CN1306949C - Tendon relaxing and dampness removing traditional Chinese medicine compound preparation and preparation method thereof - Google Patents
Tendon relaxing and dampness removing traditional Chinese medicine compound preparation and preparation method thereof Download PDFInfo
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- CN1306949C CN1306949C CNB2005100317455A CN200510031745A CN1306949C CN 1306949 C CN1306949 C CN 1306949C CN B2005100317455 A CNB2005100317455 A CN B2005100317455A CN 200510031745 A CN200510031745 A CN 200510031745A CN 1306949 C CN1306949 C CN 1306949C
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating osteoarthritis and rheumatoid arthritis, which is prepared from the following raw material medicines: herba taxilli, radix angelicae pubescentis, hippocampus, wolfberry, ginseng, radix paeoniae alba, gentiana macrophylla, cortex periplocae, teasel root, rhizoma cibotii, radix achyranthis bidentatae, pawpaw, homalomena occulta, poria cocos, angelica sinensis, mangnolia officinalis, cinnamon, fennel, ligusticum wallichii, chrysanthemum and liquorice. The invention also comprises a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation provided by the invention has small toxic and side effects and a good curative effect, and is used for treating osteoarthritis cold-dampness collateral obstruction/liver-kidney deficiency and rheumatoid arthritis cold-dampness collateral obstruction/liver-kidney deficiency, and the effective rate is not lower than 93.00%.
Description
Technical field
The present invention relates to a kind of antiheumatic Chinese medicine preparation and preparation method thereof, especially relate to a kind of antiheumatic Shujin dehumidifying compound Chinese medicinal preparation and preparation method thereof.
Background technology
At present, the antirheumatic medicine can be divided into two big classes, the one, chemical synthetic drug, mainly contain salicylic acid (aspirin etc. several), acetophenone amine (acetaminophen etc. several), pyrazolone (antondin etc. are several), fenamic acids (diclofenac etc. are several), aryl alkanoic acid class and phenylpropyl alcohol orthothiazine class (indometacin, ibuprofen etc. several), antigout drug (colchicine etc. several), other (spalestons etc.), these chemical synthetic drugs toxic and side effects clinically are big, dosage is difficult to grasp, mainly show as digestive tract reaction, GI irritation, hematuria, hepatorenal damage, leukopenia, diseases such as thrombocytopenia.The 2nd, Chinese patent medicine, the development of this type of medicine is the emphasis of nearly decades always.According to incompletely statistics, kind surplus the 1985 Chinese patent medicine kinds of listing state-promulgated pharmacopoeia and each province's drug standard in the past in reach 120, mainly contain pills such as sinew-Soothing Blood-Quickening Tablet, lumbar vertebra arthralgia pain treating bolus, Duhuo jisheng ball, tablets such as wind is pacified bitterly, the spirit of positive fresh breeze pain, medicated wine such as Guogong liquor, effective rheumatism medicine, rheumatism one are wiped externally applied liniments such as spirit, unguentum such as rheumatic bone-setting cream, rheumatism plaster, injections such as anti-rheumatism injection, ZHONGJIEFENG ZHUSHEYE.Wherein some curative effect is not good enough; Some curative effect is better, but obvious toxic and side effects is arranged, and for example, the spirit of positive fresh breeze pain occurs erythra, or side effect such as leukopenia take place a few peoples, and Radix Tripterygii Wilfordii has infringement etc. to hepatic and renal function.1985, implemented since new " new drug reviewing way ", the new Chinese medicine of the treatment numbness disease of China's approved production or trial production has antirheumatic medicinal liquor, Sialon rheumatism wine, Jinguanpian tablets etc., from sick sickness rate of numbness and characteristics thereof, new Chinese medicine since 1985 not only quantity is few, and indication is narrow relatively partially.Chinese patent CN1047315C discloses a kind of numbness powder capsule and manufacture method of disappearing, on prescription, selected to have invigorating the liver and kidney, property muscles and bones, enriching blood and replenishing vital essence, wind-damp dispelling, 21 flavor Chinese medicines of functions such as the QI invigorating of invigorating blood circulation are formed, on manufacture method, divide 8 procedures to carry out, and adopted fermentation technology, be mainly used in control middle-aged and elderly people lumbago and skelalgia, sciatica, hyperosteogeny diseases, indication is narrow relatively partially, treatment osteoarthritis cold-damp resistance network/Liver and kidney two deficient syndromes and rheumatoid arthritis cold-damp resistance network/Liver and kidney two deficient syndromes are not had definite curative effect, and manufacture method is also complicated.In addition, though osteoarthritis belongs to the sick category of numbness, its morbidity and etiology and pathogenesis have and the different characteristics of sick other the sick kinds of numbness.At the Chinese medicine of this disease characteristics prescription development, still rare at present.The exploitation of this class medicine is still current clinical pressing for.
