CN1286068C - Bionic stent generating method based on CT picture - Google Patents
Bionic stent generating method based on CT picture Download PDFInfo
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- CN1286068C CN1286068C CN 200410067533 CN200410067533A CN1286068C CN 1286068 C CN1286068 C CN 1286068C CN 200410067533 CN200410067533 CN 200410067533 CN 200410067533 A CN200410067533 A CN 200410067533A CN 1286068 C CN1286068 C CN 1286068C
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Abstract
The present invention relates to a bionic bracket generating method based on a CT picture, which comprises the following steps: converting CT image data provided by a hospital to a three-dimensional model; constructing a three-dimensional model of a defective region in view of the defective region of a bone tissue; finally, establishing a geometric descriptive model with an anisotropic porous structure according to requirements of the tissue engineering. Thereby, a three-dimensional bionic bracket model which has an interior microscopic structure, is suitable for bone seed cell growth and is used for defection repair of the used for is produced.
Description
Technical field:
This patent relates to the bionic stent generating method that is used for the bone tissue defect repair in the human tissue engineering field.Particularly a kind of bionic stent generating method based on the CT image.
Background technology:
At the CT view data that medically extensively adopts, external existing report can be converted into three-dimensional model, and be rendered as the character of different pixels gray scale for different tissues and pathology according to the CT image, can observe, judge, analyze, locate various tissues or lesion locations, this only is on the macroeconomic significance, and promptly have the modeling method of the three-dimensional bionic support model of interior microscopic porous structure for the bionical medical science model of microcosmic, still there is not report at present.In addition on the one hand, for the damaged reparation of bone tissue, its required biomimetic scaffolds model can only be to obtain by craft and physico-chemical method methods such as (be fiber bonding, gas foaming, particulate) separating out, be separated at present.The fiber bonding technology is to utilize the mode of thermal treatment or solution bonding fibrous nonwoven webs thing to form three-dimensional porous rack; The gas foaming technology is to utilize high-pressure carbon dioxide and gas pore-foaming agent to prepare the porous biomimetic scaffolds; Phase detachment technique is that to form polymkeric substance in polymer solution mutually rich and stingy, by modes such as distillation remove polymkeric substance stingy after, can obtain the polymer support of porous; Solution-cast/particle drop is analysed technology by pore-foaming agent and degradation material are mixed, and is cast to the mould molding with outer shape feature, and by the method for solution dissolving, dissolving pore-foaming agent wherein obtains porous support then.
The method for making of above-mentioned biomimetic scaffolds can not accomplish on macrostructure and the fitting like a glove of bone tissue defect, and be subjected to material and Effect of Environmental that on micromechanism the internal capillary of generation is uncontrollable.
Summary of the invention:
The object of the invention is to provide a kind of bionic stent generating method based on the CT image, can utilize the method and the existing computer software of Computer Aided Modeling, set up heterogeneous body porous structure geometric description model, thereby generation has bone seeding cell internal microstructure, suitable three-dimensional bionic support model that grow, that be used for the bone tissue defect repair.
For achieving the above object, design of the present invention is: the method for utilizing Computer Aided Modeling, be three-dimensional model with the CT image transitions at first, at the defect of bone tissue, the theory of biomimetic scaffolds and the bionical modeling method of method and bone tissue are set up in research then.
By analysis to the medicine CT data, the modeling method of medical science model three-dimensional CAD is proposed, realize the conversion of CT scan image data, employing is based on the theory of bionical manufacturing and organizational project, defect at bone tissue, the theory of biomimetic scaffolds and the bionical modeling method of method and bone tissue are set up in research, set up heterogeneous body porous structure set description model, thereby generate the three-dimensional bionic support model that is used for the bone tissue defect repair with internal microstructure.
