CN1322880C - Medicine for improving female estrogen and immunity - Google Patents
Medicine for improving female estrogen and immunity Download PDFInfo
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- CN1322880C CN1322880C CNB2005100194949A CN200510019494A CN1322880C CN 1322880 C CN1322880 C CN 1322880C CN B2005100194949 A CNB2005100194949 A CN B2005100194949A CN 200510019494 A CN200510019494 A CN 200510019494A CN 1322880 C CN1322880 C CN 1322880C
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Abstract
The present invention relates to a medicine for improving female estrogen and immunity, which is prepared by that the water solution of Chinese caterpillar fungus hyphostroma, glossy privet fruit, gold theragran, matrimony vine and red sage root are enveloped by liposome membrane materials. The present invention has reasonable prescription and effect of regulating yin, yang, qi and blood. The present invention is mainly used for the symptom range of pathological symptoms before and after menopause, etc. caused by hormone descending and paramenia of climacteric females. The adopted liposome envelope has a targeting effect which can increase the therapeutic effect of the medicine by 5 to 10 times. The present invention has low dose and saves resources. The medicine of the present invention has the effects of invigorating the kidney-qi, benefiting essence and blood, and promoting blood circulation for removing blood stasis. The present invention can increase female estrogen and enhance immunological function, and has the capability of clearing free radicals and the function of resisting senescence.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, especially a kind of medicine that improves female estrogen and immunity---can sharp Na.
Background technology
Estrogen (estradiol E
2) be one of important hormone of safeguarding female physiological function.It can safeguard the women secondary sex characteristics, safeguard women's property requirement; The protection vascular endothelial function prevents arteriosclerosis; Regulate the absorption of calcium; Sclerotin forms; Prevent that osteoporosis etc. from playing an important role.Women is after menopause, and estrogen descends rapidly, thereby causes women's autonomic nervous dysfunction, as cardiopalmus, insomnia, vexed, irritability, warm, sweating, coronary heart disease increase.Reported literature: vascular endothelial injury is the basis that arteriosclerosis takes place.Blood vessel endothelium is regulated nitric oxide (NO), Endothelin (ET) secretion of etc.ing, and adjusting blood is the current stabilization state at blood vessel, prevents platelet aggregation and is deposited on the blood vessel wall; Evidence of coronary heart diseases rises rapidly after women's menopause; Calcium forms Organic substance and all be unable to do without estrogen from absorbing to be deposited on the skeleton; Thereby Women, postmenopausal estrogen descend and cause sclerotin to lose in a large number, form osteoporosis, easily fracture.In view of the foregoing, the expert thinks that estrogen is women's protection hormone.
In order to improve the estrogen level of climacteric, menopausal women, " FUFUCHUN " arises at the historic moment.Through clinical experiment and tracking for many years, FUFUCHUN (complexs of estradiol and progestogen) can reduce the coronary heart disease incidence rate and the osteoporosis of climacteric and menopausal women really; But the incidence rate of female tumor such as carcinoma of endometrium etc. that also can raise, thereby be under suspicion.Seek a kind of method and medicine safe, that effectively improve female estrogen and become one of new research focus.
Summary of the invention
The purpose of this invention is to provide and a kind ofly be made up of botanical herbs, reasonable recipe is effective, can improve female estrogen, improve the medicine of immunologic function, delaying female aging.
The expert thinks that medicinal plants can improve female estrogen, and the program that improves is no more than physiological amount, thereby is difficult for causing cancer, is one of selection of a kind of safe raising estrogen.
