CN1280839A - Chinese-medicinal nose drops for treating acute or chronic rhinitis and its preparing process - Google Patents
Chinese-medicinal nose drops for treating acute or chronic rhinitis and its preparing process Download PDFInfo
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- CN1280839A CN1280839A CN 00114651 CN00114651A CN1280839A CN 1280839 A CN1280839 A CN 1280839A CN 00114651 CN00114651 CN 00114651 CN 00114651 A CN00114651 A CN 00114651A CN 1280839 A CN1280839 A CN 1280839A
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Abstract
A Chinese-medicinal nasal drops for treating acute and chronic rhinitis and nasosinusitis is prepared from 9 Chinese medicinal materials including magnolia flower, herba ephedrae, xanthium fruit, scutellaria root, astragalus root, etc.. It can obviously converge nasal cavity mucose and reduce its gland secretion, and inhibit the bacterial growth and resist the effect of histamine.
Description
The present invention relates to that a kind of what treat nose diseases is the Chinese medicine preparation and the processing method of primary raw material with the Chinese herbal medicine, specifically refer to Chinese medicine nasal drop for the treatment of acute or chronic rhinitis, sinusitis and preparation method thereof.
Acute and chronic rhinitis, sinusitis are the higher commonly encountered diseases of a kind of sickness rate.The early stage nasal mucosa of acute rhinitis is its property inflammation of card, and mucosa vasodilation, hyperemia, swelling, glandular secretion are vigorous, leukocyte and lymphocytic infiltration in the mucosa, secretions increase is mucus, becomes purulence soon, fibre function is weakened, the swelling of hole mouth, drain is obstructed.If in time handle, inflammation is disappeared at acute inflammation stage, unobstructed and complete the healing of drain with antibiotic medicine and vasoconstrictor.Chronic rhinitis, sinusitis patient's nasal mucosa deep artery is chronic expansion state, lose contractile function, the concha nasalis inferior spongy tissue also is chronic expansion, it is main inflammatory infiltration that lymphocyte and plasma cell are arranged around blood vessel and the body of gland, and the mucous gland function is active, secretions increase, the proper mucous membrane edema, in inflammatory process, infect for seeing with the purulence coccus more, it is the longest that what see is streptococcus, staphylococcus, Diplococcus pneumoniae, hemophilus influenza.Common clinically to acute and chronic rhinitis, sinusitis in be mingled with the allergy factor.In general on the inflammation basis, the allergen that source of disease microorganism itself and metabolite thereof or inflammation product can become nasal mucosa stimulates, and cause allergy, and allergic appearance can encourage inflammation conversely, makes the complicated or protracted course of disease of inflammation.Main Therapeutic Method to this disease has block therapy, liquid medicine injection under the concha nasalis inferior mucosa, nasal drop, laser cryotherapy and inferior turbinectomy etc. at present.The rhinitis medicine that wherein Drug therapy adopted roughly has, BIYANKANG tablet, HUODAN WAN pill, Nasivin, BIGENZHI spray, nasal drop nasal drop.Above-mentioned existing various treatment of rhinitis medicines all to a certain degree effective in cure to rhinitis, but exist some shortcomings, as oral medicine tablet, pill need be through the circulation of whole body, it is less to arrive the partial dose of nose, and is subjected to certain influence because of curative effect; And as directly being administered to the partial medicament of nose such as spray and nasal drop etc., after one week of medication, because of the vasodilation of inducing reaction property of local mucous membrane anoxia, glandular secretion is vigorous, the nasal mucosa cilium is stopped action later on, even downright bad the disappearance, tela submucosa blood plasma oozes out the formation edema, and lymphocytic infiltration is arranged in the course of time; This type of medicine does not have the antiinflammatory anti-allergic effects, has only the effect of shrinking mucosa.
The object of the present invention is to provide with natural Chinese medicine is the Chinese medicine nasal drop and preparation method thereof of a kind for the treatment of acute or chronic rhinitis of primary raw material.With by comparatively rational to patient local application and the excellent Chinese medicine of curative effect, reach dispenser conveniently, medicine directly acts on diseased region and can keep the drug effect of long period, thereby has effectively overcome the deficiency of existing treatment rhinitis medicine.
The objective of the invention is to realize in the following manner, the Chinese medicine nasal drop for the treatment of acute or chronic rhinitis, mainly form by Chinese medicine and adjuvant, wherein Chinese medicine has: Flos Magnoliae, Herba Ephedrae, Fructus Xanthii, Radix Scutellariae, big gun first, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Radix Saposhnikoviae, Herba Asari, the amount of getting of its each component are (unit of weight is gram):
Flos Magnoliae 3-7 Herba Ephedrae 50-70 Fructus Xanthii 10-14 Radix Scutellariae 10-25
Big gun first 10-14 Radix Arnebiae (Radix Lithospermi) 10-14 Radix Astragali 10-25 Radix Saposhnikoviae 10-14
The described adjuvant of Herba Asari 2-6 is meant: ethyl hydroxybenzoate 0.01-0.03 gram hydro-oxidation sodium is regulated between the PH5.5-6.5 in right amount.
