CN1313080A - Cosmetics containing nephrite powder and preparation thereof - Google Patents

Abstract

A series of cosmetic containing nephrite powder and its preparing process are disclosed. Said the series of cosmetic including astringent, powdered cosmetic, lipstick, shampoo, hair styling mousse, cream, etc contains the nephrite powder (5-99 wt.%) in order to activate cell function, promote blood circulation and metabolism, preserve moisture and protect skin and hair.

Description

The cosmetics and the manufacture method thereof that contain nephrite powder

The invention relates to the astringent that contains nephrite (Nephrite) powder, powdery cosmetic, kermes, the eyelid cosmetics, the face emulsifiable paste, shampoo, hair style fixative and haircut wet goods cosmetics and manufacture method thereof particularly have the usefulness (headache for the treatment of human body diseases about use, the insomnia, dyspepsia, brothers are numb etc.), remove the usefulness (heavy metal removal etc.) of object impurity, water correction usefulness, promote the cosmetics and the manufacture method thereof of the fine nephrite powder that the fiber of the tremolite-Actinolitum series of the usefulness of animal and plant growth is made of superfine crossed fiber microstructure.

So far, the cosmetics that are used for the human body beauty treatment, well-known is the cosmetics of chi mountain exploitation, especially recently, developing to contain to be useful on and giving the dynamopathic predetermined substances such as wrinkle or scar disappearance of flattening, multivitamin or contain the Aloe of vegetalitas kind or the cosmetics of Chinese medicine etc. for example, but so remarkable effect do not obtained.

In order to improve this point, be in cosmetics, to contain nephrite with good disease treatment usefulness.

In general, jade roughly is divided into jadeite and nephrite, and jadeite is the plumbous pyroxenite group mineral that belong to pyroxenite family, it is the monoclinic system material that constitutes by silicic acid, aluminium oxide, sodium carbonate, be the compact block of hardness as quartzy, gloss is black dark green green, is transparent or translucent.Say common " jade ", that mainly refers to jadeite.

Nephrite is the monoclinic system pyribole mineral body of inosilicate (inosilicate), in magnesia marble, be divided into nephrite and serpentinization hyperalkaline nephrite, their quality is with its fine structures shape, promptly brilliant in bundle group and the decision of fibroplastic thickness degree with the tremolite one Actinolitum, known fiber is superfine more, and quality is good more.

About such jade, according to the report in the German medical circle document (Mauda Palmer Die Verborgene " KRAF der KRISTALLE und der EDELSTEINE "), jadeite is two kinds of different Ores with nephrite, they are as most gem, contain silicon and oxygen, but jadeite is crystal formation with granular pattern relatively, so the difference of nephrite is by cellulosic, countless crystal as the hair and particle aggregate form, particularly be different from sodium and aluminum constituent in the jadeite, nephrite is with three kinds of mineral to the human body beneficial, be calcium, ferrum, magnesium is as main constituent, delivering when using nephrite recently, to hypertension, diabetes, the causing circulatory obstacle, heart disease and bring great influence by the treatment of diseases that the kidney obstacle causes, such fact also has description in " magic power of gem " (Die Magie der Edelsteine) of the Hedy of Germany Brusius book.

On the other hand, in Dong-eui-bo-gam, also write exactly: if in black rice wine and Radix Sanguisorbae wine, put into jade as the classic works of Japan's medical science, can become water, if put into just deliquescing easily of pulp-water suddenly, if Nepheritum is edible greatly with numb bean, the refuse that accumulates is for a long time excreted, 1 liter of Nepheritum and 1 liter of Radix Sanguisorbae, 1 liter of rice, 3 liters of dew are mixed together, put into bronze, brass or copper ware then and boil, Nepheritum will become water, this is called good wine, also is called the beautiful slurry of so-called angle.In addition, know according to new farming book on Chinese herbal medicine, Tang materia medica, Compendium of Materia Medica etc.: jade is ground into sesame seed to be taken greatly, can the moist vital organs of the human body, not only have the effect that the refuse that accumulates for a long time in the body is discharged fully, and digestive system is produced effect owing to remove the heat in the stomach; Effective to the anemia that bronchus is panted and body heat rising heart is felt bad; Eliminate thirsty disease; It is big to be ground into sesame seed, if take for a long time, health just becomes easily, can be long-lived; Make the function of lungs lubricated; Help the sounding of vocal cords, useful to throat; Give hair with nutrition; Nourish the function of the five internal organs; Particularly make stress disease nervous system disease abirritative effect; In other respects, when the tic that muscular tone causes, if edible white jade powder also is useful; When face or health have scar, to wipe a few days at the scar position with nephrite, scar can disappear etc.; The main constituent of nephrite almost has no side effect, to the remarkable usefulness of human body performance.

But, although known nephrite has the medical science usefulness of aforesaid brilliance to human body, because its rareness is only decorated at one's side with the jewel adornment product as parts such as necklace, ring, bracelets and used.Practical situation is particularly to need a lot of time and effort in the processing of nephrite, and need very thin attention, so if not the practician that protracted experience is arranged, just nephrite can not be carried out meticulous processing.Because be the high price product, so because economic burden, also almost not to utilizing nephrite to develop as general the articles for daily use.Therefore, people's an urgent demand is to for the various the articles for daily uses of utilizing nephrite more valuably or the research and development of medical supplies and health cosmetic products etc.

Therefore; the inventor be conceived to nephrite have give aforesaid disease treatment usefulness (headache; the insomnia; dyspepsia; brothers are numb etc.); odor destruction usefulness; the removal usefulness of object impurity (removing heavy metal etc.) etc. are to the characteristic of the useful usefulness of people; finished and studied for a long period of time and experimental result; in the manufacturing of cosmetics, add a certain amount of nephrite powder carry out mixing after; pass through de-bubbled; filter and cooling is made, provide thus and utilize enhancing metabolism and promoting blood circulation of skin and give skin moisture-keeping and flexibility of nephrite composition; prevent keratinization and protection hair; perhaps can prevent ultraviolet cosmetics and the manufacture method thereof that contains nephrite powder.

Other purposes of the present invention are, residue thing or garbage and processed nephrite powder by utilizing when the mining or deriving from during the gem fining-off can make the utilization of nephrite powder reach maximization.