Motherland's medical science thinks that " primary disease is to enclose before and after the menopause, and kidney qi degradation, Radix Semiaquilegiae will exhaust, towards conception vessel loss, vital essence deficiency, and internal organs lose in it and moisten due to foster, the imbalance of YIN and YANG.Suffer from a deficiency of the kidney is to cause a disease originally.In through also cloud: Nian Sishi and half of YIN QI consumed also ".Kidney yin was for not enough before menopause was described.Though Hu Weiqing thinks primary disease at kidney, must involve liver, the heart.Stagnation of liver-QI is a liver-yang hyperactivity.Heart-fire is prosperous to be its mark.Be the heart, liver, the how dirty disease together of kidney.Adopt the Radix Rehmanniae, the Radix Paeoniae Alba, Fructus Ligustri Lucidi etc. to form the Ping Gengtang treatment, reach the effect of nourishing the kidney for subduing the hyperactivity of liver-YANG, dispersing the stagnated live-QI to relieve the stagnation of QI, mind tranquilizing and the heart calming.Wang Lianghua etc. think that " suffering from a deficiency of the kidney is the basic of primary disease, but the pure deficiency of YIN is more rare, is that main symptom is waited when causing negative and positive two void by deficiency of YIN development, adopts the Radix Rehmanniae.Treatment such as Fructus Ligustri Lucidi, Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) also obtains better curative effect.Jing-Yue Complete Works is said: ' kind nourishing YIN person, must be in sun rescuing YIN then cloudy positive liter, and fountainhead is inexhaustible ' ".Therefore in the side of nourishing kidney yin as YANG invigorating medicines such as six drugs containing rehmanniae Tonga Radix Morindae Officinalis, Herba Epimedii, Herba Cistanches, agitate kidney qi, make the effect of nourishing YIN bigger.Qi Xiulan adopts the Radix Rehmanniae, Fructus Ligustri Lucidi, Radix Morindae Officinalis, Fructus Tritici Levis nourishing YIN to lower pathogenic fire, mind tranquilizing and the heart calming coordinating YIN and YANG.
Modern medicine thinks that climacteric syndrome is mainly the ovarian function decline.When obviously reducing near follicle colony in the menopause ovary, estrogen level obviously reduces.The variation of incretion balance situation can cause hypothalamus and autonomic nervous system maincenter functional disorder, and feedback raises luteinizing hormone releasing hormone and follotropin releasing hormone level.Appearance that it is generally acknowledged symptom is consistent with speed and program that estrogen secretion reduces.Therefore doctor trained in Western medicine is taked Hormone Replacement Therapy to climacteric syndrome.
The prescription of the raising female estrogen that I invent: Cordyceps mycelium, Fructus Ligustri Lucidi, the Radix Polygoni Multiflori, Fructus Lycii, Radix Salviae Miltiorrhizae aqueous solution are sealed through the liposome membrane material and are formed.
Cordyceps is one of rare Chinese medicine of China, has the effect of the kidney invigorating lung benefiting.Just putting down in writing this medicine in " Compendium of Materia Medica " of Li Shizhen (1518-1593 A.D.) is used for the weak patient of prolonged illness and has the effect of building body.Now change medical evidence: Cordyceps can be regulated immunization; Can improve its NK cell for tumor patient, have certain synergism killing tumor; Can reduce rejection for renal transplant recipients; Renal function can be improved for the renal insufficiency patient, the nephrotoxicity due to the aminoglycoside antibiotic can be protected; Can promote the contorted seminiferous tubules cell maturation of testis.Can improve female estrogen clinically.Do not see Cordyceps treatment female dimacteric syndrome in the literature as yet.Owing to manually turned out its mycelium, its therapeutic effect and wild similar is used for clinically at present in a large number, makes as JINSHUIBAO, conscience treasured, hundred that capsule all is the mycelium of Cordyceps different strains.Fructus Ligustri Lucidi is to occur one of maximum front three in the treatment Women prescription of being found.Radix Polygoni Multiflori: Radix Polygoni Multiflori is apt to invigorating the liver and kidney, essence and blood, black beard and hair.Experimental results show that Radix Polygoni Multiflori water steams liquid and feeds for Aged Mice and young mice, can significantly increase protein quality in the brain regulating liver-QI, can make the unlikely atrophy of Aged Mice thymus, even keep young level.Zoopery shows: Radix Polygoni Multiflori can be removed free radical, increases antioxidant ability of organism, reduces accumulating of blood vessel endothelium lipid peroxidation, improves glutathione peroxidase (GSH-P
x) activity, suppress prostacyclin dish (PGI
2) synthetic, the protection vascular endothelial cell.Radix Salviae Miltiorrhizae: climacteric syndrome patient, except that the estrogen level obviously reduces, simultaneously again with the change of hemorheological property, the patient is in various degree " thick, sticking, poly-, coagulate " state, is associated with blood high viscosity syndrome, causes thrombosis, the circulation stasis of blood stagnates, and microcirculation disturbance occurs.Therefore in the treatment climacteric syndrome, should adopt activating blood and removing stasis drug, the microcirculation improvement state makes blood flow smooth, is significant clinically.Radix Salviae Miltiorrhizae contains water-soluble components: fat-soluble compositions such as danshensu, saivianic acid A: Tanshinone I, tanshinone, Tanshinone II B ... or the like can microcirculation improvement, promote velocity of blood flow, can blood vessel dilating, bring high blood pressure down.Can improve hemorheological property, blood viscosity lowering, inhibition platelet and coagulation function, antagonism thrombosis.
