CN1287801C - Medicine composition for treating prostatitis - Google Patents
Medicine composition for treating prostatitis Download PDFInfo
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- CN1287801C CN1287801C CN 200410011185 CN200410011185A CN1287801C CN 1287801 C CN1287801 C CN 1287801C CN 200410011185 CN200410011185 CN 200410011185 CN 200410011185 A CN200410011185 A CN 200410011185A CN 1287801 C CN1287801 C CN 1287801C
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Abstract
The present invention relates to a medicinal composition for treating prostatitis, which belongs to the field of medicines. The active components of the following weight percent are 55 to 70% of resveratrol and 30 to 45% of icariin. The present invention can be prepared into preparations with one or a plurality of pharmaceutically acceptable carriers. The present invention is applied to treating prostatitis, and has the advantages of prostatitis virus resistance, accurate curative effect and no toxic side effect.
Description
Technical field
The present invention relates to the prostatitic medicine of a kind of treatment, be specially by the monomeric compound compound recipe and form.
Background technology
Resveratrol Resveratrol, chemical name: resvertrol (3 ', 4 ', 5-Trihydroxystlbene), molecular formula: C
14H
12O
3, molecular weight: 228.25, physicochemical property: tasteless, white powder, be dissolved in ethanol fully, resveratrol is a kind of polyphenol compound, and hormone-dependent tumor is had tangible preventive effect.Also can preventive effect be arranged, have antiviral and immunoregulation effect osteoporosis, acne and senile dementia.Resveratrol is a kind of free radical resisting, antioxidant, and associated function is as follows: 1, slow down aging; 2, stop the oxidation of low density lipoprotein, LDL, have the potential effect that prevents and treats cardiovascular disease; 3, influence lipid and arachidonic acid metabolic; 4, antithrombotic, antiplatelet aggregation; 5, antiinflammatory, anti-allergic effects.Resveratrol can be used as the particularly raw material of antitumor drug exploitation of health food and new drug development.
Icariin Icariin, CAS No.489-32-7, molecular formula C
33H
40O
15And molecular weight 456.7, icariin modern pharmacology experimentation shows: Herba Epimedii can increase the cardiovascular and cerebrovascular vessel blood flow, promote hemopoietic function, immunologic function and bone metabolism, have effects such as defying age, antitumor.
Summary of the invention
The object of the invention is to provide a kind of treatment prostatitic medicine.
The technical scheme that the present invention takes is: be made up of active substance as following weight percent:
Resveratrol 55%～70%
Icariin 30%～45%.
The present invention can be mixed with medicament with one or more pharmaceutically acceptable carriers or adjuvant.
Above-mentioned pharmaceutically acceptable carrier is meant the pharmaceutical carrier or the adjuvant of pharmaceutical field routine, for example: diluent, excipient and water etc., filler such as starch, dextrin, sucrose, mannitol, lactose, microcrystalline Cellulose etc.; Binding agent such as cellulose derivative, alginate, gelatin and polyethylene adjoin pyrrolidone; Wetting agent such as glycerol: disintegrating agent such as methyl starch sodium, hyprolose, cross-linked carboxymethyl cellulose, agar, calcium carbonate and sodium bicarbonate; Absorption enhancer such as quaternary ammonium compound; Surfactant such as hexadecanol, Tween 80, sodium lauryl sulphate; Alms bowl such as Kaolin and soap clay are carried in absorption; Lubricant such as Pulvis Talci, calcium stearate and magnesium, micropowder silica gel and Polyethylene Glycol etc.In medicament, can also contain other adjuvant such as flavouring agent, sweeting agent etc. in addition.
The medicament that the present invention makes can be applied to the patient by the mode of oral, rectum or parenteral.Be used for when oral, can be made into conventional solid preparation such as tablet, capsule, powder, granule etc., make other liquid preparation of liquid preparation such as water or oil-suspending agent such as syrup, mixture, elixir etc.; When being used for parenteral, can be made into solution, powder pin, water or the oiliness suspending agent etc. of injection.The preferred form of the present invention is tablet, coated tablet, capsule, granule, mixture and powder pin, injection.
The amount of application of the present invention and medicament thereof can be according to variations such as the type of route of administration, patient age, body weight, the disease of being treated and the orders of severity, and its daily dose can be 1mg/kg～600mg/kg body weight, preferred 5mg/kg～400mg/kg body weight.Can use by one or many.
The present invention is applied to treat prostatitis, not only has the resistance prostatitis virus function, and determined curative effect, has no side effect.
