CN1297284C - Chicken gallbladder extractum dripping pills and its preparation method - Google Patents
Chicken gallbladder extractum dripping pills and its preparation method Download PDFInfo
- Publication number
- CN1297284C CN1297284C CNB2004100111994A CN200410011199A CN1297284C CN 1297284 C CN1297284 C CN 1297284C CN B2004100111994 A CNB2004100111994 A CN B2004100111994A CN 200410011199 A CN200410011199 A CN 200410011199A CN 1297284 C CN1297284 C CN 1297284C
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- Prior art keywords
- extractum
- gallus domesticus
- fel gallus
- preparation
- fel
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Links
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 74
- 239000006187 pill Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 210000000232 gallbladder Anatomy 0.000 title abstract 7
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229960001091 chenodeoxycholic acid Drugs 0.000 claims abstract description 20
- RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 claims abstract description 19
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 15
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 12
- 229930195725 Mannitol Natural products 0.000 claims description 12
- 239000000594 mannitol Substances 0.000 claims description 12
- 235000010355 mannitol Nutrition 0.000 claims description 12
- 239000000758 substrate Substances 0.000 claims description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000002826 coolant Substances 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 229940126680 traditional chinese medicines Drugs 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 230000004927 fusion Effects 0.000 claims description 3
- 229940057995 liquid paraffin Drugs 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 2
- 238000003860 storage Methods 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract 5
- 238000001816 cooling Methods 0.000 abstract 1
- 239000000110 cooling liquid Substances 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 5
- 210000000941 bile Anatomy 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- 206010006451 bronchitis Diseases 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 2
- 206010006458 Bronchitis chronic Diseases 0.000 description 2
- 239000004380 Cholic acid Substances 0.000 description 2
- 201000005702 Pertussis Diseases 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 239000003613 bile acid Substances 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 2
- 229960002471 cholic acid Drugs 0.000 description 2
- 235000019416 cholic acid Nutrition 0.000 description 2
- 208000007451 chronic bronchitis Diseases 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 235000020995 raw meat Nutrition 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000003907 chenodeoxycholic acid group Chemical group 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 235000019353 potassium silicate Nutrition 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention relates to a medicine field, particularly to chicken gallbladder extractum dripping pills and a preparation method thereof. The chicken gallbladder extractum dripping pills mainly comprise 11 to 110 of chicken gallbladder extractum measured by chenodeoxycholic acid and 550 to 950 of matrixes. The preparation method comprises that the matrixes are taken and heated to melt, the chicken gallbladder extractum is added and is uniformly mixed, and then, the mixture is sealed at 80 to 90 DEG C for heat preservation. The mixture is dripped by a quantitative constant control pill dropping machine, and atoleine is used for cooling down the mixture. The mixture is drained, cooling liquid is erased, and the mixture is dried, checked and packed to obtain the chicken gallbladder extractum dripping pills. The chicken gallbladder extractum dripping pills have the advantages of simple preparation method, stable preparation, easy control of quality and low production cost. The mouth feel is obviously improved, and patients, especially children and diabetes patients can easily accept the present invention. The present invention has the characteristics of small oral dose every time, convenient transportation, convenient storage, convenient administration and enhancement of medicine compliance.
Description
[technical field]
The present invention relates to particularly a kind of Fel Gallus domesticus extractum novel form of field of medicaments and preparation method thereof.
[background technology]
The medicinal treatment pertussis of Fel Gallus domesticus, have existed since ancient times.Modern medicine study confirms that the Fel Gallus domesticus main component is chenodeoxycholic acid (CDCA), is cholic acid (CA) secondly, and wherein chenodeoxycholic acid accounts for 80% of total bile acid.Chenodeoxycholic acid has stronger antiinflammatory, cough-relieving, eliminates the phlegm, antiasthmatic activity, and its cough-relieving, relieving asthma, antiphlogistic activity occupies first of the various animal biles.Gu Xueqiu chief editor's version pharmaceutical preparation notes in 1981 are spoken of on treatment pertussis, chronic bronchitis effect, and cattle, sheep, pig, Fel Gallus domesticus are compared, and are best with Fel Gallus domesticus.After discard the dross and select the essential, remove the mucin in the Fel Gallus domesticus, extract and obtain total bile acid and make Fel Gallus domesticus extractum, and be that raw material is made oral liquid with it---" Fel Gallus domesticus oral administration solution ", in nineteen ninety-five authorize New Drug Certificate and begin to produce throw in clinical." Fel Gallus domesticus oral administration solution " is the authorized so far unique medicinal Western medicine preparation of Fel Gallus domesticus extractum (2001 traditional Chinese medicines marking-ups X-029 number).Went through clinical confirmation 10 years: chicken bile oral liquor is treated cough, the expectoration due to acute and chronic bronchitis, the upper respiratory tract infection and is panted and achieve good results, and total effective rate reaches 93.8% produce effects 63.3%.In treatment, do not find any toxicity.We can say that chicken bile oral liquor is the medicine of determined curative effect, safe without toxic side effect.But in its preparation and clinical use, also find its deficiency: one time oral dose big (10ml-20ml) or more, mouthfeel is not good, and particularly its correctives is Mel and sucrose, viscous is not well, and bile raw meat bitterness stays in the oral cavity, does not go for a long time, the patient, special diabetics and child are difficult to be accepted; Complicated process of preparation, stability is not good enough, and difficult quality control is separated out after the storage for a long time, though do not affect the treatment, influences outward appearance and uses compliance; Liquid glass bottle packing, the inconvenience transportation, inconvenience is carried, and inconvenience is taken, and compliance is relatively poor.
[summary of the invention]
The invention provides a kind of Fel Gallus domesticus extractum drop pill and preparation method thereof, in order to remedy the existing deficiency of Fel Gallus domesticus extractum oral liquid.
Fel Gallus domesticus extractum drop pill of the present invention is made of Fel Gallus domesticus extractum and substrate, and its weight consists of: Fel Gallus domesticus extractum is counted 11-110 with chenodeoxycholic acid, and substrate is 550-950.
The substrate that Fel Gallus domesticus extractum drop pill of the present invention is adopted is Polyethylene Glycol (PEG) 6000, Polyethylene Glycol (PEG) 4000, polyvinylpyrrolidone (PVP), citric acid, mannitol, xylitol, a kind of in the sorbitol or more than one.
Fel Gallus domesticus extractum drop pill preferred weight of the present invention consists of; Fel Gallus domesticus extractum counts 22 with chenodeoxycholic acid, polyethylene glycol 6000 850, mannitol 10.
Fel Gallus domesticus extractum drop pill of the present invention most preferably weight consists of: Fel Gallus domesticus extractum counts 55 with chenodeoxycholic acid, polyethylene glycol 6000 700.
The used Fel Gallus domesticus extractum of the present invention should be 2001 traditional Chinese medicines marking-ups x-29 number, the Fel Gallus domesticus extractum of " Fel Gallus domesticus oral administration solution " adnexa " Fel Gallus domesticus extractum " standard code.
Fel Gallus domesticus extractum drop pill its preparation method of the present invention step in the following order carries out:
(1) measures substrate by prescription, put and be heated to whole fusions in water-bath or the oil bath pan, add Fel Gallus domesticus extractum then, be transferred to 80-90 ℃ of airtight insulation in the insulation receiver after stirring rapidly.
(2) drip system from top to bottom with quantitatively permanent control drop pill machine, coolant is a liquid paraffin, drip speed and be 30 balls/minute, with the drop pill drop that forms to the greatest extent, and wipe liquid coolant, pour in the suction paper disc, after the intensive drying, censorship, packing, promptly.
Fel Gallus domesticus extractum drop pill of the present invention and preparation method thereof has the following advantages:
(1) preparation method and equipment needed thereby are simple, are beneficial to cleaning and labor protection, and be with short production cycle, automatization level degree height, and preparation stabilization, easy to control the quality, production cost is low.
(2) the Fel Gallus domesticus extractum drop pill is owing to stir Fel Gallus domesticus extractum and substrate congruent melting, it is dispersed among the substrate, form solid solution, covered the raw meat bitterness of Fel Gallus domesticus extractum because of the bag effect of covering of substrate, make mouthfeel be able to obvious improvement, particularly do not re-use correctives sucrose and Mel, particularly child and diabetic are easier to accept to make the patient.
(3) one times oral dose is little, each 0.2-1.0g that is grown up, and the child is convenient to the divided dose administration according to age, the state of an illness, because drop pill is the solid smooth pellet shapes, is convenient to swallow again, is convenient to buccal, is convenient to transportation, is easy to carry, and is convenient to keeping, and compliance strengthens.
[embodiment one] preparation Fel Gallus domesticus extractum drop pill 1000g
Get Fel Gallus domesticus extractum in chenodeoxycholic acid 11g, polyethylene glycol 6000 920g, mannitol 30g.
Preparation method
(1) with polyethylene glycol 6000 920g, mannitol 30g puts in the water-bath, and heating in water bath adds Fel Gallus domesticus extractum in chenodeoxycholic acid 11g to all fusions, is transferred in the insulation receiver 80-90 ℃ of airtight insulation then rapidly.
(2) drip system from top to bottom with quantitatively permanent control drop pill machine, coolant is a liquid paraffin, drip speed and be 30 balls/minute, with the drop pill drop that forms to the greatest extent, and wipe liquid coolant, pour in the suction paper disc, after the intensive drying, censorship, packing, promptly.
[embodiment two] preparation Fel Gallus domesticus extractum drop pill 1000g
Get Fel Gallus domesticus extractum in chenodeoxycholic acid 22g, polyethylene glycol 6000 850g, mannitol 30g
Preparation method is with embodiment one.
