CN1327856C - Freeze-dried qi-strengthening ginseng and astragalus powder for injection and its preparing process - Google Patents
Freeze-dried qi-strengthening ginseng and astragalus powder for injection and its preparing process Download PDFInfo
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- CN1327856C CN1327856C CNB2003101139441A CN200310113944A CN1327856C CN 1327856 C CN1327856 C CN 1327856C CN B2003101139441 A CNB2003101139441 A CN B2003101139441A CN 200310113944 A CN200310113944 A CN 200310113944A CN 1327856 C CN1327856 C CN 1327856C
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- 238000002360 preparation method Methods 0.000 claims abstract description 10
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- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 5
- 150000004676 glycans Chemical class 0.000 claims description 38
- 229920001282 polysaccharide Polymers 0.000 claims description 38
- 239000005017 polysaccharide Substances 0.000 claims description 38
- 239000000706 filtrate Substances 0.000 claims description 31
- 241000756943 Codonopsis Species 0.000 claims description 26
- 238000003756 stirring Methods 0.000 claims description 24
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 22
- 230000006837 decompression Effects 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 16
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 9
- 229930195725 Mannitol Natural products 0.000 claims description 9
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- JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
The present invention discloses a qi strengthening freeze-drying powder injection of pilose asiabell root and membranous milkvetch root, which is characterized in that the injection is an injection preparation of traditional Chinese medicines, which is composed of the effective parts of pilose asiabell root and membranous milkvetch root. The present invention also discloses a preparation method for the preparation, which is characterized in that the effective components of the pilose asiabell root and the membranous milkvetch root are extracted respectively with an alcohol extraction method and a water extraction method; after the alcohol is precipitated, the effective components are decolorized with active carbon, ultra-filtered with hollow fibre columns and then dried to obtain solid alcohol extract and water extract; the solid alcohol extract and the water extract are prepared into a solution; excipient is added to the solution; the qi strengthening freeze-drying powder injection of pilose asiabell root and membranous milkvetch root is obtained through subpackage, subzero refrigeration and drying. The preparation of the present invention has the favorable functions of benefiting the lung, strengthening the spleen, replenishing qi and nourishing blood, and the advantages of high stability, reasonable preparation process and no toxic and side effect.
Description
Affiliated technical field
The invention belongs to field of traditional Chinese medicine pharmacy, more specifically relate to a kind of injection SHENQI FUZHENG freeze-dried powder and preparation method thereof.
Background technology
SHENQI FUZHENG ZHUSHEYE is formed by Radix Codonopsis and the Radix Astragali two flavor Chinese medicine equivalent prescriptions, late tumor patient to qi-deficiency type has good efficacy clinically, centralizing function with lung benefiting spleen invigorating, benefiting qi and nourishing blood can obviously improve disease, patient's clinical symptoms, improves life quality.With the chemotherapeutic fit applications, have efficacy enhancing and toxicity reducing, improve the effect of autoimmunity.But the dosage form of injection is a liquid at present, and less stable pH value often occurs behind the storage certain hour and changes, and causes that appearance luster deepens, even occurs muddy and precipitation, makes clarity defective; Existing SHENQI FUZHENG ZHUSHEYE adopts decoction and alcohol sedimentation technique prepared (Chinese patent medicine ministry standard WS-459 (Z-065)-95 and WS-387 (Z-50)-99), precipitate with ethanol remove impurity after the water heating extraction, alcohol precipitation process is in the purification remove impurity, removed the polysaccharide in the Radix Codonopsis and the Radix Astragali, and Radix Codonopsis polysaccharide and astragalus polysaccharides have the effect (Zhang Xiaojun that improves immunity preferably, Hu Li, Lai Xiaoping, Deng. Radix Codonopsis polysaccharide is to the influence [J] of mouse immune and hemopoietic function. new Chinese medicine and clinical pharmacology 2003,14 (3): 174-176; Liu Xing is humorous, Wang Meiying, and Wu Housheng, etc. the separation of astragalus polysaccharides and immunocompetent research [J] research and development of natural products thereof, 1994,16 (1): 23; Single person of outstanding talent, Wang Shunchun, Liu Di, etc. the chemistry of astragalus polysaccharides and pharmacological research progress [J]. Shanghai Univ. of Traditional Chinese Medicine's journal 2000,14 (3): 61-65); In addition, injection products adopts ampoule filling, makes troubles for transportation and storage.
