CN1263768C - 一种蒲公英萜醇的衍生物及制法和用途 - Google Patents

一种蒲公英萜醇的衍生物及制法和用途 Download PDF

Info

Publication number
CN1263768C
CN1263768C CN 03146857 CN03146857A CN1263768C CN 1263768 C CN1263768 C CN 1263768C CN 03146857 CN03146857 CN 03146857 CN 03146857 A CN03146857 A CN 03146857A CN 1263768 C CN1263768 C CN 1263768C
Authority
CN
China
Prior art keywords
derivative
taraxerol
compound
tridecyle
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN 03146857
Other languages
English (en)
Other versions
CN1526722A (zh
Inventor
张偲
徐鲁荣
吴军
漆淑华
龙丽娟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
South China Sea Institute of Oceanology of CAS
Original Assignee
South China Sea Institute of Oceanology of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by South China Sea Institute of Oceanology of CAS filed Critical South China Sea Institute of Oceanology of CAS
Priority to CN 03146857 priority Critical patent/CN1263768C/zh
Publication of CN1526722A publication Critical patent/CN1526722A/zh
Application granted granted Critical
Publication of CN1263768C publication Critical patent/CN1263768C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及从豆科(Leguminosae)植物三叶鱼藤(Derris trifoliate)中分离得到一种新的蒲公英萜醇(Taraxerol)的衍生物(Taraxeryl tridecyle ether)及制法和用途。本发明利用色谱分离技术从豆科(Leguminosae)鱼藤属植物三叶鱼藤(Derristriofolia)中分离得到一种新的三萜醚类化合物(Taraxerol tridecyle ether)。该化合物外观为白色棱柱状结晶(氯仿-甲醇)，分子式为C43H76O，命名为：Taraxerol tridecyle ether。本发明所述的蒲公英萜醇的衍生物有杀虫、抗菌、镇痛和抗肿瘤的作用。

Description

一种蒲公英萜醇的衍生物及制法和用途
技术领域
本发明涉及从豆科(Leguminosae)植物三叶鱼藤(Derris trifoliate)中分离得到一种新的蒲公英萜醇(Taraxerol)的衍生物(Taraxeryl tridecyle ether)及用途。
背景技术
本发明利用色谱分离技术从豆科(Leguminosae)鱼藤属植物三叶鱼藤(Derristriofolia)中分离得到一种新的三萜醚类化合物(Taraxerol tridecyleether)。
发明内容
本发明利用色谱分离技术从豆科(Leguminosae)鱼藤属植物三叶鱼藤(Derris triofolia)中分离得到一种新的三萜醚类化合物(Taraxeroltridecyle ether)
该化合物外观为白色棱柱状结晶(氯仿-甲醇)，分子式为C43H76O，命名为：Taraxerol tridecyle ether。结构式如下：
结构鉴定：
由ESI-MS可知此化合物的[M+K]+为647，结合1H和13C NMR谱给出其分子式C43H76O。氢谱中，在δH0.8~2.0区域出现了8个典型的三萜上甲基单峰信号；δH5.50处的一个次甲基信号暗示此化合物中含有一个三取代双键。碳谱中，和蒲公英萜醇的碳谱数据相比较，两者的三萜骨架碳几乎相同，只是此化合物多了以下信号：δC63.0(一个亚甲基)，δC14.1(一个末端甲基)，δC29.35~29.90(几个亚甲基)，这些信号表明该化合物中含有一个长链烃基。通过二维核磁实验论证，推断该化合物为蒲公英萜醇的衍生物，且其3位上的羟基氢被一个长链烃基取代。结合ESI-MS，推测该烃基含有13个碳，因此将该化合物的结构定为如上所示，命名为Taraxerol tridecyl ether。经CA检索该化合物为新化合物，属于三萜醚类化合物。
本发明所述的蒲公英萜醇的衍生物的制法，是以三叶鱼藤地上部分为原料，粉碎后用95％和50％乙醇各提取3次，减压浓缩后得乙醇提取物。乙醇提取物依次用石油醚、乙酸乙酯、正丁醇萃取，减压浓缩得各萃取部位。乙酸乙酯部位经硅胶柱层析、Sephadex LH-20柱层析得到该化合物。
本发明所述的蒲公英萜醇的衍生物的用途为该化合物有杀虫、抗菌、镇痛和抗肿瘤的作用。
实施例
蒲公英萜醇的衍生物的制法，以三叶鱼藤地上部分为原料，粉碎后用95％和50％乙醇各提取3次，减压浓缩后得乙醇提取物。乙醇提取物依次用石油醚、乙酸乙酯、正丁醇萃取，减压浓缩得各萃取部位。乙酸乙酯部位经硅胶柱层析、Sephadex LH-20柱层析得到该化合物。具体步骤见附图1。

Claims (2)