The Chinese prescription that technical scheme of the present invention adopted is (in a weight portion):
Cordyceps mycelium 0.5～2, Fructus Ligustri Lucidi 1～4, Radix Polygoni Multiflori 0.8～4, Fructus Lycii 0.5～3, Radix Salviae Miltiorrhizae 0.8～4.
The present invention adopts the liposomal encapsulated technology of Britain, with liposomal encapsulated herbal mixture extracting solution, has the advantage that targeting is strong, curative effect is high.
Soybean lecithin: Ovum Gallus domesticus Flavus lecithin was in 7: 3 ratio system liposome membrane.
The technological process of production:
Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae were immersed 50% ethanol 12 hours, be as the criterion to soak into medicine-feeding.Other gets in Cordyceps mycelium, Radix Polygoni Multiflori, the Fructus Lycii immersion distilled water, soaks 2 hours.
There is the ethanol of Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae to pour into together immersion and boiled together in the medicinal liquid that contains Chinese medicines such as Cordyceps mycelium 2 hours, will go up clear liquid medicine and contain out (medicinal liquid 1); Residue medicinal residues adding distil water boiled 2 hours again, will go up clear liquid medicine (medicinal liquid 2) and contain out; The medicinal residues adding distil water boiled 2 hours again, and medicinal residues are leached.Merge supernatant, medicinal liquid concentrates, and concentrated solution is added contain in the container of liposome, allows liposome dissolve fully, uses ultrasonic stirring then 2～3 hours, the bottling sterilization.
In the treatment of Women, improve female estrogen (E
2) be that treatment is crucial.Involutional ovarian function decline follicle colony obviously reduces estrogen (E
2) obviously descend, feedback raises luteotropic hormone releasing hormone and follotropin level simultaneously.Women is old and feeble gradually period of women, and the traditional Chinese medical science thinks that female pathology suffers from a deficiency of the kidney, and is that neuroendocrine immunity (NEI) network function is low, and its yin and yang imbalance is based on insufficiency of kidney-YANG.Facts have proved that the warming and recuperating the kidney-YANG medicine can improve hypothalamic pituitary thyroidal axis and the gonad axis that hypothalamus monoamine neurotransmitter and hypothalamus-hypophysis are had jurisdiction over; The warming YANG medicine can be protected the NEI network function in T cell transition apoptosis and the gene regulation process thereof when aging.
This prescription has the Cordyceps mycelium of warming and recuperating the kidney-YANG, and Fructus Ligustri Lucidi, the Fructus Lycii of enriching yin and nourishing kidney also arranged, and the Radix Polygoni Multiflori of replenishing blood and nourishing liver and the Radix Salviae Miltiorrhizae of invigorating blood circulation are the rational prescribing of treatment Women theoretically.Zoopery and clinical practice confirm that also the malonaldehyde that this medicine can reduce in the animal conscience brain improves oxidation resistance, improves E
2Thereby prevention is because E better
2The cardiovascular complication that descends and cause, osteoporosis and autonomic nervous dysfunction.
The purposes of this medicine, pharmacological effect, effective dose and using method:
This medicine mainly is made up of Cordyceps, Fructus Ligustri Lucidi, the Radix Polygoni Multiflori, Fructus Lycii, Radix Salviae Miltiorrhizae and is had the kidney invigorating nourishing the liver, function of promoting blood circulation to disperse blood clots, be mainly used in climacteric women clinically because hormone descends, old and feeble and cause palpitation and insomnia, fidgety irritability, the model of warming sweating, the dizzy soreness of waist, menoxenia etc. " all diseases before and after the menopause " are raised.
Dose (oral liquid) is secondary every day, each 10ml.
