CN1317345A - Material of artificial kidney for hemodialysis and its preparing process - Google Patents
Material of artificial kidney for hemodialysis and its preparing process Download PDFInfo
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- CN1317345A CN1317345A CN 01112899 CN01112899A CN1317345A CN 1317345 A CN1317345 A CN 1317345A CN 01112899 CN01112899 CN 01112899 CN 01112899 A CN01112899 A CN 01112899A CN 1317345 A CN1317345 A CN 1317345A
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Abstract
A new material for the artificial kidney for hemodialysis is disclosed, which is a hollow fibre membrane of mixed polyether-sulfone. Its advantages include high biocompatibility, physiochemical stability and selective separability. Its preparing process is also disclosed.
Description
The invention belongs to the artificial organ technical field, be specifically related to a kind of material of artificial kidney for hemodialysis and manufacture method.
Since the sixties, the hollow-fibre membrane of cellulose and esters thereof is as hemodialyzer dialyzer commonly used.Britain had developed poly (ether sulfone) film in 1972, and higher because of its vitrification point, physical and chemical performance is stable, is the speciality polymer material that engineering is used.The report of relevant dialyzer still has KIYOTAKA SAKA1 at Journal of chemical engineering ofJAPAN, the Japanese Nikkso of report Co., Ltd. adopts polyether sulfone and polyarylate blend film forming among VOL 30 No.4.1997, and the clear 61-200805 of Japan Patent JP, JP call 62-221402 and Chinese patent CN1220183A etc. together.But there is certain limitation in existing dialyzer at aspects such as biocompatibility or transmitances.
The objective of the invention is to improve the performance of above-mentioned dialyzer, improve biocompatibility and separation efficiency etc.
The invention provides a kind of material of artificial kidney for hemodialysis, the blend polyethersulfone hollow-fibre membrane (weight percentage) that new material of the present invention is made up of following ingredients:
Polyether sulfone (the 20-30 of η=0.6-0.8)
Blended polymer 0.1-5
Porogen 0-15
Solvent 60-80
Blended polymer is the polymer or the copolymer of cellulose and esters thereof, polyvinyl in the above-mentioned component, and the blend of two kinds of high polymers can carry out when dissolving, carries out solution blending again after also can making solution respectively; Porogen is polyoxyethylene, polyvinyl alcohol or polyvinylpyrrolidone, and they can be used alone, but also also mix together; Solvent is dimethyl sulfoxide, dimethyl formamide or dimethyl acetylamide.
Another object of the present invention has provided the manufacture method of above-mentioned material of artificial kidney for hemodialysis, and this method is that blend polyethersulfone is made spinning solution, after filtration, deaeration, spinning, stretching, washing, coiling, bunchy, guarantor's orifice drying make.Specifically comprise the following steps:
1. raw material (percentage by weight)
Polyether sulfone (the 20-30 of η=0.6-0.8)
Blended polymer 0.11-5
Porogen 0-15
Solvent 60-80
2. the preparation of spinning solution:
By above-mentioned weight percentage batching, moisture high polymer is dried under 50 ℃ of-80 ℃ of conditions, high polymer and other various components of oven dry are put into container, in 50 ℃ of-90 ℃ of scopes through heat, constant temperature, stirring, dissolved 3-4 hour, promptly get spinning solution, and then after filtration, and under 35 ℃ of-45 ℃ of constant temperature, finish purification process such as deaeration;
3. dry-jet wet-spinning legal system doughnut:
Spinning solution is extruded from the spinning head of being made up of two concentric tubees under the condition of dosing pump with 5-20r/min rotating speed, spinning pressure 0.4-0.6Mpa; After the 20-800mm dry-spinning path, solvent be 0%-30%, temperature be 5 ℃-40 ℃, body lotion circulating load be doubt in the aqueous solution of 10-80L/h solid; Spun filament stretches and appropriateness retraction, the washing of 4-6 road, alcohol solution are protected the hole and handled the speed coiling of back with 10-60m/min through two-way more than four roads (axially and radially) again, promptly gets blend polyethersulfone hollow-fibre membrane provided by the present invention.