1、一种蒲公英萜醇的衍生物，其特征在于，该化合物外观为白色棱柱状结晶，分子式为C43H76O，结构式如下：
Figure C031468570002C1
2、权利要求1中所述的蒲公英萜醇的衍生物的制法，其特征在于所述的蒲公英萜醇的衍生物的制法，是利用色谱分离技术从豆科，鱼藤属植物三叶鱼藤中分离得到一种新的三萜醚类化合物，具体制法包括如下步骤：以三叶鱼藤地上部分为原料，粉碎后用95％和50％乙醇各提取3次，减压浓缩后得乙醇提取物；乙醇提取物依次用石油醚、乙酸乙酯、正丁醇萃取，减压浓缩得各萃取部位；乙酸乙酯部位经硅胶柱层析、Sephadex LH-20柱层析得到该化合物。
CN 03146857 2003-09-18 2003-09-18 一种蒲公英萜醇的衍生物及制法和用途 Expired - Fee Related CN1263768C (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 03146857 CN1263768C (zh) 2003-09-18 2003-09-18 一种蒲公英萜醇的衍生物及制法和用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 03146857 CN1263768C (zh) 2003-09-18 2003-09-18 一种蒲公英萜醇的衍生物及制法和用途

Publications (2)

Publication Number Publication Date
CN1526722A CN1526722A (zh) 2004-09-08
CN1263768C true CN1263768C (zh) 2006-07-12

Family

ID=34286654

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 03146857 Expired - Fee Related CN1263768C (zh) 2003-09-18 2003-09-18 一种蒲公英萜醇的衍生物及制法和用途

Country Status (1)

Country Link
CN (1) CN1263768C (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9201880D0 (en) * 1992-01-29 1992-03-18 Rasmussen O B Laminated films
CN101974060A (zh) * 2010-10-13 2011-02-16 沈阳亿灵医药科技有限公司 一类具有抗肿瘤活性的半合成化合物及其用途

Also Published As

Publication number Publication date
CN1526722A (zh) 2004-09-08

Similar Documents

Publication Publication Date Title
Sun et al. New hepatoprotective isoflavone glucosides from Pueraria lobata (Willd.) Ohwi
Osman et al. New isorhamnetin derivatives from Salsola imbricata Forssk. leaves with distinct anti-inflammatory activity
Huang et al. Monoterpene and sesquilignan compounds from the leaves of Crataegus pinnatifida
Cheng et al. Secondary metabolites and cytotoxic activities from the endophytic fungus Annulohypoxylon squamulosum
Iranshahi et al. Polar secondary metabolites of Ferula persica roots
Temraz et al. Steroidal saponins from the aerial parts of Tribulus alatus Del.
CN1263768C (zh) 一种蒲公英萜醇的衍生物及制法和用途
Ishimaru et al. Polyacetylene glycosides from Pratia nummularia cultures
CN1194982C (zh) 一种苯乙醇苷化合物－老鼠簕苷a的结构及其用途
Munkombwe Acetylated phenolic glycosides from Harpagophytum procumbens
KITAGAWA et al. Licorice-saponins F3, G2, H2, J2, and K2, five new oleanene-triterpene oligoglycosides from the root of Glycyrrhiza uralensis
Wang et al. Biotransformation of gentiopicroside by asexual mycelia of Cordyceps sinensis
Yu et al. Two new saponins from the aerial part of Astragalus membranaceus var. mongholicus
CN103342689A (zh) 从瓜蒌皮中分离纯化木犀草素、芹菜素和香叶木素的方法
CN108047166B (zh) 一种南鹤虱提取物及其提取方法
Elsharabasy et al. Chemical constituents from the aerial parts of Salsola inermis
CN107746421B (zh) 化合物dictyopterisin f及其在制备抗肿瘤药物中的应用
Yin et al. Two pentasaccharide resin glycosides from Argyreia acuta
Kamel et al. Cardiac glycosides from Cryptostegia grandiflora
CN107722096A (zh) 一种具有抗肿瘤作用的甾体类天然药物及其制备方法和用途
CN103113439A (zh) 从对叶大戟中制备山奈酚-3-O-β-D-葡萄糖醛酸苷的方法
Kuzovkina et al. Morphological and biochemical characteristics of genetically transformed roots of Scutellaria andrachnoides
Zhang et al. Two new spirostanol saponins from Reineckia carnea
Gan et al. A new cytotoxic cardenolide from the latex of Antiaris toxicaria
Sohn et al. Chemical constituents of the leaves of Staphylea bumalda

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
EE01 Entry into force of recordation of patent licensing contract

Assignee: Foshan Haihan Feed Co.,Ltd.

Assignor: South-sea Ocean Inst., Chine Academy of Sciences

Contract record no.: 2010440001558

Denomination of invention: New taraxerol derivative and its prepn and use

Granted publication date: 20060712

License type: Exclusive License

Open date: 20040908

Record date: 20101229

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060712

Termination date: 20160918

CF01 Termination of patent right due to non-payment of annual fee