Summary of the invention
The object of the present invention is to provide a kind of good stability, transportation to store convenient, the more rational injection SHENQI FUZHENG of preparation technology freeze-dried powder.It is characterized in that adopting alcohol extracting method and water extraction to extract its effective ingredient successively to the Radix Codonopsis and the Radix Astragali, both kept original active component in the injection, increased the polysaccharide component that has the enhance immunity effect in Radix Codonopsis and the Milkvetch Root again, adopt alcohol deposition method refining respectively alcohol extract and water extract, water extract utilizes activated carbon decolorizing, hollow fiber column ultrafilter, obtains alcohol extraction effective site respectively after two kinds of extract dryings and water is put forward polysaccharide effective site.With alcohol extraction effective site 4-12g, water is carried polysaccharide effective site 1-10g, adds injection mannitol 5-50g, sodium chloride for injection 4-12g, with water for injection wiring solution-forming 600-1400ml, regulate pH value to 7-7.5, filter, sterilize, be sub-packed in cillin bottle, frozen drying, promptly.
Content of the present invention is achieved through the following technical solutions:
One, medical material pre-treatment
Granule is chosen, cleans, dries, is ground into to medical material Radix Codonopsis, the Radix Astragali respectively.
Two, extraction process
Radix Codonopsis, the Milkvetch Root of getting equivalent are a certain amount of, add ethanol (v/v) heating and refluxing extraction 2 times of 5-15 times of 50%-90% at every turn, filter, and medicinal residues keep standby, and merging filtrate is evaporated to every 1ml and contains 2 g crude drugs; Stir and to add ethanol down, make to contain the alcohol amount and reach 60-70%, left standstill 24 hours after fully stirring, filter, filtrate is concentrated into every 1ml and contains the 3g crude drug; Stir and to add ethanol down, make to contain the alcohol amount and reach 70-80%, left standstill 24 hours after fully stirring, filter, it is dried that filtrate is concentrated into, alcohol extraction effective site.
Medicinal residues add 6-14 and doubly measure the deionization water boiling and extraction 2 times, and merge extractive liquid, filters, and filtrate decompression is concentrated into the concentrated solution that every 1ml contains the 2g crude drug; Add ethanol and leave standstill filtration for behind the 60-70% to containing the alcohol amount.Add ethanol and leave standstill for behind the 70-80% to containing the alcohol amount, filtration must precipitate, and gets the dissolving of precipitation adding distil water, and activated carbon decolorizing filters; 60 ℃ of vacuum dryings get water and carry polysaccharide crude.With the dissolving of polysaccharide crude adding distil water, cross hollow fiber column ultrafilter (molecular cut off is greater than 6000), filtrate decompression is concentrated into dried, gets polysaccharide effective site.
Three, the preparation of freeze dried ginseng-astragalus powder for injection to strengthen body's resistance
Get alcohol extraction effective site 4-12g, water is carried polysaccharide effective site 1-10g, adds injection mannitol 5-50g, sodium chloride for injection 4-12g, with water for injection wiring solution-forming 600-1400ml, regulate pH value to 7-7.5, filter, sterilize, be sub-packed in cillin bottle, frozen drying, promptly.
Prescription is:
The alcohol extraction effective site 4-12g of the Radix Codonopsis and the Radix Astragali;
The water of the Radix Codonopsis and the Radix Astragali is carried polysaccharide effective site 1-10g;
Injection mannitol: 5-50g;
Sodium chloride for injection: 4-12g;
Water for injection 600-1400ml.
Optimization formula is:
The alcohol extraction effective site 6-10g of the Radix Codonopsis and the Radix Astragali;
The water of the Radix Codonopsis and the Radix Astragali is carried polysaccharide effective site 4-8g;
Injection mannitol: 5-10g;
Sodium chloride for injection: 6-10g;
Water for injection 800-1200ml.
