CN1327850A - American ginseng extract (CNT-2000) without residual agricultural chemical and its usage - Google Patents
American ginseng extract (CNT-2000) without residual agricultural chemical and its usage Download PDFInfo
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- CN1327850A CN1327850A CN 01129254 CN01129254A CN1327850A CN 1327850 A CN1327850 A CN 1327850A CN 01129254 CN01129254 CN 01129254 CN 01129254 A CN01129254 A CN 01129254A CN 1327850 A CN1327850 A CN 1327850A
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- agricultural chemical
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- american ginseng
- radix panacis
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Abstract
A process for prepring American ginseng extract (CNT-2000) without residual agricultural chemical for treating type-II-diabetes, cardiovascular and cerebrovascular diseases, tumor and hypo immunity uses American ginseng as raw material, and includes such steps as thermal reflux extraction in 40% alcohol, macroporous resin (Amberlite XAD-4) column adsorption, and spray drying. Its advantages include high content of ginseng saponin (not less than 6%) and low residual agricultural chemical (less than 10PPb).
Description
The present invention relates to a kind of hyoscine or edible Radix Panacis Quinquefolii non agricultural chemical residuum extract (CNT-2000).This extract is used for the treatment of type ii diabetes, cardiovascular and cerebrovascular disease, tumor and immunocompromised disease, or can treat the medicine or the health food of above disease in order to exploitation.
Radix Panacis Quinquefolii can be used for treating type ii diabetes, cardiovascular and cerebrovascular disease, tumor and immunocompromised disease etc., its main effective ingredient is ginsenoside and some other active substances, this point generally acknowledged by the world of medicine, but harmful difficult degradation pesticide makes the application of Radix Panacis Quinquefolii be subjected to very big restriction to the pollution of Radix Panacis Quinquefolii.The quality of American ginseng product quality, generally reaching " persticide residue " these two test items with " content of ginsenoside " is main measurement index, and its content of ginsenoside is high more, persticide residue is more little, and then its quality is good more.All kinds of American ginseng products of managing in medicine and the health food market are a lot of at present, but these goods are just done simple physical processing to Radix Panacis Quinquefolii, mostly do not remove residual pesticide, also do not have to keep the therapeutical effect of Radix Panacis Quinquefolii comprehensively, its content of ginsenoside has only 1～2%, and active substance content is extremely low.Having high activity Radix Panacis Quinquefolii extract these therapeutical effect, high content of ginsenoside, particularly non agricultural chemical residuum extract as the product sale or as patent application yet there are no to patent.
The purpose of this invention is to provide a kind of non-insulin-dependent diabetes mellitus, cardiovascular and cerebrovascular disease, tumor and immunocompromised disease of being used for the treatment of, or can treat the medicine of above-mentioned disease or the Radix Panacis Quinquefolii non agricultural chemical residuum extract (CNT-2000) of health food in order to exploitation.The contained some other important active substances content of ginsenoside and Radix Panacis Quinquefolii is all higher in this extract, and in extracting manufacture process, removed residual pesticide wherein more up hill and dale, its content of ginsenoside is not less than 6%, various persticide residue is all less than 10PPb.
Realize the technical solution adopted in the present invention, promptly manufacturing process flow is as follows in detail for Radix Panacis Quinquefolii non agricultural chemical residuum extract (CNT-2000):
Radix Panacis Quinquefolii crude drug (supporting root section or fibrous root) → 9 times of amount 40% soak with ethanol (25～30 ℃) 3 hours, heating and refluxing extraction 2 hours, collect extracting solution, medicinal residues add 8 times of amount 40% ethanol immediately and continued heating and refluxing extraction 1.5 hours, collecting extracting solution → extracting solution merges, reclaim ethanol, vacuum concentration to 3 times amount → high speed centrifugation goes precipitation--centrifuge speed: 16000 rev/mins → clarification medicinal liquid (room temperature) goes agricultural residual by macroporous resin (Amberlite XAD-4) post of anticipating--resin demand: be 1.5 times of medical material amount; Flow velocity: 1V/ hour; Medicinal liquid by behind the resin column with the water flushing of 2V, flow velocity: 1V/ hour → medicinal liquid, flushing liquor merge and are concentrated into proportion and are about 1.1g/ml → spray drying--medicinal liquid flow velocity: 10kg per hour; Inlet temperature: 175 ± 5 ℃, leaving air temp: 85 ± 5 ℃ → exsiccant Radix Panacis Quinquefolii non agricultural chemical residuum extract (CNT-2000).(V is the resin column retention volume; " doubly amount " refers to the multiple of medical material amount)
The resin treatment method is as follows:
(1) pretreatment of resin and dress post: use soak with ethanol resin 24 hours, after the immersion, the water flushing replaces ethanol; Stir, remove the granule resin; Before the dress post, resin soaked 10-15 minute with sodium chloride solution (5～10%) earlier, washing, and reuse sodium carbonate liquor (10%) soaked 10-15 minute, washing; The column bottom is lined with screen cloth or the glass cotton that prevents under the resin streak, in post, add certain water gaging before the dress post earlier, the resin aqueous slurry is poured in the post through funnel, excessive water is emitted by the column bottom, keep the water surface to be higher than resin bed more than 3 centimetres, all transfer in the post up to all resins; Water adds from the bottom then, slowly upwards flow, increase the flow velocity of water gradually, expand near 100% up to resin bed, keep this backwash flow velocity, remove up to all air bubbles, all granules are fully expanded, stop washing, resin descends under action of gravity naturally, adjusts liquid level to more than the resin bed surface 3cm.