In the said method, during spinning blend polyethersulfone doughnut, need to be pressed into filling solution at the spinning head inner chamber, pressure is 0.0005-0.03Mpa; Filling solution is: ethanol one glycerin solution of the solvent aqueous solution of 0%-40% or the glycerin solution of 5%-40% 1 or 10%-40%.
Said method need be protected the hole and handle for preventing that the micropore distortion influence ultrafiltration and dialysis performance when the drying, and guarantor's hole agent is the alcohol-water solution or the non-aqueous solution of 2-8 carbon atom, and available a kind of alcohol, also available multiple pure mixed preparing.
With the material of artificial kidney for hemodialysis that the inventive method is made, its dialyzer area is 0.4-1.2m
2, fiber is interior through 200-250mm, wall thickness 40-60mm, pure water ultrafiltrate coefficient 2-40ml/m
2.h.mmHg, simulate blood test creatinine transmitance 〉=85%, carbamide transmitance 〉=85%, middle molecule relative mass (5000-6000) material permeance rate 〉=40%, albumin rejection 〉=98%, maximum working pressure (MWP)＞60mmHg.
The difference of material of artificial kidney for hemodialysis of the present invention and prior art is as follows:
Japan Nikkso Co., Ltd. adopts polyether sulfone and polyarylate blend film forming, and is different with the alloying agent that the present invention adopts.The clear 61-200806 of Japan Patent JP makes hollow-fibre membrane with pure polyether sulfone, does not have blended polymer, and its additive and end properties, purposes are different with the present invention.The clear 61-200805 of Japan Patent JP does not add blended polymer, is a kind of microporous filter membrane, and its end properties is different with purposes and the present invention.Its blend of the clear 62-221402 of Japan Patent JP is a polysulfones, and the present invention is cellulose and esters thereof, the polymer of polyvinyl or copolymer etc.; Contain multiple slaine polar substancess such as NaBr in its solidification liquid, the present invention is the aqueous solution of DMSO; It is a wet spinning, and the present invention is a dry-jet wet spinning.Chinese patent CN1220183A polymer is a polyether sulfone, and the present invention is a blend polyethersulfone; Its solvent is N-Methyl pyrrolidone, DMF, DMAC, and the present invention is DMSO; Its porogen is Polyethylene Glycol, polyvinylpyrrolidone, and the present invention adds the PVP+ inorganic matter for polyoxyethylene; It does not stretch to as-spun fibre and washes, and the present invention adopts multiple tracks (diameter of axle) biaxial tension (scalable ultrafiltrate coefficient) and washing; It is not mentioned to filling liquid and guarantor's hole agent, and the present invention adopts alcohol solution or non-aqueous solution.
Compared with the prior art the present invention has following advantage:
1, blend polyethersulfone hollow-fibre membrane provided by the present invention not only solved cellulose membrane can not remove in the blood in the problem of molecule relative mass noxious substance, but also improved the fragility problem of polyacrylonitrile film, blood compatibility is better than polysulfone membrane, has excellent mechanical property, the surface is Paint Gloss, not the tangible material in the easy damaged blood, be difficult for congestion, it is convenient to clean, the residual insufficiency of blood of dialyser.Made hemodialyzer and other blood purifications provide good objective condition for reducing the patient treatment expense.
2, hollow-fibre membrane chemical stability height provided by the present invention has good biocompatibility and anticoagulant property, available plurality of reagents T-ray or high-temperature steam sterilization.
3, manufacturing technology of the present invention controlling diaphragm pore size easily, guarantee the ultrafiltrate coefficient of film, and can make the hemodialyzer of the many kinds of many specifications of different ultrafiltrate coefficients, not only can make low ultrafiltrate coefficient dialyser of different formulations, also can make the high flux dialyser, to remove β
2-microglobulin and other medium molecular substances.
4, the present invention can carry out blend with homemade polyether sulfone (purified processing), the spinning hollow-fibre membrane, and price is lower than the import polysulfone membrane.
