CN1272377A - Medicine for strengthening bone and eliminating impediment - Google Patents
Medicine for strengthening bone and eliminating impediment Download PDFInfo
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- CN1272377A CN1272377A CN 99106181 CN99106181A CN1272377A CN 1272377 A CN1272377 A CN 1272377A CN 99106181 CN99106181 CN 99106181 CN 99106181 A CN99106181 A CN 99106181A CN 1272377 A CN1272377 A CN 1272377A
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Abstract
The present invention discloses a Chinese medicine for curing hyperosteogeny, lumbocrural pain, trachelodynia, shoulder pain and other rheumatalgia with obvious therapeutic effect, and is made up by using 12 Chinese medicinal materials of gastrodia root, scorpion, cibotium root, clematis root, pubescent angelica root, achyranthes root, safflower, drynaria root, ledebouriella root, wingless cockroach and leech according to a certain proportion through conventional preparation process. Said invented medicine can be made into capsule or granules.
Description
The present invention relates to a kind of medicine of strengthening bone and eliminating impediment, relate in particular to the pharmaceutical composition that a kind of Rhizoma Gastrodiae, Scorpio, Rhizoma Cibotii, Radix Clematidis, Caulis Spatholobi, Radix Angelicae Pubescentis, Niu Xi, Flos Carthami, Rhizoma Drynariae, Radix Saposhnikoviae, eupolyphaga, Hirudo are made, and this preparation of drug combination method.
Hyperosteogeny, rheumatic, rheumatoid arthritis are common frequently-occurring diseases.Rheumatic arthritis is a kind of acute or chronic whole body ICT of outbreak repeatedly, mainly encroaches on joint and heart.Mainly show as pain of joint muscle, numbness, swelling, red heat, and ankylosis, deformity.The traditional Chinese medical science thinks it mainly is because the damp that is affected by the cold, due to the pathogen impatency meridians, QI-blood circulation obstacle.Rheumatoid arthritis is called for short rheumatoid.It is a kind of chronic systemic autoimmune disease based on the joint.The each several part in all formations joint is organized all and can be invaded.Primary disease is commonly encountered diseases, frequently-occurring disease, and sending out the age well is 20～50 years old, and women's sickness rate is higher than the male.Easily encroach on little joints such as brothers refer to, toe, wrist, ankle.Be in early days red, swollen, hot, the pain and the dyskinesia; Be ankylosis or stiff late period.Motherland's medical science is called " insensitive impediment ".Rheumatic, rheumatoid arthritis all belong to the scope of traditional Chinese medical science arthromyodynia, " element is asked the numbness opinion " thought: " place, diet residence; be its sick basis ", the generation of rheumatic, rheumatoid arthritis mainly is because deficiency of vital QI, wind, cold, wet, all evil invasion and attack human bodies of heat, the multiple abscess meridians cause the QI and blood impatency and form.
Treat the Western medicine of rheumatic, rheumatoid arthritis at present, not only uncertain therapeutic efficacy is cut, and also can cause gastrointestinal symptoms such as stomachache, inappetence mostly, with infringement liver, kidney and hemocyte, also can produce drug resistance for a long time.Though, the Chinese patent medicine that some treatment rheumatic, rheumatoid arthritis are also arranged, a kind of medicine for the treatment of hyperosteogeny, lumbago and skelalgia is disclosed as Chinese patent CN 1194850A, but still have that complicated process of preparation, cost of drugs are higher, weak point is cut or the like in uncertain therapeutic efficacy; Chinese patent CN1083720A discloses a kind of treatment because of caused neck and shoulder pain of rheumatism, strain or hypertrophy and " Lingdan " moxibustion plaster, exists equally that complicated process of preparation, cost of drugs are higher, weak point is cut or the like in uncertain therapeutic efficacy; The disclosed cold-dampness pains tincture of CN 1104532A, but reflect that with the patient effect is still not fairly obvious, and cure rate is not high according to observations, and the course of treatment is long, dosage is big, take inconvenience.
An object of the present invention is to provide a kind of medicine of strengthening bone and eliminating impediment, it is on the basis of secret prescription handed down in the family from generation to generation, through secular clinical practice, experience in conjunction with diseases such as treatment by Chinese herbs arthritis, update and process, have that taking convenience, curative effect are fast, a detumescence, pain relieving is remarkable, cure rate is high characteristics.
