CN1305007A - Pistol type gas gene gun - Google Patents
Pistol type gas gene gun Download PDFInfo
- Publication number
- CN1305007A CN1305007A CN01105513A CN01105513A CN1305007A CN 1305007 A CN1305007 A CN 1305007A CN 01105513 A CN01105513 A CN 01105513A CN 01105513 A CN01105513 A CN 01105513A CN 1305007 A CN1305007 A CN 1305007A
- Authority
- CN
- China
- Prior art keywords
- magazine
- air inlet
- gene gun
- seat
- type gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 23
- 230000003139 buffering effect Effects 0.000 claims abstract description 4
- 239000011148 porous material Substances 0.000 claims description 16
- 230000008676 import Effects 0.000 claims description 4
- 230000014759 maintenance of location Effects 0.000 claims description 3
- 239000002245 particle Substances 0.000 abstract description 10
- 238000006243 chemical reaction Methods 0.000 abstract description 4
- 239000004579 marble Substances 0.000 abstract 1
- 239000003721 gunpowder Substances 0.000 description 3
- 238000009527 percussion Methods 0.000 description 3
- 239000002028 Biomass Substances 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000002220 organoid Anatomy 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Images
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Aiming, Guidance, Guns With A Light Source, Armor, Camouflage, And Targets (AREA)
Abstract
The utility model provides a gas gene rifle of pistol formula, be provided with air inlet plate (4), magazine seat (6), air outlet plate (9) and launching tube (10) forward from the back in the rifle body (1), be provided with a plurality of magazine holes with the circumference arrangement mode on magazine seat (6), each magazine hole has one end at least and the air hole periphery of air inlet plate (4) or air outlet plate (9) that correspond to cooperate with unsmooth cambered surface form after loading magazine (7), be provided with a locking pull rod (5) and a location marble (8) on air inlet plate (4), air outlet plate (9) respectively, cooperate with the both sides of magazine seat (6) respectively. The magazine base (6) of the invention has stable positioning and convenient magazine conversion operation, and simultaneously, the buffering gas storage bin (2) arranged between the compressed gas inlet pipe (12) and the gas valve (3) is combined, so that the transmitted DNA particles have stable and higher initial speed.
Description
The present invention relates to a kind of instrument of in bio-genetics, genetic material or other materials being injected cell, tissue or organoid, particularly a kind of pistol type gas gene gun.
In the bio-genetics field, particle gun is a kind of requisite instrument, initial particle gun is to adopt the gunpowder bullet to bombard, it as the patent No. 89109334 the disclosed particle gun of Chinese invention patent application " a kind of method of metastatic gene and the particle gun of metastatic gene thereof ", it utilizes " speed and the method for the proportion speed ground control bombardment of gunpowder; also can operate under the closed state He under the non-closed state with task equipment; both can bombard also and can bombard the importing that realizes foreign gene to the substance biomass cells the biomass cells that exsomatizes, thereby change biological proterties." this genoid rifle can damage to some extent to the target sample; the impurity in the gunpowder also can be injected in the sample simultaneously; its precision often is difficult to control; thereby gas percussion ripple that pressurized gas converts to the particle gun as propulsion source had appearred again utilizing afterwards; and as U.S. Pat 5865796; disclosed among the US5584807 is exactly a kind of pistol type particle gun, their scheme has included handle, the pressurized gas inlet suction port, air valve, gun barrel, magazine seat and interior magazine and set ring thereof, inlet suction port is positioned at handle bottom and is connected with the air valve that is fixed on handle top through the gas passage of handle, the air outlet of air valve is connected with gas passage in the gun barrel at the tail end of gun barrel, magazine seat and interior magazine thereof are arranged on the tail position of gun barrel, set ring is connected the muzzle of gun barrel, with so that muzzle and target maintain a certain distance, during use, inlet suction port is connected high-pressure air source, when pressure is enough, open air valve, pressurized gas enters gun barrel rapidly and forms a gas percussion ripple, and the DNA particulate that is arranged in the magazine is entered target from the muzzle ejaculation; In this design, magazine seat wherein is the runner shape of revolver, be provided with a plurality of magazine holes that hold magazine in the circumferential arrangement mode, its periphery wall of magazine seat is provided with and magazine hole corresponding positioning hole, pistol then is provided with a steady brace in the position of correspondence, both cooperatively interact make magazine seat location and make one of them magazine hole and gun barrel to directly, after shooting away a DNA particulate, make the magazine seat break away from steady brace with hand earlier, then it is rotated an angle to next magazine hole and gun barrel to directly, pilot hole on the corresponding magazine seat matched with steady brace and locate once more.Its shortcoming is, the magazine seat only depends on the steady brace location, stable inadequately, like this when a plurality of magazines are laid in simultaneously in the magazine seat, the vibrations that previous fire is brought can influence as yet the not homogeneity of the DNA particulate of emission, therefore serious meeting is polluted the DNA particulate, simultaneously, the operation of conversion magazine is also convenient inadequately, the pressurized gas that is used for launching the DNA particulate is on the other hand directly imported by compressed gas source, do not pass through the gas storage stable-pressure device,, but also can influence the initial velocity of launching the DNA particulate so not only because of the gas circuit pressure-losses influences stable gas pressure.