Example 1, spinning dialyzer:
22 parts of polyether sulfones, 2 parts of celluloses, 1 part of polyvinylpyrrolidone, 75 parts of dimethyl sulfoxide add in the dissolving machine, stir down at 60 ℃ and make spinning solution in 3 hours, and stock solution is carried out spinning technique after the deaeration after filtration.Spinning pressure 0.4Mpa, dosing pump rotating speed 6r/min, extruded velocity 2.5m/min, air bath length 250mm, length of immersion 800mm, coagulation bath composition 30%DMSO-H
2O, each washing stretching roller speed is respectively 22m/min, 27m/min, 30m/min, winding speed 29m/min.Make fiber and after soaking, dewater, cut off, protecting hole, drying, be assembled into hemodialyzer.Pure water transmitance 6mL/m
2.h.mmHg, creatinine transmitance 86%, carbamide transmitance 88%, middle molecule relative mass transmitance 56%, rate and protein retention 98.5%.
Example 2, spinning blood filter membrane:
Stock solution consists of 18 parts of polyether sulfones, 3 parts of modified polyacrylonitriles, 2 parts of Polyethylene Glycol, 75 parts of dimethyl sulfoxide.Coagulation bath composition is 10%DMSO-H
2O.All the other process conditions are with embodiment 1.The gained film can be assembled into blood filter, and the pure water transmitance is 26mL/m
2.h.mmHg, creatinine transmitance 88%, carbamide transmitance 90%, middle molecule relative mass transmitance 60%, rate and protein retention 98.2%.
Claims (8)
1. a material of artificial kidney for hemodialysis is characterized in that this material is the blend polyethersulfone hollow-fibre membrane of being made by following component.(weight percentage): polyether sulfone 20-30, blended polymer 0.1-5, porogen 0-15, solvent 60-80.
2. a kind of material of artificial kidney for hemodialysis according to claim 1, it is characterized in that wherein said blended polymer is the polymer or the copolymer of cellulose and ester thereof, polyvinyl, and the blend of two kinds of high polymers can the time be carried out in dissolving, carries out solution blending again after also can making solution respectively.
3. a kind of material of artificial kidney for hemodialysis according to claim 1 is characterized in that wherein said porogen is polyoxyethylene, polyvinyl alcohol or polyvinylpyrrolidone, and they may be used alone, can also be used in combination.
4. a kind of material of artificial kidney for hemodialysis according to claim 1 is characterized in that wherein said solvent is dimethyl sulfoxide, dimethylformamide or dimethyl acetylamide.
5. the manufacture method of a material of artificial kidney for hemodialysis as claimed in claim 1 is characterized in that this method comprises the following steps:
(1) raw material (percentage by weight)
Polyether sulfone (the 20-30 of η=0.6-0.8)
Blended polymer 0.1-5
Porogen 0-15
Solvent 60-80
(2) preparation of spinning solution
By above-mentioned weight percentage batching, moisture high polymer is dried under 50 ℃ of-80 ℃ of conditions, high polymer and other various components of oven dry are put into container, in 50 ℃ of-90 ℃ of scopes through heat, constant temperature, stirring, dissolved 3-4 hour, promptly get spinning solution, and then after filtration, and under 35 ℃ of-40 ℃ of constant temperature, finish purification process such as deaeration;
(3) dry-jet wet spinning spinning doughnut:
Spinning solution is extruded from the spinning head of being made up of two concentric tubees under the condition of dosing pump with 5-20r/min rotating speed, spinning pressure 0.4-0.6Mpa; After the 20-800mm dry-spinning path, at solvent is that 0%-30%, temperature are that 5 ℃-40 ℃, solution circulating load are to solidify in the aqueous solution of 10-80L/h, spun filament stretches and after appropriateness retraction, the washing of 4-6 road, alcohol solution protect the hole and handle through two-way more than four roads (axially and warp-wise) again, speed with 10-60m/min is reeled, and promptly gets blend polyethersulfone hollow-fibre membrane of the present invention.
6. the manufacture method of material of artificial kidney for hemodialysis according to claim 5, it is characterized in that it is the aqueous solution or the non-aqueous solution of alcohols that the guarantor hole agent of usefulness is handled in wherein said guarantor hole, monohydric alcohol, dihydroxylic alcohols or trihydroxylic alcohol for 2-8 carbon atom, they can use a kind of alcohol, also available multiple pure mixed preparing.