The manufacture method of above-mentioned Chinese medicine preparation:
1. Flos Magnoliae, Herba Ephedrae, Fructus Xanthii, Radix Scutellariae, big gun first, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Radix Saposhnikoviae, Herba Asari are added water 1500-2000 milliliter, soak decoction after 4-8 hour, decoction liquor is concentrated into the 150-250 milliliter after filtering.
2. above-mentioned concentrated solution is added the ethanol 150-250 milliliter mix homogeneously of 150-250 milliliter 95%, place after 20-30 hour, get supernatant and add thermal distillation, remove ethanol.
3. above-mentioned distillate adds 0.01-0.03 gram ethyl hydroxybenzoate, and the sodium hydroxide with 10% is transferred between the PH5.5-6.5, filter, and autoclaving, gained liquid is bottled sealing under aseptic condition.
Superior part of the present invention be with other nasal drop mutually specific energy significantly shrink nasal membrane, reduce the secretion of nasal cavity body of gland; Reduce nasal membrane to the dependence of medicine and the generation of medicamentous rhinitis; But obvious suppression bacterial growth; The antihistaminic effect is arranged.
Below in conjunction with embodiment the present invention is further described.
The Chinese medicine nasal drop for the treatment of acute or chronic rhinitis mainly is made up of Chinese medicine and adjuvant, and wherein Chinese medicine has: Flos Magnoliae, Herba Ephedrae, Fructus Xanthii, Radix Scutellariae, big gun first, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Radix Saposhnikoviae, Herba Asari, the amount of getting of its each component are (unit of weight is gram):
Flos Magnoliae 3-7 Herba Ephedrae 50-70 Fructus Xanthii 10-14 Radix Scutellariae 10-25
Big gun first 10-14 Radix Arnebiae (Radix Lithospermi) 10-14 Radix Astragali 10-25 Radix Saposhnikoviae 10-14
Herba Asari 2-6
Described adjuvant is meant: ethyl hydroxybenzoate 0.01-0.03 gram hydro-oxidation sodium is regulated between the PH5.5-6.5 in right amount.
The manufacture method of above-mentioned Chinese medicine preparation:
1. Flos Magnoliae, Herba Ephedrae, Fructus Xanthii, Radix Scutellariae, big gun first, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Radix Saposhnikoviae, Herba Asari are added water 1500-2000 milliliter, soak decoction after 4-8 hour, decoction liquor is concentrated into the 150-250 milliliter after filtering.
2. above-mentioned concentrated solution is added the ethanol 150-250 milliliter mix homogeneously of 150-250 milliliter 95%, place after 20-30 hour, get supernatant and add thermal distillation, remove ethanol.
3. above-mentioned distillate adds 0.01-0.03 gram ethyl hydroxybenzoate, and the sodium hydroxide with 10% is transferred between the PH5.5-6.5, filter, and autoclaving, gained liquid is bottled sealing under aseptic condition.
Embodiment one: choose following Chinese medicine and adjuvant (unit of weight is gram)
Flos Magnoliae 6 Herba Ephedraes 60 Fructus Xanthii 12 Radix Scutellariaes 20
Big gun first 12 Radix Arnebiae (Radix Lithospermi)s 12 Radixs Astragali 24 Radix Saposhnikoviaes 12
Herba Asari 3
Described supplementary product consumption is: ethyl hydroxybenzoate 0.02 adds 10% sodium hydroxide to be regulated between the PH5.5-6.5.
The manufacture method of above-mentioned Chinese medicine preparation:
1. Flos Magnoliae, Herba Ephedrae, Fructus Xanthii, Radix Scutellariae, big gun first, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Radix Saposhnikoviae, Herba Asari are added 2000 milliliters in water, soak decoction after 6 hours, decoction liquor is concentrated into 200 milliliters after filtering.
2. the 200 milliliters of mix homogeneously of ethanol that above-mentioned concentrated solution added 200 milliliter 95% were placed after 24 hours, got supernatant and added thermal distillation, removed ethanol.
3. above-mentioned distillate adds 0.02 gram ethyl hydroxybenzoate, and the sodium hydroxide with 10% is transferred between the PH 5.5-6.5, filter, and autoclaving, gained liquid is bottled sealing under aseptic condition.
Embodiment two: choose following Chinese medicine and adjuvant (unit of weight is gram)
Flos Magnoliae 3 Herba Ephedraes 50 Fructus Xanthii 10 Radix Scutellariaes 10
Big gun first 10 Radix Arnebiae (Radix Lithospermi)s 10 Radixs Astragali 10 Radix Saposhnikoviaes 10
Herba Asari 2
Described supplementary product consumption is: ethyl hydroxybenzoate 0.015 adds 10% sodium hydroxide to be regulated between the PH5.5-6.5.