To achieve the above object, the invention provides a kind of cosmetics that contain nephrite powder, it is characterized in that, with respect to astringent, powdery cosmetic, kermes, eyelid cosmetics, face emulsifiable paste, shampoo, hair style fixative, the full cosmetics of the wet goods of haircuting of 100 weight portions, contain the nephrite powder of 5～99 weight portions.

In order to make above-mentioned nephrite powder sense of touch good, be preferably formed as 100～1000 purpose granularities.

Above-mentioned nephrite powder preferably uses tremolite nephrite in the magnesia marble, is defined as negative value δ ¹⁸The tremolite nephrite of O.

The ratio of components of the nephrite powder of above-mentioned use is as follows.

＜semiquantitative assay value (%) 〉

Silicon 34

Magnesium 10

Calcium 4.9

Ferrum 0.23

Aluminum 0.16

Copper 0.17

Cobalt 0.046

Manganese 0.14

Stannum 0.024

Beryllium 0.00072

Silver 0.0013

Titanium 0.0038

Nickel 0.0028

Chromium 0.0030

Other are 0 years old.

In addition, in order to achieve the above object, the present invention also provides the manufacture method of the cosmetics that contain nephrite powder, it is characterized in that, in astringent, powdery cosmetic, kermes, eyelid cosmetics, face emulsifiable paste, shampoo, hair style fixative, the wet goods cosmetics of haircuting are made, with respect to these cosmetics of 100 weight portions, contain the nephrite powder of 5～99 weight portions, carry out de-bubbled, filtration and cooling then.

Above-mentioned nephrite powder preferably uses tremolite nephrite in the magnesia marble, is defined as negative value δ ¹⁸The tremolite nephrite of O.

The granular size of the nephrite powder of Shi Yonging is suitable with 100～350 orders generally in the present invention, but should increase when soft, and it is favourable using the nephrite powder of the more subparticle about 350～1000 orders.If the granular size of nephrite powder is littler than above-mentioned scope, then the rugosity of goods is very big, is inappropriate.

In addition, when the addition of nephrite powder is lower than 5 weight portions, can not expect the effect that produces by adding nephrite, be inappropriate therefore.The addition of nephrite powder is many more, improve the intrinsic usefulness of nephrite more, but if the addition of nephrite powder is too much, the raw-material character of reduction is not only arranged, particularly soft, make the danger of goods fragility, and because nephrite powder is a high price, the goods unit price is risen, therefore preferably below 99 weight portions of cosmetics gross weight.

Above-mentioned astringent is an emollient astringent (moistening astringent of giving skin moisture-keeping and flexibility; milky lotion; the skin moistening astringent; moisturizer; skin moisturizer; moistening emulsion etc.); promote the massage astringent of blood circulation of skin and flexibility; clean and eliminate the cosmetic cleanout fluid; cut off the ultraviolet solar protection agent of life (protection emulsion; ultraviolet protective agent etc.); make the soft ancon liquid of the softish cutin of cutin; the suppurative mastitis of protection hair; palm astringent that health one palm is used and health astringent etc.

Above-mentioned nephrite powder is nontoxic to human body, has non-stimulated characteristic.Because such characteristic, nephrite powder all can use in which type of cosmetics, even but in these cosmetics, the special composition of readjusting the distribution agent, dentifrice that is suitable as astringent, powdery cosmetic, kermes, eyelid cosmetics, face emulsifiable paste, shampoo, hair style fixative, the wet goods of haircuting uses.That is, nephrite powder is because stability of solution, avirulence and the transparency, and uses in astringent; Because adsorptivity and covering power are used as the powdery cosmetic composition of (comprising the solidification cosmetics); Because odorless, tasteless, avirulence, the water solublity of height can be as the composition of kermes; In addition, owing to avirulence, nonirritant, be used as the composition of the eyeliner that is the eyelid cosmetics; Since give tonicity to skin, can be as the composition of face emulsifiable paste; Owing to improving health effect, be used as the composition of shampoo; In addition, owing to avirulence and stability, also be used as the composition of toothpaste.

When making, during combinations such as other high polymers that use when nephrite powder and manufacturing cosmetics, low molecular weight compound, inorganic compound, spice, antiseptic, can freely use with being not particularly limited and make about cosmetics of the present invention.Which type of in addition, in the cosmetics of forming by compositions, all can use.About the manufacturing of cosmetics and the material that uses in making, can be with reference to together and many embodiment, document and report in the technology new cosmetic conduct and learning (a light well man of great physical prowess writes) of issuing as the cosmetic conduct and learning (Ikeda ferrum is write) of South Mountain hall distribution and bibliogony.

For example, to make astringent is example, be temperature (about 60～70 ℃) heating for dissolving waters (distilled water, wetting agent, chelate, alkali, pigment etc.) in regulation, temperature (about 70～75 ℃) heating for dissolving oil phase (containing the oil content, surfactant, medicament, UV absorbent, antiseptic, spice of higher fatty acids etc.) in regulation at first adds aqueous phase with it and prepares softening.To wherein adding the nephrite powder adjusted in advance, mix (approximately keeping 60～70 ℃), utilize powerful softening device (intimate mixing device) that softening particle and nephrite powder are reached evenly then, in de-bubbled, filter after, utilize heat exchanger etc. to cool off and reach goodsization.The manufacturing of other cosmetics is in addition also carried out similarly with above-mentioned.

Further specify the present invention below with reference to accompanying drawing and following examples.In the accompanying drawings:

Fig. 1 is the crystal structure figure of the nephrite powder that utilizes among the present invention with scanning electron microscope (SEM) expression.

Fig. 2 is the electron scanning micrograph less than the silkworm silk of handling with the Yu Fenshui that utilizes among the present invention.

Fig. 3 is the electron scanning micrograph of the silkworm silk handled with the Yu Fenshui that utilizes among the present invention.

Fig. 4 is the curve chart that the activity change of the test group (Mus on the 20th) behind the Yu Fenshui that utilizes among the present invention is drunk in expression.

Fig. 5 is the culture fluid cumulative volume result of variations of the hair Folium Digitalis Purpureae cell of breeding is observed in expression in growth medium a curve chart.

Fig. 6 is the curve chart that expression hair Folium Digitalis Purpureae cell volume changes.

Fig. 7 is the curve chart of the live body weight change of expression cell.

Fig. 8 is the curve chart that the dry weight of expression cell changes.

Fig. 9 is the curve chart that the pH of expression hair Folium Digitalis Purpureae growth medium changes.