7. the blend polyethersulfone hollow-fibre membrane that makes according to claim 1 can be used as dialyzer.
8. the manufacture method of material of artificial kidney for hemodialysis according to claim 5, the artificial kidney hemodialyzer that the blend polyethersulfone doughnut dialyzer that makes is assembled into, membrane area wherein is 0.4-1.2m
2, fibre inner diameter 200-250 μ m, wall thickness 60-70 μ m, pure water ultrafiltrate coefficient 2-40mL/m
2HmmHg, simulate blood test creatinine transmitance 〉=85%, carbamide transmitance 〉=85%, middle molecule relative mass (5000-6000), material permeance rate 〉=40%, albumin rejection 〉=98%, maximum working pressure (MWP) 760mmHg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01112899 CN1094380C (en) | 2001-05-17 | 2001-05-17 | Material of artificial kidney for hemodialysis and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01112899 CN1094380C (en) | 2001-05-17 | 2001-05-17 | Material of artificial kidney for hemodialysis and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1317345A true CN1317345A (en) | 2001-10-17 |
| CN1094380C CN1094380C (en) | 2002-11-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01112899 Expired - Fee Related CN1094380C (en) | 2001-05-17 | 2001-05-17 | Material of artificial kidney for hemodialysis and its preparing process |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427191C (en) * | 2005-12-28 | 2008-10-22 | 上海应用技术学院 | Production of hollow fibrous air single external skin separating film with polyether sulphone |
| CN102961977A (en) * | 2012-12-17 | 2013-03-13 | 中国科学院宁波材料技术与工程研究所 | Preparation method of polylactic-acid hollow fiber dialysis membrane |
| CN104906971A (en) * | 2015-05-20 | 2015-09-16 | 苏州市贝克生物科技有限公司 | Cellulose acetate/polyethylene glycol blood dialysis membrane and preparation method thereof |
| CN104984670A (en) * | 2015-06-24 | 2015-10-21 | 苏州乔纳森新材料科技有限公司 | Blood purification membrane and preparation method thereof |
| CN106943612A (en) * | 2015-11-18 | 2017-07-14 | B·布莱恩·阿维图姆股份公司 | Dialyzer is sterilized and test completeness method |
| CN107185418A (en) * | 2017-06-13 | 2017-09-22 | 江南大学 | A kind of electropositive hemodialysis membrane and preparation method thereof |
-
2001
- 2001-05-17 CN CN 01112899 patent/CN1094380C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100427191C (en) * | 2005-12-28 | 2008-10-22 | 上海应用技术学院 | Production of hollow fibrous air single external skin separating film with polyether sulphone |
| CN102961977A (en) * | 2012-12-17 | 2013-03-13 | 中国科学院宁波材料技术与工程研究所 | Preparation method of polylactic-acid hollow fiber dialysis membrane |
| CN104906971A (en) * | 2015-05-20 | 2015-09-16 | 苏州市贝克生物科技有限公司 | Cellulose acetate/polyethylene glycol blood dialysis membrane and preparation method thereof |
| CN104984670A (en) * | 2015-06-24 | 2015-10-21 | 苏州乔纳森新材料科技有限公司 | Blood purification membrane and preparation method thereof |
| CN106943612A (en) * | 2015-11-18 | 2017-07-14 | B·布莱恩·阿维图姆股份公司 | Dialyzer is sterilized and test completeness method |
| CN106943612B (en) * | 2015-11-18 | 2021-05-14 | B·布莱恩·阿维图姆股份公司 | Method for sterilizing and testing the integrity of dialyzers |
| CN107185418A (en) * | 2017-06-13 | 2017-09-22 | 江南大学 | A kind of electropositive hemodialysis membrane and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1094380C (en) | 2002-11-20 |
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Owner name: DONGHUA UNIV.; SHANGHAI YIERKANG MEDICINE EQUIPMEN Free format text: FORMER NAME OR ADDRESS: DONGHUA UNIV. |
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