The manufacture method of above-mentioned Chinese medicine preparation:
1. Flos Magnoliae, Herba Ephedrae, Fructus Xanthii, Radix Scutellariae, big gun first, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Radix Saposhnikoviae, Herba Asari are added 1500 milliliters in water, soak decoction after 6 hours, decoction liquor is concentrated into 150 milliliters after filtering.
2. the 150 milliliters of mix homogeneously of ethanol that above-mentioned concentrated solution added 150 milliliter 95% were placed after 24 hours, got supernatant and added thermal distillation, removed ethanol.
3. above-mentioned distillate adds 0.015 gram ethyl hydroxybenzoate, and the sodium hydroxide with 10% is transferred between the PH 5.5-6.5, filter, and autoclaving, gained liquid is bottled sealing under aseptic condition.
The treatment works well to acute and chronic rhinitis, sinusitis clinically in the present invention, removes and can significantly shrink nasal membrane, reduces the secretion of nasal cavity body of gland; Also have antiinflammatory and antianaphylactic effect.Be better than naphazoline commonly used now, its statistics is as follows: total number of persons produce effects enabledisable effective percentage the present invention 827 635 162 30 96% naphazolines 809 520 40 179 72%
Claims (3)
1. the Chinese medicine nasal drop of a treating acute or chronic rhinitis, mainly form by Chinese medicine and adjuvant, it is characterized in that described Chinese medicine is meant: Flos Magnoliae, Herba Ephedrae, Fructus Xanthii, Radix Scutellariae, big gun first, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Radix Saposhnikoviae, Herba Asari, the amount of getting of its each component are (unit of weight is gram):
Flos Magnoliae 3-7 Herba Ephedrae 50-70 Fructus Xanthii 10-14 Radix Scutellariae 10-25
Big gun first 10-14 Radix Arnebiae (Radix Lithospermi) 10-14 Radix Astragali 10-25 Radix Saposhnikoviae 10-14
The described adjuvant of Herba Asari 2-6 is meant: ethyl hydroxybenzoate 0.01-0.03 gram hydro-oxidation sodium is regulated between the PH 5.5-6.5 in right amount.
2. the Chinese medicine nasal drop of a kind for the treatment of acute or chronic rhinitis according to claim 1 is characterized in that the preferential following prescription (unit of weight is gram) that adopts in the above-mentioned prescription
Flos Magnoliae 6 Herba Ephedraes 60 Fructus Xanthii 12 Radix Scutellariaes 20
Big gun first 12 Radix Arnebiae (Radix Lithospermi)s 12 Radixs Astragali 24 Radix Saposhnikoviaes 12
Herba Asari 3 described supplementary product consumptions are: ethyl hydroxybenzoate 0.02 gram adds 10% sodium hydroxide to be regulated between the PH5.5-6.5.
3. the manufacture method of the Chinese medicine nasal drop of a treating acute or chronic rhinitis is characterized in that:
A. Flos Magnoliae, Herba Ephedrae, Fructus Xanthii, Radix Scutellariae, big gun first, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Radix Saposhnikoviae, Herba Asari are added water 1500-2000 milliliter, soak decoction after 4-8 hour, decoction liquor is concentrated into the 150-250 milliliter after filtering.
B. above-mentioned concentrated solution is added the ethanol mix homogeneously of 150-250 milliliter 95%, place after 20-30 hour, get supernatant and add thermal distillation, remove ethanol.
C. above-mentioned distillate adds 0.01-0.03 gram ethyl hydroxybenzoate, and the sodium hydroxide with 10% is transferred between the PH5.5-6.5, filter, and autoclaving, gained liquid is bottled sealing under aseptic condition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00114651 CN1112200C (en) | 2000-06-21 | 2000-06-21 | Chinese-medicinal nose drops for treating acute or chronic rhinitis and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00114651 CN1112200C (en) | 2000-06-21 | 2000-06-21 | Chinese-medicinal nose drops for treating acute or chronic rhinitis and its preparing process |
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| Publication Number | Publication Date |
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| CN1280839A true CN1280839A (en) | 2001-01-24 |
| CN1112200C CN1112200C (en) | 2003-06-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 00114651 Expired - Fee Related CN1112200C (en) | 2000-06-21 | 2000-06-21 | Chinese-medicinal nose drops for treating acute or chronic rhinitis and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100431590C (en) * | 2005-11-08 | 2008-11-12 | 上海中医药大学 | Chinese medicinal composition for treating cough and asthma |
| CN102614259A (en) * | 2011-06-03 | 2012-08-01 | 宋协勘 | Chinese medicine for treating chronic suppurative nasosinusitis |
-
2000
- 2000-06-21 CN CN 00114651 patent/CN1112200C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100431590C (en) * | 2005-11-08 | 2008-11-12 | 上海中医药大学 | Chinese medicinal composition for treating cough and asthma |
| CN102614259A (en) * | 2011-06-03 | 2012-08-01 | 宋协勘 | Chinese medicine for treating chronic suppurative nasosinusitis |
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| Publication number | Publication date |
|---|---|
| CN1112200C (en) | 2003-06-25 |
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