CN1289627A - Method and equipment for cyclic ultrasonic breaking and extraction of active components in medicinal plant - Google Patents
Method and equipment for cyclic ultrasonic breaking and extraction of active components in medicinal plant Download PDFInfo
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Abstract
A method for extracting active components of medical plant includes such steps as loading crushed medical plant and extracting medium in extractor, mechanical stirring to make the mixture flow through ultrasonic field, and circulated ultrasonic breaking and extracting. Its equipment is composed of tower body, central pipe, ultrasonic wave generator and stirring controller. The ultrasonic probe and stirring propeller are in the central pipe positioned in the tower center. Its advantages are simple operation and high efficiency.
Description
The present invention relates in the technology of bioengineering downstream the medicinal plant effective ingredient carry leaching method and device, particularly the cyclic ultrasonic breaking leach extraction method and the device of medicinal plant effective ingredient.
Kind surplus the medicinal plant that has been found that nearly 5000, the active ingredient that they contain plays an important role in the struggle of the mankind with various diseases.At present, the leaching process of medicinal plant effective ingredient is: Gu raw material pulverizing → extraction → liquid/separation → clear liquid (solid residue returns and extracts or the discard) → thick product of decompression distillation → paste (organic solvent recycles or the aqueous solution discards) → separation and purification → medical product, wherein extraction and separation and purification are the steps of two most criticals.Because the separation and purification treatment amount of thick product is less, adopts fractional precipitation, post precipitating to separate and remain main method at present, thereby extract the key that has just become to improve the whole process flow rate of recovery, reduced financial cost.
The medicinal plant effective ingredient comprises polysaccharide, flavonoids, terpene, steroidal class, alkaloid and phenol sexual element etc., and its extracting method has nothing in common with each other.When the polysaccharide product in the medicinal plant extracts, adopting boiling water or alcohol reflux to stir extracts, crude extract is again with degreasings such as benzinums, separate with the precipitation method at last, intermediate processing has fractional precipitation, lead salt precipitation, quaternary salt deposit etc., such as, the extraction preceding method of northeast thunder godvine polysaccharide, bitter leaves tea glucoside, algal polysaccharides, its shortcoming is an extraction temperature height (being generally 80-100 ℃), extraction time is long, the impurity composition stripping is many etc.Heating extracting or cold soakings such as ethanol are adopted in the extraction of flavone compound in the plant, and flavonoid glycosides adopts alkali to extract the acid precipitation and extracts, and as extract glycosides displayed from the sophora bud is spent, generally extract rutin with 80 ℃ of left and right sides hot-water extraction of pH=8-9.Alkaloid extraction in the plant generally adopts organic solvent, acidity, neutrality or weak alkaline aqueous solution to extract respectively according to different target products, and volatile component adopts steam distillation.Terpenoid generally adopts solvent refluxing to extract in the plant.Steroidal drug in the plant, as cardiac glycoside, the phenol sexual element, also similar as the leaching process of cumarin etc.
In a word, being used for the method that the medicinal plant effective ingredient extracts at present mainly contains: decocting method, percolation, steam distillation, organic solvent extraction method (cold-maceration, reflux extraction), supercritical fluid extraction etc.Steam distillation is extracted the extraction be mainly used in plant volatile oil, produces sweet wormwood through steam distillation as the Xiamen, dewater the pale yellow oily liquid body, productive rate 0.2%-0.5% (see slaughter cry of a deer etc.Acta Pharmaceutica Sinica, 1981,16 (5): 366.).Organic solvent extraction is the extracting method of present widely used medicinal plant effective ingredient.The organic solvent that uses mainly comprises: alcohols, as methyl alcohol, ethanol etc.; Ethers is as ether, benzinum etc.; Alkanes is as n-hexane, cyclohexane, carrene, chloroform, gasoline etc.Sweet wormwood stem and the leaf dry as usefulness such as Vonwiller are raw material, at room temperature extract with methyl alcohol, behind the mechanical agitation 24h, filter, methyl alcohol is removed in the filtrate decompression distillation, and the black concentrate of thickness is dissolved in ether-aqueous solution, with extracted by ether 2 times, ether extracted liquid adds sodium carbonate liquor and extracts, and alkaline extract cools off the back and transfers to pH=1 with concentrated hydrochloric acid in frozen water, at room temperature use extracted by ether again 3 times, the extract anhydrous sodium sulfate dehydration, reduction vaporization is to doing, and concentrate dissolves with the methanol solution that contains this sulfonic acid, stirring reaction 3 days, can extract simultaneously and obtain qinghaosu and Arteannuic acid (Vonwiller S C, et al.Planta Med., 1993,59:562).Klayman etc. will introduce a fine variety after the sweet wormwood fragmentation of U.S.'s growth from China, extract with low boiling point solvent, and low boiling point solvent can be carrene, chloroform, ether, acetone, benzinum (30 ℃-60 ℃) etc., and the result shows that the benzinum extraction effect is best.Dried sweet wormwood extracts 48h with the benzinum of boiling, and the dark sugar slurry that reduction vaporization obtains again with the chloroform dissolving, and adds acetonitrile simultaneously and helps to remove wherein wax.After removing insoluble matter, filter, reduction vaporization obtain paste qinghaosu crude product (Klayman D L.Science, 1985,228:1049).
Pueraria lobota sends out grade joyous the artemisia annua chemical analysis is carried out CO
2What extraction was extracted studies show that the qinghaosu supercritical CO
2Solvent method (gasoline and Diluted Alcohol) during the recovery rate of extraction is produced than traditional industry improves 11%-59%, improves more than 2 times than the conventional gasoline method, and extraction time shortens greatly, cost reduces, control different temperatures, pressure, time, also can obtain compositions such as 18 alcohol (Ge Fahuan, etc.Chinese medicine, 1994,17 (8): 31; Ge Fahuan, etc.Chinese medicine, 1995,18 (6): 316).
As everyone knows, the most important condition of extracting medicinal effective ingredient from medicinal plant is that extract can enter the extraction medium fast and efficiently, extracts medium and comprises the aqueous solution and organic solvent etc.Because the effective ingredient of medicinal plant is present in the cell born of the same parents mostly, generally need be with clasmatosis in the leaching process.The chemically fragmenting method since its process in chemical reaction, cause variations such as extract structural property easily and lose activity, the Mechanical Crushing method is difficult to cell effectively broken again, and the broken bad natural medicinal component of plant class that directly causes spreads in extracting medium slowly, increase extraction time, influence whole process yield, increase cost, and influence the quality of products obtained therefrom.
At present, people have begun ultrasonic wave is used for medicinal plant effective ingredient extraction process, such as from rheum officinale, extract anthraquinone class composition (Guo Xiaowu etc., Shaanxi Normal University's journal, 1991,19 (3), 89-90); From coptis rhizome, extract berberine (Guo Xiaowu etc., CHINA JOURNAL OF CHINESE MATERIA MEDICA, 1995,20 (11), 673-675), from the sophora bud, extract rutin (Guo Xiaowu etc., Shaanxi Normal University's journal, 1996,24 (1), 50-52), from the coptis, extract jamaicin (Guo Xiaowu etc., Shaanxi Normal University's journal, 1997,25 (1), 47-49), all mentioned the extraction process that ultrasonic wave is used for active components in medicinal plant, and obtained than promising result.Ultrasonic wave is used for the broken marine bioactivity material that extracts of marine alga and has also obtained effect preferably, as ultrasonic wave be used for the salt algae broken extract carrotene (rood is bright etc., Qingdao Marine University's journal, 1992,22 (3), 18-22); When adopting chemistry and Mechanical Crushing method all can not from dragon must algae, obtain desirable phycobilisome, adopt ultrasonic wave to extract and obtained complete phycobilisome, and effect better (rood is bright etc., applied acoustics, 1997,16 (1), 47-48).Yet the said extracted method all is that the on a small scale static batch (-type) in laboratory extracts.
In sum, though the existing certain methods of the extraction of active ingredients of plants is available, often have following shortcoming: (1) extracts the temperature height, may destroy the biologically active of extract; (2) because the process mass transfer force is little, the liquid film that feed particles surface extraction medium forms can not upgrade in time, and extraction time is long, and other impurity stripping is simultaneously also more; (3) cell and raw material can not be effectively broken, and product can not effectively discharge in the cell, and extraction recovery is low; (4) organic volatile extraction dielectric dissipation is high, causes extraction cost to increase; (5) extraction element is intermittent operation, and unit interval and unit volume disposal ability are low etc.Because the problems referred to above directly have influence on the utilization rate of medicinal plant, influence the cost and the quality of final products, limited the extensive use of medicinal plant effective ingredient.In recent years,, be several milliliters to the tens milliliters small-scale extractions in laboratory, and be intermittently operated, and it is available still not have extraction equipment efficient, that be easy to amplify so far though the research of the ultrasonication of utilizing extraction is arranged.Laboratory using: ultrasonic probe is directly put into the container that the extraction feed liquid is housed, and the ultrasonic wave effect makes the plant cell fragmentation.But there is following shortcoming in this ultrasonic extracting method and the device that the container that extracts feed liquid is housed directly ultrasonic probe put into: owing to be at quiescent atmosphere, hyperacoustic transmission is slow, the decay of intensity is fast, the ultrasonic field sphere of action is very little, near the broken overlong time of the localized raw materials of ultrasonic probe, and place far away can't obtain ultrasonication, causes the ultrasonic wave effective rate of utilization low, and the degree of crushing homogeneity is poor, be difficult to engineering and amplify, thereby limited applying of ultrasonic extraction process.
The object of the invention is: solve the defective that exists in the existing medicinal plant effective ingredient extraction process: extract the temperature height, extraction time is long, yield is low, the ultrasonic wave that uses in the high and present laboratory of extraction dielectric dissipation is extracted as static intermittently extraction, exist the ultrasonic field sphere of action little, effective rate of utilization is low, be difficult to problems such as engineering amplification, and a kind of method of utilizing the mechanical agitation circulating ultrasonic to extract is provided, strengthen clasmatosis, the feed particles fragmentation, feed particles surface liquid film upgrades fast, reduce the various resistance to mass tranfers in the leaching process greatly, increasing broken uniformity of feed particles and target product spreads in extracting medium, transmit, the uniformity that distributes, solve existing extraction equipment simultaneously and be difficult to the difficult problem that engineering is amplified, use for suitability for industrialized production and provide a kind of, and the cyclic ultrasonic breaking leach extraction method and the device of the medicinal plant effective ingredient of energy continuous operation.
Embodiment of the present invention are as follows:
The cyclic ultrasonic breaking leach extraction method of medicinal plant effective ingredient provided by the invention, its processing step is as follows:
1. the medicinal plant raw meal is broken into 20 orders-80 purpose particulate material;
2. medicinal plant particulate material and volatility or non-volatile extraction medium are added respectively and form the raw material extract in the extraction element;
3. raw material extract circular flow under churned mechanically situation is carried out cyclic ultrasonic breaking and extracts through ultrasonic field, its mixing speed is 400-900rpm, and mixing time is 10-90 minute, and the ultrasound intensity in the ultrasonic field is 60-600w:
4. remove the solid material residue, decompression distillation is reclaimed and is extracted medium, obtains the thick product of medicinal plant effective ingredient;
5. the thicker product of medicinal plant effective ingredient is carried out separation and purification, promptly obtain the active components in medicinal plant product.
This method is applicable to from the plant cell of medicinal land plant, sea-plant and bioreactor culture, tissue and organ etc. extracts various natural medicinal components.At different extraction media, adopt volatility (as benzinum etc.) and non-volatile (as aqueous solution etc.) medium respectively, carry out the various medicinal components of cyclic ultrasonic breaking lixiviate, the present invention has following advantage:
In leaching process, adopt the mechanical agitation round-robin method to make to be extracted material liquid and constantly circulate, guarantee the medicinal plant effective ingredient in extracting medium fast, evenly disperse, thereby increase effective ingredient from solid material to the motive force the liquid extraction medium, shorten extraction time.
Adopt effective fragmentation of intensified by ultrasonic wave solid material particle and plant cell, make the continuous circular flow of medium in the whole reactor cross ultrasonic field by circulating of lixiviate medium, improve the ultrasonic field utilization ratio, reduce ultrasonic generator power, extract temperature and obviously reduce, and can regulate.Circulating ultrasonic stirs the uniformity that the method for extracting is not only strengthened clasmatosis, feed particles fragmentation, increased target product diffusion in extracting medium, transmits, distributes, and solves simultaneously to be difficult to the problem that engineering is amplified; And with conventional extracting method relatively, it is less not only to extract in the product impurity, but also can reduce solvent consumption.
Be applicable to the cyclic ultrasonic breaking leaching device of the medicinal plant effective ingredient of the inventive method, it is characterized in that: mainly comprise tower body, central tube, supersonic generator and stirring control device, the central tube that has the microcirculation hole on the tube wall is positioned among the tower body with one heart, on the central tube, the lower end respectively with tower body on, annular space is left in the lower end, the ultrasonic probe of supersonic generator puts in from the tower body bottom and is positioned at central tube, stretch into by the tower body upper end and be positioned at central tube by the pusher paddle that stirs control device control, the liquid of mounting strap seal cover on the one side charging aperture of tower body top, Gu feed hopper, tower body top opposite side is provided with discharging opening; The cyclic ultrasonic breaking leaching device of active components in medicinal plant of the present invention also comprises temperature controller, the temp probe and the heating tube of temperature controller are arranged in tower body, in order to prevent to extract the medium volatilization and promote to extract medium back flow, also can be with condenser pipe on the bucket neck of liquid, solid feed hopper, the condenser pipe upper and lower end is respectively equipped with condensation-water drain and condensed water import; The central tube support is fixed on central tube in the tower body with one heart; During use, medicinal plant solid particle raw material that will be through pulverizing and extract medium respectively by liquid, solid feed hopper in charging aperture adds tower body, start and stir control device and drive pusher paddle and promote to extract feed liquid and flow downward along central tube, again respectively by flowing out in the annular space at the bottom of central tube and the tower, conversion direction, it is mobile to make progress along the space between tower body and the central tube, is formed downwards along central tube by pusher paddle promotion to circulate again, and reaches the purpose that ultrasonication is extracted.Multistage if desired continuous crushing extracts, the cyclic ultrasonic breaking leaching device series connection of a plurality of active components in medicinal plant of the present invention can be used, between the adjacent dual stage apparatus difference in height is set, the solid-liquid mixed liquor just can be realized the broken extraction of multistage continuous ultrasound from the charging aperture of upper level device discharging opening inflow next stage device.
Further describe the present invention below in conjunction with drawings and Examples:
Accompanying drawing 1: the cyclic ultrasonic breaking leaching device structural representation of the active components in medicinal plant of the inventive method, wherein:
Liquid, solid feed hopper 1 condenser pipe 2 temp probes 3
Temperature controller 4 heating tubes 5 supports 6
Supersonic generator 7 ultrasonic probes 8 microcirculation holes 9
Central tube 10 dischargings 11 pusher paddles 12
Stir control device 13 seal covers 14 charging apertures 15
Tower body 16 condensed water imports 17 condensed waters go out 18.
Fig. 1 is the cyclic ultrasonic breaking leaching device structural representation of the active components in medicinal plant of the inventive method, as seen from the figure, this device mainly comprises tower body 16, central tube 10, supersonic generator 7 and stirring control device 13, the central tube 10 that tube wall is provided with microcirculation hole 9 is positioned among the tower body 16 with one heart, on the central tube 10, the lower end respectively with tower body 16 on, annular space is left in the lower end, the ultrasonic probe 8 of supersonic generator 7 puts in the central tube 10 from tower body 16 bottoms, the pusher paddle 12 that stirs control device 13 controls is put in by tower body 16 upper ends and is positioned at central tube 10, the liquid of mounting strap seal cover 14 on the one side charging aperture 15 of tower body 16 tops, Gu feed hopper 1, tower body 16 top opposite sides are provided with discharging opening 11; The cyclic ultrasonic breaking leaching device of active components in medicinal plant of the present invention also comprises temperature controller 4, the temp probe 3 and the heating tube 5 of temperature controller 4 are arranged in tower body 16, in order to prevent to extract the medium volatilization and promote to extract medium back flow, also can on the bucket neck of liquid, solid feed hopper 1, be with condenser pipe 2, the condenser pipe upper and lower end is respectively equipped with condensation-water drain 18 and condensed water import 17, and central tube support 6 is fixed on central tube 10 in the tower body 16 with one heart.During use, medicinal plant solid particle raw material and extraction medium through pulverizing are added in the tower bodies 16 through charging aperture 15 by liquid, solid feed hopper 1 respectively, starting the pusher paddle 12 promotion extraction feed liquids of stirring control device 13 drives flows downward along central tube 10, again respectively by flowing out in the annular space at the bottom of central tube 10 and the tower, conversion direction, upwards flow along the annular space between tower body 16 and the central tube 10, promote to circulate by pusher paddle 12 again, and reach the purpose that cyclic ultrasonic breaking extracts along central tube 10 downward formation.If need carry out multistage continuous crushing extracts, the cyclic ultrasonic breaking leaching device series connection of a plurality of active components in medicinal plant of the present invention can be used, be provided with difference in height between the adjacent dual stage apparatus, extract the discharging 11 inflow next stage device charging apertures 15 of feed liquid, can realize that just multistage continuous crushing extracts from the upper level device.
Embodiment 1:
With method provided by the invention and device, from dried artemisia leaf, extract qinghaosu, its concrete grammar step is:
1. dried artemisia leaf is ground into 40 purpose particulate material;
2. get these 40 purpose particulate material, 20 grams and volatility extraction medium benzinum (30-60 ℃) and add respectively in the cyclic ultrasonic breaking leaching device that divides the active components in medicinal plant of inventing of the present invention for 600 milliliters, form the raw material extract;
With the raw material extract under mechanical agitation circular flow through ultrasonic field, carry out ultrasonication to being extracted material liquid effectively, be about to particulate material and volatility and extract the medium benzinum by liquid, Gu feed hopper 1 adds in the tower body 16 through charging aperture 15, (mixing speed is 700rpm to start the pusher paddle 12 of stirring control device 13 drives, mixing time is 60 minutes), promoting to extract feed liquid flows downward along central tube 10, again respectively by flowing out in the annular space at the bottom of central tube 10 and the tower, conversion direction, upwards flow along the annular space between tower body 16 and the central tube 10, promote to circulate by pusher paddle 12 again along central tube 10 downward formation, and reach the purpose that ultrasonication is extracted, in the present embodiment, temperature controller 4 extracts temperature about 50 ℃ by heating tube 5 and temp probe 3 controls, the ultrasound intensity of the ultrasonic probe 8 of supersonic generator 7 is 60W, the single ultrasonic time is 60 minutes, present embodiment also can use a plurality of cyclic ultrasonic breaking leaching device series connection, be provided with difference in height between the adjacent dual stage apparatus, extract the discharging opening 11 inflow next stage device charging apertures 15 of feed liquid, can realize that just multistage continuous crushing extracts from the upper level device.Use determined by ultraviolet spectrophotometry: the rate of recovery of extracting qinghaosu with extracting method of the present invention and device reaches 83%, only is 46% and there is not the ultrasonic agitation extraction, and it only is 28% that Soxhlet is extracted, and it only is 18% that the room temperature cold soaking extracts.
4. remove the solid material residue, reclaim benzinum, obtain the thick product of qinghaosu;
5. the thicker product of qinghaosu is carried out separation and purification, promptly obtain medicinal qinghaosu product.
Embodiment 2:
With method provided by the invention and device, from dried artemisia leaf, extract qinghaosu, its concrete grammar step is with embodiment 1, and different is that dried artemisia leaf is milled to 60 orders, 20 grams, extract 600 milliliters of mixing of medium benzinum (30-60 ℃) with volatility, under 40 ℃, the mixing speed of pusher paddle is 400rpm, mixing time 20 minutes, the ultrasound intensity of ultrasonic probe is 400W, ultrasonic wave effect 20 minutes.High performance liquid chromatography (HPLC) is measured, and the qinghaosu rate of recovery of extracting with extracting method of the present invention and device reaches 80%, only is 42% and there is not the ultrasonic agitation extraction, and it only is 26% that Soxhlet is extracted, and it only is 16% that the room temperature cold soaking extracts.
Embodiment 3:
With method provided by the invention and device, from mouse tail algae, extract algal polysaccharides, its concrete grammar step is:
1. mouse tail algae is ground into 80 purpose particulate material;
2. get in the cyclic ultrasonic breaking leaching device that 400 milliliters of this 80 purpose particulate material 20 grams and non-volatile extraction WATER AS FLOW MEDIUM (pH=6) add active components in medicinal plant of the present invention respectively formation raw material extract;
With this raw material extract under mechanical agitation circular flow through ultrasonic field, effectively the raw material extract is carried out ultrasonication, be about to particulate material and non-volatile extraction WATER AS FLOW MEDIUM by liquid, Gu feed hopper 1 adds in the tower body 16 through charging aperture 15, (mixing speed is 800rpm to start the pusher paddle 12 of stirring control device 13 drives, mixing time is 30 minutes), promoting to extract feed liquid flows downward along central tube 10, again respectively by flowing out in the gap at the bottom of central tube 10 and the tower, conversion direction, upwards flow along the space between tower body 16 and the central tube 10, promote to circulate by pusher paddle 12 again along central tube 10 downward formation, and reach the purpose that ultrasonication is extracted, in the present embodiment, temperature controller 4 extracts temperature in room temperature by heating tube 5 and temp probe 3 controls, the ultrasound intensity of the ultrasonic probe 8 of supersonic generator 7 is 100W, the single ultrasonic time is 30 minutes, present embodiment also can use a plurality of cyclic ultrasonic breaking leaching device series connection, be provided with difference in height between the adjacent dual stage apparatus, extract the discharging opening 11 inflow next stage device charging apertures 15 of feed liquid, can realize that just multistage continuous crushing extracts from the upper level device.Use the present invention, its polysaccharide extract rate reaches 1.86%, adds 400 ml waters (pH=6.0) (no ultrasonic disruption) under 80 ℃ of stirring conditions with 20 grams, 80 order mouse tail algae powder, and the recovery rate 1.76% that extracted 5 hours is compared slightly high.
4. remove the solid material residue, the clear liquid precipitation with alcohol obtains the thick product of algal polysaccharides;
5. the thicker product of algal polysaccharides is carried out separation and purification, promptly obtain medicinal algal polysaccharides.
Embodiment 4:
With embodiment 3,10 grams, the 20 order mouse tail algaes of oven dry are added 400 ml waters (pH=6.0) adding extraction element, extract, the ultrasound intensity of its ultrasonic field is 600W, ultrasonic probe is continuous action 10 minutes at room temperature, stirring control device control mixing speed is 900rpm, mixing time is 10 minutes, use the present invention, its polysaccharide extract rate reaches 2.90%, add 400 ml waters (pH=6.0) (no ultrasonic disruption) under 100 ℃ of stirring conditions with 10 grams, 20 order mouse tail algae powder, the recovery rate 2.75% that extracted 4 hours is compared slightly high.
Claims (5)
1. the cyclic ultrasonic breaking leach extraction method of a medicinal plant effective ingredient, its processing step is as follows:
1. the medicinal plant raw meal is broken into 20 orders-80 purpose particulate material;
2. medicinal plant particulate material and extraction medium are added formation raw material extract in the extraction element respectively;
3. raw material extract circular flow under churned mechanically situation is carried out cyclic ultrasonic breaking and extracts through ultrasonic field, its mixing speed is 400-900rpm, and mixing time is 10-90 minute, and the ultrasound intensity in the ultrasonic field is 60-600w;
4. remove the solid material residue, decompression distillation is reclaimed and is extracted medium, obtains the thick product of medicinal plant effective ingredient;
5. the thicker product of medicinal plant effective ingredient is carried out separation and purification, promptly obtain the active components in medicinal plant product.
2. the cyclic ultrasonic breaking leaching device of the medicinal plant effective ingredient of the described method of claim 1, it is characterized in that: mainly comprise tower body, central tube, supersonic generator and stirring control device, the central tube that has the microcirculation hole on the tube wall is positioned among the tower body with one heart, on the central tube, the lower end respectively with tower body on, annular space is left in the lower end, the ultrasonic probe of supersonic generator puts in from the tower body bottom and is positioned at central tube, stretch into by the tower body upper end and be positioned at central tube by the pusher paddle that stirs control device control, the liquid of mounting strap seal cover on the one side charging aperture of tower body top, Gu feed hopper, tower body top opposite side is provided with discharging opening.
3. by the cyclic ultrasonic breaking leaching device of the described medicinal plant effective ingredient of claim 2, it is characterized in that: also comprise temperature controller, the temp probe and the heating tube of temperature controller are arranged in tower body.
4, the cyclic ultrasonic breaking leaching device by the described medicinal plant effective ingredient of claim 2 is characterized in that: also can be with condenser pipe on the bucket neck of liquid, solid feed hopper, the condenser pipe upper and lower end is respectively equipped with condensation-water drain and condensed water import.
5. by the cyclic ultrasonic breaking leaching device of the described medicinal plant effective ingredient of claim 2, it is characterized in that: support is fixed on central tube in the tower body with one heart.
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