The specific embodiment
Further verify the present invention below by Pharmacodynamic test of active extract.
Experimental example 1: on Carrageenan causes the influence of rat prostate inflammation
1, test material
1.1 the healthy Wistar rat of experimental animal, body weight 130-140g and 280g-320g; Kunming mice, body weight 20-22g provides by zoopery portion of preclinical medicine institute of Jilin University.
1.2 the compound preparation that the pharmaceutical carrier of trial drug the present invention and pharmaceutical field routine is made, hereinafter to be referred as: the resveratrol compound preparation is provided by pharmaceutical college of Jilin University; XIAOZHILING ZHUSHEYE, Ji'an, Jilin Province pharmaceutical factory produces, lot number: 021210.
1.3 test apparatus: ES-60J electronic analytical balance (Longteng Electronic Weighing Instrument Co., Ltd., Shenyang)
2, test method and result
60 of extracting male Wistar rats, body weight 280-300g, be divided into 6 groups at random by body weight, it is the blank group, model group, positive controls (QIANLIEKANG PIAN 120mg/kg), the resveratrol compound preparation is big, in, small dose group (60mg/kg, 20mg/kg, 6mg/kg), gastric infusion, continuous 7 days, blank and model group give 0.5% sodium carboxymethyl cellulose of equal volume, 1h after the administration on the 6th undergos surgery under the aseptic condition behind the pentobarbital sodium intraperitoneal injection of anesthesia, and the seminal vesicle on the prostate head lobe only injects 1% carrageenin normal saline solution 0.1ml/, in postoperative 24h whole rat anesthesias are cut open the belly and respectively to get prostatic fluid 10ul, with the total white blood cells of microscopy unit volume prostatic fluid; Get 1 of prostatic fluid in addition, mirror is observed lecithin density down, according to lecithin density judged result at each.The results are shown in Table 1, contain a large amount of lecithin in the normal prostatic liquid, hugely during prostatitis have a liking for a large amount of lipids of cytophagy, make lecithin minimizing in the prostate, leukocyte count obviously increases, lecithin increase in the prostatic fluid after the administration, leukocyte count reduces, compare resveratrol compound preparation heavy dose and middle dosage with model group and can make leukocyte count minimizing (P＜0.05) in the prostatic fluid, lecithin increases (p＜0.01, P＜0.05).
Lecithin density grade scale, 4 grade lecithin corpusculums are intensive; 3 grade lecithin corpusculums are dispersed in; 2 grade lecithin corpusculums as seen; 1 grade lecithin corpusculum is accidental; 0 grade of no lecithin.
Table 1 resveratrol compound preparation on Carrageenan cause the rat prostate inflammation influence (x ± s, n=10)
| Group | Dosage (mg/kg) | The leukocyte number (individual/ul) | Lecithin density (level) |
| Agent in the white Herba chenopodii compound recipe of agent in big dose of white Herba chenopodii compound recipe of the blank white Herba chenopodii compound recipe of model resveratrol | — — 1200 60 20 6 | 197.4±88.9 3554.3±424.8 △ 2760.3±300.9 * 2651.2±406.9 * 2841.2±438 * 3266.7±478.1 | 3.4±0.52 1.4±0.70 △ 2.4±0.84 ** 2.5±0.53 ** 2.2±0.63 * 1.7±0.67 |
Compare with model group
*P＜0.05,
*Compare with the blank group p＜0.01
△P＜0.01
2 pairs of xiaozhiling injections of experimental example cause the prostatitic influence of rat chronic
1, test material
With experimental example 1.
2, test method and result
60 of extracting male Wistar rats, body weight 300-320g, behind the pentobarbital sodium intraperitoneal injection of anesthesia, aseptic condition hypogastric region median incision, through abdominal cavity proposes bladder and both sides seminal vesicle, exposure invests the prostate notopodium of seminal vesicle inboard, only inject 25% XIAOZHILING ZHUSHEYE 0.2ml/, blank group is injected the normal saline of equal volume, suture muscles, skin.Postoperative was divided into 6 groups on the 7th day at random, be the blank group, model group, positive controls (resveratrol 20mg/kg), the large, medium and small dosage group of resveratrol compound preparation (60mg/kg, 20mg/kg, 6mg/kg), administration was put to death after 30 days, cutd open immediately to get prostata tissue and weigh, and fixed with 10% formalin, conventional dehydration, section, HE dyeing, optical microscope is observed the prostata tissue morphological change down.
