamin D
3, vitamin K
3can promote that human body is to the absorption of calcium, and help calcium to precipitate in skeleton.
The present invention compared with prior art its beneficial effect is: with Radix Puerariae extract, Radix gynurae segeti powder, chondroitin sulfate, glucosamine, reducing swelling and alleviating pain, eliminate intraarticular noxious substance, remove osteoarthritic inflammation, repair cartilaginous tissue, increase articular cartilage density, increase articular cavity lubricating fluid, repair joint; Supplement the nutrition needed for skeleton with collagen protein, calcium lactate, improve skeleton toughness; With vitamin D
3, vitamin K
3promote calcium absorption, help calcium to precipitate in skeleton, increase bone density.The present invention is directed to the physiological feature of old people and many-sided symptom of senile osteoporosis, provide a kind of functional food, pass through scientific matching, play the synergism of formula, can reducing swelling and alleviating pain, remove osteoarticular inflammation, and mend with nutrient substance such as osteoarthrosis desirable proteins, calcium, then with vitamin D
3, vitamin K
3promote that human body is to the absorption of calcium, and help calcium to precipitate in skeleton, fundamentally improve the osteoporosis problem of middle-aged and elderly people.
Detailed description of the invention
Be below specific embodiment of the invention case, further illustrate technical scheme of the present invention.
Embodiment 1 increases the preparation method that bone density improves osteoporotic functional food
Increase bone density of the present invention improves osteoporotic functional food, and its formula material and shared number are: calcium lactate 18 ~ 23 parts, chondroitin sulfate 8 ~ 12 parts, Radix Puerariae extract 15 ~ 20 parts, collagen protein 15 ~ 20 parts, 10 ~ 15 parts, Radix gynurae segeti powder, glucosamine 8 ~ 14 parts, vitamin K
30.001 ~ 0.005 part, vitamin D
30.002 ~ 0.004 part.
Its preparation method comprises the following steps:
1, Radix Puerariae extract preparation: pulverized by Radix puerariae root, crosses 60 mesh sieves, adds the ethanol of 70%, 60 DEG C of-70 DEG C of ultrasonic assistant extract twice, each 30min, for the first time 10 times amount ethanol, second time 8 times amount ethanol, centrifuging and taking supernatant, sucking filtration, merging filtrate, filtrate reduced in volume is to extractum shape, lyophilization, pulverizing, for subsequent use.
2, Radix gynurae segeti powder preparation: by dry Radix gynurae segeti tuber, superfine grinding, sieves for subsequent use.
3, calcium lactate, vitamin D is taken by formulation ratio
3, vitamin K
3, chondroitin sulfate, Radix Puerariae extract, collagen protein, Radix gynurae segeti powder, glucosamine, mix homogeneously, tabletting, film coating, to obtain final product.
Embodiment 2 increases the zoopery that bone density improves osteoporotic functional food
For verifying effect of the present invention, carry out zoopery according to the method that " health food inspection and assessment technical specification (2003 editions) " specify.
1, experiment material
(1) laboratory animal: the ablactation SD rat be born about 4 weeks, female, about body weight 70g.
(2) instrument: atomic absorption spectrophotometer, borne densitometers, precimeter, zootomy apparatus, animal balance, 105 DEG C of baking ovens.
(3) reagent: nitric acid, perchloric acid, lanthanum chloride, calcium standard solution 500 μ g/mL
2, experimental technique
(1) dosage grouping
By the present invention according to 0.2g/kg (low dose group), 0.5g/kg (middle dosage group), 1.5g/kg (high dose group) formula feed, lower calcium feedstuff matched group (200mg/kg feedstuff), high dose calcium carbonate control group are set respectively.
(2) test method: after rat adapted to through a week, fasting 12 hours, weighs in, and is divided into 5 groups at random by body weight, and often organize 10, sub-cage rearing, drinks deionized water to avoid obtaining calcium from drinking water.Per os gavage, to sample, is 3 months to the sample time, routine weighing during nursing, feeds after 3 months and puts to death, and separates right side femur, measures femur length, bake to constant weight in 105 DEG C of baking ovens, weighs key heavy.Femur mid point and femur distal end bone density is measured with borne densitometers.Calcium content of bone and the feedstuff calcium content of animal subject is measured with atomic absorption method.
3, experimental result
(1) the present invention is on the impact of rat body weight
The impact that table 1 the present invention increases rat body weight
From data in table, the body weight of each rat of experimental session all has increase in various degree, but contemporaneity respectively organizes the body weight no significant difference of rat, illustrates that the present invention can not affect the normal growth growth of rat.
