CN1261071C - 用于对视网膜反射能力改变成象的系统和方法 - Google Patents

用于对视网膜反射能力改变成象的系统和方法 Download PDF

Info

Publication number
CN1261071C
CN1261071C CNB998105465A CN99810546A CN1261071C CN 1261071 C CN1261071 C CN 1261071C CN B998105465 A CNB998105465 A CN B998105465A CN 99810546 A CN99810546 A CN 99810546A CN 1261071 C CN1261071 C CN 1261071C
Authority
CN
China
Prior art keywords
retina
imaging
image
irradiator
retinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB998105465A
Other languages
English (en)
Chinese (zh)
Other versions
CN1316887A (zh
Inventor
阿米兰·格林瓦尔德
达林·纳尔逊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of CN1316887A publication Critical patent/CN1316887A/zh
Application granted granted Critical
Publication of CN1261071C publication Critical patent/CN1261071C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A61B3/1241Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eye Examination Apparatus (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Image Processing (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Electrotherapy Devices (AREA)
CNB998105465A 1998-07-31 1999-07-29 用于对视网膜反射能力改变成象的系统和方法 Expired - Lifetime CN1261071C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL125614 1998-07-31
IL12561498A IL125614A (en) 1998-07-31 1998-07-31 System and method for non-invasive imaging of retinal function

Publications (2)

Publication Number Publication Date
CN1316887A CN1316887A (zh) 2001-10-10
CN1261071C true CN1261071C (zh) 2006-06-28

Family

ID=11071807

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998105465A Expired - Lifetime CN1261071C (zh) 1998-07-31 1999-07-29 用于对视网膜反射能力改变成象的系统和方法

Country Status (10)

Country Link
US (1) US6478424B1 (https=)
EP (1) EP1100370B1 (https=)
JP (1) JP4409091B2 (https=)
CN (1) CN1261071C (https=)
AT (1) ATE218835T1 (https=)
AU (1) AU5063099A (https=)
DE (1) DE69901838T2 (https=)
HK (1) HK1041192B (https=)
IL (1) IL125614A (https=)
WO (1) WO2000006015A1 (https=)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070091265A1 (en) * 2002-01-18 2007-04-26 Kardon Randy H System and method for optical imaging of human retinal function
WO2003061460A2 (en) * 2002-01-18 2003-07-31 Universiy Of Iowa Research Foundation Device and method for optical imaging of retinal function
JP4615865B2 (ja) 2002-04-02 2011-01-19 エダ リサーチ アンド ディベロップメント カンパニー リミティド 静止したバックグラウンド中の移動物質の特徴づけ
US6709109B1 (en) 2002-04-16 2004-03-23 University Of South Florida Differential spectroscopic imaging of the human retina
US7222961B2 (en) * 2002-08-05 2007-05-29 Kestrel Corporation Method for detecting a functional signal in retinal images
EP1592336B1 (en) 2002-12-02 2012-08-22 Yeda Research And Development Co., Ltd. Characterization of arteriosclerosis by optical imaging
JP2004267616A (ja) * 2003-03-11 2004-09-30 Canon Inc 眼科機器
DE10331013A1 (de) * 2003-07-09 2005-03-03 Carl Zeiss Meditec Ag Vorrichtung und Verfahren für ein ophthalmologisches Gerät, vorzugsweise eine Funduskamera
ES2600876T3 (es) 2003-09-04 2017-02-13 The Uab Research Foundation Procedimiento y aparato de detección de adaptación a oscuridad deteriorada
DE10357734B4 (de) * 2003-12-05 2009-10-01 Imedos Gmbh Universelles ophthalmologisches Untersuchungsgerät und ophthalmologisches Untersuchungsverfahren
US7706863B2 (en) 2004-01-21 2010-04-27 University Of Washington Methods for assessing a physiological state of a mammalian retina
US7512436B2 (en) * 2004-02-12 2009-03-31 The Regents Of The University Of Michigan Method of evaluating metabolism of the eye
WO2005084526A1 (ja) * 2004-02-20 2005-09-15 Riken 網膜機能の光学計測方法と装置
DE102004008675B4 (de) * 2004-02-20 2009-05-07 Imedos Gmbh Bildgebendes Verfahren zur Erfassung medizinisch relevanter Unterschiede von Strukturen und Eigenschaften eines Untersuchungsobjektes und dazu geeignete Vorrichtung
JP4458935B2 (ja) * 2004-06-01 2010-04-28 株式会社ニデック 視野計
JP5255277B2 (ja) * 2004-10-05 2013-08-07 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 網膜疾患の検診装置
JP4612396B2 (ja) * 2004-11-10 2011-01-12 株式会社ニデック 網膜機能計測装置
JP4646027B2 (ja) * 2005-03-03 2011-03-09 株式会社ニデック 網膜機能計測装置
JP5079240B2 (ja) * 2006-02-06 2012-11-21 株式会社ニデック 網膜機能計測装置
US8129105B2 (en) 2006-04-13 2012-03-06 Ralph Zuckerman Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy
JP2007319393A (ja) * 2006-05-31 2007-12-13 Nidek Co Ltd 網膜機能計測装置
GB0612096D0 (en) * 2006-06-19 2006-07-26 Greater Glasgow Nhs Board Functional imaging of the retina
DE102006030382A1 (de) * 2006-06-29 2008-01-03 Carl Zeiss Meditec Ag Verfahren und Vorrichtung zur optischen Detektion am Auge
US8155730B2 (en) * 2006-10-24 2012-04-10 The Research Foundation Of State University Of New York Composition, method, system, and kit for optical electrophysiology
ATE492203T1 (de) * 2006-11-02 2011-01-15 Heidelberg Engineering Gmbh Verfahren und gerät zur netzhautdiagnostik
US7648239B2 (en) * 2007-05-01 2010-01-19 Richard Spaide Autofluorescence photography using a fundus camera
WO2008133693A1 (en) * 2007-05-01 2008-11-06 Richard Spaide Autofluorescence photography using a fundus camera
JP2008295971A (ja) * 2007-06-04 2008-12-11 Nidek Co Ltd 眼底カメラ
KR101643953B1 (ko) * 2007-11-13 2016-07-29 더 리젠츠 오브 더 유니버시티 오브 미시건 눈과 관련된 질환을 검출하기 위한 방법 및 장치
US8403862B2 (en) 2007-12-20 2013-03-26 Yeda Research And Development Co. Ltd. Time-based imaging
PL2268193T3 (pl) * 2008-03-27 2017-07-31 Cognoptix, Inc. Obrazowanie oczu w celu wykrywania chorób neurodegeneracyjnych
JP2010172614A (ja) * 2009-01-30 2010-08-12 Topcon Corp 機能イメージング眼科装置
BRPI1006732B8 (pt) * 2009-03-04 2021-06-22 Aaren Scientific Inc lente dimensionada para uso num olho humano
WO2011017550A2 (en) * 2009-08-05 2011-02-10 The Johns Hopkins University Programmable multispectral illumination system for surgery and visualization of light-sensitive tissues
EP2301424B1 (de) * 2009-09-29 2015-07-08 OD-OS GmbH Ophthalmoskop mit einer Laservorrichtung
WO2011059405A1 (en) * 2009-11-12 2011-05-19 Agency For Science, Technology And Research Method and device for monitoring retinopathy
US20120001932A1 (en) * 2010-07-02 2012-01-05 Burnett William R Systems and methods for assisting visually-impaired users to view visual content
AU2011292233B2 (en) 2010-08-16 2015-05-21 Cognoptix, Inc. System and method for detecting amyloid proteins
JP5666206B2 (ja) * 2010-08-31 2015-02-12 株式会社ニデック 視機能検査装置
JP5702991B2 (ja) 2010-11-19 2015-04-15 キヤノン株式会社 画像処理装置及び画像処理方法
GB2500930A (en) 2012-04-05 2013-10-09 Stfc Science & Technology A retinal densitometer
JP6255662B2 (ja) * 2012-11-16 2018-01-10 株式会社ニデック 眼底撮影装置
WO2015095344A1 (en) * 2013-12-17 2015-06-25 University Of Chicago Voltage sensitive composition and method of use thereof
CN105574861B (zh) * 2015-12-14 2018-05-08 上海交通大学 无标记的血流成像方法及系统
EP3332695B1 (en) * 2016-12-09 2021-05-26 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Measurement device
CN108670192B (zh) * 2018-04-21 2019-08-16 重庆贝奥新视野医疗设备有限公司 一种动态视觉刺激的多光谱眼底成像系统及方法
CN109146985B (zh) * 2018-09-09 2019-06-14 深圳硅基仿生科技有限公司 视网膜刺激器的图像处理方法、装置及视网膜刺激器
US11089954B2 (en) 2018-09-21 2021-08-17 MacuLogix, Inc. Method and apparatus for guiding a test subject through an ophthalmic test
FI129056B (en) * 2019-05-31 2021-06-15 Aalto Univ Foundation Sr METHOD AND APPARATUS FOR DETERMINING CHANGES IN THE RETENTAL AND / OR BRAIN TEMPERATURE
EP4445828A4 (en) * 2021-12-07 2025-11-26 Univ Korea Res & Bus Found AUTOFLUORESCENCE IMAGING DEVICE AND ITS OPERATING METHOD, AUTOFLUORESCENCE IMAGE EVALUATION DEVICE AND ITS EVALUATION METHOD

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4569354A (en) * 1982-03-22 1986-02-11 Boston University Method and apparatus for measuring natural retinal fluorescence
US5150292A (en) 1989-10-27 1992-09-22 Arch Development Corporation Method and system for determination of instantaneous and average blood flow rates from digital angiograms
US5186173A (en) 1990-08-14 1993-02-16 Drexel University Method for in vivo measurement of oxygen concentration levels
US5400791A (en) * 1991-10-11 1995-03-28 Candela Laser Corporation Infrared fundus video angiography system
US5485229A (en) 1994-05-24 1996-01-16 Allergan, Inc. Method and apparatus for determining electrical activity in the retinal nerve fiber layer using intrinsic birefringent properties of retinal ganglion cell axons

Also Published As

Publication number Publication date
ATE218835T1 (de) 2002-06-15
EP1100370A1 (en) 2001-05-23
DE69901838T2 (de) 2003-01-30
WO2000006015A1 (en) 2000-02-10
DE69901838D1 (de) 2002-07-18
EP1100370B1 (en) 2002-06-12
CN1316887A (zh) 2001-10-10
IL125614A (en) 2003-01-12
AU5063099A (en) 2000-02-21
US6478424B1 (en) 2002-11-12
IL125614A0 (en) 1999-03-12
JP2002521115A (ja) 2002-07-16
HK1041192A1 (en) 2002-07-05
JP4409091B2 (ja) 2010-02-03
HK1041192B (zh) 2006-12-15

Similar Documents

Publication Publication Date Title
CN1261071C (zh) 用于对视网膜反射能力改变成象的系统和方法
Aitken et al. Use of intrinsic optical signals to monitor physiological changes in brain tissue slices
CA2648931C (en) Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy
US7118217B2 (en) Device and method for optical imaging of retinal function
US9010935B2 (en) Systems and methods for noninvasive analysis of retinal health and function
JP4139563B2 (ja) 血管中の個々の赤血球の動きの画像化および分析
US20100004545A1 (en) Method of Evaluating Metabolism of the Eye
US20070211211A1 (en) method for detecting a functional signal in retinal images
CA2048697A1 (en) Optical imaging system for neurosurgery
Feng et al. In vivo monitoring blood‐brain barrier permeability using spectral imaging through optical clearing skull window
US20140320820A1 (en) Method and device for monitoring retinopathy
Rector et al. In vivo observations of rapid scattered light changes associated with neurophysiological activity
Normann et al. Photoreceptor contributions to contrast sensitivity: Applications in radiological diagnosis
CN107137073A (zh) 一种基于甲壁血流分析的青光眼和糖尿病等微循环系统疾病检测技术
Broendsted et al. Human lens transmission of blue light: a comparison of autofluorescence-based and direct spectral transmission determination
CN119385591B (zh) 一种经眼的黑质多巴胺能神经退变的功能检测系统和方法
US20140364709A1 (en) Non-Invasive Ocular Analyte Sensing System
US8833942B2 (en) Method and device for monitoring retinopathy
Valenti The Anterior Visual System
EP3755994B1 (en) Image-processing apparatus and image-processing method for detection of irregularities in tissue
Uchimura et al. Surround modulation in cortical orientation map revealed by optical imaging and its dependency on receptive field eccentricity
Hipwell Digital angiography in ophthalmology
Tsytsarev et al. Voltage-Sensitive Dye and Intrinsic Signal Optical Imaging: Advantages and Disadvantages for Functional Brain Mapping
Theelen Scanning laser imaging of the retina. Basic concepts and clinical applications
Yao et al. Fast optical recording of light-flash evoked neural activation in amphibian retina

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: YEDA RES & DEV

Free format text: FORMER OWNER: AMIRAM GRINVALD

Effective date: 20021010

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20021010

Address after: Rehovot

Applicant after: Yeda Research and Development Co., Ltd.

Address before: Rehovot

Applicant before: Amiram Grinvald

C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term

Granted publication date: 20060628

CX01 Expiry of patent term