Advantage of the present invention and good effect:
1, reasonable recipe, we are made up of medicines such as Cordyceps mycelium, Fructus Ligustri Lucidi, Radix Polygoni Multiflori, Fructus Lycii, Radix Salviae Miltiorrhizaes.Fructus Ligustri Lucidi, Radix Polygoni Multiflori, Fructus Lycii satisfied the climacteric women hepatic and renal YIN deficiency, through insufficiency of blood, increased Yang invigorating medicine Cordyceps again, kidney qi is rouse oneself; Cloudy positive and rise, and fountainhead is inexhaustible.The while Radix Salviae Miltiorrhizae has also solved the stasis of blood due to the deficiency of kidney-QI, makes smooth blood flow.Full side has the effect of YIN and YANG balance regulating QI and blood.
2, owing to adopt the liposomal encapsulated targeting that has, make curative effect increase by 5～10 times, therefore every kind of survival dose few, saved resource, reduce the generation of side effect, be a kind of improvement of form of Chinese drug.
3, we have the effect of the kidney invigorating gas, benefiting essence-blood, blood circulation promoting and blood stasis dispelling, therefore have multiple function, as improve other hypophysis-target gland s function, improve thyroxine, adrenal cortex function.
4, we have the free radical of removing ability.Think that at present it is one of old and feeble reason that free radical increases.We have anti-aging effects, thereby the protective tissue internal organs prevent degeneration or apoptosis.
5, improve female estrogen
Estrogen is the protectiveness hormone of keeping female physiological function, and improving female estrogen is the arrival of delaying female aging.Year March in April, 2002-2005, I collected the 40-67 of the court year climacteric women totally 50 examples altogether, measured estradiol (E
2), testosterone (T), short follicle give birth to plain (FSH) and interstitialcellstimulating hormone (ICSH) (LH); Oral then medicine of the present invention can sharp Na, every day secondary, each 10ml, one totally month.Repeat said determination again, the result preceding E that takes medicine
2Be 63.2478pg/ml; Be 102.805 ± 57.8384 after taking medicine, t=6.91465, P＜0.0001, difference has utmost point significance; Being 89.71 ± 67.792 before T takes medicine, is 116.8 ± 93.838 after taking medicine, t=2.3875, p＜0.05; LH and FSH then zero difference P all greater than 0.05.FUFUCHUN can improve female estrogen, but also can cause carcinoma of endometrium, whether can the natural plants that female estrogen is increased also cause carcinoma of endometrium? bibliographical information: natural plants causes that the estrogen of female pathology requirement increases, rather than the pathologic increase, thereby can not cause carcinoma of endometrium.This paper observes the endometrium that 20 examples are taken during can sharp Na, and wherein 2 examples were taken more than 3 years, did not all find endometrial thickening, and the case that we observe is still few, is still waiting further confirmation.Zoopery also proves: the E2 that this medicine can improve jenny compares median dose with matched group and heavy dose of group has significant difference (attached laboratory report portion).
6, improve immunity
CD
3Cell is represented the sum of mature T lymph in the peripheral blood, CD
4Show generally (Th) on the t helper cell that it has the effect of auxiliary B cell and other T cytoactives.CD
8Be expressed in T more and suppress on the cell (Ts), it creates antagonism by inhibition Th cytoactive, and body forms and the inhibitory action of cell-mediated immune response.When Th descends and Ts effect increase is CD
4/ CD
8During decline, immunity of organism is suppressed more serious.The NK cell can be regulated bone marrow stem cell, thymocyte cell and B cell differentiation as the main cell of immunity of organism function for monitoring, and the various kinds of cell factors such as secretion IL-2 form the immunomodulating network.Leukemia and lymphoma 88 examples that we select in January, 2002～2003 to be in hospital year June, being divided into can sharp Na group (medication group) secondary every day (each 10ml) 46 example, and male's 29 examples, women's 17 examples, chemotherapy add wherein leukemia 20 examples, lymphoma 26 examples; Simple chemotherapy group 42 examples, wherein male 26 examples, women's 16 examples, leukemia 18 examples wherein, lymphoma 24 examples, logotype one month detects T cell subsets, NK cell immunoglobulin before and after the treatment.The result shows: through a treatment in month, and CD before and after the simple chemotherapy group
3Drop to 54.52% from 57.96 ± 7.86L%, CD
4WW36.31 ± 7.77 drop to 32.01 ± 7.76, CD
8Drop to 29.11 ± 6.68, CD from 30.23 ± 7.82
4/ CD
8Rise to 1.43 ± 0.33 from 1.26 ± 0.51, NK cell (%) rises to 12.39 ± 6.68 from 10.21 ± 4.56.And can sharp Na+chemotherapy group, CD
3Rise to 61.9 ± 7.76, P＜0.05, CD from 57.96 ± 7.86
4Rise to 39.96 ± 7.78, P＜0.05 from 36.33 ± 7.79; CD8 drops to 25.68 ± 7.96, P＜0.01, CD from 31.01 ± 7.81
4/ CD
8Rise to 1.61 ± 0.32 from 1.22 ± 0.51, the NK cell rises to 15.39, P＜0.01 from 9.24 ± 4.33; Compare CD after medication group treatment back and the simple chemotherapy
3P＜0.001; CD
4P＜0.001; CD
8P＜0.05; CD
4/ CD
8P＜0.01; NK cell P＜0.05; The immunoglobulin aspect, medication group treatment back IgM is higher than before the treatment and horizontal P＜0.001 after the simple chemotherapy, does not change and have obviously before and after IgA and the IgG treatment.Explanation can sharp Na can improve patient's immunologic function.