Purpose of the present invention provides a kind of magazine seat positioning stablity, magazine conversion operations pistol type gas gene gun easily with regard to being at above-mentioned prior art present situation.
Another object of the present invention is to provide a kind of DNA particulate of launching to have the pistol type gas gene gun of stable initial velocity.
The object of the present invention is achieved like this: the pistol type gas gene gun includes the rifle body, the pressurized gas inlet pipe penetrates to be connected to from the small of the stock of rifle body and is positioned at the intravital air valve of rifle, it is characterized in that in the rifle body, also being provided with from back to front air inlet disk, the magazine seat, give vent to anger and coil and transmitting tube, air valve is connected with the pore of air inlet disk, be provided with a plurality of magazine holes that hold magazine in the circumferential arrangement mode on the magazine seat, the front and back end in magazine hole respectively with the pore of transmitting tube, the pore of air inlet disk offsets and to directly, and each magazine hole has at least behind the magazine end to match with concavo-convex cambered surface form with corresponding pore periphery in filling, air inlet disk, giving vent to anger to coil is respectively arranged with a locking pull bar and a location hoodle, matches with a side central blind hole of magazine seat and the center pit of opposite side respectively.
The aperture, magazine hole of the air vent aperture of described air inlet disk and magazine seat is good with equal pore import apertures greater than transmitting tube.
Described pressurized gas inlet pipe is to have certain volumetrical buffering gas storage storehouse and communicate to good with air valve by one.
Compared with prior art; magazine seat of the present invention is stablized spacing because of having at least three locating points; and when conversion magazine hole, only need the angle that it rotation is suitable get final product; safe in utilization, stable; easy to operate; because the aperture, magazine hole of the air vent aperture of air inlet disk and magazine seat is all greater than the pore import aperture of transmitting tube; therefore under the much compression gas condition, can make the DNA particulate obtain higher initial velocity; and the setting in gas storage storehouse makes the stable gas pressure of air inlet disk, therefore also makes the DNA particulate of being launched have stable initial velocity.In addition, the present invention is a pistol-like, therefore not only can be used for gene studies, can also be directly used in the human body gene treatment as treatment tool.
Description of drawings.
Fig. 1 is the structure cross-sectional schematic of the embodiment of the invention.
Fig. 2 is the A-A sectional view of Fig. 1.
Fig. 3 is the A-A sectional view when taking out magazine seat 6.
Fig. 4 is the partial enlarged drawing after the particle gun among Fig. 1 applies DNA particulate 71.
Partial enlarged drawing when Fig. 5 is a particle gun emission DNA particulate 71 among Fig. 1.
Embodiment describes in further detail the present invention below in conjunction with accompanying drawing.