Summary of the invention
The object of the present invention is to provide a kind of toxic and side effects little, eutherapeutic antiheumatic Shujin dehumidifying compound Chinese medicinal preparation and preparation method thereof.
The present invention's Shujin dehumidifying compound Chinese medicinal preparation is made by the crude drug of following weight: Herba Taxilli 18g-150g; Radix Angelicae Pubescentis 18g-150g; Hippocampus 12g-100g; Fructus Lycii 12g-100g; Radix Ginseng 12g-100g; Radix Paeoniae Alba 12g-100g; Radix Gentianae Macrophyllae 12g-100g; Cortex Periplocae 12g-100g; Radix Dipsaci 12g-100g; Rhizoma Cibotii 12-100g; Radix Achyranthis Bidentatae 12-100g; Fructus Chaenomelis 12g-100g; Rhizoma Homalomenae 12g-100g; Poria 12-100g; Radix Angelicae Sinensis 12g-100g; Cortex Magnoliae Officinalis 12-100g; Cortex Cinnamomi 12g-100g; Fructus Foeniculi 12g-100g; Rhizoma Chuanxiong 12-100g; Flos Chrysanthemi 6g-50g; Radix Glycyrrhizae 6g-50g.
Preferred version is: Herba Taxilli 65g-80g, Radix Angelicae Pubescentis 65g-80g, Hippocampus 40g-55g, Fructus Lycii 40g-55g, Radix Ginseng 40g-55g, Radix Paeoniae Alba 40g-55g, Radix Gentianae Macrophyllae 40g-55g, Cortex Periplocae 40g-55g, Radix Dipsaci 40g-55g, Rhizoma Cibotii 40-55g, Radix Achyranthis Bidentatae 40-55g, Fructus Chaenomelis 40g-55g, Rhizoma Homalomenae 40g-55g, Poria 40g-55g, Radix Angelicae Sinensis 40g-55g, Cortex Magnoliae Officinalis 40g-55g, Cortex Cinnamomi 40g-55g, Fructus Foeniculi 40g-55g, Rhizoma Chuanxiong 40g-55g, Flos Chrysanthemi 20g-28g, Radix Glycyrrhizae 20g-28g.