The present invention will be further described by embodiment
Embodiment 1
1 prescription: the Radix Codonopsis 40 gram Radixs Astragali 40 grams
2 technologies: get recipe quantity Radix Codonopsis, Milkvetch Root, heating and refluxing extraction 2 times adds 8 times of amounts of 80% ethanol at every turn and extracted 1 hour, filters, and medicinal residues keep standby; Filtrate merges, and is evaporated to every 1ml and is equivalent to the 2g crude drug, adds ethanol and stirs to make and contain the alcohol amount and reach 70%, leaves standstill 24 hours; Filter, filtrate decompression is concentrated into every 1ml and is equivalent to the 3g crude drug, adds ethanol again and stirs to make and contain the alcohol amount and reach 80%, leaves standstill 24 hours; Filter, filtrate decompression is concentrated into dried, obtains alcohol extraction effective site.Medicinal residues add the deionization water boiling and extraction 2 times, add 6 times of amount deionized waters at every turn and decoct 1 hour, and merge extractive liquid, filters, and filtrate decompression concentrates, and add ethanol and stir to make and contain the alcohol amount and reach 70%, leave standstill, and filter.Get precipitation adding distil water dissolving, add ethanol and stir to make and contain the alcohol amount and reach 80%, leave standstill, filter, precipitate 60 ℃ of vacuum dryings, get water and carry polysaccharide crude.1% solution is made in the dissolving of polysaccharide crude adding distil water, used 0.1% activated carbon decolorizing, filter, cross hollow fiber column ultrafilter (molecular cut off is greater than 6000), filtrate decompression is concentrated into dried, gets polysaccharide effective site.Get alcohol extraction position 8g, water is carried polysaccharide effective site 6g, adds the injection water and makes dissolving, adds sodium chloride 8g, with mannitol 10g, regulates pH value to 7.0-7.5, adds 0.1% activated carbon decolorizing, filter, and sterilization, frozen drying, promptly.
Embodiment 2
1 prescription: the Radix Codonopsis 40 gram Radixs Astragali 40 grams
2 technologies: get recipe quantity Radix Codonopsis, Milkvetch Root heating extraction 2 times, add 10 times of amounts of 70% ethanol at every turn and extracted 1 hour, filter, medicinal residues keep standby, and filtrate merges, and is evaporated to every 1ml and is equivalent to the 2g crude drug, add ethanol and stir to make and contain the alcohol amount and reach 70%, left standstill 24 hours; Filter, filtrate decompression is concentrated into every 1ml and is equivalent to the 3g crude drug, adds ethanol again and stirs to make and contain the alcohol amount and reach 80%, leaves standstill 24 hours; Filter, filtrate decompression is concentrated into dried, obtains alcohol extraction effective site.Medicinal residues add 6 times of amount deionized waters at every turn and decoct,, extracts 2 times, each 1 hour, merge extractive liquid, filtered, and filtrate decompression concentrates, and adds ethanol and stirs to make and contain the alcohol amount and reach 70%, leaves standstill filtration.Get precipitation adding distil water dissolving, filtrate adds ethanol stirs to make and contains the alcohol amount and reach 80%, leaves standstill, and filters, and precipitate 60 ℃ of vacuum dryings, gets water and carries polysaccharide crude.1% solution is made in the dissolving of polysaccharide crude adding distil water, used 0.1% activated carbon decolorizing, filter, cross hollow fiber column ultrafilter (molecular cut off is greater than 6000), filtrate decompression is concentrated into dried, gets polysaccharide effective site.Get alcohol extraction position 8g, water is carried polysaccharide effective site 6g, adds the injection water and makes dissolving, adds sodium chloride 6g, with mannitol 20g, regulates pH value to 7.0-7.5, uses 0.1% activated carbon decolorizing, filter, and sterilization, frozen drying, promptly.
