CN1301744C - Formula for Weitaihe (stomach medicine) and preparation process thereof - Google Patents
Formula for Weitaihe (stomach medicine) and preparation process thereof Download PDFInfo
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- CN1301744C CN1301744C CNB031145396A CN03114539A CN1301744C CN 1301744 C CN1301744 C CN 1301744C CN B031145396 A CNB031145396 A CN B031145396A CN 03114539 A CN03114539 A CN 03114539A CN 1301744 C CN1301744 C CN 1301744C
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- Prior art keywords
- radix
- fructus
- medicine
- gastritis
- parched
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000003814 drug Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 210000002784 stomach Anatomy 0.000 title abstract description 10
- 208000007882 Gastritis Diseases 0.000 claims abstract description 15
- 208000004300 Atrophic Gastritis Diseases 0.000 claims abstract description 9
- 208000036495 Gastritis atrophic Diseases 0.000 claims abstract description 9
- 208000016644 chronic atrophic gastritis Diseases 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims abstract description 9
- 208000007107 Stomach Ulcer Diseases 0.000 claims abstract description 7
- 208000023652 chronic gastritis Diseases 0.000 claims abstract description 7
- 201000005917 gastric ulcer Diseases 0.000 claims abstract description 7
- 230000001154 acute effect Effects 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 5
- 241000756943 Codonopsis Species 0.000 claims description 4
- 241000218176 Corydalis Species 0.000 claims description 4
- 239000009636 Huang Qi Substances 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 239000010271 massa medicata fermentata Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 235000021419 vinegar Nutrition 0.000 claims description 4
- 239000000052 vinegar Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 239000010135 fructus aurantii immaturus Substances 0.000 claims description 2
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 1
- 208000012895 Gastric disease Diseases 0.000 abstract description 5
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 208000018556 stomach disease Diseases 0.000 abstract description 5
- 241000282414 Homo sapiens Species 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 230000006870 function Effects 0.000 abstract description 3
- 238000011160 research Methods 0.000 abstract description 3
- 208000017667 Chronic Disease Diseases 0.000 abstract 1
- 208000027219 Deficiency disease Diseases 0.000 abstract 1
- 230000036541 health Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 230000036285 pathological change Effects 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 abstract 1
- 210000001835 viscera Anatomy 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 9
- 241000721047 Danaus plexippus Species 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 230000002496 gastric effect Effects 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 229940069428 antacid Drugs 0.000 description 2
- 239000003159 antacid agent Substances 0.000 description 2
- 230000001458 anti-acid effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 229960000905 indomethacin Drugs 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 241001269238 Data Species 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000013455 disruptive technology Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A spleen and a stomach are sources of life and has an important basic function for health. Gastropathy is a common disease as well as a frequently occurring disease, and is one of chronic diseases which obsess human beings for long. If the gastropathy is not treated in time, other viscera diseases can be caused and malignant pathologic change of the stomach can also be easily caused. Medicine which has unique therapeutic functions for acute gastritis, chronic gastritis, gastric ulcer and particularly atrophic gastritis, namely deficiency diseases called by Chinese medicine can be obtained by the formula and the preparation process of Jiao's Weitaihe of the present invention. Proved by scientific research and clinical application, the medicine has the advantages of exact therapeutic effects, safety and reliability.
Description
The present invention relates to a kind ofly form by natural Chinese medicine, to acute or chronic gastritis, gastric ulcer, particularly be the medicine that atrophic gastritis has unique therapeutical effect to the alleged stuffy sensation of deftciency type disease of the traditional Chinese medical science, the prescription and the processing technology of Jiao ' s Weitaihe stomach calm and peaceful (calm and peaceful) hereinafter to be referred as stomach.
Chinese former vast, the human quality is widely different, the southern natural environmental condition in north is different, focuses in elucidating " interior warp " as classical Chinese medicine works " element is asked ", thinks during about the viewpoint of human daily life diet and etiology and pathogenesis, because geographical conditions difference, living habit different " five sides' the people " has " beautiful its food " person, and " China eats and fertile fat " person is arranged, and " happy breast food " person is arranged, " having a liking for acid " person is arranged, " eating sundry foods and getting few manual labor " person etc. is arranged.And think " territory in south, it is underground, a little less than the water and soil, has the people to have a liking for acid ", " territory in the north, its ground height is lived on the highland, and wind and cold ice is ice-cold. the wild place of its folk music breast food ".This shows that five sides' the people all " give birth to the relative superiority or inferiority of ground, mountains and rivers soil with works of god.Place, basic necessities of life residence is respectively from its desire." the geographical environment transition of a national residential area, historical origin and cultural tradition have close influence to people's dietary structure.Therefore, the gastropathy reason also is not quite similar.
The prior art solution to the problems described above is more, but less long-term system keeps track research, and because herb resource geographical distribution difference, prescription and technology are different, add reasons such as human quality's difference and adaptability, clinical in the still difficult needs that satisfy the patient.Particularly treat the prior art scheme of atrophic gastritis, fail to solve preferably always, gastropathy changes each stage in the evolution, uses the contradiction and the unification of medicine.In order to change the shortcoming that prior art exists, the technical solution used in the present invention is compared with the prior art, go up except the combination principle of paying attention to monarch from filling a prescription, screening, test by science, determined best formula technique scheme, formulated each medicine optimal dose, the notion of used monarch, secondary monarch, minister first in compatibility, helping, make has been found the dose relationship rule of monarch drug, secondary monarch drug.Used the secondary monarch drug that gastric acid is had dual regulation, thereby having solved always insurmountable gastritis needs antacid, atrophic gastritis to need the disruptive technology scheme of antacid, simultaneously, the preparation technology that the present invention adopts, a large amount of experimental datas of foundation have determined to use the best-of-breed technology scheme of the classification of drug of Different Preparation.Kept pharmaceutically active effectively, extract the effective ingredient of medicine to greatest extent, the proportional relation that forms according to the size of the length of the course of treatment and dosage, solved the prescription contradiction that exists in each stage therapeutic scheme of gastropathy, make it to obtain synergism and unification in the present invention, thereby the cure rate of gastrotherapy is significantly improved.
Prescription of the present invention is made up of two parts:
Universe side:
60～80 perfume (or spice) 40～60 of Fructus Amomi 36～66 Fructus Amomi Rotunduss, 36～66 Rhizoma Cyperis
Fructus Aurantii Immaturus 60～80 Radix Bupleuri 60～80
Technology: get the original producton location medical material, by season, adopt a word used in person's names by medicinal part, drying by traditional concocting method, is made mix homogeneously behind the decoction pieces in advance, pulverizes, and sieves, and the fine powder after sieving device is in addition collected; Coarse powder decocts with water twice, adds 12 times of water gagings at every turn and decocts 1 hour, and collecting decoction, filtration, filtrate are condensed into relative density 1.15 (60 degrees centigrade time survey) clear paste, and device is collected in addition;
Female side:
The Radix Astragali 120～180 Radix Codonopsis 60～90 Rhizoma Corydalis (vinegar system) 80～95
Massa Medicata Fermentata (stir-fry) 80～95 Fructus Hordei Germinatus (stir-fry) 80～95
Fructus Crataegi (stir-fry) 80～95 Radix Paeoniae Albas 60～80 Rhizoma Atractylodis Macrocephalaes 60～80
Semen Raphani 60～80
Technology: get the original producton location medical material, by season, adopt a word used in person's names by the position, drying, by traditional concocting method, make mix homogeneously behind the decoction pieces, add 12 times of water gagings and decoct three times, 1.5 hours for the first time, it respectively is 1 hour for the second time and for the third time, collecting decoction, filtration, filtrate are condensed into clear paste and the above-mentioned fine powder and the clear paste mixing of relative density 1.15 (60 degrees centigrade time survey), and granulation, drying are by a certain amount of splendid attire or make solids and get final product.
Medicine content of the present invention is the granule of yellowish-brown, feeble QI, mildly bitter flavor.The used primary crude drug of the present invention all should conform to the listed standard of state-promulgated pharmacopoeia latest edition.
The present invention also can further illustrate by following example:
Universe side:
Fructus Amomi 36 Fructus Amomi Rotunduss 36 Rhizoma Cyperis 60
The Radix Aucklandiae 40 Fructus Aurantii Immaturuss 60 Radix Bupleuri 60
Female side:
The Radix Astragali 120 Radix Codonopsis 60 Rhizoma Corydalis (vinegar system) 80
Massa Medicata Fermentata (stir-fry) 80 Fructus Hordei Germinatus (stir-fry) 80 Fructus Crataegis (stir-fry) 80
The Radix Paeoniae Alba 60 Rhizoma Atractylodis Macrocephalaes 60 Semen Raphanis 60
Press universe side's technology respectively, be collected in after female side's technology is produced in the same container behind the mix homogeneously, granulate, drying is by a certain amount of splendid attire or become solid content promptly.
The medicine that obtains by calm and peaceful prescription of stomach of the present invention and technology, specify clinical researches such as The Fourth Military Medical University, The People's Hospital, the Shaanxi Province academy of traditional Chinese medicine, Xi'an Jiaotong University Medical College to use proof through responsible departments of the government, the present invention is to acute or chronic gastritis, gastric ulcer, be that atrophic gastritis has unique treatment and preventive effect to the alleged stuffy sensation of deftciency type disease of the traditional Chinese medical science particularly, safety has no side effect.
The present invention is to alcohol-induced mice gastric injury; The rat stomach injury of indometacin and alcohol-induced; The rat stomach injury that pylorus ligation brings out reaches aspects such as gastric juice pH value, total acidity, gastric activity, analgesia, antiinflammatory and gastrointestinal peristalsis functions, observe proof through The Fourth Military Medical University's pharmacodynamic experiment, the calm and peaceful 3000mg/Kg of stomach, 1500mg/Kg can resist the proinflammatory effect of dimethylbenzene effectively, significantly alleviate mice that ethanol, indometacin, pylorus ligation brings out and the acute gastric injury degree of rat; Can significantly reduce total acidity, the raising pepsin activity of gastric juice, and have remarkable analgesia and antiinflammatory action.The calm and peaceful protective effect to above-mentioned gastric injury model of stomach presents dose-effect relationship preferably.
Claims (3)
1, a kind of medicine for the treatment of acute or chronic gastritis, gastric ulcer, atrophic gastritis is characterized in that it is made by following raw materials by weight proportions:
A. Fructus Amomi 36～66 Fructus Amomi Rotunduss 36～66 Rhizoma Cyperis 60～80 Radix Aucklandiae 40～60
Fructus Aurantii Immaturus 60～80 Radix Bupleuri 60～80;
B. the Radix Astragali 120～180 Radix Codonopsis 60～90 Rhizoma Corydalis (processed with vinegar) 80～95
Fry Massa Medicata Fermentata 80～95 Fructus Hordei Germinatus (parched)s 80～95
Fructus Crataegi (parched) 80～95 Radix Paeoniae Albas 60～80 Rhizoma Atractylodis Macrocephalaes 60～80
Semen Raphani 60～80.
2, the medicine of treatment acute or chronic gastritis according to claim 1, gastric ulcer, atrophic gastritis, wherein the weight proportion of each crude drug is:
A. Fructus Amomi 36 Fructus Amomi Rotunduss 36 Rhizoma Cyperis 60 Radix Aucklandiae 40 Fructus Aurantii Immaturuss 60 Radix Bupleuri 60;
C. the Radix Astragali 120 Radix Codonopsis 60 Rhizoma Corydalis (processed with vinegar) 80
Fry Massa Medicata Fermentata 80 Fructus Hordei Germinatus (parched)s 80 Fructus Crataegi (parched) 80
The Radix Paeoniae Alba 60 Rhizoma Atractylodis Macrocephalaes 60 Semen Raphanis 60.
