CN1299653C - Bionic artificial joint capsule and its making method - Google Patents
Bionic artificial joint capsule and its making method Download PDFInfo
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- CN1299653C CN1299653C CNB2004100162638A CN200410016263A CN1299653C CN 1299653 C CN1299653 C CN 1299653C CN B2004100162638 A CNB2004100162638 A CN B2004100162638A CN 200410016263 A CN200410016263 A CN 200410016263A CN 1299653 C CN1299653 C CN 1299653C
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- Prior art keywords
- joint capsule
- nylon
- artificial joint
- chitosan
- medical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
Abstract
The present invention relates to a bionic artificial joint capsule and a making method thereof. The bionic artificial joint capsule of the present invention is a double-layer or three-layer or four-layer artificial joint capsule made of biologic medical nylon, biologic medical organosilicon and chitosan. The making method for the bionic artificial joint capsule comprises the following steps: firstly, fixing the biologic medical nylon onto the surface of a mould of the artificial joint capsule; then, uniformly coating the high-elasticity medical organosilicon on the surface of a nylon layer, heat-curing the organosilicon for 3-10 minutes at temperature of 140 DEG C to 180 DEG C, and carrying out stripping; coating the chitosan or derivant acetic acid solution thereof on the surface of a nylon / Silicone rubber double membrane, naturally airing the chitosan or the derivant acetic acid solution thereof, and hereby, the bionic artificial joint capsule with a chitosan / nylon / Silicone rubber multilayer structure is produced. The artificial joint capsule of the present invention can seal synovial fluid and wear particles in the artificial joint, which solves the storage problem of the synovial fluid, ensures the long-term lubrication effect of the synovial fluid, reduces the abrasion and can also prevent the foreign body reaction caused by that the wear particles leak to enter the human body due to artificial joint materials. Simultaneously, the artificial joint capsule of the present invention has the advantages of good biocompatibility, simple manufacturing process, low cost and excellent application prospect.
Description
Technical field
The present invention relates to a kind of biomimetic prosthetic joint capsule and preparation method thereof.
Background technology
People's joint is the special organ of a class, is the not only bio-tribology system of transmitted load but also transmitting movement.People's joint is made up of the joint capsule of articular surface, ossa articularia, cartilage, knuckle synovia and supply synovial fluid, is the tribology system of very marvellous and an excellent performance.Though the working condition of human synovial most evil bad (particularly joint of the lower extremity), the tribological property of this system shows superiorly unusually, and coefficient of friction is minimum, and does not almost have wearing and tearing, can work more than 70 years usually.Certainly also accident can appear, and the one, objective and subjective reason causes articular system generation pathological changes, forms arthritis, causes that the knuckle synovia secretory volume reduces, insufficient lubrication, the serious even artificial joint that will change the outfit; The 2nd, wound disables, and loses its function, or suffers from the osteoma excision, and artificial joint also will change the outfit.Calculate that according to investigation China has 100～1,500,000 joint patients need do artificial operation on joint.Therefore, prolong artificial joint service life, improve its biocompatibility, be the big problem that is related to millions upon millions of person health.
At present, existing artificial joint does not design the function of supply synovial fluid and storage synovial fluid, and the tissue fluid that just depends on the non-constant of lubricity is lubricated, thereby joint rubbing surface serious wear, and wear extent is big.Simultaneously, the foreign body reaction that is caused by wear particle can shorten artificial joint service life.Discovering in recent years, it is relevant that become flexible the foreign body reaction that constantly increases in a large number and cause with wear particle (abrasive dust) late period of artificial joint, because a large amount of abrasive dusts can cause that macrophage and mononuclear cell gather in a large number, and produce the various kinds of cell factor and cause osteoblast and osteoclast unbalance on formation, quantity and metabolic function, bring out bone resorption, thereby cause the bone dissolving very serious, thereby make prosthetic loosening, sinking, lose its motor function, must undergo surgery and overhaul, this has brought huge misery and economic loss to the patient undoubtedly.For this reason, done a large amount of research both at home and abroad on artificial joint design, material and face coat, expectation changes pair materials and reduces wear and abrasive dust, but does not significantly improve the artificial joint lubrication state, and the relevant issues that wear particle causes still exist in a large number.
Summary of the invention
One of purpose of the present invention is to provide a kind of biomimetic prosthetic joint capsule, and it has the synovial fluid of storage and prevents that the wear particle leakage from entering intravital function.
Second purpose of purpose of the present invention is to provide the preparation method of above-mentioned biomimetic prosthetic joint capsule
For achieving the above object, the present invention adopts following technical proposals:
A kind of biomimetic prosthetic joint capsule, it comprises upper and lower fastening section and middle part cystic structures section, and its characteristics are that this artificial joint capsule has double-decker, and its substrate adopts netted or solid medical nylon, and its thickness is the 0.1-2 millimeter; Face coat adopts the high resiliency medical grade silicon rubber, and its thickness is the 0.1-2 millimeter.
The inner surface of above-mentioned substrate also has coating, and this coating adopts chitosan or derivatives thereof, and its thickness is 20 nanometers-2 millimeter.
The inner surface of above-mentioned substrate and the outer surface of face coat or coating, this coating adopts chitosan or derivatives thereof, and its thickness is 20 nanometers-2 millimeter.
A kind of manufacture method that is used for the biomimetic prosthetic joint capsule is characterized in that, the concrete processing step of this method is as follows:
A) bio-medical nylon is fixed in artificial joint capsule die surface and keep shape;
B) the medical organosilyl A of high resiliency, B component are pressed 1: 1 abundant mix homogeneously of part by weight, evenly be coated on the nylon layer surface, under 140 ℃ of-180 ℃ of temperature, be heating and curing 3-10 minute, demoulding can make a kind of nylon/silicon rubber bilayer bionic structure artificial joint capsule;
C) inner surface at substrate also has coating, the chitosan or derivatives thereof is dissolved in 2% spirit of vinegar, be mixed with weight ratio and be chitosan/dilute acetic acid solution of 3%, and the chitosan dilute acetic acid solution is coated on the inner surface of the above-mentioned nylon for preparing/silicon rubber bilayer film, it is the nylon layer surface, natural air drying can make the bionical artificial joint capsule of a kind of chitosan/nylon/silicone rubber three-decker.
Another kind is used for the manufacture method of biomimetic prosthetic joint capsule, it is characterized in that, the concrete processing step of this method is as follows:
A) bio-medical nylon is fixed in artificial joint capsule die surface and keep shape;
B) the medical organosilyl A of high resiliency, B component are pressed 1: 1 abundant mix homogeneously of part by weight, evenly be coated on the nylon layer surface, under 140 ℃ of-180 ℃ of temperature, be heating and curing 3-10 minute, demoulding can make a kind of nylon/silicon rubber bilayer bionic structure artificial joint capsule;
C) in the outer surface or the coating of the inner surface and the face coat of substrate, the chitosan or derivatives thereof is dissolved in 2% spirit of vinegar, be mixed with weight ratio and be 3% dilute acetic acid solution, again the above-mentioned nylon for preparing/silicon rubber bilayer film is positioned in chitosan/dilute acetic acid solution, soak and absorb 0.5-24 hour, take out, natural air drying can make a kind of two-sided bionical artificial joint capsule that the chitosan/nylon/silicone rubber four-layer structure of chitosan is all arranged.
Compared with prior art, the present invention has following conspicuous advantage and outstanding characteristics: artificial joint capsule of the present invention is a storage, antiseep mechanism.Because the existence of this " capsule ", all seal synovial fluid and wear particle in the artificial joint, not only can solve the storage problem of synovial fluid, guarantee the synovial fluid long term lubricating effect, reduce wearing and tearing, but also can prevent to enter the foreign body reaction that causes in the body owing to the wear particle seepage that artificial joint material produces, therefore can realize reducing to wear and tear and the expectation function of abrasive particle side reaction, prolong the service life of artificial joint.Simultaneously, artificial joint capsule of the present invention has good biocompatibility, manufacturing process is simple, and cost is low, has a good application prospect.
Description of drawings
Fig. 1 is the structural representation of one embodiment of the present of invention.
Fig. 2 is the structural representation of second embodiment of the present invention.
Fig. 3 is the structural representation of the 3rd embodiment of the present invention.
The specific embodiment
Embodiment one: referring to Fig. 1, bio-medical nylon is fixed in artificial joint capsule die surface and keeps shape; With the A of the medical organosilicon MED-4950 of 5g high resiliency, the B component evenly is coated on netted nylon thin layer surface by 1: 1 abundant mix homogeneously of part by weight, to thickness be 2 millimeters, under 180 ℃ of temperature, solidified 10 minutes.Demoulding can make the double-deck bionical artificial joint capsule of nylon/organosilicon.
Embodiment two: referring to Fig. 2, bio-medical nylon is fixed in artificial joint capsule die surface and keeps shape; With the A of 5g high resiliency medical grade silicon rubber MED-4950, the B component evenly is coated on bio-medical nylon thin layer surface by 1: 1 abundant mix homogeneously of part by weight, to thickness be 0.5 millimeter; Under 140 ℃ of temperature, solidified 3 minutes, make nylon/silicon rubber bilayer composite membrane, demoulding.Again chitosan is dissolved in 2% spirit of vinegar, is mixed with the chitosan/dilute acetic acid solution of 3% (weight ratio).Above-mentioned double-layered compound film is positioned in chitosan/dilute acetic acid solution, soak and absorb 20 hours, take out natural air drying, can make a kind of two-sided bionical artificial joint capsule that the chitosan/nylon/silicone rubber four-layer structure of chitosan coat is all arranged, the thickness of inside and outside chitosan coat respectively is 1 millimeter.
Embodiment three: referring to Fig. 3, bio-medical nylon is fixed in artificial joint capsule die surface and keeps shape; With the A of 5g high resiliency medical grade silicon rubber MED-4950, the B component evenly is coated on nylon thin layer surface by 1: 1 abundant mix homogeneously of part by weight, reach under 1 millimeter 160 ℃ of temperature to thickness, solidified 7 minutes, and made nylon/silicon rubber bilayer composite membrane, demoulding is stand-by; The 5g chitosan is dissolved in 2% dilute acetic acid solution, makes the chitosan dilute acetic acid solution.Again the chitosan dilute acetic acid solution is coated on the inner surface of nylon/silicon rubber bilayer composite membrane, i.e. nylon layer inner surface, to thickness be 2 millimeters, natural air drying can make three layers of bionical artificial joint capsule of chitosan/nylon/silicone rubber that single face contains chitosan.
Claims (5)
1. biomimetic prosthetic joint capsule, it comprises upper and lower fastening section and middle part cystic structures section, and its characteristics are that this artificial joint capsule has double-decker, and its substrate (1) adopts netted or solid medical nylon, and thickness is the 0.1-2 millimeter; Face coat (2) adopts the high resiliency medical grade silicon rubber, and its thickness is the 0.1-2 millimeter.
2. biomimetic prosthetic joint capsule according to claim 1 is characterized in that, also has coating (3) at the inner surface of substrate (1), and this coating (3) adopts the chitosan or derivatives thereof, and its thickness is 20 nanometers-2 millimeter.
3. biomimetic prosthetic joint capsule according to claim 1 is characterized in that, still is coating (3,4) at the inner surface of substrate (1) and the outer surface of face coat (2), and this coating (3,4) adopts the chitosan or derivatives thereof, and its thickness is 20 nanometers-2 millimeter.
