CN1316966C - Otacosane alcohol extract micro-encapsulation powder and preparation method thereof - Google Patents
Otacosane alcohol extract micro-encapsulation powder and preparation method thereof Download PDFInfo
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- CN1316966C CN1316966C CNB200510076612XA CN200510076612A CN1316966C CN 1316966 C CN1316966 C CN 1316966C CN B200510076612X A CNB200510076612X A CN B200510076612XA CN 200510076612 A CN200510076612 A CN 200510076612A CN 1316966 C CN1316966 C CN 1316966C
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- arabic gum
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Abstract
The present invention discloses octacosanol extract microcapsule powder and a preparation method thereof. The octacosanol extract microcapsule powder contains an octacosanol extract, an emulsifying agent, Arabic gum, beta-hydroxyl propyl-cyclodextrin and maltose, wherein the octacosanol extract account for 2.5 to 10% of the total mass of the emulsifying agent, the Arabic gum, the beta-hydroxyl propyl-cyclodextrin and the maltose, and the quality ratio of the Arabic gum to the beta-hydroxyl propyl-cyclodextrin to the maltose to the emulsifying agent is 1: 0.5 to 1.5: 1.5 to 2.5: 2 to 4. The present invention adopts a micro-encapsulation technique to solubilize the octacosanol extract, and the solubility of the obtained octacosanol extract microcapsule powder in water can reach over 95%; thereby, the biological availability of the octacosanol extract microcapsule powder is improved, and various physiological activity functions can be effectively exerted. Furthermore, the microcapsule powder has the advantages of low water content, stable performance and good flowing performance, and can be combined with other powder materials or liquid materials well, so that the application range of the microcapsule powder can be widened to satisfy the requirements of different production conditions.
Description
Technical field
The present invention relates to Otacosane alcohol extract micro-encapsulation powder and preparation method thereof.
Background technology
Octacosanol is a kind of high-carbon fatty alcohol, can extract acquisition from raw materials such as rice bran wax, cerosin and insect wax, has effects such as significant resisting fatigue, blood fat reducing, increase sexual function, has good application potential in food, medicine and cosmetics.The extracting method of octacosanol is comparative maturity, octacosanol content is 12-90% in the gained octacosane alcohol extract, but, because the solubility property extreme difference of octacosane alcohol extract, can only be dissolved in the limited several deleterious organic solvent and water insoluble, its outstanding biological function is difficult to performance, and this makes the application of octacosane alcohol extract in health food and medicine be restricted.
Microencapsulation technology is the novel dosage form technology that development in recent years is got up, and is mainly used in the micro encapsulation of essence, spice, vitamin, enzyme preparation etc.Technology that microencapsulation technology is actually a kind of " packing ", the selection of the quality of its effect and wall material is closely related.A kind of ideal wall material should possess the characteristics of following several respects: good flowability is arranged during (1) high concentration; (2) can the emulsifying heartwood, and emulsification system had Stabilization; (3) have film property, heartwood intactly can be embedded in its inside; (4) easily dry, easily dissolving; (5) edibility and economy.
Summary of the invention
The purpose of this invention is to provide a kind of Otacosane alcohol extract micro-encapsulation powder and preparation method thereof with good solubility.
Otacosane alcohol extract micro-encapsulation powder provided by the present invention contains octacosane alcohol extract, emulsifying agent, arabic gum, β-hydroxypropyl cyclodextrin and maltose; Wherein, the octacosane alcohol extract is the 2.5-10% of emulsifying agent, arabic gum, β-hydroxypropyl cyclodextrin and maltose gross mass, arabic gum: β-hydroxypropyl cyclodextrin: maltose: the mass ratio of emulsifying agent is 1: 0.5-1.5: 1.5-2.5: 2-4.
Wherein, in Otacosane alcohol extract micro-encapsulation powder of the present invention the octacosane alcohol extract be preferably emulsifying agent, arabic gum, β-hydroxypropyl cyclodextrin and maltose gross mass 5%; Arabic gum: β-hydroxypropyl cyclodextrin: maltose: the mass ratio of emulsifying agent is preferably 1: 1: 2: 4; Emulsifying agent is preferably Tween 80.