Figure 10 is the curve chart that the pH of the growth medium of expression interpolation nephrite powder changes.

Figure 11 is result's the figure of the status condition of the analytic engine exported of expression.

Figure 12 is the figure of the analysis result exported of expression.

It is as follows to utilize aforesaid method manufacturing to contain the Formulation Example of cosmetics of relevant nephrite powder of the present invention, but is not limited to these Formulation Examples.＜Formulation Example 1 〉: astringent

10.0 parts of ethanol (weight)

5.0 parts of nephrite powders (350～1000 order)

5.0 parts of wetting agents (propylene glycol)

0.1 part of oleyl alcohol

1.2 parts of polyoxyethylene sorbitan fatty acid esters

78.45 parts of distilled water

Antioxidant is an amount of

Antiseptic is an amount of＜Formulation Example 2 〉: the hair style fixative

30.0 parts of nephrite powders (weight)

5.0 parts of ethanol

5.0 parts of glycerol

20.0 parts of distilled water

3.0 parts of dodecyl sodium sulfates

0.01 part of saccharide

2.0 parts of spice

2.0 parts of lubricants

Pigment is an amount of＜Formulation Example 3 〉: kermes

10 parts of nephrite powders (weight)

80 parts of distilled water

2 parts of pectin

0.1 part of wetting agent

Water colo(u)r is an amount of

Spice is an amount of

Antiseptic is an amount of＜Formulation Example 4 〉: circumocular cosmetics

5 parts of nephrite powders (weight)

2.0 parts of spermols

0.2 part of anhydrosorbitol monooleate ester

6.0 parts of propylene glycol

7.0 parts of ethanol

75.0 parts of distilled water

Antiseptic is an amount of

Pigment is an amount of＜Formulation Example 5 〉: the smears of face

20 parts of nephrite powders (weight)

5 parts of carboxymethyl celluloses

2 parts of glycerol

5 parts of ethanol

60 parts of distilled water

Spice is an amount of

Antiseptic is an amount of＜Formulation Example 6 〉: shampoo

10 parts of nephrite powders (weight)

13 parts of ethanol

1.0 parts of polyoxyethylene sorbitol acid anhydride laurates

2.0 parts of glycerol

70 parts of distilled water

Antiseptic is an amount of

Antioxidant is an amount of＜Formulation Example 7 〉: powdery cosmetic

70.0 parts of nephrite powders (weight)

4.5 parts of zinc white

4.5 parts of zinc stearates

11.0 parts of pectin

Spice is an amount of

Pigment is an amount of＜Formulation Example 8 〉: powdery cosmetic

75 parts of nephrite powders (weight)

8 parts in mineral oil

8 parts of cellulose derivatives

Distilled water is an amount of

Spice is an amount of

Pigment is an amount of

To the goods that obtain from above-mentioned Formulation Example carry out skin irritation effect and the result of the test of effects such as wrinkle of flattening as follows.＜experimental example 1 〉: skin irritation test

With men and women 50 people that grow up is object, and the cosmetics that coating is made according to above-mentioned Formulation Example of the present invention on the soft skin of last ancon inboard after 12 hours, are investigated whether skin irritation, erythema, scratchy, anaphylaxis etc. are taken place.Result such as following table 1.

Table 1

Skin irritation	Respondent's number (%)
		Do not change on the skin at all	????45(90％)
Have scratchyly a little after removing, but disappear at once	????2(4％)
		Coating portion has red tide a little, but disappears after 1～2 hour	????3(6％)
The significant stimulation taken place	????0(0％)

＜experimental example 2 〉: the wrinkle effect of flattening

With 20 people of the women more than 30 years old is object, after before going to bed, washing one's face, remove aqueous vapor on the face, after 1～3 minute, with the cosmetics (astringent and face smears etc.) that only coating is made according to Formulation Example on the wrinkle of the eyelid in left side, remove the mode of cosmetics when washing one's face in the morning and continue to use the effect that occurred in 1 month, compare with the eyelid (contrast) on right side.In addition, after above-mentioned experimental period finishes, end the use of goods of the present invention, carry out the disappearance degree test of effect.Result such as following table 2.

Table 2

Effect	Respondent's number (%)
		Wrinkle significantly reduces or eliminates	????4(20％)
It is quite shallow that the degree of depth of wrinkle becomes	????12(60％)
		The degree of wrinkle relaxes a little	????3(15％)
Can not judge rightly	????1(5％)

And, using cosmetics of the present invention after 1 month, the above-mentioned respondent (19 people) who produces the wrinkle mitigation and/or the wrinkle effect of flattening uses the eyelid that interrupts 1 all backs and right side to compare at goods, the eyelid in left side feels that the number of replying of these goods result of use is 17 people (89%), confirms the persistence of the wrinkle effect of flattening of the present invention.Impinge upon the performance in the above-mentioned experimental example 1,2, not only wrinkle relaxes cosmetics of the present invention or the effect of flattening (95%) is good especially, and the persistence of effect also shows well, and is almost non-stimulated when being coated on the skin.Following experimental example is the experiment of the influence of biology being carried out about the usefulness of the nephrite powder that contains in cosmetics of the present invention and nephrite powder, shown in result's table described as follows.

Table 3

＜lead content test 〉
		Test portion	Beautiful powder
The test portion character	White powder
		Job number	The federal IW 091394-4 of the attached institute of U.S. F.D.A
Method	Atomic absorption spectroscopy
		The result	Do not detect

Table 4

＜heavy metal (Pb etc.) 〉
		Test portion	Beautiful powder
The test portion character	White
		Job number	Federal IW 080894-4
Method	????USP?23
		The result	Do not detect

Table 5

＜inorganic matter precipitation test 〉
		Test portion	Beautiful powder
The test portion character	White
		Job number	Federal IW 080894-4
Method	As following
		The result	As following

Handle the 100g test portion with autoclave, with the extraction of 1 premium on currency, analytical extraction liquid.

Table 6

Amalyzing substances	The result	Detection limit
			Arsenic (As)	????ND	????0.05
Barium (Ba)	????ND	????0.20
			Cadmium (Cd)	????0.007	????0.005
Chlorine (Cl)	????ND	????1
			Chromium (Cr)	????ND	????0.01
Copper (Cu)	????ND	????0.05
			Ferrum (Fe)	????ND	????0.10
Plumbous (Pb)	????ND	????0.05
			Manganese (Mn)	????ND	????0.02
Hydrargyrum (Hg)	????ND	????0.0005
			Nitrate (NO 3)	????ND	????0.1
Selenium (Se)	????ND	????0.05
			Silver (Ag)	????ND	????0.01
Sulfate (SO 4)	????2	????1
			Zinc (Zn)	????ND	????0.01

(ND=concentration is less than detection limit or do not detect)

Impinge upon in the above-mentioned experimental result and show, the nephrite powder that uses among the present invention does not detect harmful lead, heavy metal, other toxic components, therefore confirm, and be safe for example being used for occasion such as suckling sucker for drinking purposes.＜experimental example 3 〉

The nephrite of having investigated use in the present invention in this experiment is to growth promoter of silkworm and the influence of silk quality (with reference to Fig. 1, Fig. 2, Fig. 3).

1. material and method

1, for test silkworm kind: the white jade silkworm

2, feeding time: November～December

3, method for breeding: constant temperature, constant humidity, full age, Folium Mori are raised

4, for a test number: contrast-150 2 repeatedly

Handle-130 2 repeatedly

5, contents processing: contrast-spreading distilled water, administration Folium Mori

Processing-spreading nephrite water, the administration Folium Mori

Processing time: since 2 the length of time silkworm

Table 7

＜raising the result that finishes with beautiful powder water treatment 〉
									Distinguish	Repeatedly	The larva number of having handled	The larval phase in 5 ages		Total larval phase		The nymphosis percentage rate
Day	Time	Day	Time	????％	Index
							????1	????150				????7	????7	????23	????7	????91.3
Matched group	????2	????150	????7	????7	????23				????7	????76.6	????100
							On average	????150				????7	????7	????23	????7	????84.0
	????1	????130	????7	????15	????23				????15	????74.1
						Matched group	????2	????130				????7	????15	????23	????15	????68.2	????85
	On average	????130	????7	?15	????23				????15	????71.2

Distinguish	Repeatedly	Cocoon yield (Kg/10000) index	Cocoon weight		Cocoon tare weight amount		Cocoon skin percentage rate
									????g	Index	????cg	Time	??％	Index
				??1	????17.9	??2.08		??43.0								?20.7
Matched group	??2	????15.0???100							??1.96	????100	??39.0	?100	?19.9	????100
				On average	????16.5	??2.02		??41.0								?20.3
	??1	????16.2							??2.14		??44.0		?20.6
			Processed group	??2	????14.6?????93	??2.14	????106	??45.0							?109	?21.0	????102
	On average	????15.4							??2.14		??44.5		?20.8

Table 8

＜from spinning the cocoon of beautiful powder water treatment 〉
								Distinguish	Silk length (m)	Silk weight (cg)		Silk thickness (d)	Non-shearing length (m)	Non-cut-out silk weight (cg)	Spinning ability (%)
Matched group	??1222	?33.7		?2.48	??3.47	?23.4	?69
								Processed group	??1283	?36.3		?2.55	??1.005	?28.5	?78
Distinguish	Unprocessed silk percentage rate (%)		Degree of refining (counting)		Sticky limit (g/d)	Percentage elongation unprocessed (%) silk weight (Kg)
								Matched group	?19.68		????95		????3.80	?3.47????????2.75
Processed group	?16.96		????96		????3.93	?1.005???????2.61

Table 9

＜the variation of the larva weight of generation〉by the jade processing
					Distinguish	Larva weight from the decortication of the 3rd extra shell	Larva weight from the decortication of the 4th extra shell	The 3rd day weight in 5 ages	Ripe larva
Matched group	????0.46	????1.85	?20.80	?47.4
					Processed group	????0.47	????1.94	?23.03	?52.2

Table 10

＜blood glucose the amount that produced by beautiful solution-treated reduces effect 〉
				The silkworm extract	The blood glucose amount		The minimizing effect of blood glucose amount
With the maltose injection ' (A)	With silkworm extract injection (B)	Reduction (C=A-B) efficient
			Water treatment		mg/100ml	?mg/ml	?mg/ml??????％
	64.0±1.87	?27.7±1.70		?36.3??????56.7
			With beautiful solution-treated		69.6±1.62	?20.7±1.62	?48.9??????70.3

': before the injection of silkworm extract＜result 〉

1, about the weight of larva, complete complete nephrite water treatment in length of time group is heavier than the matched group that is the distilled water treatment region, becomes the about 0.48g of each body weight of matured silkworm especially.

2, it is low more about 15% than matched group that nymphosis ratio, nephrite freshen the food group, is 71.2%; Receiving the silk amount for 10,000 and hang down 7% than matched group, is 15.4%.

3, it is heavily about 6% that nephrite freshens the full silk weight ratio matched group of food group, is 2.14g; Silkworm is heavy also heavily about 9%, is 44.5g.It is high by 2% that silk layer ratio pressed index than matched group.

4, nephrite freshens the spinning achievement comparison of food group according to organizing comprehensively well.Particularly the filament length degree is long, and silk amount is many, and Xie Xu leads also than matched group high about 9% aspect the silk number, so the Xie Xusi amount is quite a lot of.

5, aspect silk quality, it is thick a little that nephrite freshens food group fiber number, and intensity elongation and raw silk amount ratio are than matched group height, but it is few to receive the silk amount, and therefore 10,000 raw silk amount is lacked than matched group.

6, the silk surface texture shows big difference between matched group and the treatment region.

7, the crystal structure that has freshened the nephrite of food is most advanced and sophisticated bald club shaped structure.＜experimental example 4 〉

In this experiment, the activity change of Mus on the 20th of the beautiful powder drinking water that added the nephrite powder that uses in the invention has been drunk in observation.Experimental result as shown in Figure 4, in stable effect experiment, Mus on the 20th of positive controls after having drunk ゥ バ PVC ト (annotate: name of the country) medicine 5 minutes, nervus centralis begins to stabilize, after 30 minutes, recover normal gradually, the fluctuating of activity ratio appears in Mus on the 20th of general matched group, sees the trend of all minimizings.Drink the similar general matched group of activity ratio of the test group (Mus on the 20th) of beautiful powder drinking water, but the meansigma methods of all activity ratios compared as can be known, not only than general matched group height, and and positive controls relatively, more significant difference is arranged.＜experimental example 5 〉

In the present embodiment, nephrite powder is carried out the infrared ray experiment.

