CN1288735A - Slow-releasing concentrated common perilla seed oil tablet and its preparation - Google Patents
Slow-releasing concentrated common perilla seed oil tablet and its preparation Download PDFInfo
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- CN1288735A CN1288735A CN 00109891 CN00109891A CN1288735A CN 1288735 A CN1288735 A CN 1288735A CN 00109891 CN00109891 CN 00109891 CN 00109891 A CN00109891 A CN 00109891A CN 1288735 A CN1288735 A CN 1288735A
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- slow
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- oleum perillae
- fruit oil
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Abstract
The present invention relates to a high-concentration perialla fruit oil slow-release tablet and its preparation method. The composition of the described slow-release tablet comprises (wt%) perilla fruit oil (in which alpha-linoleic acid content is greater than 60%) 50, clathrate beta-CD cyclodextrin 2-10, slow-release agent ethyl cellulose 5-10, excipient starch 10-15, antioxidant vitamin E or nordihydroguaiaretic acid 0.05-0.15 and corrective 0.05-0.1. Its preparation method includes the following steps: firstly, using supercritical CO2 extraction method to prepare perilla fruit oil, according to said ratio mixing the above-mentioned all ingredients and stirring them to make the perilla fruit oil undergo the processes of clathration, solidification, dispersion and stabilizing, sieving with 0.9 mm sieve, drying at 60 deg.C, adding 5-10% of excipient talcum powder, sieving with 3.6 mm sieve, drying for 1 hr. at 60 deg.C, and taabletting, the weight of every tablet is 0.5-1g.
Description
The invention belongs to a kind of functional health care product that from natural active matter, obtains and preparation method thereof, be specifically related to a kind of slow-releasing concentrated common perilla seed oil tablet and method for making thereof.
Folium Perillae is a kind of Chinese herbal medicine, and Oleum Perillae is a kind of polyene unsaturated fatty acid that extracts from Fructus Perillae, and Main Ingredients and Appearance is alpha-linolenic acid (C
18H
30O
2) 40-70%, Palmic acid (C
16H
32O
2) 10%, linoleic acid C
18H
32O
21.5%, oleic acid (C
18H
34O
2) 7%, stearic acid (C
18H
36O
2) 4%, other fatty acids (C
19-C
21) 4%, the palmitoleic acid trace.Wherein alpha-linolenic acid is the parent of W-3 series fatty acid, be human body must and can not self synthetic fatty acid.
Jilin Province's institute of Traditional Chinese Medicine and materia medica adopted the extractive method of solvent to extract Oleum Perillae in 1998, and the alpha-linolenic acid yield that this method obtains is low, and the content of alpha-linolenic acid is low in the Oleum Perillae.
Shanxi Deere health supercritical green engineering company limited adopted CO in 1998
2The supercritical, high pressure method (＞30MPa) method of extraction obtains alpha-linolenic acid content up to the Oleum Perillae more than 60% and yield＞more than 35%, after this be made into the soft capsule oral agents again.Its defective is that product be difficult for to be preserved, and abnormal flavour is arranged when taking slightly, dissolves rapidly after entering the intestines and stomach, and concentration is concentrated, and is difficult for absorbing metabolism.
The objective of the invention is to Oleum Perillae tablet of developing a kind of easy preservation, free from extraneous odour, effective ingredient energy slow release and preparation method thereof.
The component and the weight ratio thereof of Oleum Perillae tablet of the present invention are as follows:
Oleum Perillae (wherein alpha-linolenic acid＞60%) 50, clathrate β-CD cyclodextrin 2-10, slow releasing agent ethyl cellulose 5-10, excipient starch 10-15, antioxidant vitamin E or nor-hydrogen guaiaretic acid 0.05-0.15 and correctives 0.05-0.1.
Described Oleum Perillae adopts the CO of band rectifying column
2Supercritical extraction unit makes, and sees for details following.
The preparation method of product of the present invention is as follows:
By said components and weight ratio each component is mixed, make active ingredient Oleum Perillae enclose, curing, dispersion, stable, with the screening of 0.9mm sieve, 60 ℃ dry down, restock Pulvis Talci 5-10 figuration amyloplastid, sieve with the 3.6mm sieve, drying is 1 hour under 60 ℃, full powder tabletting pelletize, tablet amounts 0.5 gram/sheet or 1 gram/sheet.
The supercritical CO of described Oleum Perillae
2The extracting process accompanying drawings is as follows:
Fig. 1 is the Oleum Perillae supercritical CO
2The extraction equipment flow chart.
As shown in the figure, 1 is CO
2Pump, 2 is the entrainer pump, and 3 for giving hot device, and 4 is extractor, and 5 is the solid material frame, and 6 is separator, and 7 is CO
2Depurator, 8 is condenser, 9 is CO
2Gas cylinder.
Be crushed to below the 1mm material frame 5 of packing into, CO at the purple perilla seed2Through gas cylinder 9, condenser 8, pump 1, give hot device 3 and enter extractor 4, extract and CO from the bottom2Extractant is through second-stage separator 6, and the product perilla herb oil is discharged CO from its bottom2Discharge from its top, through clarifier 7 and condenser After 8, enter systemic circulation and use, need add entrainer (such as ethanol time), use pump 2.
50 ℃ of extraction temperature, pressure 32-38MPa, separation temperature 40-50 ℃, pressure 6-11MPa.