The preparation method of octacosanol microscapsule powder of the present invention comprises the steps: 1) emulsifying: with arabic gum, β-hydroxypropyl cyclodextrin and maltose, under the emulsifying agent effect, in water, form former emulsion with the octacosane alcohol extract; 2) homogenizing: the former emulsion of gained is carried out homogenizing, form the homogenizing emulsion; 3) micro encapsulation:, obtain described octacosanol microscapsule powder with gained homogenized milk liquid microcapsuleization.
For the ease of the biphase better mixing of profit, the step 1) emulsifying agent is preferably Tween 80, and Tween 80 has very strong hydrophilic, the micellar tendency of formation is arranged in aqueous solution, be polar group towards water, hydrocarbon chain and oil phase interact, thereby form stable ultrathin membrane at oil-water interfaces.Emulsification times is 4-6 hour, and emulsifying temperature is 75-85 ℃.Step 2) homogenization pressure is 30-40MPa, and homogenizing time is 10-15 minute.Adopting the former emulsion viscosity that the inventive method obtained is 22-30mPas, and emulsion is compared with former breast behind the homogenizing, and stability is brought up to more than 98%, and viscosity degradation is to 16-20mPas, the homogeneous exquisiteness.
The method that above-mentioned homogenizing emulsion is carried out micro encapsulation is a lot, mainly contains three major types kinds more than 20 such as chemical method, physical-chemical process, physical mechanical method.Realize that by the physical mechanical method technology of micro encapsulation has spray drying method, method, air suspension, static combined techniques and the porous centrifuging etc. of congealing of spraying, wherein spray drying method is most widely used.Because prepared emulsion viscosity is low, therefore selecting feeding temperature is room temperature (20 ℃), and spray-dired condition is: inlet temperature is 170-180 ℃, and leaving air temp is 90-95 ℃, and flow velocity is 5-6ml/min.The gained Otacosane alcohol extract micro-encapsulation powder is white in color, water solublity and good dispersion, and dissolubility is greater than 95% in the water.
The present invention selects arabic gum, β-hydroxypropyl cyclodextrin and three kinds of materials of maltose as micro encapsulation wall material, wherein used gumwater viscosity is low, and contain the protein that has emulsification about 1%, its emulsibility and good film-forming property are very favourable for the preparation of microcapsule; β-hydroxypropyl cyclodextrin is owing to introduce hydroxypropyl on the circulus body of cyclodextrin, not only can the embedding oily matter, and have excellent water solublity; Maltose helps increasing solid content, improves the compactness of microcapsule wall, and the result shows that the formed compound wall materials of three is a kind of micro encapsulation wall material of function admirable.The present invention adopts microencapsulation technology that the octacosane alcohol extract is carried out solubilising, the method that using emulsion technology combines with spray drying technology, its dissolubility and emulsifying dispersivity are improved, thereby improve its bioavailability, more effectively bring into play its multiple physiological active functions; And, because the microscapsule powder water content is low, stable in properties, free-running property is good, and is good with other powder or the liquid material compatibility, therefore, can enlarge its range of application, satisfies the needs of different working conditions.
The specific embodiment
The preparation of embodiment 1, Otacosane alcohol extract micro-encapsulation powder
Used octacosane alcohol extract is according to document (Chen F, T Cai, Zhao G, Liao X, Guo L and Hu X.Optimizing conditions for the purification of crude octacosanol extract from rice bran waxby molecular distillation analyzed using response surface methodology.J Food Eng 70:47-53 (2005) .) prepare, wherein the mass content of octacosanol is 28%.
In heater (80 ℃), 4g compound wall materials (being made up of at 1: 1: 2 according to mass ratio arabic gum, maltose, β-hydroxypropyl cyclodextrin) is dissolved in the 40ml water, add 4ml Tween 80 mixings again.Take by weighing 0.4g octacosane alcohol extract, after 90 ℃ of heat fused, while stirring it is added in the aqueous solution of above-mentioned compound wall materials gradually.After all adding, the speed stirring and emulsifying 4h with 6000rpm forms former emulsion; Should former emulsion under 35MPa pressure, homogenizing 15min forms the homogenizing emulsion; This homogenizing emulsion is carried out spray drying, and the selection feeding temperature is room temperature (20 ℃), and spray-dired condition is: 174 ℃ of inlet temperature, 91 ℃ of leaving air temps, flow velocity 5mL/min-6mL/min.Micro encapsulation efficient reaches 92.7%, and the micro encapsulation productive rate is 94.9%, and the dissolubility of gained microscapsule powder in water is greater than 95%.