Table 11

Test portion	Beautiful powder
		The test portion character	White
Inspection method	????Perkin?Elmer?137
		The result	As described below

＜in infrared spectrum 〉

Form: oxolane liquefaction thin film

The pattern consistent occur, show as the electromagnetic wave that radiates wavelength 6～52 μ with polycarbonate resin.＜experimental example 6 〉

In this experimental example, the biological oxygen required amount for the chemistry of the nephrite powder test portion that uses among the present invention experimentizes according to following table 12 and table 13.

Table 12

Test portion	Beautiful powder
		The test portion character	White
Method	Standard method
		The result	As described below

Table 13

Distinguish	Water (contrast is used)	Beautiful powder adds
			5 days BOD	????224mg/l	????223mg/l
????COD	????115mg/l	????110mg/l

＜experimental example 7 〉

In this experimental example, the experiment that the nephrite powder that carries out using among the present invention according to table 14 impacts test block (rabbit).

Table 14

＜the 1 time eye irritant test 〉
		Test portion	Beautiful powder
The test portion character	Off-white powder
		Method	As described below
The result	As described below

Method: the United States Federal login Vol 43, No.163-1978.8.22, p.37359

Experimentation: place the extract of 0.1ml on the upturned palpebra inferior of the eyelid of a side, before placement, clamp upper eyelid and 1 second of palpebra inferior lightly.The eye of opposite side is not handled in contrast example and is observed.The eye of the processing of 6 rabbits is not placed not cleanly, and the eye of 3 rabbits has just been handled the back and cleaned 1 minute with the tepid water that flows.Before handling, utilize fluorescence method to check eye in advance, only use in test not show corneal injury person with test portion.24 hours, 48 hours, 72 hours, 7 days and 14 days observation pathological changes after handling eye.Shown in its result table 15 described as follows.

Table 15

The lesion degree of＜eye 〉
							Rabbit	Time	Cornea is the corneal transparence area not	The iris value	The conjunctiva red tide	Chemosis	The conjunctiva secretion
	?24h	????0????0	????0	?0	????0	????0
							??#1	?48h	????0????0	????0	?0	????0	????0
Do not clean	?72h	????0????0	????0	?0	????0	????0
								??7d	????0????0	????0	?0	????0	????0
Count		Cornea (0)	Iris (0)		Conjunctiva (0)
								?24h	????0????0	????0	?0	????0	????0
??#2	?48h	????0????0	????0	?0	????0	????0
							Do not clean	?72h	????0????0	????0	?0	????0	????0
	??7d	????0????0	????0	?0	????0	????0
							Count		Cornea (0)	Iris (0)		Conjunctiva (0)
	?24h	????0????0	????0	?0	????0	????0
							??#3	?48h	????0????0	????0	?0	????0	????0
Do not clean	?72h	????0????0	????0	?0	????0	????0
								??7d	????0????0	????0	?0	????0	????0
Count		Cornea (0)	Iris (0)		Conjunctiva (0)
								?24h	????0????0	????0	??0	????0	????0

??#4	48h	?0????0	????0	?0	????0	?0
							Do not clean	72h	?0????0	????0	?0	????0	?0
	?7d	?0????0	????0	?0	????0	?0
							Count		Cornea (0)	Iris (0)		Conjunctiva (0)
	24h	?0????0	????0	?0	????0	?0
							??#5	48h	?0????0	????0	?0	????0	?0
Do not clean	72h	?0????0	????0	?0	????0	?0
								?7d	?0????0	????0	?0	????0	?0
Count		Cornea (0)	Iris (0)		Conjunctiva (0)
							??#6	?48h	?0????0	????0	?0	????0	?0
Do not clean	72h	?0????0	????0	?0	????0	?0
								?7d	?0????0	????0	?0	????0	?0
Count		Cornea (0)	Iris (0)		Conjunctiva (0)
								24h	?0????0	????0	?0	????0	?0
??#7	48h	?0????0	????0	?0	????0	?0
							Do not clean	72h	?0????0	????0	?0	????0	?0
	?7d	?0????0	????0	?0	????0	?0
							Count		Cornea (0)	Iris (0)		Conjunctiva (0)
	24h	?0????0	????0	?0	????0	?0
							??#8	48h	?0????0	????0	?0	????0	?0
Do not clean	72h	?0????0	????0	?0	????0	?0
								?7d	?0????0	????0	?0	????0	?0
Count		Cornea (0)	Iris (0)		Conjunctiva (0)
								24h	?0????0	????0	?0	????0	?0
??#9	48h	?0????0	????0	?0	????0	?0
							Do not clean	72h	?0????0	????0	?0	????0	?0
	?7d	?0????0	????0	?0	????0	?0
							Count		Cornea (0)	Iris (0)		Conjunctiva (0)

I, cornea

(A) opacity-density (Read Range)

Normally-0

Diffusion zone disperses one to see iridescent thin portion-1 brightly

Translucent area, the iridescent thin portion not distinct a little-2 of easy identification

The milky zone, do not see iridescent thin portion, almost can not discern the size-3 of pupil

Opaque, do not see iris-4

(B) area of cornea

Normally-0

Below 1/4 but be not 0-1

More than 1/4, below 1/2-2

More than 1/2, below 3/4-3

More than 3/4, all areas following-4

Count A * B * 5, total maximum=80

II, iris

(A) value

Normally-0

Blood stasis around normal above, overlapping, congested, swelling, cornea (these symptoms are with size arbitrarily, separately or combination appearance), as if iris still with regard to light reflex (slow reaction is remarkable)-1

To light do not react, hemorrhage, overall destruction (these symptoms a kind of or whole)-2

A * 5, the possibility of counting maximum=10 always

III, conjunctiva

(A) red tide (conjunctiva that only is related to eyelid)

Normally-0

Blood vessel is hyperemia-1 really more than normally

More diffusion, darker peony appear.Distinguish each blood vessel-2 easily

Diffusion is as beef red-2

(B) edema

No swelling-0

(the instantaneous film that comprises eye) transnormal any swelling phenomenon-1

Eyelid partly turns over and swelling significantly-2

The half way closure of eyelid, swelling-3

The half way of eyelid and even closed fully, swelling-4

(C) secretion

Normally-0

Not with normal different any phenomenon (not comprising)-1 from the observed a small amount of secretions in intact animal's inboard canthus

Wetted secretions-2 on the eyebrow of eyelid and eyelid adjacency only

Occupy suitable area-3 enclosing near the eyes

Count (A+B+C) * 2, total maximum=20

Conclusion: conclude that this test portion does not stimulate eye.Therefore conclude in the cosmetic preparation that is adapted at eyelid and use.

Table 16

＜1 time skin irritation test 〉
		Test portion	Beautiful powder
The test portion character	White powder
		Method	As described below
The result	As described below

Method: the United States Federal login Vol 43, No 163

CTFA (The Cosmetic, Roiletry and Fragrance Association, Washington, technical manual D.C)

Experimentation: use the sticking experimental technique of subsides of peeling off skin and original skin to white rabbit.Hair cuts weak point from back and rib abdomen.Selected 2 zones from the 10cm that breaks an agreement are as the patch position.Epidermis is cut at 4 places in patch zone in a zone lessly, with skin peeling (wherein 2 vertically stay, and carry out in " tic-tac-toe " (well word shape) mode).Use thin rubber band and adhesive tape that 1 inch quadrate surgery absorbent carbasus patch is adhered to.Amount with 0.5ml (g) below the patch at each position imports test portion.24 hours expose the time during the health of rubber treated cloth parcel animal.Animal does not move activity during exposing.Get except that behind the patch, estimate the reaction that occurs at each position according to counting of following record, the result is as follows.(with reference to table 17).

The evaluation of dermoreaction

Erythema and temporary transient skin form

No erythema-0

Ruo erythema (degree that scarcely is found out)-1 extremely

Clear and definite Shi Bie erythema-2

Common and even very big erythema-3

Very big erythema (Radix Betae color red) and even some temporary transient skins form (dark damage)-4

Swelling forms

No swelling-0

Extremely Ruo swelling (degree that scarcely is found out)-1

Some swelling (edge in zone is obviously clear)-2

The swelling of prevalence (about 1mm)-3

Table 17

24 hours					72 hours
									Rabbit	Skin originally		The skin of wearing and tearing		Skin originally		The skin of wearing and tearing
??ER	???ED	???ER	????ED	????ER	????ED	?ER	???ED
								????#1		??0	????0	????0	????0	????0	????0	?0	????0
????#2	??0	????0	????0	????0	????0	????0	?0		????0
								????#3		??0	????0	????0	????0	????0	????0	?0	????0
????#4	??0	????0	????0	????0	????0	????0	?0		????0
								????#5		??0	????0	????0	????0	????0	????0	?0	????0
????#6	??0	????0	????0	????0	????0	????0	?0		????0

Conclusion: conclude that this test portion does not stimulate skin.Therefore conclude and be adapted at using in the skin cosmetic preparation.

Table 18

＜acute oral toxicity ((0.5g)/100g body weight) experiment 〉
		Test portion	Nephrite powder
The test portion character	White powder
		Method	As described below
The result	As following table 19

Table 19

Mus	Sex	Initial stage body weight (g)	Dosage (ml)	Later stage body weight (g)	Avirulence is arranged
						????1	?F	?207	????1.0	????219	Do not have
????2	?F	?211	????1.1	????226	Do not have
						????3	?F	?215	????1.1	????225	Do not have
????4	?F	?208	????1.0	????217	Do not have
						????5	?F	?200	????1.0	????213	Do not have
????6	?M	?227	????1.1	????235	Do not have
						????7	?M	?216	????1.1	????224	Do not have
????8	?M	?205	????1.0	????218	Do not have
						????9	?M	?210	????1.0	????224	Do not have
????10	?M	?212	????1.1	????221	Do not have

The manufacturing of test portion: in the distilled water of sterilization, put into a part of test portion, extracted after boiling in 10 minutes, utilize intubate to give medicament extract with the amount of every 100g body weight 0.5g.

Conclusion: test portion meets to be called must not have the toxic standard of per os.＜experimental example 8 〉

This experimental example is to rely on biological intelligence system of core He institution of higher education engineering research department to have finished experimentation and result in order to find out the various influences to biology of the nephrite powder that uses among the present invention.In this experimental example, because 70% is water in the key element of formation human body, so under related judgement between the variation of water and the influence to human body, with hard water is which type of influence the object investigation has, and then the effect of bringing about the propagation of giving digitalis (Digitalis) plant cell experimentizes.

(1) variation of hard water

Experiment 1

Respectively move into the 100ppm hard water 50ml of manual manufacture respectively in 4 flasks after, nephrite was placed about 10 minutes in the bottom of 2 flasks therein.

For the variation of investigating hardness use titrimetry, this titrimetry utilize ethylenediaminetetraacetic acid (below, be called " EDTA ".Tire 2.9412).Use the buffer 1ml of pH10, use EBT as indicator.

The amount of the EDTA of the moment that color by hard water changes with EDTA is measured the variation of hardness.At this moment, the past in time has color to return original situation, but in this experimental example, measures as benchmark with the moment that changes.

As a result 1

Hard water needs the EDTA of 1.70ml at 100ppm.

Need 1.25ml EDTA after the nephrite experiment.Therefore the hardness of 100.00ppm is reduced to 73.53ppm.That is, 100.00 hardness is softened 26.47%.

Experiment 2

To move in the beaker according to the hard water 200ml of the 100ppm that makes with experiment 1 identical method and flood nephrite.After about 30 minutes with moisture to the 3 scleroscopic variation of flask pilot scale of beaker.In order to carry out more accurate experiment, the color of hard water also after changing with EDTA, drops into EDTA when extremely or else changing, measure the hardness of this moment in this experimental example.

As a result 2

The hard water of 100ppm before the nephrite experiment becomes respectively

89.62ppm

91.19ppm

89.62ppm

Average 90.14ppm, so hardness reduces 9.9%.

Experiment 3

Current experiment uses general tap water to experimentize.In container, put into tap water, move in 6 flasks after, hardness is measured after about 5 minutes in the bottom that nephrite is placed on 3 flasks wherein.

As a result 3

The tap water that does not carry out the nephrite experiment is

97.48ppm

97.48ppm

97.48ppm

Average 97.48ppm

Tap water after the nephrite experiment is

91.19ppm

91.19ppm

91.19ppm

Average 91.19ppm, so hardness reduces 6.5%.