3, the preparation method of the medicine of treatment acute or chronic gastritis according to claim 1, gastric ulcer, atrophic gastritis is characterized in that: sieve raw material medicated powder is broken among the A, fine powder device is in addition collected; Coarse powder decocts with water twice, adds 12 times of water gagings at every turn, decocts collecting decoction, the clear paste of relative density 1.15 when filtrate is condensed into 60 ℃ 1 hour; Crude drug among the B is added 12 times of water gagings at every turn decoct three times, 1.5 hours for the first time, for the second time with each one hour for the third time, synthetic decocting liquid, filtration, the clear paste of relative density 1.15 when filtrate is condensed into 60 ℃; With granulate behind above-mentioned fine powder and the two kinds of clear paste mix homogeneously, drying, splendid attire or make solid promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031145396A CN1301744C (en) | 2003-03-12 | 2003-03-12 | Formula for Weitaihe (stomach medicine) and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031145396A CN1301744C (en) | 2003-03-12 | 2003-03-12 | Formula for Weitaihe (stomach medicine) and preparation process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1483441A CN1483441A (en) | 2004-03-24 |
| CN1301744C true CN1301744C (en) | 2007-02-28 |
Family
ID=34152562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031145396A Expired - Lifetime CN1301744C (en) | 2003-03-12 | 2003-03-12 | Formula for Weitaihe (stomach medicine) and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1301744C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318064C (en) * | 2005-01-10 | 2007-05-30 | 孙喜灵 | Medicine for treating chronic atrophic gastritis and its preparation method |
| CN1315504C (en) * | 2005-11-08 | 2007-05-16 | 周卓和 | Extract for treating functional indigestion and its medicine composition |
| CN101204568B (en) * | 2006-12-20 | 2011-09-14 | 姜寅光 | Digestion-promoting preparation and preparation method thereof |
| CN103386073B (en) * | 2013-08-09 | 2014-12-17 | 汤华涛 | Traditional Chinese medicine for treating gastric ulcer |
| CN103623296A (en) * | 2013-12-03 | 2014-03-12 | 天津中新药业集团股份有限公司达仁堂制药厂 | Preparation method of extract of traditional Chinese medicine with functions of regulating qi, relieving pain, invigorating stomach and promoting digestion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098635A (en) * | 1993-08-10 | 1995-02-15 | 赵成启 | The medicine and the manufacture method of treatment gastropathy |
| CN1113798A (en) * | 1994-06-18 | 1995-12-27 | 臧明礼 | Chinese drug for curing gastropathy |
-
2003
- 2003-03-12 CN CNB031145396A patent/CN1301744C/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098635A (en) * | 1993-08-10 | 1995-02-15 | 赵成启 | The medicine and the manufacture method of treatment gastropathy |
| CN1113798A (en) * | 1994-06-18 | 1995-12-27 | 臧明礼 | Chinese drug for curing gastropathy |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1483441A (en) | 2004-03-24 |
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| C06 | Publication | ||
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| C10 | Entry into substantive examination | ||
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| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Jiao Gang Document name: Notification of registration procedures and notice of patent for invention |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Xi'an Tianyi Pharmaceutical Co.,Ltd. Assignor: Jiao Zhiyuan Contract fulfillment period: 2007.3.30 to 2012.4.27 Contract record no.: 2009610000023 Denomination of invention: Formula for Weitaihe (stomach medicine) and preparation process thereof Granted publication date: 20070228 License type: Exclusive license Record date: 20091123 |
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| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2007.3.30 TO 2012.4.27; CHANGE OF CONTRACT Name of requester: XI'AN TIANYI PHARMACEUTICAL CO.,LTD. Effective date: 20091123 |
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Effective date of registration: 20221010 Address after: 710000 Room 1411, Block B, Hi tech Ginza, No. 6, Gaoxin Road, Hi tech Zone, Xi'an, Shaanxi Patentee after: Shaanxi Jiaoshi Weitaihe Pharmaceutical Co.,Ltd. Address before: 710002, Shaanxi province Xi'an Lianhu District Liang Jia archway 28 Ruyi building, Shaanxi people's livelihood Institute of medical and health care Patentee before: Jiao Zhiyuan |
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Granted publication date: 20070228 |