Solution of the present invention mainly is based on understanding and the rule of treatment of motherland's traditional medicine to the etiology and pathogenesis of arthromyodynia, theory with China's medical science " general rule is not bitterly; pain is then obstructed " " numbness person closes also " is guidance, with dispelling cold by warming the meridian, removing obstruction in the collateral to relieve pain is the rule of treatment, from traditional Chinese medical science treasure-house, filter out the Chinese medicine of expelling wind and removing dampness, disperse blood stasis and dredge collateral, in conjunction with Drug therapy rheumatic, the rheumatoid arthritis of modern medicine and pharmacology treatment primary disease, treating both the principal and secondary aspects of a disease, and obtained satisfied curative effect.
Medicine of the present invention is made (consumption is a weight portion) by following component: Rhizoma Gastrodiae 11-19 part, Scorpio 8-16 part, Rhizoma Cibotii 11-19 part, Radix Clematidis 11-19 part, Caulis Spatholobi 25-35 part, Radix Angelicae Pubescentis 11-19 part, cattle sunset 11-19 part, Flos Carthami 25-35 part, Rhizoma Drynariae 25-35 part, Radix Saposhnikoviae 6-14 part, eupolyphaga 8-16 part, Hirudo 11-20 part.
The formula optimization weight proportion scope of preparation medicine of the present invention is:
Rhizoma Gastrodiae 13-17 part, Scorpio 10-14 part, Rhizoma Cibotii 13-17 part, Radix Clematidis 13-17 part, Caulis Spatholobi 27-33 part, Radix Angelicae Pubescentis 13-17 part, cattle sunset 13-17 part, Flos Carthami 28-33 part, Rhizoma Drynariae 27-33 part, Radix Saposhnikoviae 8-12 part, eupolyphaga 10-14 part, Hirudo 14-18 part.
Medicine optimum weight proportioning of the present invention is:
15 parts in Rhizoma Gastrodiae, 12 parts of Scorpios, 15 parts of Rhizoma Cibotii, 15 parts of Radix Clematidis, 30 parts of Caulis Spatholobis, 15 parts of Radix Angelicae Pubescentiss, 15 parts of cattle sunset, 30 parts on Flos Carthami, 30 parts of Rhizoma Drynariae, 10 parts of Radix Saposhnikoviaes, 12 parts of eupolyphaga, 16 parts of Hirudoes.
Above-mentioned each component is made medicine production method of the present invention is:
1. take by weighing Rhizoma Gastrodiae, Scorpio, Rhizoma Cibotii, Radix Clematidis, Caulis Spatholobi, Radix Angelicae Pubescentis, Niu Xi, Flos Carthami, Rhizoma Drynariae, Radix Saposhnikoviae, eupolyphaga, Hirudo decoction pieces, drying;
With deionized water in 25～70 ℃ of vacuum extraction secondaries, for the first time add 10～12 times of amounts of deionized water, extracted 3 hours; For the second time add 8～10 times of amounts of deionized water, extracted 2 hours, merge extractive liquid, discards residue;
3. concentrated extracting solution gets thick paste (surveying than reheating is 1.30～1.35), and oven dry obtains thick paste, is prepared into capsule according to the preparation method of Chinese medicinal capsule agent routine, packing/go into No. 0 capsule.
Clinical use result shows that medicine of the present invention has following advantage:
1. the present invention brings into play the length of motherland's medical science, according to the etiology and pathogenesis of primary disease, in conjunction with modern medicine and pharmacology treatment asthma, treating both the principal and secondary aspects of a disease, it is not enough slowly to have overcome simple Chinese medicine effect, and has strengthened drug effect, reduced dosage, toxic and side effects reduces, and has obtained satisfied curative effect;
2. pharmaceutical composition of the present invention, preparation method is simple, does not need complex device, and the little factory that possesses general pharmacy condition all can produce, and has avoided complex apparatus and expensive.
3. capsule of the present invention, have volume little, take and store that convenient transportation, produce effects are fast, the curative effect advantages of higher, overcome that the powder dosage is big, mouthfeel difference and oral liquid formulations must clarify, make that effective ingredient is lost in a large number, herb resource waste, production cost improve the also affected shortcoming of curative effect.