According to above-mentioned design, the present invention adopts following technical proposals:
A kind of bionic stent generating method based on the CT image, the CT view data is being converted on the basis of three-dimensional model, defect at bone tissue, construct the three-dimensional model of this defect, last requirement according to organizational project, set up heterogeneous body porous structure geometric description model, thereby generation has bone seeding cell internal microstructure, suitable three-dimensional bionic support model that grow, that be used for the bone tissue defect repair; The step of concrete modeling method is:
1) extract the patient CT data that provided by hospital, the CT data must meet dicom standard;
2) the CT data are converted to three-dimensional model, the method that the CT data is converted to three-dimensional model is: utilize image pre-service, image segmentation, rim detection and configuration sampling and the abstraction function of computing machine medical software, the CT data are converted to three-dimensional model;
3) at the defect of bone tissue, construct the three-dimensional model of this defect, the modeling method of structure bone tissue defect three-dimensional model: utilize image pre-service, image segmentation, rim detection and configuration sampling and the abstraction function of computing machine medical software, the CT data are converted to three-dimensional model;
4) on the basis of bone tissue defect three-dimensional model, the building method of constructing the biomimetic scaffolds model of the biomimetic scaffolds model interior microscopic porous structure with interior microscopic porous structure is: according to the defect three-dimensional model, set up diameter and be respectively 0.3mm, 0.4mm, 0.5mm, the degree of depth is greater than this defect model largest contours size, three mutually orthogonal cylindrical holes, respectively these three cylindrical holes are gone out the space by the planar array method construct then and be respectively 0.35mm, 0.45mm, 0.55mm array hole, these array holes must travel through whole defect three-dimensional model; Resulting model promptly has the suitable of interior microscopic porous structure
Close the biomimetic scaffolds model that is used for the bone tissue defect repair of bone seeding cell growth.
The function of above-mentioned computer aided design software comprises: when defect is symmetrical, then adopt mirror method; When defect near the rule, promptly cylindrical, conical, spherical, then adopt the voxel method; And need carry out entity also, friendship, difference operation, adopt boolean operation method.
Above-mentioned computing machine medical software adopts Mimics 7.30 medical softwares; Described computer graphical process software adopts Magics 7.1 PaintShops; Described computer model is rebuild software and is adopted Imageware 10.0 Model Reconstruction softwares; Described computer aided design software adopts UG NX 2 computer aided design softwares.
The present invention compared with prior art, have following conspicuous outstanding substantive distinguishing features and marked improvement: the present invention has adopted the method and the existing computer software of Computer Aided Modeling, set up the three-dimensional model of bone tissue defect, again according to the requirement of organizational project, set up heterogeneous body porous structure geometric description model, three-dimensional bionic support model by its generation has internal microstructure, is suitable for the bone seeding cell growth, is applicable to the reparation that bone tissue is damaged.
Description of drawings:
Fig. 1 is based on the bionic stent generating method FB(flow block) of CT image.
Fig. 2 is patient's head CT data plot image pattern that one embodiment of the invention is used.
Fig. 3 is the three-dimensional model diagram of patient's head shown in Figure 2.
Fig. 4 is the defect three-dimensional model diagram by the foundation of CAD method of patient's head shown in Figure 2.
Fig. 5 is the independently defect three-dimensional model diagram shown in Fig. 4.
Fig. 6 is the biomimetic scaffolds illustraton of model of independent defect shown in Figure 5.
Embodiment:
Details are as follows for a preferred embodiment of the present invention: present embodiment is according to what hospital provided the damaged patient's head CT view data of bone tissue to be arranged, and obtains to have the defect biomimetic scaffolds model of internal microcellular structure by Computer Processing.Its method is: according to patient's Bone CT image, at first convert thereof into three-dimensional skeleton model, set up the three-dimensional model of bone tissue defect afterwards by this skeleton model, structure has the biomimetic scaffolds model of the suitable bone seeding cell growth of interior microscopic porous structure then.