Embodiment 3
1 prescription: the Radix Codonopsis 40 gram Radixs Astragali 40 grams
2 technologies: get recipe quantity Radix Codonopsis, Milkvetch Root, heating and refluxing extraction 2 times adds 8 times of amounts of 80% ethanol at every turn and extracted 1 hour, filters, and medicinal residues keep standby; Filtrate merges, and is evaporated to every 1ml and is equivalent to the 2g crude drug, adds ethanol and stirs to make and contain the alcohol amount and reach 70%, leaves standstill 24 hours; Filter, filtrate decompression is concentrated into every 1ml and is equivalent to the 3g crude drug, adds ethanol again and stirs to make and contain the alcohol amount and reach 80%, leaves standstill 24 hours; Filter, filtrate decompression is concentrated into dried, obtains alcohol extraction effective site.Medicinal residues add the deionization water boiling and extraction 2 times, add 6 times of amount deionized waters at every turn and decoct 1 hour, and merge extractive liquid, filters, and filtrate decompression concentrates, and add ethanol and stir to make and contain the alcohol amount and reach 70%, leave standstill, and filter.Get precipitation adding distil water dissolving, add ethanol and stir to make and contain the alcohol amount and reach 80%, leave standstill, filter, precipitate 60 ℃ of vacuum dryings, get water and carry polysaccharide crude.1% solution is made in the dissolving of polysaccharide crude adding distil water, used 0.1% activated carbon decolorizing, filter, cross hollow fiber column ultrafilter (molecular cut off is greater than 6000), filtrate decompression is concentrated into dried, gets polysaccharide effective site.Get alcohol extraction position 8g, water is carried polysaccharide effective site 6g, adds the injection water and makes dissolving, adds sodium chloride 6g, adds lactose 10g, regulates pH value to 7.0-7.5, adds 0.1% activated carbon decolorizing, filter, and sterilization, frozen drying, promptly.
Embodiment 4
1 prescription: the Radix Codonopsis 40 gram Radixs Astragali 40 grams
2 technologies: get recipe quantity Radix Codonopsis, Milkvetch Root, heating and refluxing extraction 2 times adds 8 times of amounts of 60% ethanol at every turn and extracted 1 hour, filters, and medicinal residues keep standby; Filtrate merges, and is evaporated to every 1ml and is equivalent to the 2g crude drug, adds ethanol and stirs to make and contain the alcohol amount and reach 60%, leaves standstill 24 hours; Filter, filtrate decompression is concentrated into every 1ml and is equivalent to the 3g crude drug, adds ethanol again and stirs to make and contain the alcohol amount and reach 70%, leaves standstill 24 hours; Filter, filtrate decompression is concentrated into dried, obtains alcohol extraction effective site.Medicinal residues add the deionization water boiling and extraction 2 times, add 6 times of amount deionized waters at every turn and decoct 1 hour, and merge extractive liquid, filters, and filtrate decompression concentrates, and add ethanol and stir to make and contain the alcohol amount and reach 60%, leave standstill, and filter.Get precipitation adding distil water dissolving, add ethanol and stir to make and contain the alcohol amount and reach 70%, leave standstill, filter, precipitate 60 ℃ of vacuum dryings, get water and carry polysaccharide crude.1% solution is made in the dissolving of polysaccharide crude adding distil water, used 0.1% activated carbon decolorizing, filter, cross hollow fiber column ultrafilter (molecular cut off is greater than 6000), filtrate decompression is concentrated into dried, gets polysaccharide effective site.Get alcohol extraction position 8g, water is carried polysaccharide effective site 6g, adds the injection water and makes dissolving, adds sodium chloride 4g, and with mannitol 5g, lactose 5g regulates pH value to 7.0-7.5, adds 0.1% activated carbon decolorizing, filter, and sterilization, frozen drying, promptly.
The pharmacodynamic experiment of freeze dried ginseng-astragalus powder for injection to strengthen body's resistance
Freeze dried ginseng-astragalus powder for injection to strengthen body's resistance is basic identical with SHENQI FUZHENG ZHUSHEYE on the composition of the crude drug of prescription, but because the improvement on the process, make freeze dried ginseng-astragalus powder for injection to strengthen body's resistance not only in extracting composition, add the polysaccharide composition that can strengthen human immunity, and aspect pharmacodynamics, also shown better effect.
With immune organ weight, the peritoneal macrophage phagocytic function is an index, has compared freeze dried ginseng-astragalus powder for injection to strengthen body's resistance and SHENQI FUZHENG ZHUSHEYE to the active influence of mouse immune, and SHENQI FUZHENG freeze-dried powder effect is significantly better than SHENQI FUZHENG ZHUSHEYE as a result.