(2) regeneration of resin is handled: after adsorbent resin ran to terminal point, earlier with the 2V water elution, flow velocity 1V/ hour, water lotion discarded; Put the water purification washing liquid then, with 95% soak with ethanol 24 hours, reuse 3V 95% ethanol carried out eluting, and elution flow rate 1V/ hour, (collect eluant, ethanol is reclaimed in distilling under reduced pressure, and is standby); Wash ethanol at last, resin regeneration finishes.Regenerating resin can supply next production application immediately, or it is stored in 30% alcoholic solution.(V is the resin column retention volume)
The present invention compares with other American ginseng products, has following feature:
(1) the present invention is the higher water solublity Radix Panacis Quinquefolii extract of activity substance content, not only is easy to be absorbed by the body, and is well suited for and makes various preparations; And all kinds of American ginseng products of managing on medicine and the health food market at present mostly are only Radix Panacis Quinquefolii to be made product after the simple physical processing, and the utilization rate of taking its active ingredient of back is extremely low.
(2) among the present invention Radix Panacis Quinquefolii to mainly contain the effective constituent content of ginsenoside higher, be not less than 6%; And its content of ginsenoside of all kinds of American ginseng products in the market mostly is 1～2%.
(3) the residual pesticide removal is more thorough among the present invention, and the residual quantity of various pesticide is all less than 10PPb, and the residual pesticide total amount generally also surpasses only 25PPb; And all kinds of American ginseng products are not in the market mostly removed residual pesticide, and the residual quantity of its various pesticide is 20～200PPb, and the residual pesticide total amount can reach 200～1000PPb.
(4) important active substances content is higher among the present invention, persticide residue is extremely low, so it has kept the clinical pharmacology effect of Radix Panacis Quinquefolii more all sidedly, simultaneously without any toxic and side effects, uses very safe; All kinds of American ginseng products in the market are low because of its activity substance content, high its clinical efficacy that makes of persticide residue is relatively poor, use also very dangerous simultaneously.
The following stated embodiment describes qualitative character of the present invention in detail:
Example 1: product batch number 20010106.Used medical material is a fibrous root; The medical material amount is 14kg, gets extract (CNT-2000) 3.58kg, and yield is 25.57%; The extract content of ginsenoside is 13.81%, various persticide residue is all less than 10PPb, and the total amount of residual pesticide is 13.40PPb.
Example 2: product batch number 20010223.Used medical material is a fibrous root; The medical material amount is 15kg, gets extract (CNT-2000) 3.905kg, and yield is 26.03%; The extract content of ginsenoside is 10.61%, various persticide residue is all less than 10PPb, and the total amount of residual pesticide is 12.84PPb.
Example 3: product batch number 20010227.Used medical material is a supporting root; The medical material amount is 15kg, gets extract (CNT-2000) 4.125kg, and yield is 27.50%; The extract content of ginsenoside is 8.17%, various persticide residue is all less than 10PPb, and the total amount of residual pesticide is 7.42PPb.
Claims (2)
1. a Radix Panacis Quinquefolii non agricultural chemical residuum extract (CNT-2000), the qualitative character of this extract is: content of ginsenoside is not less than 6%, various persticide residue is all less than 10PPb.
2. the described Radix Panacis Quinquefolii non agricultural chemical residuum of claim 1 extract (CNT-2000) is used for the treatment of type ii diabetes, cardiovascular and cerebrovascular disease, tumor and immunocompromised disease, or can treat the medicine or the health food of above disease in order to exploitation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01129254 CN1327850A (en) | 2001-06-19 | 2001-06-19 | American ginseng extract (CNT-2000) without residual agricultural chemical and its usage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01129254 CN1327850A (en) | 2001-06-19 | 2001-06-19 | American ginseng extract (CNT-2000) without residual agricultural chemical and its usage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1327850A true CN1327850A (en) | 2001-12-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01129254 Pending CN1327850A (en) | 2001-06-19 | 2001-06-19 | American ginseng extract (CNT-2000) without residual agricultural chemical and its usage |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100345610C (en) * | 2006-02-28 | 2007-10-31 | 南开大学 | Method of removing pesticide residual in natural extracts by adsorbing resin process |
| US7645465B2 (en) * | 2002-04-08 | 2010-01-12 | Kuan Industrial Co., Ltd. | Method of preparing a pharmaceutical composition comprising fermented ginseng |
| CN103550273A (en) * | 2013-11-04 | 2014-02-05 | 湖南绿蔓生物科技股份有限公司 | Method for extracting low-pesticide-residue ginsenoside from ginsengs |
| CN106265801A (en) * | 2016-07-19 | 2017-01-04 | 云南尧科技开发有限公司 | One panax species extract and preparation technology thereof safely and efficiently |
-
2001
- 2001-06-19 CN CN 01129254 patent/CN1327850A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7645465B2 (en) * | 2002-04-08 | 2010-01-12 | Kuan Industrial Co., Ltd. | Method of preparing a pharmaceutical composition comprising fermented ginseng |
| CN100345610C (en) * | 2006-02-28 | 2007-10-31 | 南开大学 | Method of removing pesticide residual in natural extracts by adsorbing resin process |
| CN103550273A (en) * | 2013-11-04 | 2014-02-05 | 湖南绿蔓生物科技股份有限公司 | Method for extracting low-pesticide-residue ginsenoside from ginsengs |
| CN103550273B (en) * | 2013-11-04 | 2016-03-30 | 湖南绿蔓生物科技股份有限公司 | A kind of method extracting the residual ginsenoside of low agriculture from Radix Ginseng |
| CN106265801A (en) * | 2016-07-19 | 2017-01-04 | 云南尧科技开发有限公司 | One panax species extract and preparation technology thereof safely and efficiently |
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