(2) nephrite is to the influence of hair Folium Digitalis Purpureae (Digitalis lanata) suspension plant cell proliferation

1. nephrite is to the influence of the hair Folium Digitalis Purpureae cell growth in growth medium

Fig. 5 is a curve chart of showing not observe in 11 days the culture fluid cumulative volume variation of carrying out cell proliferation in growth medium.Fig. 6 is the curve chart that the expression cell volume changes, and the proportional increase of the cell of growing along with the process of time because the evaporation of culture medium takes place, has become the such factor of reflection so the cumulative volume of culture fluid changes.Especially, the evaporation of humidity in the atmosphere or temperature and culture medium has confidential relation, and such a factor cell growth speed is also brought influence.

As shown in the figure, compare with the matched group that does not use nephrite when using nephrite, show that the cumulative volume of culture fluid reduces a little.

This be because when using nephrite along with the evaporation of culture medium or the exhaustion of nutritional labeling, show the cell speed of growth faster than matched group, so can offset the rapid minimizing of exhausted culture medium to a certain degree.Such phenomenon is shown in Figure 6 as the change in volume of measuring sedimentary cell only, and it is more than the matched group increase of not using nephrite to observe when continuing to use nephrite in the 4th day to the 11st day behind the inoculating cell cell volume, so can infer such fact.Thereby, show the cell speed of growth faster than the matched group that does not use nephrite when using nephrite.The cumulative volume that such result can be described as the culture fluid that payment causes by the exhaustion of nutrient and culture medium evaporation reduces the result that the minimizing speed of cumulative volume is more slack-off than matched group.In addition,, observe the tendency that also showed progressive cell volume increase, therefore think to confirm such result from the 4th day with the result that the cell volume that only increases compares.

As the method for measuring proliferative activity, measuring becomes the cell live body weight and the dry weight of general benchmark.If in general, the growth curve of whole cell is with the curve representation of S font, but with its classification, then can be divided into 4 stages to classify.During acclimatizing culture medium, can be divided into: the propagation that does not have cell, stopping at quality does not increase the induction period of state (Lagphase): one through being this period that rapidly growth rate increases quality, shows the write music logarithmic (log) phase (Exponential phase) of line of steeply inclined; Growth becomes maximum, breeds the state of shrinking back to a certain degree, is not presented at the stable phase (Stationary phase) that this above quality increases; Then because exhaustion and the discharge of toxic component and the saturation of cell density of nutritional labeling, the death phase (Deadphase) that all cell volumes or quality reduce at cell rupture and in the dead tendency.

Fig. 7 and Fig. 8 are the results who measures cell live body weight and dry weight.

Fig. 7 defers to the growth curve in these 4 stages.After the 7th day, do not use the matched group of nephrite after showing low slightly growth rate, to stop propagation, and the minimizing of showed cell live body quality, different with this matched group is to show when using nephrite that propagation continues to 10 days later tendencies.This should note the following fact when changing relatively as the nutritional labeling concentration of glucose of the main metabolism matrix in the culture medium: even the concentration in, the culture medium almost exhausted at this nutrient becomes at 0 o'clock, also show cell growth constantly.As the matched group that does not use nephrite, generally be when nutritional labeling is exhausted, stop propagation, show the tendency that the speed of growth reduces, but when using nephrite, have the nephrite cell growth influential from showing different therewith phenomenons, inferring.

Such result but demonstrated cell on the 3rd day later on according to carrying out proliferate than matched group faster speed, the phenomenon that showed as Fig. 7 from later the 9th day also as shown in Figure 8.The result is, near the cell that growth is got up nephrite in growth medium be not that such matched group is compared, the growth that demonstrates pair cell has desirable influence.Show the hair Folium Digitalis Purpureae plant cell during about 10 days growth limit, when using nephrite to cultivate, even more do not renew culture medium later on to 10 days, the necrosis of cell etc. does not take place yet, keep steady statue, on the contrary, because shown the phenomenon of expression cell proliferation,, expectation uses so can be used as for the optimized favorable method of cell growth and concentration in the production process that is used for utility production.

2. nephrite is to the influence of medium pH variation

Fig. 9 is the curve chart that the pH in the expression cell growth medium changes, and Figure 10 is the curve chart that the pH of the growth medium behind the expression interpolation nephrite powder changes.

Fig. 9 is the pH variation that is determined in the culture medium when using nephrite and does not use the culture medium in the matched group of nephrite.Matched group shows the interior pH tendentiousness of culture medium when being applicable to general plant cell, although after reducing gradually in time, but still can see the phenomenon of keeping with line to a certain degree.But, when using nephrite, to showed in the 7th day and the similar situation of matched group after, see the tendency that increases a little, but from be presented at culture fluid the direct result of Figure 10 of the result of the growth medium of interpolation nephrite powder, such phenomenon appears terrifically.Show that with the matched group that does not add nephrite powder the pH that reduces constantly is opposite, when adding nephrite powder, show the tendency of keeping this value to a certain degree, infer that its reason is to be had an effect by the ionic reaction that mineralogical composition produced that contains in the nephrite.

3. water quality is to the analysis experimental result of nephrite

Figure 11 is the figure of status condition that expression contains the Water Test Kits of the nephrite powder that uses among the present invention, and Figure 12 is the analysis result figure that expression contains the water quality of the nephrite powder that uses among the present invention.

If to the data of each test portion arrangement, just shown in table 20～table 23 from Figure 11 and Figure 12.Table 20 is to put into 20g nephrite piece through after 48 hours in solution, and test portion 1 is measured each analysis project.In table 20, therefore the influence that is produced by nephrite appears in variable quantity hardly that do not have each to measure project.

Table 21 be the outside of solution place 20g nephrite piece through 48 hours after, the variation of each analysis project also appears in measured value to each analysis project of test portion 2 hardly in this experiment.

Table 23 be the outside of solution place the nephrite piece through 48 hours after, the variation of each analysis project also appears in measured value to each analysis project of test portion 4 hardly in this experiment.But, when test portion 3, being determined at and putting into 20g nephrite powder each analysis item destination data in the solution through 48 hours test portion, these data are shown in Table 22, but as known from Table 22, many variations occur.This variation is as follows.