Referring to Fig. 1, the step of this method is:
(1) at first obtains the patient CT data that meet dicom standard that provide by hospital;
(2) by the functions such as image pre-service, image segmentation, rim detection, configuration sampling and extraction of Mimics software, patient CT data are analyzed and handled, and be converted to three-dimensional model;
(3) according to the form of the bone tissue defect in patient's three-dimensional model, by the Computer Aided Modeling method of softwares such as Magics, Imageware and UG NX, promptly mirror method, voxel method and boolean operation method etc. are set up the three-dimensional model of bone tissue defect;
(4) according to the defect three-dimensional model, set up diameter and be respectively 0.3mm, 0.4mm, 0.5mm, the degree of depth greater than this defect model largest contours size, mutually orthogonal three cylindrical holes, respectively these three cylindrical holes are gone out the array hole that the space is respectively 0.35mm, 0.45mm, 0.55mm by the planar array method construct then, these array holes must travel through whole defect three-dimensional model; What obtain at last is exactly to have the biomimetic scaffolds model that is used for the bone tissue defect repair of growing for intercommunicated suitable bone seeding cell between interior microscopic porous structure, each hole.
The concrete operations step is as follows:
(1) provide head that the damaged patient's head CT view data (referring to Fig. 2) of bone tissue is arranged by hospital by internet channels such as medium CD or FTP, file layout meets dicom standard;
(2) modeling methods such as the pre-service of machine image, image segmentation, rim detection, configuration sampling and extraction are converted to three-dimensional model (referring to Fig. 3) with the CT data as calculated, and concrete operations are:
I. in Mimics software, choice menus File → Import Images in the dialog box that occurs, chooses the CT view data that will change, selects Add Auto, presses the Convert option then, and data are read in; And select Open in Mimics, the image data that reads in is opened;
Ii. choice menus Segmentation → Calculate 3D in the dialog box that occurs, chooses the image data of opening under the Mask option, presses the Calculate option then, calculates three-dimensional model;
Iii. select File → CTM, in the dialog box that occurs, under the Name option, choose three-dimensional modeling data, select Add again, press Next option and Finish option then, the STL form of output three-dimensional model;
(3) the bone tissue defect in patient's head three-dimensional model is set up defect three-dimensional model (referring to Fig. 4) by mirror method, voxel method and boolean operation method etc., concrete operations are:
I. in Magics7.1 software, choice menus File → Load Part opens the three-dimensional model file of the STL form of previous step output;
Ii. choice menus Edit → Mirror in the dialog box that occurs, selects YZ-Plane as imaging plane, and chooses Create Copy and Center of Part option, presses OK then, is about to the complete side mirror of skull and looks like to copy to a damaged side;
Iii. choice menus Tools → Cut ﹠amp; Punch in the dialog box that occurs, selects the Indicate option, selects the mirror-image copies part (scope of circle choosing, shape outline are less than damaged part) at damaged place then with the cursor circle, simultaneously at Cut﹠amp; In the Punch dialog box, choose the Round option, and its Radius is set to 10mm, presses the Cut option at last, so just obtained required defect three-dimensional model (STL form);
Iv. choice menus File → Export → Point Cloud converts the defect three-dimensional model of STL form to point cloud format, so that Imageware software reads;
V. open Imageware software, choice menus File → Open, the defect model file of the point cloud format of previous step output is opened, method according to three-dimensional reconstruction, by menu Construct → CurveFrom Cloud → Fit Curve curve construction, by menu Construct → Surface FromCloud → Uniform Surface constructing curve;
Vi. choice menus File → Save As, the defect three-dimensional model curved surface that structure is good saves as the file of IGES form, so that UG NX software reads;
Vii. open UG NX software, choice menus File → New, a newly-built file, choice menus File → Import → IGES then, the defect three-dimensional model curved surface file that the input previous step is preserved, select Application → Modeling, enter modeling environment, select Insert → Feature Operation → Sew, three curved surfaces choosing model then respectively are (promptly, side and following), it is stitched into an entity, and its seamed edge carried out rounding, chamfering radius is 0.5mm, at last this model is independently saved as a file (referring to Fig. 5), is convenient to subsequent operation;
(4) the patient's head defect three-dimensional model that obtains according to previous step, set up diameter and be respectively 0.3mm, 0.4mm, 0.5mm, the degree of depth greater than this defect model largest contours size, mutually orthogonal three cylindrical holes, respectively these three cylindrical holes are gone out the array hole that the space is respectively 0.35mm, 0.45mm, 0.55mm by the planar array method construct then, these array holes must travel through whole defect three-dimensional model, and concrete operations are:
I. choice menus Insert → Form Feature → Datum CSYS, make up a user coordinate system and three mutually orthogonal auxiliary surfaces, they are respectively XY face (being positioned at the bottom surface of model), YZ face (being positioned at the left surface of model) and ZX face (being positioned at the positive front of model), and each face and model are no more than 2mm at interval;
Ii. choice menus Insert → Form Feature → Hole punches on three mutually orthogonal auxiliary surfaces respectively, and the aperture is respectively 0.3mm, 0.4mm, 0.5mm, and the degree of depth is 100mm, and model must be passed in the center, hole;
Iii. choice menus Insert → Feature Operation → Instance → Rectangular Array, the hole that previous step is generated is at the level and the vertical direction array of auxiliary surface separately respectively, array spacings is respectively 0.35mm, 0.45mm, 0.55mm, and the final array hole that generates must travel through whole defect three-dimensional model;
What (5) obtain at last is exactly to have to be intercommunicated patient's head defect biomimetic scaffolds model (referring to Fig. 6) between interior microscopic porous structure, each hole.