For showing the therapeutic effect of medicine of the present invention, now provide following clinical data to arthromyodynias such as hyperosteogeny, rheumatic, rheumatoid arthritiss:
Adopt medicine of the present invention (dosage form is a capsule) treatment rheumatic arthritis, matched group adopts the disclosed cold-dampness pains tincture of CN 1104532A:
1. physical data
This organizes diagnosis of rheumatoid arthritis standard (Lou Yuqian chief editor, the sick complete works of Chinese numbness, the 1st edition, Beijing that 109 routine patients all revised by Americanism damp disease association (ARA) in 1987; China Science Tech Publishing House, 1993:158-159).Be divided into medicament capsule group of the present invention (being called for short the treatment group) 79 examples at random, cold-dampness pains tincture group (abbreviation matched group) 30 examples.Male 32 examples are organized in treatment, women 47 examples; 25～67 years old age, average 43 years old; Course of disease half a year～13 year, average 4 years 7 months; Rheumatic arthritis 49 examples wherein, rheumatoid arthritis 30 examples; Erythrocyte sedimentation rate 27～4,0mm,/h1 9 examples, above 17 examples of 41mm/h, anti-chain " O "＞1:400 person's 35 examples, positive 22 examples of serum rheumatoid factor (SRF), person's 21 examples that there is the abnormal change in X line joint mutually, bone density are lower than normal person's 48 examples.Matched group man 12 examples, women 18 examples; 21～61 years old age, average 37.2 years old; Course of disease half a year～13 year, average 4 years 3 months; Rheumatic arthritis 17 examples wherein, rheumatoid arthritis 13; Anti-chain " O "＞1:400 person's 11 examples, erythrocyte sedimentation rate 31～40mm/h6 example, above 5 examples of 41mm/h, positive 8 examples of serum rheumatoid factor (SRF), person's 7 examples that there is the abnormal change in X line joint mutually, bone density are lower than normal person's 20 examples.Two groups of cases all have pathological changes arthralgia, acid to expand or swelling and dysfunction.
2. Therapeutic Method
The treatment group adopts medicament composition capsule of the present invention, one time 3, every day twice, sooner or later one after each meal; Matched group adopts the disclosed wind-cold-dampness ache of CN 1104532A to separate tincture, a 20ml, every day three times, one after each meal.Be for 6 weeks two groups of courses of treatment.
Statistical procedures adopts x
2Check.
3. result
A) curative effect determinate standard: disappearances such as the joint is red, swollen, sour, bloated, function improve or
Recover normal, it is normal for facing that anti-chain " O ", rheumatoid factor, erythrocyte sedimentation rate recover
Bed control; Morning deadlock, arthralgia, acid is expanded etc. and to be clearly better or to disappear anti-chain
" O " recovers normal, and erythrocyte sedimentation rate decline or erythrocyte sedimentation rate, rheumatoid factor are just being recovered
Often, but arthralgia disappear as yet and be produce effects; Morning deadlock, joint red, swollen,
Bitterly, acid remission such as expand, the blood testing index is improved as effectively.Disease
Shape, sign no change, erythrocyte sedimentation rate, anti-chain " O ", rheumatoid factor no change
For invalid.
B) therapeutic outcome: as shown in table 1.
Table 1
| Group | The example number | Clinic control | Produce effects | Effectively | Invalid | Effectively total |
| Treatment | ??79 | ??25(31.6) | ??39(49.4) | ??9(11.4) | ??6(7.6) | ??73(92.4) * |
| Contrast | ??30 | ??6(20.0) | ??10(33.3) | ??6(20.0) | ??8(26.7) | ??22(73.3) * |
*P＜0.01
Two groups clinic control and obvious effective rate are respectively 81.0% and 53.3%, and total effective rate is respectively 92.4% and 73.3%.Learn check by statistics, two groups clinic control and obvious effective rate, total effective rate compare x
2Be respectively 8.35 and 7.06, P all＜0.01 has significant difference.
Followed up a case by regular visits to 1 year, the treatment group is cured recurrence 3 examples (12.0%) in 25 examples, and matched group is cured recurrence 4 examples (66.7%) in 6 examples, and two groups more also have significant difference (P＜0.01).
Following embodiment is detailed description of the present invention, is not in the present invention is limited to.
Embodiment
1. take by weighing raw material by following proportioning, drying:
Rhizoma Gastrodiae 15 weight portions, Scorpio 12 weight portions, Rhizoma Cibotii 15 weight portions, Radix Clematidis 15 weight portions, Caulis Spatholobi 30 weight portions, Radix Angelicae Pubescentis 15 weight portions, cattle sunset 15 weight portion, Flos Carthami 30 weight portions, Rhizoma Drynariae 30 weight portions, Radix Saposhnikoviae 10 weight portions, eupolyphaga 12 weight portions, Hirudo 16 weight portions.