1, injection SHENQI FUZHENG freeze-dried powder and SHENQI FUZHENG ZHUSHEYE are to the influence of mouse immune organ
36 of Kunming kind white mice (being provided by Military Medical Science Institute zoopery center) are provided, and body weight is divided into 3 groups at random at 20 ± 2g.Ip dosage is 200mg/kg, and successive administration 7 days, with the mice sacrificed by decapitation, is got thymus, spleen is weighed, and is that index is calculated index and spleen index and thymus index with the mg/g body weight, the results are shown in Table 1 at last administration next day.Injection SHENQI FUZHENG freeze-dried powder can obviously increase the thymic weight of normal mouse, and SHENQI FUZHENG ZHUSHEYE does not then have this effect.Injection SHENQI FUZHENG freeze-dried powder and SHENQI FUZHENG ZHUSHEYE all can significantly increase mouse spleen weight, see Table 1.
Table 1 SHENQI FUZHENG freeze-dried powder and SHENQI FUZHENG ZHUSHEYE to the influence of mouse immune organ (x ± s, n=12)
| Group | Dosage (mg/kg) | Thymus index (mg/g) | Index and spleen index (mg/g) |
| Contrast | - | 17.544±2.98 | 48.30±7.35 |
| Injection SHENQI FUZHENG freeze-dried powder | 200 | 21.365±5.12 * | 131.25± 14.23 *** |
| Positive control (SHENQI FUZHENG ZHUSHEYE) | 200 | 17.891±3.05 | 121.23± 16.45 *** |
Compare with matched group:
*P＜0.05
* *P＜0.01
2, injection SHENQI FUZHENG freeze-dried powder and SHENQI FUZHENG ZHUSHEYE are to the influence of Turnover of Mouse Peritoneal Macrophages phagocytic function
Administering mode is the same, and last administration next day, the sacrificed by decapitation mice is cut off mouse peritoneal skin rapidly, and aseptic injection Hank ' s solution 3mL gently rubs abdominal part, extracts peritoneal fluid, the centrifugal 10min of 1000r/min.Use the phosphate buffer standardize solution, add 0.5% chicken red blood cell 0.2mL, in 37 ℃, the 5%CO2 incubator is hatched 30min.Centrifugal push jack, with the dyeing of Rui Shi liquid, microscopy calculates and engulfs percent and phagocytic index, the results are shown in Table 2.Injection SHENQI FUZHENG freeze-dried powder and SHENQI FUZHENG ZHUSHEYE all can increase the quantity of Turnover of Mouse Peritoneal Macrophages, but the short phagocytosis of injection SHENQI FUZHENG freeze-dried powder is more remarkable than SHENQI FUZHENG ZHUSHEYE, sees Table 2.
The influence that table 2 injection SHENQI FUZHENG freeze-dried powder and SHENQI FUZHENG ZHUSHEYE are engulfed Turnover of Mouse Peritoneal Macrophages (x ± s, n=12)
| Group | Dosage (mg/kg) | Phagocytic index | Phagocytic percentage (%) |
| Matched group | 0.000±0.000 | 0.00±0.00 | |
| Injection SHENQI FUZHENG freeze-dried powder | 200 | 5.02±3.12 ** | 0.263± 0.157 * |
| Positive control (SHENQI FUZHENG ZHUSHEYE) | 200 | 0.73±0.61 * | 0.013± 0.010 |
Compare with matched group:
*P＜0.05
*P＜0.01
Claims (8)
1 one kinds of freeze dried ginseng-astragalus powder for injection to strengthen body's resistance is characterized in that it is is that the effective site and the freeze-dried excipient of 1: 1 ratio united extraction is prepared from by the Radix Codonopsis and the Radix Astragali by weight, and it consists of:
The alcohol extraction effective site 4-12g of the Radix Codonopsis and the Radix Astragali;
The water of the Radix Codonopsis and the Radix Astragali is carried polysaccharide effective site 1-10g;
Freeze-dried excipient 5-50g;
Sodium chloride for injection 4-12g;
Water for injection 600-1400ml.
2 freeze dried ginseng-astragalus powder for injection to strengthen body's resistance as claimed in claim 1 is characterized in that it consists of:
The alcohol extraction effective site 6-8g of the Radix Codonopsis and the Radix Astragali;
The water of the Radix Codonopsis and the Radix Astragali is carried polysaccharide effective site 4-8g;
Freeze-dried excipient 5-10g;
Sodium chloride for injection 6-10g;
Water for injection 800-1200ml.