The chronic prostatitis lesion degree table of integrals
| The inflammatory cell infiltration degree | The fibroblast hypertrophy |
| 0 inflammatory cell does not see that accidental 2 inflammatory cells of 1 inflammatory cell are kitchen range family shape 3 inflammatory cell strips 4 adenomatosis, inflammatory cell lumps | 0 does not see the big lamellar of focal shape 3 fibroblast lamellars, 4 fibroblasts of visible 2 fibroblasts of fibroblast 1 fibroblast |
According to above inflammatory cell infiltration degree judged result, have or not the significance difference with t check comparison administration group and matched group.The results are shown in Table 2.Compare with the blank group, the prostata tissue weight in wet base obviously increases weight after the rat modeling, and the weight of prostate index obviously increases, and inflammatory cell infiltration and fibroblast hyperplasia degree integration obviously increase (p＜0.01) and show the model establishment; After heavy dose of group of resveratrol compound preparation and the administration of middle dosage group, prostata tissue weight in wet base and weight of prostate index all have (p＜0.01 that reduces in various degree, P＜0.05), heavy dose of group inflammatory cell infiltration and fibroblast hyperplasia degree also reduce (p＜0.01, P＜0.05), effect is suitable with positive drug QIANLIEKANG PIAN group, the middle dosage group cellular infiltration degree (p＜0.01) that also can reduce inflammation.As seen the resveratrol compound recipe has Chinese People's Anti-Japanese Military and Political College's Mus chronic prostatitis effect.
Table 2 resveratrol compound preparation to the prostatitic influence of rat chronic (x ± s, n=10)
| Group | Dosage mg/kg | Prostate weight in wet base mg | Prostate exponent m g/g | The inflammatory cell infiltration degree | The fibroblast hyperplasia degree |
| The white Herba chenopodii compound recipe of agent is little dose in big dose of white Herba chenopodii compound recipe of the normal control model contrast white Herba chenopodii compound recipe of QIANLIEKANG PIAN | — — 1200 60 20 6 | 7.1±0.24 8.26±0.64 △ 7.10±0.79 ** 7.7±0.42 * 7.85±0.42 8.00±0.70 | 2.01±0.09 2.65±0.25 △ 2.08±0.33 ** 2.17±0.12 ** 2.4±0.18 * 2.45±0.22 | 0 3.1±0.57 △ 1.7±0.48 ** 1.6±0.52 ** 2.1±0.74 ** 2.7±0.95 | 0 2.5±0.85 △ 1.8±0.63 * 1.7±0.67 * 2.0±0.67 2.3±0.82 |
Compare with model group
*P＜0.01,
*Compare with blank group p＜0.05
△P＜0.01
Experimental example 3 xylol cause the influence of mice ear
1, test material
With experimental example 1.
2, test method and result
Get 40 body weight 20-22g of male mice, be divided into 5 groups at random, be blank group carboxymethyl cellulose (0.5%), positive controls (resveratrol 230mg/kg), the large, medium and small dosage group of resveratrol compound preparation (80mg/kg, 20mg/kg, 5mg/kg).Gastric infusion is 3 days continuously, under etherization 100% dimethylbenzene 0.2ml is evenly coated in two sides, ear front and back, a mice left side behind the last administration 45min, and auris dextra compares.Put to death 1.5 after hour mice taken off neck, cut two ears, lay round auricle at the same position of left and right sides ear respectively, weigh with the 9mm diameter device that fans the air along the auricle baseline.Left auricle weight with every Mus deducts auris dextra sheet weight difference value representation inflammatory swelling degree.And t check between matched group work group.Table 3 result as seen, the big or middle dosage group of resveratrol compound preparation swelling degree obviously reduces (p＜0.01, P＜0.05) than the blank group, suppression ratio is respectively 59.09% and 55.96%.The resveratrol compound preparation has significantly anti-acutely inflamed effect.
The white Herba chenopodii compound preparation of table 3 to the influence of mice ear (x ± s, n=8)
| Group | Dosage (mg/kg) | The swelling degree | Suppression ratio (%) |
| Agent in the white Herba chenopodii compound recipe of agent in big dose of white Herba chenopodii compound recipe of the white Herba chenopodii compound recipe of model resveratrol | — 230 80 20 | 0.0076±0.0037 0.003±0.0028 * 0.003±0.0024 ** 0.0035±0.0017 * 0.0051±0.0013 | — 61.76 60.09 53.97 32.95 |
Compare * p＜0.05, * * p＜0.01 with model group
4 pairs of ovalbumins of experimental example cause the influence of rat paw edema
1, test material
With experimental example 1.