7, remove oxygen-derived free radicals, defying age (attached laboratory report portion)
Oxygen-derived free radicals mainly refers to O
2And OH, the influence of body there is duality, favourable aspect shows regulates arachidonic metabolism, and what stimulate phagocyte and neutrophil cell engulfs sterilizing function and immunologic process; Harmful aspect shows and can make many biomacromolecules such as nucleic acid-protein, film polyunsaturated fatty acids cause super oxidation reaction, makes biomacromolecule interlinkage or fracture occur, causes the destruction of cellularity and function.Bibliographical information old people erythrocyte peroxidating qi enzyme (SOD) activity is obviously low than the adolescent, P＜0.01, and difference has significance.The product malonaldehyde (MDA) of opposite lipid peroxide is then obviously than adolescence height.Zoopery proves that also the erythrocyte sod of Aged Mice and catalase (CAT) activity are starkly lower than young mice level.The oxidation resistance of old (or animal) descends, free radical increases, and it is induced, and the generation age pigment---lipofuscin increases.At present, think that free radical increases that to descend with antioxidant ability of organism be one of reason of body aging.If can improve antioxidant ability of organism, removing free radical increases, then delaying sanility.This group experiment showed, and give Cordyceps, Fructus Ligustri Lucidi, the Radix Polygoni Multiflori, Fructus Lycii, the made solution of Radix Salviae Miltiorrhizae, external can be to " O
2" and OH remarkable removing and inhibitory action are arranged.The SOD that measures blood and brain after 7 days for the rat oral gavage administration, GSH, GSH-PX, CAT, the MDA isoreactivity, the result shows can sharp Na also have the effect of significant removing oxygen-derived free radicals in vivo, alleviates the cell injury that oxygen-derived free radicals causes.
The specific embodiment
Embodiment 1: to produce 10000ml
Cordyceps mycelium 500 grams
Fructus Ligustri Lucidi 1000 grams
Radix Polygoni Multiflori 800 grams
Fructus Lycii 500 grams
Radix Salviae Miltiorrhizae 800 grams
Preparation process:
Get 1000 gram Fructus Ligustri Lucidi, 800 gram Radix Salviae Miltiorrhizaes, immersed 2000ml 50% ethanol 12 hours, be as the criterion to soak into medicine-feeding.Get Cordyceps mycelium 500 grams (production of Nanchang JINSHUIBAO factory), Radix Polygoni Multiflori 800 grams, Fructus Lycii 500 grams immerse in the 10000ml distilled water and soaked 2 hours.
Having the ethanol of Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae to pour into together immersion boiled in the medicinal liquid that contains Chinese medicines such as Cordyceps mycelium 2 hours together.To go up clear liquid medicine and contain out about 6000ml (medicinal liquid 1); Residue medicinal residues adding distil water boiled 2 hours to 10000ml.To go up the about 6000ml of clear liquid medicine (medicinal liquid 2) pours in the medicinal liquid 1; Medicinal liquid 2 medicinal residues adding distil waters boiled 2 hours to 10000ml, and medicinal residues are leached, and clear liquid medicine in the merging is concentrated into 10000ml then.