Advantage of the present invention is as follows:
1. the activity of product of the present invention or alpha-linolenic acid content are up to more than 60%, and health care is good.
2. add sustained release agent in the tablet, the active ingredient alpha-linolenic acid slowly discharged in stomach, Utilize optimum absorption and metabolism.
3. tablet glue soft capsule is easily preserved, taking convenience, good mouthfeel.
Embodiments of the invention are as follows:
Embodiment 1
Seed is broken to 8 kilograms of the following Fructus Perillae of 1mm, and the material frame 5 of 24 liters of packing into is at 50 ℃ of extraction temperature, pressure 32MPa, CO
2Flow 100Kg/ extracts at present, 40 ℃ of temperature, carries out flash trapping stage under the pressure 11MPa, carries out secondary and separate under 50 ℃, 6MPa, 8 hours extraction time, 3.08 kilograms of the perilla oils of transparent clear, it crosses oxygen value is 5.4, acid value 2.5, alpha-linolenic acid 60%, oily yield 38.5%.
Get above-mentioned perilla oil 50 and restrain, β-CD cyclodextrin 2 grams, slow releasing agent ethyl cellulose 5 grams, excipient starch 10 grams, antioxidant vitamin E0.05 gram, correctives 0.05 restrains, and makes the tablet of 0.5 gram/sheet as stated above.
Embodiment 2
8 kilograms of Fructus Perillae, 60 ℃ of extraction temperature, pressure 38MPa, 45 ℃ of flash trapping stage temperature, pressure 12MPa, 58 ℃ of secondary separation temperatures, pressure 6.5MPa extracted 8 hours, got 3.16 kilograms of perilla oils, it crosses oxygen value 5.9, acid value 3.2, alpha-linolenic acid＞60%, oily yield 39.5%.
Get above-mentioned Oleum Perillae 50 grams, β-CD cyclodextrin 10 grams, slow releasing agent ethyl cellulose 10 grams, excipient starch 15 grams, nor-pair of hydrogen of antioxidant agent wood acid 0.15 gram of healing, correctives 0.1 gram is made tablet as stated above.All the other are with embodiment 1.
Claims (3)
1. slow-releasing concentrated common perilla seed oil tablet, it is characterized in that comprising following components in part by weight: Oleum Perillae (wherein α-linoleic acid＞60%) 50, clathrate β-CD cyclodextrin 2-10, slow releasing agent ethyl cellulose 5-10, excipient starch 10-15, antioxidant vitamin E or nor-hydrogen guaiaretic acid 0.05-0.15, correctives 0.05-0.1.
2. the method for making of Oleum Perillae tablet as claimed in claim 1 is characterized in that using earlier supercritical CO
2Method of extraction makes Oleum Perillae, by above-mentioned weight ratio each component is mixed, and makes the Oleum Perillae enclose, solidify, disperse, stable, with the screening of 0.9mm mesh screen, 60 ℃ dry down, restock 5-10 figuration Pulvis Talci, the screening of usefulness 3.6mm screen cloth, 60 ℃ are following dry 1 hour, the powder compression molding, 0.5-1 gram/sheet.
3. method for making as claimed in claim 2 is characterized in that described supercritical CO
2The parameter of extracting process is: 50 ℃ of extraction temperature, pressure 32-38MPa, separation temperature 40-50 ℃, pressure 6-11MPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00109891 CN1288735A (en) | 2000-07-12 | 2000-07-12 | Slow-releasing concentrated common perilla seed oil tablet and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00109891 CN1288735A (en) | 2000-07-12 | 2000-07-12 | Slow-releasing concentrated common perilla seed oil tablet and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1288735A true CN1288735A (en) | 2001-03-28 |
Family
ID=4579936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00109891 Pending CN1288735A (en) | 2000-07-12 | 2000-07-12 | Slow-releasing concentrated common perilla seed oil tablet and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1288735A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003086469A1 (en) * | 2002-03-19 | 2003-10-23 | Eco Animal Health Ltd | Ethyl cellulose-containing veterinary sustained release injection |
| WO2003102072A1 (en) * | 2002-05-30 | 2003-12-11 | Granate Seed Limited | Starch products involving a starch-lipid complex, their preparation and uses |
| CN105495590A (en) * | 2015-12-18 | 2016-04-20 | 华北制药秦皇岛有限公司 | Perilla frutescens kernel chewable tablet and preparation method thereof |
| CN113144667A (en) * | 2021-04-01 | 2021-07-23 | 深圳市通产丽星科技集团有限公司 | Purification method and purification system for post-consumer recycled plastic |
-
2000
- 2000-07-12 CN CN 00109891 patent/CN1288735A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003086469A1 (en) * | 2002-03-19 | 2003-10-23 | Eco Animal Health Ltd | Ethyl cellulose-containing veterinary sustained release injection |
| WO2003102072A1 (en) * | 2002-05-30 | 2003-12-11 | Granate Seed Limited | Starch products involving a starch-lipid complex, their preparation and uses |
| CN105495590A (en) * | 2015-12-18 | 2016-04-20 | 华北制药秦皇岛有限公司 | Perilla frutescens kernel chewable tablet and preparation method thereof |
| CN113144667A (en) * | 2021-04-01 | 2021-07-23 | 深圳市通产丽星科技集团有限公司 | Purification method and purification system for post-consumer recycled plastic |
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| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |