CN1262288C - Preparing method of licorice extracturm by means of producing refuse with glycyrrhizin - Google Patents
Preparing method of licorice extracturm by means of producing refuse with glycyrrhizin Download PDFInfo
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- CN1262288C CN1262288C CN 03146259 CN03146259A CN1262288C CN 1262288 C CN1262288 C CN 1262288C CN 03146259 CN03146259 CN 03146259 CN 03146259 A CN03146259 A CN 03146259A CN 1262288 C CN1262288 C CN 1262288C
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- acid
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- liquorice
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- glycyrrhizic acid
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Abstract
The present invention relates to a method for preparing liquorice extract by waste substances of liquorice acid extracted from liquorice(Chinese traditional Chinese herbal medicine), comprises the following steps: liquorice waste residues are lixiviated by alcohol and ammonia solution at 40 to 100DEG C for 1 to 10 hours; the obtained lixiviating liquid is filtered, and filter liquid is used for standby; alkali is added to waste liquid which is obtained through acid deposition of liquorice acid, the pH value of the solution is in weak acid or is neutral, and insoluble substances are filtered for standby; plant protein, polysaccharide, amino acid, etc. are heated, and dissolve in water, the centrifugal separation is carried out, and supernatant liquid is taken for standby; the obtained three kinds of liquid in the steps are thoroughly mixed, and are concentrated to thick paste at 40 to 100DEG C, and the liquorice extract is obtained. The present invention uses waste residues and waste liquid which are generated in the process of preparing liquorice acid to prepare the liquorice extract, the environment is protected, and the existing liquorice resources are fully utilized.
Description
Technical field
The present invention relates to extract the method that the garbage that is produced in the glycyrrhizic acid process prepares Radix Glycyrrhizae extractum by China tradition Chinese herbal medicine Radix Glycyrrhizae.
Background technology
Radix Glycyrrhizae is pulse family (Leguminosae) Glycyrrhiza shrub shape herbaceos perennial, have another name called MEICAO, sweet, the sweet root of honey, it is broad-spectrum simply Chinese medicine material, have the reputation of " state is old ", " soft gold ", " ten sides, nine grass ", the main place of production is in northeast, North China and the Northwest of China.Radix Glycyrrhizae has also obtained extensive use at food service industry, tobacco business, cosmetic industry except being widely used at field of medicaments.Simultaneously, because that it has is cold-resistant, heat-resisting, drought-enduring, anti-good characteristic such as saline and alkaline, suitable natural disposition is strong, and vitality is vigorous, so Radix Glycyrrhizae becomes one of important plant resources of arid, semiarid zone, is a kind of very important sand-fixation plant.In recent years, because a large amount of man-made recoveries of the wild Radix Glycyrrhizae resources in ground such as Ningxia, Inner Mongol, Xinjiang, this area's desertification is obvious day by day, and environment goes from bad to worse.Country has now issued relevant laws and regulations, limits the exploitation of wild Radix Glycyrrhizae.Therefore, Radix Glycyrrhizae resource originally very in short supply is more in short supply.How to make full use of existing Radix Glycyrrhizae resource and become the focus that this field researcher is paid close attention to.
At present, the production method of Radix Glycyrrhizae extractum mainly is directly to pass through the solvent lixiviate by the Chinese herbal medicine Radix Glycyrrhizae, and the evaporating surplus solvent prepares Radix Glycyrrhizae extractum then.Prepare by Radix Glycyrrhizae and have a large amount of licorice slags in the production process of glycyrrhizic acid and produce, produce with a large amount of waste liquids simultaneously.Studies show that in recent years contained a large amount of utilities (as: Angelica Polysaccharide, protein, licoflavone class material, glycyrrhizic acid etc.) in these waste residues, the waste liquid.At present, Radix Glycyrrhizae production garbage main methods is to burn or after simple process, directly discharge.Both wasted valuable Radix Glycyrrhizae resource, the environment around having polluted again.Therefore, the comprehensive development and utilization of the garbage of Radix Glycyrrhizae becomes one of new focus of Radix Glycyrrhizae area research in recent years.
Based on above-mentioned background, the present invention develops a kind of method that is prepared Radix Glycyrrhizae extractum by the garbage that produces in the glycyrrhizic acid production process.
Summary of the invention
The technical solution adopted in the present invention is as follows:
A kind ofly produce the method that garbage prepares Radix Glycyrrhizae extractum, may further comprise the steps by glycyrrhizic acid:
I. lixiviate
Licorice slag (1) [annotate: licorice slag of the present invention (1) is in the glycyrrhizic acid preparation process, and Radix Glycyrrhizae is cut into slices after the water high-temp extracting, filters the gained filtering residue] is following to pure ammonia solution lixiviate 1～10 hour at 40-100 ℃; And with the filtration of gained lixiviating solution, filtrate for later use;
II. the processing of the waste liquid (3) behind the glycyrrhizic acid acid precipitation
[annotate: the waste liquid (3) behind the glycyrrhizic acid acid precipitation of the present invention goes out glycyrrhizic acid with Acid precipitation for licorice extract after concentrating with the waste liquid behind the glycyrrhizic acid acid precipitation (3), gained filtrate after filtration again] add alkali, transfer this solution pH value to weak acid or neutrality, standby behind the elimination insoluble matter;
III. concentrate
Above-mentioned steps I, II gained liquid are fully mixed, under 40-100 ℃, be concentrated into the thick paste shape, promptly get Radix Glycyrrhizae extractum;
Comprise that also [annotate: vegetable protein of the present invention, polysaccharide, aminoacid etc. (2) are in the glycyrrhizic acid preparation process with vegetable protein, polysaccharide, aminoacid etc. (2), licorice extract is after concentrating, the vegetable protein of separating out, polysaccharide, aminoacid etc. again through alcohol precipitation] add the hot water dissolving, centrifugalize, get supernatant and add among the Step II I, be concentrated into paste after being mixed together evenly with the liquid of step I, II gained.Described pure ammonia solution is the aqueous solution that contains ethanol 5-50%, ammonia 5-10%.
The present invention utilize in the glycyrrhizic acid production process the waste residue that produces and waste liquid prepare Radix Glycyrrhizae extractum, both protected environment, make full use of existing Radix Glycyrrhizae resource again.
The specific embodiment of the present invention is provided in detail by following examples and accompanying drawing thereof.
Description of drawings
Accompanying drawing is a schematic flow sheet of the present invention.
The specific embodiment
In the glycyrrhizic acid preparation process, behind the water lixiviate Radix Glycyrrhizae section at high temperature certain hour, filter, filtrate being used to prepares glycyrrhizic acid, and filtering residue is licorice slag of the present invention (1).
In the glycyrrhizic acid preparation process, licorice extract must concentrate earlier before the preparation glycyrrhizic acid, added the ethanol precipitating then, and vegetable protein in the concentrated solution, polysaccharide, aminoacid are separated out, to reduce follow-up glycyrrhizic acid purification burden.Vegetable protein, polysaccharide, aminoacid that this step separates out are (2) such as vegetable protein of the present invention, polysaccharide, aminoacid.
In the glycyrrhizic acid preparation process, the licorice extract after concentrating goes out glycyrrhizic acid with Acid precipitation, and after filtration, filtering residue is a glycyrrhizic acid inclusion compound, needs further refining; Filtrate then is the waste liquid (3) behind the glycyrrhizic acid acid precipitation of the present invention;
As shown in the figure, this method step is as follows:
I. lixiviate
Get 100 gram licorice slags (1) and place the 500ml conical flask, add and contain 5～50% ethanol, the aqueous solution 350ml of 5～10% ammonia, under the condition of 40～100 ℃ of waters bath with thermostatic control, sealing lixiviate 3 hours; Then, the gained lixiviating solution is filtered filtrate for later use with cloth formula funnel while hot;
II. the processing of (2) such as vegetable protein, polysaccharide, aminoacid
Get vegetable protein of the present invention, polysaccharide, aminoacid (2) 10～100 grams and add the hot water dissolving, centrifugal 10min under the condition of 4500 commentaries on classics/min, it is standby to get supernatant;
III. the processing of the waste liquid (3) behind the glycyrrhizic acid acid precipitation
Waste liquid (3) 5～200ml behind the extracting liquorice acid acid precipitation add alkali, transfer this solution pH value to 5～7, and are standby behind the elimination insoluble matter;
IV. concentrate
Above-mentioned steps I, II, III gained liquid are fully mixed, under 40～100 ℃, be concentrated into the thick paste shape, promptly get Radix Glycyrrhizae extractum.
If abundant lixiviate has been passed through in used Radix Glycyrrhizae section, licorice slag can be directly used in the preparation of cellulose and lignin, needn't be used for the Radix Glycyrrhizae extractum preparation.The Radix Glycyrrhizae extractum preparation method adopts II, III, the IV step of the above-mentioned specific embodiment under this situation.
The above, it only is preferred embodiment of the present invention, be not that the present invention is done any pro forma restriction, any personnel that are familiar with this technology may utilize the technology contents of above-mentioned announcement to be changed or be modified to the equivalent embodiment of equivalent variations, every content that does not break away from technical solution of the present invention,, all still belong in the scope of technical solution of the present invention any simple modification, equivalent variations and modification that above embodiment did according to technical spirit of the present invention.
Claims (4)
1, a kind of when extracting glycyrrhizic acid the garbage that produces prepare the method for Radix Glycyrrhizae extractum, it is characterized in that: said method comprising the steps of:
I. lixiviate
Licorice slag (1) is following to pure ammonia solution lixiviate 1～10 hour at 40-100 ℃; And with the filtration of gained lixiviating solution, filtrate for later use;
II. the processing of the waste liquid (3) behind the glycyrrhizic acid acid precipitation
Waste liquid behind the glycyrrhizic acid acid precipitation (3) is added alkali, transfer this solution pH value to weak acid or neutrality, standby behind the elimination insoluble matter;
III. concentrate
Above-mentioned steps I, II gained liquid are fully mixed, under 40-100 ℃, be concentrated into the thick paste shape, promptly get Radix Glycyrrhizae extractum.
2. according to claim 1 when extracting glycyrrhizic acid the garbage that produces prepare the method for Radix Glycyrrhizae extractum, it is characterized in that described pure ammonia solution is the aqueous solution that contains ethanol 5-50%, ammonia 5-10%.
3. according to claim 2 when extracting glycyrrhizic acid the garbage that produces prepare the method for Radix Glycyrrhizae extractum, it is characterized in that also comprising vegetable protein, polysaccharide, aminoacid (2) are added the hot water dissolving, centrifugalize, get supernatant and add among the Step II I, be concentrated into paste after being mixed together evenly with the liquid of step I, II gained.
One kind when extracting glycyrrhizic acid the garbage that produces prepare the method for Radix Glycyrrhizae extractum, it is characterized in that: said method comprising the steps of:
I. the processing of vegetable protein, polysaccharide, aminoacid (2)
Vegetable protein, polysaccharide, aminoacid (2) are added the hot water dissolving, centrifugalize, it is standby to get supernatant;
II. the processing of the waste liquid (3) behind the glycyrrhizic acid acid precipitation
Waste liquid behind the glycyrrhizic acid acid precipitation (3) is added alkali, transfer this solution pH value to weak acid or neutrality, standby behind the elimination insoluble matter;
III. concentrate
Above-mentioned steps I, II gained liquid are fully mixed, under 40-100 ℃, be concentrated into the thick paste shape, promptly get Radix Glycyrrhizae extractum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03146259 CN1262288C (en) | 2003-07-07 | 2003-07-07 | Preparing method of licorice extracturm by means of producing refuse with glycyrrhizin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03146259 CN1262288C (en) | 2003-07-07 | 2003-07-07 | Preparing method of licorice extracturm by means of producing refuse with glycyrrhizin |
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| CN1565593A CN1565593A (en) | 2005-01-19 |
| CN1262288C true CN1262288C (en) | 2006-07-05 |
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| CN 03146259 Expired - Fee Related CN1262288C (en) | 2003-07-07 | 2003-07-07 | Preparing method of licorice extracturm by means of producing refuse with glycyrrhizin |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101878912A (en) * | 2010-06-17 | 2010-11-10 | 新疆天山制药工业有限公司 | Method for preparing low-content liquorice extract from acid waste water of glycyrrhizic acid powder |
| CN101878911A (en) * | 2010-06-17 | 2010-11-10 | 新疆天山制药工业有限公司 | Method for preparing low-content liquorice extract from acid waste water of glycyrrhizic acid powder |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108359020A (en) * | 2018-01-18 | 2018-08-03 | 新疆乌拉尔甘草开发有限责任公司 | A kind of isolation and purification method of Radix Glycyrrhizae Thick many candies |
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2003
- 2003-07-07 CN CN 03146259 patent/CN1262288C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101878912A (en) * | 2010-06-17 | 2010-11-10 | 新疆天山制药工业有限公司 | Method for preparing low-content liquorice extract from acid waste water of glycyrrhizic acid powder |
| CN101878911A (en) * | 2010-06-17 | 2010-11-10 | 新疆天山制药工业有限公司 | Method for preparing low-content liquorice extract from acid waste water of glycyrrhizic acid powder |
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| CN1565593A (en) | 2005-01-19 |
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