Embodiment 2,
Used octacosane alcohol extract is according to document (Chen F, T Cai, Zhao G, Liao X, Guo L and Hu X.Optimizing conditions for the purification of crude octacosanol extract from rice bran waxby molecular distillation analyzed using response surface methodology.J Food Eng 70:47-53 (2005) .) preparation, and after the routine distillation, obtain, wherein the mass content of octacosanol is 50%.
Take by weighing 0.6g octacosane alcohol extract, after 90 ℃ of heat fused, add 4ml Tween 80, stir, as oil phase; 4g compound wall materials (being made up of at 1: 0.5: 1.5 according to mass ratio arabic gum, maltose, β-hydroxypropyl cyclodextrin) is dissolved in the 40mL water, as water.(75 ℃) join aqueous phase gradually with oil phase while stirring in heater, and the speed stirring and emulsifying 6h with 6000rpm forms former emulsion; Should former emulsion under 40MPa pressure, homogenizing 10min forms the homogenizing emulsion; This homogenizing emulsion is carried out spray drying, and the selection feeding temperature is room temperature (20 ℃), and spray-dired condition is: 177 ℃ of inlet temperature, 91 ℃ of leaving air temps, flow velocity 5ml/min-6ml/min.Micro encapsulation efficient reaches 96.0%, and the micro encapsulation productive rate is 98.2%, and the dissolubility of gained microscapsule powder in water is greater than 95%.
Embodiment 3,
Used octacosane alcohol extract is according to document (Chen F, T Cai, Zhao G, Liao X, Guo L and Hu X.Optimizing conditions for the purification of crude octacosanol extract from rice bran waxby molecular distillation analyzed using response surface methodology.J Food Eng 70:47-53 (2005) .) preparation, and obtain through routine distillation, wherein the mass content of octacosanol is 50%.
Take by weighing 0.2g octacosane alcohol extract, after 90 ℃ of heat fused, add 4ml Tween 80, stir, as oil phase; 4g compound wall materials (being made up of at 1: 1.5: 2.5 according to mass ratio arabic gum, maltose, β-hydroxypropyl cyclodextrin) is dissolved in the 40mL water, as water.(85 ℃) join aqueous phase gradually with oil phase while stirring in heater, and the speed stirring and emulsifying 4h with 6000rpm forms former emulsion; Should former emulsion under 30MPa pressure, homogenizing 15min forms the homogenizing emulsion; This homogenizing emulsion is carried out spray drying, and the selection feeding temperature is room temperature (20 ℃), and spray-dired condition is: 170 ℃ of inlet temperature, 91 ℃ of leaving air temps, flow velocity 5ml/min-6ml/min.Micro encapsulation efficient reaches 96.7%, and the micro encapsulation productive rate is 98.9%, and the dissolubility of gained microscapsule powder in water is greater than 95%.
Claims (9)
1, a kind of Otacosane alcohol extract micro-encapsulation powder contains octacosane alcohol extract, Tween 80, arabic gum, β-hydroxypropyl cyclodextrin and maltose; Wherein, described octacosane alcohol extract is the 2.5-10% of described Tween 80, arabic gum, β-hydroxypropyl cyclodextrin and maltose gross mass, and the mass ratio of described arabic gum: β-hydroxypropyl cyclodextrin: maltose: Tween 80 is 1: 0.5-1.5: 1.5-2.5: 2-4.
2, octacosanol microscapsule powder according to claim 1 is characterized in that: described octacosane alcohol extract be described Tween 80, arabic gum, β-hydroxypropyl cyclodextrin and maltose gross mass 5%; The mass ratio of described arabic gum: β-hydroxypropyl cyclodextrin: maltose: Tween 80 is 1: 1: 2: 4.