With deionized water in 70 ℃ of vacuum extraction Rhizoma Gastrodiaes, Scorpio, Rhizoma Cibotii, Radix Clematidis, Caulis Spatholobi, Radix Angelicae Pubescentis, Niu Xi, Flos Carthami, Rhizoma Drynariae, Radix Saposhnikoviae, eupolyphaga, Hirudo secondary, for the first time add 10 times of amounts of water, extracted 3 hours; For the second time add 8 times of amounts of water, extracted 2 hours, merge extractive liquid, discards residue;
3. concentrated extracting solution gets thick paste (surveying than reheating is 1.30～1.35), and oven dry obtains thick paste, is prepared into capsule according to the preparation method of Chinese medicinal capsule agent routine, divides the capsule of packing into No. 0, and every capsules contains 450mg medicated powder.
Usage and consumption: an oral 2-3 grain, one day twice, morning and evening taking medicine after meal.
Claims (6)
1. the medicine of a strengthening bone and eliminating impediment is characterized in that it is the medicament of being made by the following weight proportion raw material: Rhizoma Gastrodiae 11-19 part, Scorpio 8-16 part, Rhizoma Cibotii 11-19 part, Radix Clematidis 11-19 part, Caulis Spatholobi 25-35 part, Radix Angelicae Pubescentis 11-19 part, cattle sunset 11-19 part, Flos Carthami 25-35 part, Rhizoma Drynariae 25-35 part, Radix Saposhnikoviae 6-14 part, eupolyphaga 8-16 part, Hirudo 11-20 part.
2. the medicine of strengthening bone and eliminating impediment as claimed in claim 1, wherein the weight proportion of each raw material be Rhizoma Gastrodiae 13-17 part, Scorpio 10-14 part, Rhizoma Cibotii 13-17 part, Radix Clematidis 13-17 part, Caulis Spatholobi 27-33 part, Radix Angelicae Pubescentis 13-17 part, cattle sunset 13-17 part, Flos Carthami 28-33 part, Rhizoma Drynariae 27-33 part, Radix Saposhnikoviae 8-12 part, eupolyphaga 10-14 part, Hirudo 14-18 part.
3. the medicine of strengthening bone and eliminating impediment as claimed in claim 1, wherein the weight proportion of each raw material is 15 parts in Rhizoma Gastrodiae, 12 parts of Scorpios, 15 parts of Rhizoma Cibotii, 15 parts of Radix Clematidis, 30 parts of Caulis Spatholobis, 15 parts of Radix Angelicae Pubescentiss, 15 parts of cattle sunset, 30 parts on Flos Carthami, 30 parts of Rhizoma Drynariae, 10 parts of Radix Saposhnikoviaes, 12 parts of eupolyphaga, 16 parts of Hirudoes.
4. as the medicine of claim 1,2 or 3 described strengthening bone and eliminating impediments, it is characterized in that said medicament is a said dosage form on any pharmaceutics.
5. the medicine of strengthening bone and eliminating impediment as claimed in claim 4 is characterized in that said medicament is a capsule.
6. the medicine of strengthening bone and eliminating impediment as claimed in claim 4, its feature sky is a granule in said medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99106181 CN1272377A (en) | 1999-04-30 | 1999-04-30 | Medicine for strengthening bone and eliminating impediment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99106181 CN1272377A (en) | 1999-04-30 | 1999-04-30 | Medicine for strengthening bone and eliminating impediment |
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| Publication Number | Publication Date |
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| CN1272377A true CN1272377A (en) | 2000-11-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99106181 Pending CN1272377A (en) | 1999-04-30 | 1999-04-30 | Medicine for strengthening bone and eliminating impediment |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001091766A3 (en) * | 2000-06-01 | 2002-09-12 | Theralife Inc | Compositions for treating hand and wrist discomfort containing herbals and/or nutritional supplements and/or minerals and/or vitamins |
| WO2001091778A3 (en) * | 2000-06-01 | 2002-10-17 | Theralife Inc | Compositions for treating neck and shoulder discomfort containing herbals and/or nutritional supplements and/or minerals and/or vitamins |
-
1999
- 1999-04-30 CN CN 99106181 patent/CN1272377A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001091766A3 (en) * | 2000-06-01 | 2002-09-12 | Theralife Inc | Compositions for treating hand and wrist discomfort containing herbals and/or nutritional supplements and/or minerals and/or vitamins |
| WO2001091778A3 (en) * | 2000-06-01 | 2002-10-17 | Theralife Inc | Compositions for treating neck and shoulder discomfort containing herbals and/or nutritional supplements and/or minerals and/or vitamins |
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