The present invention's Shujin dehumidifying compound Chinese medicinal preparation can be made into capsule, tablet, various dosage forms such as granule.Its preparation method may further comprise the steps: (1) with Radix Angelicae Pubescentis, Cortex Periplocae, Rhizoma Homalomenae, Cortex Magnoliae Officinalis, Fructus Foeniculi, each 65%-75% of Cortex Cinnamomi (weight), Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Dipsaci, each 45%-55% of Flos Chrysanthemi (weight) mix by proportioning, are ground into fine powder, and be standby; (2) Hippocampus is ground into fine powder, standby; (3) Herba Taxilli, Radix Ginseng, Radix Gentianae Marcrophyllae are used 65%-75% (volume) ethanol water reflux, extract, secondary, for the first time add 6-10 and doubly measure, extracted 2-3 hour, add 4-8 for the second time and doubly measure, extracted 1.5-2.5 hour, merge extractive liquid, filters, behind the filtrate recycling ethanol, being concentrated into relative density is the clear paste of 1.15-1.18 (60 ℃ of surveys Celsius), or drying under reduced pressure, or spray drying, standby; (4) ten flavors such as (3) step gained medicinal residues Radix Angelicae Pubescentis remaining with it, Cortex Periplocae, Rhizoma Homalomenae, Cortex Magnoliae Officinalis, Fructus Foeniculi, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Dipsaci, Flos Chrysanthemi and all the other Fructus Lycii, the Radix Paeoniae Alba, Rhizoma Cibotii, Radix Achyranthis Bidentatae, Cortex Magnoliae Officinalis, Poria, Radix Glycyrrhizae etc. seven are distinguished the flavor of, decoct with water twice, add for the first time 5-7 times of water gaging, decocted 1.5-2.5 hour, add for the second time 3-5 times of water gaging, decocted 1-2 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.15-1.18 (60 ℃ of survey), or drying under reduced pressure, or spray drying, standby; (5) (3) step gained alcohol extract and (4) step gained water extract are merged, add (2) step gained Hippocampus fine powder, mixing, drying is pulverized, and sieves, add (1) step gained fine powder again, mixing promptly gets the active active ingredient raw materials medicine of product of the present invention.
Then, can make capsule respectively, tablet, various dosage forms such as granule according to conventional method.Used adjuvant can be any in sucrose, dextrin, starch, Pulvis Talci, medicinal calcium carbonate, lactose, beta-schardinger dextrin-, hydroxyl beta-schardinger dextrin-, microcrystalline Cellulose, polyvinylpolypyrrolidone, sodium carboxymethylstarch, 30 POVIDONE K 30 BP/USP 30, micropowder silica gel, the low-substituted hydroxypropyl cellulose etc. or several.
Character this product is yellowish-brown granule or powder, feeble QI perfume (or spice), sweet in the mouth suffering.
Product toxic and side effects of the present invention is little, good effect.Treatment osteoarthritis cold-damp resistance network/Liver and kidney two deficient syndromes and rheumatoid arthritis cold-damp resistance network/Liver and kidney two deficient syndromes, effective percentage is not less than 93.00%.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1
Prescription: Herba Taxilli 72g, Radix Angelicae Pubescentis 72g, Hippocampus 48g, Fructus Lycii 48g, Radix Ginseng 48g, Radix Paeoniae Alba 48g, Radix Gentianae Macrophyllae 48g, Cortex Periplocae 48g, Radix Dipsaci 48g, Rhizoma Cibotii 48g, Radix Achyranthis Bidentatae 48g, Fructus Chaenomelis 48g, Rhizoma Homalomenae 48g, Poria 48g, Radix Angelicae Sinensis 48g, Cortex Magnoliae Officinalis 48g, osmanthus 48g, Fructus Foeniculi 48g, Rhizoma Chuanxiong 48g, Flos Chrysanthemi 24g, Radix Glycyrrhizae 24g.