3, the preparation method of the described octacosanol microscapsule powder of claim 1 comprises the steps: 1) emulsifying: with arabic gum, β-hydroxypropyl cyclodextrin and maltose, under Tween 80 effects, in water, form former emulsion with the octacosane alcohol extract; 2) homogenizing: the former emulsion of gained is carried out homogenizing, form the homogenizing emulsion; 3) micro encapsulation:, obtain described octacosanol microscapsule powder with gained homogenized milk liquid microcapsuleization.
4, preparation method according to claim 3 is characterized in that: the emulsification times in the described step 1) is 4-6 hour, and emulsifying temperature is 75-85 ℃.
5, according to claim 3 or 4 described preparation methoies, it is characterized in that: the described octacosane alcohol extract of step 1) is the 2.5-10% of described Tween 80, arabic gum, β-hydroxypropyl cyclodextrin and maltose gross mass, and the mass ratio of described arabic gum: β-hydroxypropyl cyclodextrin: maltose: Tween 80 is 1: 0.5-1.5: 1.5-2.5: 2-4.
6, preparation method according to claim 5 is characterized in that: described octacosane alcohol extract be described Tween 80, arabic gum, β-hydroxypropyl cyclodextrin and maltose gross mass 5%; The mass ratio of described arabic gum: β-hydroxypropyl cyclodextrin: maltose: Tween 80 is 1: 1: 2: 4.
7, according to claim 3 or 4 described preparation methoies, it is characterized in that: step 2) in described homogenization pressure be 30-40MPa, homogenizing time is 10-15 minute.
8, according to claim 3 or 4 described preparation methoies, it is characterized in that: the described micro encapsulation in the step 3) adopts spray drying method to carry out.
9, preparation method according to claim 8 is characterized in that: described spray-dired condition is: inlet temperature is 170-180 ℃, and leaving air temp is 90-95 ℃, and flow velocity is 5-6ml/min.
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101066258B (en) * | 2006-06-20 | 2010-05-26 | 深圳海创医药科技发展有限公司 | Inclusion compound of higher fatty alcohol and its preparation |
| CN102247322B (en) * | 2011-07-13 | 2013-01-16 | 广东省食品工业研究所 | Octacosanol micro-emulsion and preparation method thereof |
| CN109965167B (en) * | 2019-04-15 | 2022-02-15 | 江南大学 | Octacosanol sports drink and preparation method thereof |
| CN111685321A (en) * | 2020-06-09 | 2020-09-22 | 江西省科学院生物资源研究所 | Rice bran fatty alkanol microcapsule and preparation method and application thereof |
| CN112890172B (en) * | 2021-01-29 | 2023-05-02 | 中国林业科学研究院资源昆虫研究所 | Higher alkanol microcapsule, preparation method and application thereof in effervescent tablets |
| CN112999191B (en) * | 2021-03-03 | 2023-03-24 | 江西省科学院生物资源研究所 | Polycosanol microcapsule and preparation method and application thereof |
| CN112972413A (en) * | 2021-03-16 | 2021-06-18 | 江西省科学院生物资源研究所 | Traditional Chinese medicine effervescent tablet containing policosanol and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6049752A (en) * | 1983-08-29 | 1985-03-19 | Sanyuu Shoji Kk | Nutrient food composition |
| CN1321627A (en) * | 2000-04-30 | 2001-11-14 | 雷少华 | Method for extracting high-grade primary fat alcohol mixture by using cerosin |
| CN1344704A (en) * | 2001-04-30 | 2002-04-17 | 曹树稳 | Prepn and application of octacosanol |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6049752A (en) * | 1983-08-29 | 1985-03-19 | Sanyuu Shoji Kk | Nutrient food composition |
| CN1321627A (en) * | 2000-04-30 | 2001-11-14 | 雷少华 | Method for extracting high-grade primary fat alcohol mixture by using cerosin |
| CN1344704A (en) * | 2001-04-30 | 2002-04-17 | 曹树稳 | Prepn and application of octacosanol |
Non-Patent Citations (1)
| Title |
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| 二十八烷醇的应用与制备 西部粮油，第3期 2003 * |
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