As shown in Figure 1 and Figure 2, the pistol type particle gun include rifle body 1 and be positioned at its air inlet disk 4, magazine seat 6, give vent to anger the dish 9, transmitting tube 10, pressurized gas inlet pipe 12 penetrates from the small of the stock of rifle body through being positioned at the intravital buffering gas storage of rifle storehouse 2 and is connected with air valve 3, air valve 3 is selected magnetic valve for use in the present embodiment, and its emission control trigger 11 is installed on the small of the stock;
Be provided with the set ring 62 of a cross section semicircular in shape under the magazine seat 6, the peristome of set ring 62 is provided with a flexure strip 61, the one side bends and by the side of screw retention at set ring 62, magazine seat 6 promptly is shelved on this set ring 62, as Fig. 2, shown in Figure 3;
Be provided with six magazine holes that can hold magazine 7 in the circumferential arrangement mode on the magazine seat 6, the front and back end in magazine hole offsets with the pore of the pore of transmitting tube 10, air inlet disk 4 respectively and to directly, and wherein the aperture, magazine hole of the air vent aperture of air inlet disk 4 and magazine seat 6 is good with equal pore import apertures greater than transmitting tube 10; Magazine 7 in the front end of magazine seat is filled in the magazine hole, the front end indent of magazine 7, the pore periphery of transmitting tube 10 then has corresponding evagination, both make concavo-convex cambered surface form and cooperate; The center, front side of magazine seat 6 is provided with pit, and is arranged on the hoodle 8 of dish on 9 of giving vent to anger and matches; The back center of magazine seat 6 has a blind hole, and L type locking pull bar 5 passes air inlet disk 4 and penetrates this blind hole, as the rotation fulcrum of magazine seat 6;
For make locking pull bar 5 in use not reason vibration come off, can be provided with an extension spring 51 at the free end of locking pull bar 5, the other end of extension spring 51 is fixed on the air inlet disk 4, as shown in Figure 1.According to above-mentioned, magazine seat 6 has at least three locating points, therefore is stabilized spacing.
During use, at first take off magazine seat 6: will lock pull bar 5 and pull out magazine seat 6, magazine seat 6 promptly can eject the rifle body automatically under the restoring force effect of flexure strip 61, referring to Fig. 3; The magazine 7 that then will be coated with DNA particulate 71 is packed in the magazine hole of magazine seat 6, again magazine seat 6 is pressed in people's rifle body and with locking pull bar 5 and lock, referring to Fig. 4, at last high-pressure gas pipeline and inlet pipe 12 joints are joined, (when being generally 2.5～5MPa), cocking, open air valve 3, the gas percussion ripple will carry DNA particulate 71 and inject in sample or the living specimen by transmitting tube 10 this moment when air pressure reaches applying pressure, finish a gene and lead the people, referring to Fig. 5; After a DNA particulate shoots away, only need to rotate magazine seat 6 six ten degree, the pore that can make its next magazine hole and interior magazine 7 and the air inlet disk 4 and the dish 9 of giving vent to anger is ready to launch to directly next time.After six magazine seats 6 all use by turns, take off magazine seat 6 once more, repeat aforesaid operations, can carry out next round work.
Claims (9)
1. pistol type gas gene gun, include the rifle body, the pressurized gas inlet pipe penetrates to be connected to from the small of the stock of rifle body and is positioned at the intravital air valve of rifle, it is characterized in that in the rifle body, also being provided with from back to front air inlet disk, the magazine seat, give vent to anger and coil and transmitting tube, air valve is connected with the pore of air inlet disk, be provided with a plurality of magazine holes that hold magazine in the circumferential arrangement mode on the magazine seat, the front and back end in magazine hole respectively with the pore of transmitting tube, the pore of air inlet disk offsets and to directly, and each magazine hole has at least behind the magazine end to match with concavo-convex cambered surface form with corresponding pore periphery in filling, air inlet disk, giving vent to anger to coil is respectively arranged with a locking pull bar and a location hoodle, matches with a side central blind hole of magazine seat and the center pit of opposite side respectively.
2. pistol type gas gene gun as claimed in claim 1, the aperture, magazine hole that it is characterized in that the air vent aperture of described air inlet disk and magazine seat are all greater than the pore import aperture of transmitting tube.
3. pistol type gas gene gun as claimed in claim 1 or 2 is characterized in that described pressurized gas inlet pipe has certain volumetrical buffering gas storage storehouse by one and communicates with air valve.