[embodiment three] preparation Fel Gallus domesticus extractum drop pill 1000g
Get Fel Gallus domesticus extractum in chenodeoxycholic acid 33g, polyethylene glycol 6000 800g.Mannitol 15g.
Preparation method is with embodiment one.
[embodiment four] preparation Fel Gallus domesticus extractum drop pill 1000g
Get Fel Gallus domesticus extractum in chenodeoxycholic acid 55g, polyethylene glycol 6000 700g.
Preparation method is with embodiment one.
[embodiment five] preparation Fel Gallus domesticus extractum drop pill 1000g
Get Fel Gallus domesticus extractum in chenodeoxycholic acid 66g, polyethylene glycol 6000 630g.
Preparation method is with embodiment one.
[embodiment six] preparation Fel Gallus domesticus extractum drop pill 1000g
Get Fel Gallus domesticus extractum in chenodeoxycholic acid 88g, polyethylene glycol 6000 550g, mannitol 30g.
Preparation method is with embodiment one.
[embodiment seven] preparation Fel Gallus domesticus extractum drop pill 1000g
Get Fel Gallus domesticus extractum in chenodeoxycholic acid 99g, polyethylene glycol 6000 520g, mannitol 40g.
Preparation method is with embodiment one
[embodiment eight] preparation Fel Gallus domesticus extractum drop pill 1000g
Get Fel Gallus domesticus extractum in chenodeoxycholic acid 110g, polyethylene glycol 6000 500g, mannitol 50g.
Preparation method is with embodiment one
Claims (4)
1, a kind of Fel Gallus domesticus extractum drop pill is made of Fel Gallus domesticus extractum, substrate, and it is characterized in that weight consists of: Fel Gallus domesticus extractum is counted 11-110 with chenodeoxycholic acid, and substrate is 550-950;
Above-mentioned Fel Gallus domesticus extractum is for meeting 2001 traditional Chinese medicines marking-ups X-029 number, the Fel Gallus domesticus extractum of " Fel Gallus domesticus oral administration solution " adnexa " Fel Gallus domesticus extractum " standard code;
Above-mentioned substrate is polyethylene glycol 6000, Macrogol 4000, polyvinylpyrrolidone PVP, citric acid, mannitol, xylitol, a kind of in the sorbitol or more than one.
2. Fel Gallus domesticus extractum drop pill according to claim 1, it is characterized in that weight consists of: Fel Gallus domesticus extractum counts 22 with chenodeoxycholic acid, polyethylene glycol 6000 850, mannitol 10.
3. Fel Gallus domesticus extractum drop pill according to claim 1, it is characterized in that weight consists of: Fel Gallus domesticus extractum counts 55 with chenodeoxycholic acid, polyethylene glycol 6000 700.
4. the preparation method of the Fel Gallus domesticus extractum drop pill of a claim 1, step is carried out in the following order:
(1) measures substrate by claim 1 prescription: polyethylene glycol 6000, Macrogol 4000, polyvinylpyrrolidone PVP, citric acid, mannitol, xylitol, a kind of in the sorbitol or more than one are put and are heated to whole fusions in water-bath or the oil bath pan, add Fel Gallus domesticus extractum then, be transferred in the insulation receiver 80-90 ℃ of airtight insulation after stirring rapidly;
Above-mentioned Fel Gallus domesticus extractum is for meeting 2001 traditional Chinese medicines marking-ups X-029 number, the Fel Gallus domesticus extractum of " Fel Gallus domesticus oral administration solution " adnexa " Fel Gallus domesticus extractum " standard code;
(2) drip system from top to bottom with quantitatively permanent control drop pill machine, coolant is a liquid paraffin, drip speed and be 30 balls/minute, with the drop pill drop that forms to the greatest extent, and wipe liquid coolant, in the paper disc of going into to absorb water, after the intensive drying, censorship, packing, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100111994A CN1297284C (en) | 2004-11-05 | 2004-11-05 | Chicken gallbladder extractum dripping pills and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100111994A CN1297284C (en) | 2004-11-05 | 2004-11-05 | Chicken gallbladder extractum dripping pills and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1631378A CN1631378A (en) | 2005-06-29 |
| CN1297284C true CN1297284C (en) | 2007-01-31 |
Family
ID=34845582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100111994A Expired - Fee Related CN1297284C (en) | 2004-11-05 | 2004-11-05 | Chicken gallbladder extractum dripping pills and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1297284C (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163131A (en) * | 1996-04-25 | 1997-10-29 | 宝鸡制药厂 | Fengdan oral liquid and its preparation process |
-
2004
- 2004-11-05 CN CNB2004100111994A patent/CN1297284C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163131A (en) * | 1996-04-25 | 1997-10-29 | 宝鸡制药厂 | Fengdan oral liquid and its preparation process |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1631378A (en) | 2005-06-29 |
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Granted publication date: 20070131 Termination date: 20131105 |