The capsule method for making
(1) get Radix Angelicae Pubescentis 50.4g, Cortex Periplocae, Rhizoma Homalomenae, Cortex Magnoliae Officinalis, Fructus Foeniculi, each 33.6g of Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, each 24g of Radix Dipsaci, Flos Chrysanthemi 12g, mixed powder is broken into fine powder, and is standby; (2) get hippocampus 3 3.6g and be ground into fine powder, standby; (3) get Herba Taxilli, Radix Ginseng, Radix Gentianae Marcrophyllae with 70% (volume) alcohol reflux secondary, for the first time add 8 times of amounts, extracted 2.5 hours, add 6 times of amounts for the second time, extracted 2 hours, merge extractive liquid, filters, behind the filtrate recycling ethanol, being concentrated into relative density is the clear paste of 1.15-1.18 (60 ℃ of surveys Celsius), or drying under reduced pressure, or spray drying, standby; (4) ten flavors such as (3) step gained medicinal residues and remaining Radix Angelicae Pubescentis, Cortex Periplocae, Rhizoma Homalomenae, Cortex Magnoliae Officinalis, Fructus Foeniculi, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Dipsaci, Flos Chrysanthemi and all the other Fructus Lycii, the Radix Paeoniae Alba, Rhizoma Cibotii, Radix Achyranthis Bidentatae, Cortex Magnoliae Officinalis, Poria, Radix Glycyrrhizae etc. seven are distinguished the flavor of, decoct with water twice, add for the first time 6 times of water gagings, decocted 2 hours, add for the second time 4 times of water gagings, decocted 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.15-1.18 (60 ℃ of survey), or drying under reduced pressure, or spray drying, standby; (5) just (3) step gained ethanol extract and (4) step gained water extract merge, and add (2) step gained Hippocampus fine powder, mixing, and drying is pulverized, and sieves, and adds (1) step gained fine powder again, mixing; (6) granulate, drying, encapsulated (every dress 0.5g) makes 1000.
The capsule content is yellowish-brown granule or powder, feeble QI perfume (or spice), sweet in the mouth suffering.
Differentiate
(1) get this product content and put the microscopically observation: stone cell is dispersed in more, and it is square or oval to be class, diameter 30-60 μ m, and the hole ditch is obvious, and the wall that has is " U " shape and thickens, and the intracavity that has contains needle-like calcium oxalate crystal.Calcium oxalate cluster crystal is present in the elongate thin parietal cell, is circle bunch shape, and diameter reaches 20 μ m.Prism of calcium oxalate becomes stringer to be present in the parenchyma cell, diameter 90-20 μ m.
(2) get this product content 5g, add methanol 30ml, reflux 1 hour filters, and filtrate is put evaporate to dryness in the water-bath, and residue adds methanol 2ml dissolving, as need testing solution.Other gets the 4-methoxysalicylaldehyde reference substance, adds methanol and makes the solution that every 1ml contains 1mg, in contrast product solution.According to thin layer chromatography (China
(2) get this product content 5g, add methanol 30ml, reflux 1 hour filters, and filtrate is put evaporate to dryness in the water-bath, and residue adds methanol 2ml dissolving, as need testing solution.Other gets the 4-methoxysalicylaldehyde reference substance, adds methanol and makes the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw need testing solution 5 μ l, reference substance solution 2 μ l, put respectively on same silica gel g thin-layer plate, with petroleum ether (60～90 ℃)-ethyl acetate-glacial acetic acid (20: 3: 0.5) is developing solvent, launches, and takes out, dry, spray is with the dinitrophenylhydrazine test solution.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(3) get this product content 2g, add ethanol 30ml, supersound process 20 minutes, filter, filtrate is put evaporate to dryness in the water-bath, and residue adds dilute hydrochloric acid 20ml makes dissolving, with chloroform extraction 3 times, each 20ml merges sodium hydroxide solution, add hydrochloric acid and regulate pH value, reuse chloroform extraction 3 times, each 20ml to 1-2, combined chloroform liquid is used anhydrous sodium sulfate dehydration, evaporate to dryness, residue adds methanol 1ml makes dissolving, as need testing solution; Other gets magnolol and honokiol reference substance, adds methanol and makes the mixed solution that contains 1mg among every 1ml, in contrast product solution.According to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000) test, draw each 5 μ l of above-mentioned two kinds of solution, put in same silica gel G F respectively
254On the lamellae, be developing solvent, launch, take out, dry, put under the ultra-violet lamp (254nm) and inspect with benzene-methanol (27: 1).In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(4) get this product content 5g, the 20ml that adds diethyl ether, dipping spends the night, and filters, and filtrate volatilizes, and residue adds chloroform 1ml makes dissolving, as need testing solution.Other gets Radix Angelicae Pubescentis control medicinal material 2g, shines medical material solution in pairs with legal system.According to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000) test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with normal hexane-benzene-ethyl acetate (2: 1: 1) is developing solvent, launches, and takes out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the fluorescence speckle of same color.