4. pistol type gas gene gun as claimed in claim 1 or 2, it is characterized in that under described magazine seat, being provided with the set ring of a cross section semicircular in shape, the peristome of set ring is provided with a flexure strip, the one side bends and by the side of screw retention at set ring, the magazine seat promptly is shelved on this set ring.
5. pistol type gas gene gun as claimed in claim 3, it is characterized in that under described magazine seat, being provided with the set ring of a cross section semicircular in shape, the peristome of set ring is provided with a flexure strip, the one side bends and by the side of screw retention at set ring, the magazine seat promptly is shelved on this set ring.
6. pistol type gas gene gun as claimed in claim 1 or 2 is characterized in that locking pull bar and is the L type, and its free end is provided with an extension spring, and the other end of extension spring is fixed on air inlet disk or gives vent to anger and coils.
7. pistol type gas gene gun as claimed in claim 3 is characterized in that locking pull bar and is the L type, and its free end is provided with an extension spring, and the other end of extension spring is fixed on air inlet disk or gives vent to anger and coils.
8. pistol type gas gene gun as claimed in claim 4 is characterized in that locking pull bar and is the L type, and its free end is provided with an extension spring, and the other end of extension spring is fixed on air inlet disk or gives vent to anger and coils.
9. pistol type gas gene gun as claimed in claim 5 is characterized in that locking pull bar and is the L type, and its free end is provided with an extension spring, and the other end of extension spring is fixed on air inlet disk or gives vent to anger and coils.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011055138A CN1156578C (en) | 2001-02-27 | 2001-02-27 | Pistol type gas gene gun |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011055138A CN1156578C (en) | 2001-02-27 | 2001-02-27 | Pistol type gas gene gun |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1305007A true CN1305007A (en) | 2001-07-25 |
| CN1156578C CN1156578C (en) | 2004-07-07 |
Family
ID=4654591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011055138A Expired - Fee Related CN1156578C (en) | 2001-02-27 | 2001-02-27 | Pistol type gas gene gun |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1156578C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008031257A1 (en) * | 2006-08-22 | 2008-03-20 | Hai-Lung Huang | A percussion-controlling device of gene gun |
| CN100446823C (en) * | 2006-09-19 | 2008-12-31 | 宁波新芝生物科技股份有限公司 | A non-traumatic interfere treatment system |
| CN102250757A (en) * | 2011-07-20 | 2011-11-23 | 宁波新芝生物科技股份有限公司 | Particle gun |
| CN107648029A (en) * | 2017-10-12 | 2018-02-02 | 深圳市优力威医疗科技有限公司 | A kind of Pneumatic Lithotripsy formula shock wave treatment instrument with impact head buffer structure |
-
2001
- 2001-02-27 CN CNB011055138A patent/CN1156578C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008031257A1 (en) * | 2006-08-22 | 2008-03-20 | Hai-Lung Huang | A percussion-controlling device of gene gun |
| CN100446823C (en) * | 2006-09-19 | 2008-12-31 | 宁波新芝生物科技股份有限公司 | A non-traumatic interfere treatment system |
| CN102250757A (en) * | 2011-07-20 | 2011-11-23 | 宁波新芝生物科技股份有限公司 | Particle gun |
| CN102250757B (en) * | 2011-07-20 | 2013-01-09 | 宁波新芝生物科技股份有限公司 | Gene gun |
| CN107648029A (en) * | 2017-10-12 | 2018-02-02 | 深圳市优力威医疗科技有限公司 | A kind of Pneumatic Lithotripsy formula shock wave treatment instrument with impact head buffer structure |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1156578C (en) | 2004-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: NINGBO SCIENTZ BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: ZHOU FANG Effective date: 20140128 |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 315010 NINGBO, ZHEJIANG PROVINCE TO: 315000 NINGBO, ZHEJIANG PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20140128 Address after: 315000 Zhejiang Province, Ningbo national hi tech Zone Hibiscus Road No. 65 Patentee after: Ningbo Scientz Biotechnology Co., Ltd. Address before: Study on Ningbo scientz watey 315010 Zhejiang Province, Ningbo City Road No. 9 striker Patentee before: Zhou Fang |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040707 Termination date: 20150227 |
|
| EXPY | Termination of patent right or utility model |