2, test method and result
Get 40 of male rats, body weight 120-140g is divided into 5 groups at random, i.e. blank group carboxymethyl cellulose (0.5%), resveratrol group 250mg/kg, the large, medium and small dosage group of resveratrol compound preparation (60mg/kg, 20mg/kg, 6mg/kg).Gastric infusion is 3 days continuously, behind the last administration 45min at the rat right hind leg foot sole of the foot freshly prepared Ovum Gallus domesticus album of subcutaneous injection 0.1ml (10%), in injecting back 30min and 1h, 2h, 3h, 4h, 5h, 6h with moccasin chi measurement ankle girth, calculate the swelling degree, and t check between matched group work group.Causing scorching back 1-5h from the heavy dose of group of the visible resveratrol compound preparation of table 4 as a result, middle dosage group relatively has notable difference (P＜0.05) causing scorching back 2-4h paw swelling and blank group, and the resveratrol compound preparation has tangible antiinflammatory action.
The white Herba chenopodii compound preparation of table 4 to the influence (swelling degree) of rat paw edema (x ± s, n=8)
| Group | Dosage (mg/kg) | Cause scorching back swelling degree | ||||||
| 30min | 1h | 2h | 3h | 4h | 5h | 6h | ||
| The white Herba chenopodii compound recipe of agent is little dose in big dose of white Herba chenopodii compound recipe of the white Herba chenopodii compound recipe of model resveratrol | — 160 60 20 6 | 3.44±2.01 1.35±1.14 * 1.84±0.80 1.75±0.73 1.95±1.45 | 4.06±1.99 1.8±1.12 * 2.11±0.92 * 2.22±1.15 2.88±1.29 | 4.83±2.60 1.97±1.09 * 2.38±1.06 * 2.06±0.93 * 3.68±1.34 | 4.41±2.42 1.65±1.09 * 2.19±1.20 * 1.53±0.81 * 3.93±1.13 | 3.49±1.92 1.18±1.02 *1.44±0.96 *1.57±0.95 *2.72±1.08 | 2.39±1.38 0.88±0.64 * 0.74±0.55 * 1.17±0.58 1.8±0.97 | 1.53±1.39 0.92±0.6 0.63±0.53 0.99±0.48 0.67±0.70 |
Compare with model group
*P＜0.05
5 pairs of bullate influences of rat granuloma of experimental example
1, test material
With experimental example 1.
2, test method and result
Get 40 body weight 120-140g of male rat, be divided into 5 groups (grouping and dosage are with tests 2.4) at random, in the abdominal part cropping, sterilize after the chloral hydrate anesthesia; Cut a 0.5cm osculum, free skin is to oxter, the left and right sides, and implants 50 ± 1mg sterilization cotton balls respectively, begins gastric infusion the same day, once a day, continuous 7 days, opened former otch on the 8th day, cotton balls and perivascular granulation tissue are stripped out together, 70 ℃ of oven dry are weighed.Deducting cotton balls weight with this weight promptly is granulomatous weight, and t check between matched group work group, and calculates suppression ratio.The big or middle dosage group of resveratrol compound preparation granuloma weight is significantly less than blank group (p＜0.01, P＜0.05) as seen from Table 5, and suppression ratio is respectively 35.65% and 32.4%.The resveratrol compound preparation has tangible anti-chronic inflammatory disease effect.
The white Herba chenopodii compound preparation of table 5 to the bullate influence of rat granuloma (x ± s, n=8)
| Group | Dosage (mg/kg) | Granuloma induced by implantation of cotton pellets heavy (g/100g body weight) | Suppression ratio (%) |
| The white Herba chenopodii compound recipe of agent is little dose in big dose of white Herba chenopodii compound recipe of the white Herba chenopodii compound recipe of model resveratrol | — 160 60 20 6 | 0.0952±0.0257 0.0619±0.0079 * 0.0601±0.0072 ** 0.0643±0.0119 * 0.081±0.087 | — 34.94 35.65 32.4 13.38 |
Compare with model group
*P＜0.05,
*P＜0.01
The influence of 6 pairs of mice hot plate tests of experimental example
1, test material is with experimental example 1.