Claims (3)
1. bionic stent generating method based on the CT image, the CT view data is being converted on the basis of three-dimensional model, defect at bone tissue, construct the three-dimensional model of this defect, last requirement according to organizational project, set up heterogeneous body porous structure geometric description model, thereby generation has bone seeding cell internal microstructure, suitable three-dimensional bionic support model that grow, that be used for the bone tissue defect repair; The step that it is characterized in that concrete modeling method is:
1) extract the patient CT data that provided by hospital, patient CT data must meet dicom standard;
2) the CT data are converted to three-dimensional model, the method that the CT data is converted to three-dimensional model is: utilize image pre-service, image segmentation, rim detection and configuration sampling and the abstraction function of computing machine medical software, the CT data are converted to three-dimensional model;
3) at the defect of bone tissue, construct the three-dimensional model of this defect, the modeling method of the three-dimensional model of structure bone tissue defect is: utilize computer graphical process software, computer model to rebuild software and computer aided design software, set up the three-dimensional model of bone tissue defect;
4) on the basis of bone tissue defect three-dimensional model, structure has the biomimetic scaffolds model of interior microscopic porous structure, the building method of the biomimetic scaffolds model of interior microscopic porous structure is: according to the defect three-dimensional model, set up diameter and be respectively 0.3mm, 0.4mm, 0.5mm, the degree of depth is greater than this defect model largest contours size, three mutually orthogonal cylindrical holes, respectively these three cylindrical holes are gone out the space by the planar array method construct then and be respectively 0.35mm, 0.45mm, 0.55mm array hole, these array holes must travel through whole defect three-dimensional model; Resulting model promptly has the biomimetic scaffolds model that is used for the bone tissue defect repair of the suitable bone seeding cell growth of interior microscopic porous structure.
2. the described bionic stent generating method based on the CT image of claim 1 is characterized in that comprising the function of computer aided design software: when defect is symmetrical, then adopt mirror method; When defect near the rule, promptly cylindrical, conical, spherical, then adopt the voxel method; And need carry out entity also, friendship, difference operation, then adopt boolean operation method.
3. the bionic stent generating method based on the CT image according to claim 1 and 2 is characterized in that described computing machine medical software adopts Mimics 7.30 medical softwares; Described computer graphical process software adopts Magics 7.1 PaintShops; Described computer model is rebuild software and is adopted Imageware 10.0 Model Reconstruction softwares; Described computer aided design software adopts UG NX 2 computer aided design softwares.
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| CN102716512A (en) * | 2012-06-29 | 2012-10-10 | 上海大学 | Method for preparing medicine graded sustained-release bone repair body |
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| CN109966026B (en) * | 2019-04-10 | 2020-09-18 | 重庆大学 | Preparation method of functional gradient artificial bone scaffold based on curve interference |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102716512A (en) * | 2012-06-29 | 2012-10-10 | 上海大学 | Method for preparing medicine graded sustained-release bone repair body |
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