The preparation of blank liposome film material:
Take by weighing soybean lecithin 140 grams, Ovum Gallus domesticus Flavus lecithin 60 grams, cholesterol 100 grams, vitamin E 5 grams place vial, add the dissolving of 1000ml chloroform, move in the eggplant-shape bottle, rotate to chloroform and volatilize fully, form thin film on the bottle wall.
The concentrated solution adding is contained in the container of liposome, allow liposome dissolve fully, used ultrasonic stirring then 2 hours, the bottling sterilization.
Embodiment 2: in 10000ml
Cordyceps mycelium 2000 grams
Fructus Ligustri Lucidi 4000 grams
Radix Polygoni Multiflori 4000 grams
Fructus Lycii 3000 grams
Radix Salviae Miltiorrhizae 4000 grams
Preparation process:
With Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae, immersed 3000ml 50% ethanol 12 hours, be as the criterion to soak into medicine-feeding.Get Cordyceps mycelium, Radix Polygoni Multiflori, Fructus Lycii, immerse in the 10000ml distilled water and soaked 2 hours.
Having the ethanol of Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae to pour into together immersion boiled in the medicinal liquid that contains Chinese medicines such as Cordyceps mycelium 2 hours together.To go up clear liquid medicine and contain out about 6000ml (medicinal liquid 1); Residue medicinal residues adding distil water boiled 2 hours to 10000ml.To go up the about 6000ml of clear liquid medicine pours in the medicinal liquid 1; The medicinal residues adding distil water boiled 2 hours to 10000ml, and medicinal residues are leached, and clear liquid medicine in the merging is concentrated into 10000ml then.
Preparation liposome membrane material is with example 1.
The concentrated solution adding is contained in the container of liposome, allow liposome dissolve fully, used ultrasonic stirring then 3 hours, the bottling sterilization.
The present invention also can be made into capsule, tablet class oral administered dosage form except that oral liquid.
Claims (1)
1, a kind of medicine that improves women's estradiol level and immunologic function, it is characterized in that preparing: by weight by following method, Cordyceps mycelium 0.5～2, Fructus Ligustri Lucidi 1～4, Radix Polygoni Multiflori 0.8～4, Fructus Lycii 0.5～3, Radix Salviae Miltiorrhizae 0.8～4 are made Chinese medicine extraction liquid, use soybean lecithin: Ovum Gallus domesticus Flavus lecithin is that the liposome membrane that 7: 3 ratios are made is sealed, and makes oral liquid.
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| CNB2005100194949A CN1322880C (en) | 2005-09-23 | 2005-09-23 | Medicine for improving female estrogen and immunity |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100194949A CN1322880C (en) | 2005-09-23 | 2005-09-23 | Medicine for improving female estrogen and immunity |
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| CN1762456A CN1762456A (en) | 2006-04-26 |
| CN1322880C true CN1322880C (en) | 2007-06-27 |
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ID=36746915
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| CNB2005100194949A Expired - Fee Related CN1322880C (en) | 2005-09-23 | 2005-09-23 | Medicine for improving female estrogen and immunity |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020241958A1 (en) * | 2019-05-28 | 2020-12-03 | 동아제약 주식회사 | Composition for preventing or treating woman menopause symptoms, comprising cordyceps militaris concentrate as active ingredient |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793177B (en) * | 2012-09-07 | 2013-11-27 | 广州安德生物科技有限公司 | Biological adhesion type cordyceps militaris liposome and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061342A (en) * | 1991-08-14 | 1992-05-27 | 河南省驻马店地区制药厂 | " Shou Kang " antiaging health care medicine and prescription thereof |
| CN1129568A (en) * | 1995-02-22 | 1996-08-28 | 窦玉君 | Activating health-care tea |
-
2005
- 2005-09-23 CN CNB2005100194949A patent/CN1322880C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061342A (en) * | 1991-08-14 | 1992-05-27 | 河南省驻马店地区制药厂 | " Shou Kang " antiaging health care medicine and prescription thereof |
| CN1129568A (en) * | 1995-02-22 | 1996-08-28 | 窦玉君 | Activating health-care tea |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020241958A1 (en) * | 2019-05-28 | 2020-12-03 | 동아제약 주식회사 | Composition for preventing or treating woman menopause symptoms, comprising cordyceps militaris concentrate as active ingredient |
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