4. a manufacture method that is used for the biomimetic prosthetic joint capsule is characterized in that, the concrete processing step of this method is as follows:
A. bio-medical nylon is fixed in artificial joint capsule die surface and keeps shape;
B. the medical organosilyl A of high resiliency, B component are pressed 1: 1 abundant mix homogeneously of part by weight, evenly be coated on the nylon layer surface, under 140 ℃ of-180 ℃ of temperature, be heating and curing 3-10 minute, demoulding can make a kind of nylon/silicon rubber bilayer bionic structure artificial joint capsule;
If c. the inner surface at substrate (1) also has coating (3), the chitosan or derivatives thereof is dissolved in 2% spirit of vinegar, be mixed with the chitosan/dilute acetic acid solution of weight ratio 3%, and the chitosan dilute acetic acid solution is coated on the inner surface of the above-mentioned nylon for preparing/silicon rubber bilayer film, it is the nylon layer surface, natural air drying can make the bionical artificial joint capsule of a kind of chitosan/nylon/silicone rubber three-decker.
5. manufacture method that is used for the biomimetic prosthetic joint capsule, it is characterised in that specifically step is as follows:
A. bio-medical nylon is fixed in artificial joint capsule die surface and keeps shape;
B. the medical organosilyl A of high resiliency, B component are pressed 1: 1 abundant mix homogeneously of part by weight, evenly be coated on the nylon layer surface, under 140 ℃ of-180 ℃ of temperature, be heating and curing 3-10 minute, demoulding can make a kind of nylon/silicon rubber bilayer bionic structure artificial joint capsule;
If still be coating (3,4) c. at the inner surface of substrate (1) and the outer surface of face coat (2), the chitosan or derivatives thereof is dissolved in 2% spirit of vinegar, be mixed with weight ratio and be 3% dilute acetic acid solution, again the above-mentioned nylon for preparing/silicon rubber bilayer film is positioned in chitosan/dilute acetic acid solution, soak and absorb 0.5-24 hour, take out, natural air drying can make a kind of two-sided bionical artificial joint capsule that the chitosan/nylon/silicone rubber four-layer structure of chitosan is all arranged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100162638A CN1299653C (en) | 2004-02-12 | 2004-02-12 | Bionic artificial joint capsule and its making method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100162638A CN1299653C (en) | 2004-02-12 | 2004-02-12 | Bionic artificial joint capsule and its making method |
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| Publication Number | Publication Date |
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| CN1557267A CN1557267A (en) | 2004-12-29 |
| CN1299653C true CN1299653C (en) | 2007-02-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100162638A Expired - Fee Related CN1299653C (en) | 2004-02-12 | 2004-02-12 | Bionic artificial joint capsule and its making method |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249990B (en) * | 2008-03-11 | 2010-06-09 | 东华大学 | Method for rapidly removing metal copper ion from waste water |
| EP2361640A1 (en) * | 2010-02-25 | 2011-08-31 | Université de Liège | Cell cultivation in chitosan alginate hydrogel beads |
| CN202200304U (en) * | 2011-05-17 | 2012-04-25 | 赵德政 | Closed lubricant bionic joint device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2398986Y (en) * | 1999-09-09 | 2000-10-04 | 谭明生 | Artificial joint cpasule for preventing wear particles from diffusion |
| WO2002041808A1 (en) * | 2000-11-22 | 2002-05-30 | Milorad Mitkovic | Insulator of particles created between the articulating components of artificial joints |
| CN2565426Y (en) * | 2002-09-05 | 2003-08-13 | 上海大学 | Joint prosthesis |
| WO2003103544A1 (en) * | 2002-06-10 | 2003-12-18 | Kazuho Iesaka | A prosthetic joint |
-
2004
- 2004-02-12 CN CNB2004100162638A patent/CN1299653C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2398986Y (en) * | 1999-09-09 | 2000-10-04 | 谭明生 | Artificial joint cpasule for preventing wear particles from diffusion |
| WO2002041808A1 (en) * | 2000-11-22 | 2002-05-30 | Milorad Mitkovic | Insulator of particles created between the articulating components of artificial joints |
| WO2003103544A1 (en) * | 2002-06-10 | 2003-12-18 | Kazuho Iesaka | A prosthetic joint |
| CN2565426Y (en) * | 2002-09-05 | 2003-08-13 | 上海大学 | Joint prosthesis |
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| CN1557267A (en) | 2004-12-29 |
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Granted publication date: 20070214 Termination date: 20140212 |