2, test method and result get 40 of female mices, body weight 18-20g, be divided at random 5 groups (grouping and dosage are with tests 2.3) behind gastric infusions with stopwatch record mice after dropping into hot plate to the pain threshold of the time that metapedes occurs licking (s) as this Mus.Reject pain threshold less than 5s, greater than 60s or the mice of hopping response occurs.Pain threshold after the record administration when 15min, 30min, 60min, 90min, 120min surpasses 60s as the threshold of pain, by 60s.Calculate the threshold of pain and improve percentage rate, and the comparable group differences.The results are shown in Table the heavy dose of group of 6 visible resveratrol compound preparations 30min, 60min, 90min, 120min after administration, the resveratrol group is 60min, 90min, 120min after administration, dosage group 90min, 120min after administration in the resveratrol compound preparation, small dose group is 120min after administration, and obviously improve than the blank group threshold of pain.As seen the resveratrol compound preparation has significant analgesia role.
Table 6 resveratrol compound preparation to the influence of mice hot plate test (x ± s, n=8)
| Group | Dosage (mg/kg) | Pain territory (s) before the administration | Pain territory (s) after the administration | ||||
| 15min | 30min | 60min | 90min | 120min | |||
| The white Herba chenopodii compound recipe of agent is little dose in big dose of white Herba chenopodii compound recipe of the white Herba chenopodii compound recipe of model resveratrol | — 230 80 20 5 | 20.72±13.61 16.71±7.23 20.53±7.45 19.38±7.49 17.81±6.38 | 25.36±18.13 20.74±17.36 33.26±17.81 20.01±6.07 19.84±4.70 | 16.98±11.61 20.95±11.49 45.07±14.79 ** 25.68±15.57 22.91±8.50 | 21.42±15.73 41.99±19.56 * 43.49±18.34 * 28.56±13.64 25.18±18.83 | 19.78±9.06 42.13±19.83 *51.31±15.71 **38.52±16.67 *30.61±8.65 * | 15.3±7.43 41.39±3.95 * 51.88±12.82 ** 42.22±15.71 * 38.1±14.25 ** |
Compare with model group
*P＜0.05
*P＜0.01
The influence of 7 pairs of mouse writhing reactions of experimental example
1, test material
With experimental example 1.
2, test method and result
Get 40 of mices, male and female half and half, body weight 18-20g is divided into 5 groups (grouping and dosage are with tests 2.3) at random.30 minutes pneumoretroperitoneums of gastric infusion are injected 1% acetic acid 0.2ml, and every mice turns round the body number of times, and t check between matched group work group, and calculate the analgesia percentage rate in back 20 minutes of the numeration injection.The results are shown in Table 7, resveratrol group and the large, medium and small dosage group of resveratrol compound preparation mouse writhing number of times obviously reduce (P＜0.05), and visible resveratrol compound preparation has significant analgesia role.
The influence that table 7 resveratrol compound preparation reacts mouse writhing (x ± s, n=8)
| Group | Dosage (mg/kg) | Turn round the body number of times | Suppression ratio (%) |
| The white Herba chenopodii compound recipe of agent is little dose in big dose of white Herba chenopodii compound recipe of the white Herba chenopodii compound recipe of model resveratrol | — 230 80 20 5 | 71.5±12.02 11.13±15.85 * 38.2±15.32 * 40±7.8 * 45.7±15.13 * | — 84.44 46.64 44.13 36.17 |
Compare with model group
*P＜0.01
Observe resveratrol compound preparation on Carrageenan and cause the antiinflammatory action that rat aseptic prostatitis and XIAOZHILING ZHUSHEYE cause rat aseptic chronic prostatitis.Observe resveratrol compound preparation xylol and cause mice ear, ovalbumin causes the influence of rat paw edema acute inflammation and the swollen chronic inflammatory disease of rat granuloma.Observe of the influence of resveratrol compound preparation to mice hot plate test and mouse writhing test.Trial drug divides three dosage groups, and the rat dosage is heavy dose of (60mg/kg), middle dosage group (20mg/kg), and small dose group (6mg/kg) is equivalent to Resveratrol content and is respectively 30mg/kg, 10mg/kg, 3mg/kg; The mice dosage is heavy dose of (80mg/kg), middle dosage group (20mg/kg), small dose group (5mg/kg), be equivalent to Resveratrol content and be respectively 40mg/kg, 10mg/kg, 2.5mg/kg, the prescription proportioning is resveratrol: icariin=(55-70): (30-45).Establishing positive controls in Chinese People's Anti-Japanese Military and Political College's