(5) get this product content 5g, add methanol 25ml, reflux 1 hour is put cold, filter, filtrate evaporate to dryness to the water-bath, residue adds water 15ml, and heating makes dissolving, put cold, with ether extraction 3 times, each 15ml, merge ether solution, extract 3 times, each 15ml with 2% sodium carbonate liquor, divide and get alkali liquor, add benzene 15ml and extract, discard benzene liquid, add hydrochloric acid and regulate pH value, add diethyl ether again and extract 3 times, each 15ml to 2-3; Combined ether liquid volatilizes, and residue adds methanol 1ml makes dissolving, as need testing solution.Other gets the ferulic acid reference substance, adds methanol and makes the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with benzene-glacial acetic acid-methanol (30: 1: 3) is developing solvent, launch, take out, dry, spray develops the color with 1% liquor ferri trichloridi-2% potassium ferricyanide solution (1: 1).In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
Check: should meet every regulation relevant under the capsule item (appendix IL of Chinese Pharmacopoeia version in 2000).
Assay
Measure according to high performance liquid chromatography (appendix VID of Chinese Pharmacopoeia version in 2000).
Chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica, and methanol-water (28: 72) is a mobile phase, and the detection wavelength is 230nm, and number of theoretical plate calculates by the peoniflorin peak should be not less than 1000.
The preparation precision of reference substance solution takes by weighing the peoniflorin reference substance 15mg that is dried to constant weight through phosphorus pentoxide, put in the 100ml measuring bottle, add dissolve with methanol, and be diluted to scale, and shaking up, precision is measured 10ml, put in the 50ml measuring bottle, add 10% methanol and be diluted to scale, shake up, promptly get (containing peoniflorin 30 μ g among every 1ml).
The content under the content uniformity item is got in the preparation of need testing solution, and porphyrize takes by weighing about 1g, and accurate the title decides, put in the 50ml measuring bottle, add methanol 40ml, supersound process 30 minutes is taken out, put and be chilled to room temperature, add methanol and be diluted to scale, shake up, filter, discard filtrate just, precision is measured subsequent filtrate 25ml, puts in the evaporating dish water bath method, residue adds water 5ml, puts in the water-bath heating 3 minutes, puts coldly, moves in the 10ml measuring bottle, thin up shakes up to scale, filters, and filtrate is as need testing solution.
Accurate reference substance solution and each the 10 μ l of need testing solution of drawing of algoscopy inject chromatograph of liquid respectively, measure, and calculate, promptly.
Every of this product contains the Radix Paeoniae Alba by peoniflorin (C
23H
28O
11) calculate, must not be less than 0.30mg.
This product has liver and kidney tonifying, expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, bone and muscle strengthening, reducing swelling and alleviating pain effect, is applicable to that mainly the treatment differential diagnosis in tcm belongs to the osteoarthritis and the rheumatoid arthritis of cold-damp resistance network, Liver and kidney two deficiency syndrome time.
Usage and dosage: oral, a 4-5 grain, 3 times on the one.
The present embodiment product, through clinical trial, the adult every day 3 times, serve on for 4 weeks by each oral 2.0 grams, treatment osteoarthritis cold-damp resistance network/Liver and kidney two deficiency syndrome patients 106 examples, clinical cure person 22 examples (20.75%) wherein, produce effects person's 47 examples (44.34%), responder's 30 examples (28.30%), invalid 7 examples (6.60%), total effective rate 93.40%.Treatment rheumatoid arthritis cold-damp resistance network/Liver and kidney two deficiency syndrome 100 examples, clinical cure 24 examples (24.00%) wherein, produce effects 40 examples (40.00%), effective 29 examples (29.00%), invalid 7 examples (7.00%), total effective rate 93.00%.
Through the clinical observation than system, obvious adverse reaction do not occur in the test, the clinical practice safety is good.
Embodiment 2
(1) of prescription and preparation method-(5) step is with embodiment 1; (6) granulate, drying with 8% hydroxypropyl cellulose (stomach dissolution type), 70% ethanol liquid bag film-coat, is made granule 1000g, pack (every bag of 10g).
Embodiment 3
(1) of prescription and preparation method-(5) step is with embodiment 1; (6) add dextrin again, starch is an amount of, mixing is granulated, tabletting with 8% hydroxypropyl cellulose (stomach dissolution type), 70% ethanol liquid bag film-coat, is made 1000, gets product.
Claims (5)
1, a kind of Shujin dehumidifying Chinese medicine preparation is characterized in that, makes the raw materials of effective components medicine and consists of: Herba Taxilli 18g-150g, Radix Angelicae Pubescentis 18g-150g, Hippocampus 12g-100g, Fructus Lycii 12g-100g, Radix Ginseng 12g-100g, Radix Paeoniae Alba 12g-100g, Radix Gentianae Macrophyllae 12g-100g, Cortex Periplocae 12g-100g, Radix Dipsaci 12g-100g, Rhizoma Cibotii 12-100g, Radix Achyranthis Bidentatae 12-100g, Fructus Chaenomelis 12g-100g, Rhizoma Homalomenae 12g-100g, Poria 12-100g, Radix Angelicae Sinensis 12g-100g, Cortex Magnoliae Officinalis 12-100g, Cortex Cinnamomi 12g-100g, Fructus Foeniculi 12g-100g, Rhizoma Chuanxiong 12-100g, Flos Chrysanthemi 6g-50g; Radix Glycyrrhizae 6g-50g.
2, Shujin dehumidifying Chinese medicine preparation according to claim 1 is characterized in that, is made by the crude drug of following weight: Herba Taxilli 65g-80g, Radix Angelicae Pubescentis 65g-80g, Hippocampus 40g-55g, Fructus Lycii 40g-55g, Radix Ginseng 40g-55g, Radix Paeoniae Alba 40g-55g, Radix Gentianae Macrophyllae 40g-55g, Cortex Periplocae 40g-55g, Radix Dipsaci 40g-55g, Rhizoma Cibotii 40-55g, Radix Achyranthis Bidentatae 40-55g, Fructus Chaenomelis 40g-55g, Rhizoma Homalomenae 40g-55g, Poria 40g-55g, Radix Angelicae Sinensis 40g-55g, Cortex Magnoliae Officinalis 40g-55g, Cortex Cinnamomi 40g-55g, Fructus Foeniculi 40g-55g, Rhizoma Chuanxiong 40g-55g, Flos Chrysanthemi 20g-28g, Radix Glycyrrhizae 20g-28g.
3, Shujin dehumidifying Chinese medicine preparation according to claim 2 is characterized in that, is made by the crude drug of following weight: Herba Taxilli 72g, Radix Angelicae Pubescentis 72g, Hippocampus 48g, Fructus Lycii 48g, Radix Ginseng 48g, Radix Paeoniae Alba 48g, Radix Gentianae Macrophyllae 48g, Cortex Periplocae 48g, Radix Dipsaci 48g, Rhizoma Cibotii 48g, Radix Achyranthis Bidentatae 48g, Fructus Chaenomelis 48g, Rhizoma Homalomenae 48g, Poria 48g, Radix Angelicae Sinensis 48g, Cortex Magnoliae Officinalis 48g, Cortex Cinnamomi 48g, Fructus Foeniculi 48g, Rhizoma Chuanxiong 48g, Flos Chrysanthemi 24g, Radix Glycyrrhizae 24g.
4, according to the preparation method of claim 1 or 2 or 3 described Shujins dehumidifying Chinese medicine preparation, it is characterized in that, may further comprise the steps: (1) is with described Radix Angelicae Pubescentis, Cortex Periplocae, Rhizoma Homalomenae, Cortex Magnoliae Officinalis, Fructus Foeniculi, each 65%-75% of Cortex Cinnamomi (weight), described Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Dipsaci, each 45%-55% of Flos Chrysanthemi (weight), mix, be ground into fine powder, standby; (2) described Hippocampus is ground into fine powder, standby; (3) described Herba Taxilli, Radix Ginseng, Radix Gentianae Marcrophyllae are used 65%-75% (volume) ethanol water reflux, extract, secondary, for the first time add 6-10 and doubly measure, extracted 2-3 hour, add 4-8 for the second time and doubly measure, extracted 1.5-2.5 hour, merge extractive liquid, filters, behind the filtrate recycling ethanol, be concentrated into the clear paste that relative density is 1.15-1.18, or drying under reduced pressure, or spray drying, standby; (4) (3) step gained medicinal residues are mixed with its remaining Radix Angelicae Pubescentis, Cortex Periplocae, Rhizoma Homalomenae, Cortex Magnoliae Officinalis, Fructus Foeniculi, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Dipsaci, Flos Chrysanthemi and described Fructus Lycii, the Radix Paeoniae Alba, Rhizoma Cibotii, Radix Achyranthis Bidentatae, Cortex Magnoliae Officinalis, Poria, Radix Glycyrrhizae, decoct with water twice, add for the first time 5-7 times of water gaging, decocted 1.5-2.5 hour, add for the second time 3-5 times of water gaging, decocted 1-2 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.15-1.18, or drying under reduced pressure, or spray drying, standby; (5) (3) step gained alcohol extract and (4) step gained water extract are merged, add (2) step gained Hippocampus fine powder, mixing, drying is pulverized, and sieves, add (1) step gained fine powder again, mixing promptly gets the active active ingredient raw materials medicine of product of the present invention.
5, the preparation method of Shujin dehumidifying Chinese medicine preparation according to claim 4, it is characterized in that, with described Radix Angelicae Pubescentis, Cortex Periplocae, Rhizoma Homalomenae, Cortex Magnoliae Officinalis, Fructus Foeniculi, each 70% (weight) of Cortex Cinnamomi, with described Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Dipsaci, each 50% (weight) of Flos Chrysanthemi, mix, be ground into fine powder; Described Herba Taxilli, Radix Ginseng, Radix Gentianae Marcrophyllae with 70% (volume) ethanol water reflux, extract, secondary, are added 8 times of amounts for the first time, extracted 2.5 hours, add 6 times of amounts for the second time, extracted 2 hours; With described (3) step gained medicinal residues Radix Angelicae Pubescentis remaining, Cortex Periplocae, Rhizoma Homalomenae, Cortex Magnoliae Officinalis, Fructus Foeniculi, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Dipsaci, Flos Chrysanthemi and described Fructus Lycii, the Radix Paeoniae Alba, Rhizoma Cibotii, Radix Achyranthis Bidentatae, Cortex Magnoliae Officinalis, Poria, Radix Glycyrrhizae with it, mix, add for the first time 6 times of water gagings, decocted 2 hours, for the second time add 4 times of water gagings, decocted 1.5 hours.
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| CN103006946B (en) * | 2012-12-26 | 2014-02-19 | 湖南敬和堂制药有限公司 | Chinese medicinal composition for treating osteoarthritis and rheumatoid arthritis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1121830A (en) * | 1994-07-09 | 1996-05-08 | 刘润保 | Chinese medicine powder capsule for eliminating numbness and preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121830A (en) * | 1994-07-09 | 1996-05-08 | 刘润保 | Chinese medicine powder capsule for eliminating numbness and preparing method thereof |
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