Harmful Cr and Pb, Ni, Co changed a lot after 48 hours.When not putting into nephrite powder, promptly Cr is 45.30mg before the reaction, becomes 0 and put into nephrite powder after 48 hours, is removed, and Pb also becomes 0 from 13.76mg, fully removes.Ni is reduced to 1.733mg from 51.8mg, and Co also is reduced to 11.94mg from 52.69mg.Mg as one of essential elements in the human body increases to 55.74mg from 48.36mg, though and the composition of nephrite self in conjunction with and increase, do not have the variation of hardness.

The hydrogen ion concentration of distilled water is pH3.5, has acidity, but is pH6.8 after reaction, becomes neutrality, and conductivity also reduces sharp.The every 1g of absorption affinity is about 3～4 mmlq (equivalent), is physically a large amount of.

Preceding and the reacted analysis result test portion 1 of reaction in table 20 solution: the nephrite piece (20g) in the solution

Project	Before the reaction	Reaction back (48h)	Variable quantity
				????pH	????3.5	?3.82	????-
????Ni	????51.8mg	?51.75mg	????-
				????Co	????52.69mg	?52.54mg	????-
????Cr	????45.30mg	?43.88mg	????-
				????Mg	????48.36mg	?48.59mg	????-
????Pb	????13.76mg	?13.90mg	????-

The analysis result test portion 2 of table 21 when the outside placement of solution nephrite piece: the nephrite piece (20g) outside the solution

Project	Before the reaction	Reaction back (48h)	Variable quantity
				????pH	????3.5	????3.65	????-
????Ni	????51.8mg	????48.92mg	????-
				????Co	????52.69mg	????49.83mg	????-
????Cr	????45.30mg	????41.23mg	????-
				????Mg	????48.36mg	????47.97mg	????-
????Pb	????13.76mg	????15.1mg	????-

Analysis result test portion 3 when table 22 adds nephrite powder in solution: the nephrite powder in the solution (20g)

Project	Before the reaction	Reaction back (48h)	Variable quantity
				????pH	?????3.5	?6.8	????+3.3
????Ni	????51.8mg	?1.733mg	????-50.06mg
				????Co	????52.69mg	?11.94mg	????-40.75mg
????Cr	????45.30mg	????0mg	????-45.30mg
				????Mg	????48.36mg	?55.74mg	????+7.38mg
????Pb	????13.76mg	????0mg	????-13.76mg

The analysis result test portion 4 of table 23 when the outside placement of solution nephrite powder: the nephrite powder outside the solution (20g)

Project	Before the reaction	Reaction back (48h)	Variable quantity
				????pH	????3.5	????3.7	??-
????Ni	????51.8mg	?51.53mg	??-
				????Co	????52.69mg	?52.55mg	??-
????Cr	????45.30mg	?43.0mg	??-
				????Mg	????48.36mg	????48.39mg	??-
????Pb	????13.76mg	?14.29mg	??-

As mentioned above, for the hair Folium Digitalis Purpureae plant suspension cell that has nephrite near 1 week of cultivation of placing, show about propagation more than 30% when not having nephrite.This or even in the good propagation result who does not also see for the various experiments that the cultivation effect of the Folium Digitalis Purpureae plant cell of hair in the past that is used for high-concentration culturing is carried out.In addition, in the experiment that hard water is brought what variation about nephrite, learn,, also can make water softening even nephrite does not contact with water.Particularly, in to the water constituent analysis experiment of using distilled water, make the nephrite powder precipitation, observe in the component analysis after through 48 hours, when pH increased, Ni, Co composition reduced, remove etc. at Cr, Pb, when heavy metal removes, cause the specific phenomenon of phenomenons such as Mg increase.

Like this, though relevant nephrite powder of the present invention is not also clearly found out in theory, but do not contact with water, just do not change hardness of water, in addition, not only make mao Folium Digitalis Purpureae plant suspension cell propagation more than 30%, and the minimizing of Ni, Co composition, harmful heavy metal composition is removed in the removals of Cr, Pb etc., be considered to really nephrite powder electromagnetic wavelength effects of radiation and utilize the ionic reaction of the mineralogical composition that contains in the nephrite to cause.The usefulness that the goods of firm basis the invention described above that should be such occur is also provable, especially, should say that probably these experimental results fully prove, because the characteristic of nephrite powder and the influence of nephrite when using the cosmetics contain nephrite powder of the present invention, the skin health of human body is brought useful effect.

As mentioned above; make cosmetics by add nephrite powder according to the present invention; when using the goods of making thus; composition performance activating cell function, blood circulation promoting that produces from nephrite and remarkable medical science function such as enhance metabolism, have protection skin flexibility and moisture retention, prevent keratinization, prevent ultraviolet, the effect of wrinkle resistant and protection hair.

Claims (6)

1, the cosmetics that contain nephrite powder, the astringent of wherein relative 100 weight portions, powdery cosmetic, kermes, eyelid cosmetics, face emulsifiable paste, shampoo, hair style fixative, the full cosmetics of the wet goods of haircuting contain the nephrite powder of 5～99 weight portions.

2, the cosmetics that contain nephrite powder as claimed in claim 1 is characterized in that, above-mentioned nephrite powder is 100～1000 purpose granularities.

3, the cosmetics that contain nephrite powder as claimed in claim 1 is characterized in that, above-mentioned nephrite powder is the tremolite nephrite in the magnesia marble, is defined as negative value δ ¹⁸O.

4, as each described cosmetics that contain nephrite powder in the claim 1～3, it is characterized in that the percentage composition of the nephrite powder of above-mentioned use is as follows in semi-quantitative analysis:

Silicon 34,

Magnesium 10,

Calcium 4.9,

Ferrum 0.23,

Aluminum 0.16,

Copper 0.17,

Cobalt 0.046,

Manganese 0.14,

Stannum 0.024,

Beryllium 0.00072,

Silver 0.0013,

Titanium 0.0038,

Nickel 0.0028,

Chromium 0.0030,

Other are 0 years old.

5, the cosmetics manufacture method that contains nephrite powder, it is characterized in that, in the manufacturing of astringent, powdery cosmetic, kermes, eyelid cosmetics, face emulsifiable paste, shampoo, hair style fixative, the wet goods cosmetics of haircuting, the described cosmetics of relative 100 weight portions contain the nephrite powder of 5～99 weight portions.

6, the cosmetics manufacture method that contains nephrite powder as claimed in claim 5 is characterized in that, above-mentioned nephrite powder is the tremolite nephrite in the magnesia marble, is defined as negative value δ ¹⁸O.

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