Mus prostatitis test is QIANLIEKANG PIAN (1.2g/kg), and establishing positive controls in anti-general inflammation and the analgesic test is resveratrol (rat 160mg/kg, mice 230mg/kg).Result of the test shows: cause in the test of rat aseptic prostatitis at carrageenin, resveratrol compound preparation heavy dose (60mg/kg) and middle dosage (20mg/kg) can make leukocyte count minimizing (P＜0.05) in the prostatic fluid, lecithin increases (p＜0.01, P＜0.05); Cause in the test of rat aseptic chronic prostatitis in XIAOZHILING ZHUSHEYE, the prostata tissue weight that resveratrol compound preparation heavy dose (60mg/kg) can suppress aseptic chronic prostatitis rat increases (P＜0.05), heavy dose of (60mg/kg), in dosage (20mg/kg) can alleviate inflammatory cell infiltration degree (p＜0.01) in the prostata tissue of aseptic chronic prostatitis rat, heavy dose of (60mg/kg) can suppress fibroblast hypertrophy (P＜0.05); In anti-mice caused by dimethylbenzene xylene ear swelling test, resveratrol compound preparation heavy dose and middle dosage can suppress the Mice Auricle inflammatory swelling (p＜0.01, P＜0.05) that dimethylbenzene causes; Cause in the swollen test of rat foot at anti-ovalbumin, resveratrol compound preparation heavy dose and middle dosage can suppress to cause the paw swelling (P＜0.05) of scorching back 1-5h and 2-4h respectively; Resveratrol compound preparation heavy dose and middle dosage can alleviate granuloma weight (p＜0.01, P＜0.05) in Chinese People's Anti-Japanese Military and Political College's Mus granuloma induced by implantation of cotton pellets test; In the mice hot plate test, resveratrol compound preparation heavy dose and middle dosage can improve the mice threshold of pain (p＜0.01, P＜0.05); In the mouse writhing test, resveratrol compound preparation heavy dose, middle dosage and low dose all can reduce mouse writhing number of times (P＜0.05).Conclusion resveratrol compound preparation has the resistance prostatitis effect, and has inhibition inflammation in late period morning and analgesic activity.
Embodiment 1
Contain following active component:
Resveratrol 550g
Icariin 450g
Embodiment 2
Contain following active component:
Resveratrol 650g
Icariin 350g
Embodiment 3
Contain following active component:
Resveratrol 700g
Icariin 300g
Embodiment 4
Resveratrol and icariin compositions 600g among the embodiment 1
Dextrin 350g
Sodium carboxymethyl cellulose 50g
Magnesium stearate 15g
With resveratrol among the embodiment 1 and icariin compositions, dextrin, sodium carboxymethyl cellulose, magnesium stearate mix homogeneously, cross 80 mesh sieves, with dry granulation mechanism grain,, irritate in capsule, promptly with 60 mesh sieve granulate.
Claims (2)
1, the prostatitic pharmaceutical composition of a kind of treatment is characterized in that: be made up of active component as following weight percent:
Resveratrol 55%～70%
Icariin 30%～45%.
2, the prostatitic pharmaceutical composition of a kind of treatment according to claim 1 is characterized in that: can be mixed with medicament with one or more pharmaceutically acceptable carriers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410011185 CN1287801C (en) | 2004-10-29 | 2004-10-29 | Medicine composition for treating prostatitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410011185 CN1287801C (en) | 2004-10-29 | 2004-10-29 | Medicine composition for treating prostatitis |
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| CN1628687A CN1628687A (en) | 2005-06-22 |
| CN1287801C true CN1287801C (en) | 2006-12-06 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958310A (en) * | 2015-05-22 | 2015-10-07 | 大连大学 | Sirt1 activating agent and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108452311A (en) * | 2012-11-13 | 2018-08-28 | 纽斯尔特科学公司 | Composition for enhancing energetic supersession and method |
| CN107518398A (en) * | 2017-07-05 | 2017-12-29 | 上海拜汶医药科技有限公司 | A kind of nutrient protected and improve male prostate function |
| CN107822135A (en) * | 2017-09-01 | 2018-03-23 | 上海拜汶医药科技有限公司 | A kind of preparation method for the nutrient protected and improve male prostate function |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958310A (en) * | 2015-05-22 | 2015-10-07 | 大连大学 | Sirt1 activating agent and application thereof |
| CN104958310B (en) * | 2015-05-22 | 2018-09-25 | 大连大学 | Sirt1 activator and its application |
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