(2) the present invention is on the impact of rat femur length, femur weight, calcium content of bone
Table 2 the present invention is on the impact of rat femur length, femur weight, calcium content of bone
P*≤0.05 compared with low calcium matched group, p**≤0.01 compared with low calcium matched group.
From data in table 2, the femur length of each group of rat and femur weight no significant difference, middle dose of test group calcium content of bone compared with low calcium matched group has explicitly difference, tested group of high dose, high dose calcium carbonate control group compared with low calcium matched group calcium content of bone there were significant differences.
(3) the present invention is on the impact of Mouse Bone density
Table 3 the present invention is on the impact of rat bone density
P*≤0.05 compared with low calcium matched group, p**≤0.01 compared with low calcium matched group
From data in table 3, middle dose of test group femur central point density and bone distal end density compared with low calcium matched group have notable difference, tested group of high dose compared with low calcium matched group femur central point density and bone distal end density there were significant differences.
Embodiment 3 crowd observation experiment
Subject Population: experiment choose living standard and living habit similar 50-60 year, 60-70 year, 70-80 year each 10 people.
Experimental technique: understood each experimenter's osteoarthrosis symptom by inquiry before experiment starts, and carry out the inspection of a Whole Body Bone Scanning density, record check result to test crowd.Take this product to Subject Population, every day twice, each 2, after 30 days, the osteoarthrosis symptom of each experimenter is understood in inquiry again, carries out the inspection of a Whole Body Bone Scanning density, and the results contrast before starting with experiment, record osteoporotic improvement situation.
Experimental result:
Better improvement: pain symptom disappears substantially, bone density significantly increases
General improvement: pain symptom alleviates, bone density slightly increases
Without improve: pain symptom without improvement and bone density do not increase
Table 4 crowd observation experiment result
From data in table 4, the osteoporosis symptoms of each experimental group crowd all has improvement in various degree, and improvement rate reaches 60-70%.Illustrate that the present invention can improve arthralgia, eliminate arthritis, supplement skeleton nutrition, increase bone density, fundamentally improve senile osteoporosis.
Claims (2)
1. increase bone density and improve an osteoporotic functional food, its formula material and proportioning are: calcium lactate 18 ~ 23 parts, chondroitin sulfate 8 ~ 12 parts, Radix Puerariae extract 15 ~ 20 parts, collagen protein 15 ~ 20 parts, 10 ~ 15 parts, Radix gynurae segeti powder, glucosamine 8 ~ 14 parts, vitamin K
30.001 ~ 0.005 part, vitamin D
30.002 ~ 0.004 part.
2. according to claim 1ly a kind ofly increase the preparation method that bone density improves osteoporotic functional food, it is characterized in that being made up of following steps:
(1) Radix Puerariae extract preparation: pulverized by Radix puerariae root, crosses 60 mesh sieves, adds the ethanol of 70%, 60 DEG C of-70 DEG C of ultrasonic assistant extract twice, each 30min, for the first time 10 times amount ethanol, second time 8 times amount ethanol, centrifuging and taking supernatant, sucking filtration, merging filtrate, filtrate reduced in volume is to extractum shape, lyophilization, pulverizing, for subsequent use;
(2) Radix gynurae segeti powder preparation: by dry Radix gynurae segeti tuber, superfine grinding, for subsequent use;
(3) calcium lactate, vitamin D is taken by claim 1 formulation ratio
3, vitamin K
3, chondroitin sulfate, Radix Puerariae extract, collagen protein, Radix gynurae segeti powder, glucosamine, mix homogeneously, tabletting, film coating, to obtain final product.
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| CN105495599A (en) * | 2015-12-29 | 2016-04-20 | 镇江恒顺生物工程有限公司 | Blood-fat reducing soft capsule and preparing method thereof |
| CN110584120A (en) * | 2019-09-25 | 2019-12-20 | 东莞自然衡健康科技有限公司 | Bone health composition |
| CN110720515A (en) * | 2019-10-25 | 2020-01-24 | 李玉保 | Bone collagen polypeptide composite nutrient for improving bone mineral density and preparation method thereof |
| CN111135284A (en) * | 2019-12-11 | 2020-05-12 | 武汉跃莱健康产业有限公司 | Composition for improving bone mineral density and preparation method and application thereof |
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Application publication date: 20151223 |