3 according to freeze dried ginseng-astragalus powder for injection to strengthen body's resistance described in the claim 1, it is characterized in that its freeze-dried excipient is meant the mixture of a kind of in mannitol and the lactose or two kinds.
The preparation method of 4 one kinds of freeze dried ginseng-astragalus powder for injection to strengthen body's resistance, it is characterized in that: (1) gets Radix Codonopsis, Milkvetch Root equivalent, after the pre-treatment, add alcohol reflux 2 times, filter, medicinal residues keep standby, merging filtrate is evaporated to every 1ml and contains the 2g crude drug, for the first time precipitate with ethanol, stir and add ethanol down, left standstill 24 hours after fully stirring, filter, filtrate decompression is concentrated into every 1ml and contains the 3g crude drug, precipitate with ethanol for the second time, stir adding ethanol down, left standstill 24 hours after fully stirring, filter, filtrate decompression is concentrated into dried, gets alcohol extraction effective site;
(2) get medicinal residues after the alcohol extraction, add the deionization water boiling and extraction 2 times, merge extractive liquid, filters, filtrate decompression is concentrated into the concentrated solution that every 1ml contains the 2g crude drug, precipitate with ethanol leaves standstill for the first time, filters, get the dissolving of precipitation adding distil water, activated carbon decolorizing filters, for the second time precipitate with ethanol, leave standstill, filter, 60 ℃ of vacuum dryings of gained precipitation get water and carry polysaccharide crude, the polysaccharide crude adding distil water is dissolved, cross molecular cut off greater than 6000 hollow fiber column ultrafilter, filtrate decompression is concentrated into dried, water be put forward polysaccharide effective site;
(3) get alcohol extraction effective site 4-12g, water is carried polysaccharide effective site 1-10g, adds injection mannitol 5-50g, sodium chloride for injection 4-12g, with water for injection wiring solution-forming 600-1400ml, regulate pH value to 7-7.5, filter, sterilize, be sub-packed in cillin bottle, frozen drying, promptly.
5 concentration of alcohol that add alcohol reflux according to claim 4 are 50%-90%.
6 concentration of alcohol that add alcohol reflux according to claim 4 are 60%-80%.
7 first time according to claim 4 precipitate with ethanol concentration of alcohol be 60%-70%.
8 second time according to claim 4 precipitate with ethanol concentration of alcohol be 70%-80%.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1320920C (en) * | 2005-01-21 | 2007-06-13 | 邹巧根 | Freeze-dried powder injection of glossy privet fruit and astragalus root for strengthening body resistance and its making method |
| CN1320921C (en) * | 2005-01-21 | 2007-06-13 | 邹巧根 | Small injection of glossy privet fruit and astragalus root and its making method |
| CN1311864C (en) * | 2005-01-21 | 2007-04-25 | 邹巧根 | Infusion liquid of glossy privet fruit and astragalus root for strengthening body resistance and its making method |
| CN1320896C (en) * | 2005-04-13 | 2007-06-13 | 丽珠集团利民制药厂 | Dangshen astragalus composition for regulating immunity and its preparation method |
| CN100349579C (en) * | 2005-11-18 | 2007-11-21 | 广东大光药业有限公司 | Composition of ginseng-astragalus polysaccharides and its preparing method |
| CN100417396C (en) * | 2006-03-14 | 2008-09-10 | 北京国丹药物技术开发有限公司 | Preparing method of body resistance-strengthening ginseng-astragalus injection |
| CN101084979B (en) * | 2006-06-08 | 2012-02-01 | 天津天士力之骄药业有限公司 | Medicinal preparation for cancer auxiliary treatment and its preparation method |
| CN109939136A (en) * | 2017-12-21 | 2019-06-28 | 北京盈科瑞创新药物研究有限公司 | A kind of sucking body resistance-strengthening ginseng-astragalus pharmaceutical solutions and preparation method thereof |
| CN113599412A (en) * | 2021-03-10 | 2021-11-05 | 丽珠集团利民制药厂 | Application of radix codonopsis and radix astragali composition in preparation of medicine for preventing and treating symptoms related to advanced tumor |
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